This study integrates sustainability and microbiome science, proposing yeast-based nanotechnology as a biocompatible strategy to address early-life antimicrobial resistance challenges.

This study reveals marine microorganisms as scalable, diverse bioactive sources while highlighting the urgent need for standardized, integrative discovery frameworks.

Marine cyanobacteria and beneficial microbes provide eco-friendly solutions for agriculture, biotechnology, and sustainable industrial applications.

Provides a comprehensive roadmap for novel antimicrobial strategies to combat multidrug-resistant infections and improve patient outcomes.

Marine microbial metabolites offer diverse chemical scaffolds for novel therapeutics addressing antibiotic resistance and emerging diseases.

This work demonstrates that microbiome restoration is central to preventing Clostridioides difficile recurrence and improving sustainable treatment outcomes.

Understanding microbe-mediated predator–prey interactions enables sustainable soil pest management and resilient agroecosystems.

Understanding plant microbiomes enables sustainable, eco-friendly strategies for crop protection and productivity enhancement.

Clarifies how microalgal diversity underpins scalable bioindustrial performance, guiding evidence-based strain selection, process optimization, and sustainable biotechnology deployment worldwide development.

Marine actinobacteria offer resistance-aware, microbiome-friendly therapeutic pathways to address acne vulgaris amid rising antibiotic failure.

Harnessing microbial biosynthetic diversity provides sustainable pathways for discovering novel bioactive compounds with pharmaceutical and industrial applications.

Integrating novel targets, advanced technologies, and underexplored ecosystems is essential to overcome antimicrobial resistance and revive antibiotic discovery.

This review clarifies how structurally diverse natural products selectively target cancer cells and microbial virulence pathways absent in humans.

Marine microbiomes offer a statistically validated and underexplored pathway for accelerating bioactive compound discovery through genome-enabled strategies.

Marine-derived bioactive compounds offer sustainable, effective alternatives to chemical algicides and antimicrobial agents with minimal ecological impact.

Understanding hvAB mechanisms informs treatment strategies and guides development of targeted interventions against multidrug-resistant, hypervirulent pathogens.

This review highlights aromatic polyketides as scalable, genome-enabled solutions for overcoming antimicrobial resistance and revitalizing antibiotic discovery pipelines.

Targeting polymicrobial oral biofilms with novel natural and engineered therapies offers sustainable solutions against escalating antimicrobial resistance.

Understanding microalgal metabolite responses aids sustainable biotechnology and environmental adaptation strategies.

This study integrates ecological and human health evidence, clarifying how microcystins move through agricultural systems and influence environmental and public health risks.

Understanding fungal diversity supports sustainable agriculture, human nutrition, and the development of innovative biotechnological applications.

This study provides quantitative evidence linking enzyme function and marine diversity to enhanced carotenoid yields, guiding targeted metabolic engineering strategies for industry.

This review demonstrates sustainable enzyme production from agro-industrial waste via solid-state fermentation, advancing circular bioeconomy, waste valorization, and eco-friendly bioremediation technologies.

This study, integrating thermodynamic principles, metabolic engineering, and microbial consortia, provides innovative strategies to enhance microbial biofuel productivity and sustainability.

The systematic exploration of bioactive secondary metabolites (SMs) holds critical significance for medicine, agriculture, and biotechnology. These metabolites represent a treasure trove of structurally diverse molecules with the potential to address urgent global health challenges,

Mapping microbial and human genomic dark matter enables targeted therapeutics and sustainable biotechnological innovations.