Microbial Bioactives

Brandenburg, K. M., Krock, B., Klip, H. C. L., Sluijs, A., Garbeva, P., & Van de Waal, D. B. (2021). Intraspecific variation in multiple trait responses of Alexandrium ostenfeldii towards elevated pCO(2). Harmful Algae, 101, 101970. https://doi.org/10.1016/j.hal.2020.101970

Burgunter-Delamare, B., et al. (2024). Exchange or eliminate: The secrets of algal-bacterial relationships. Plants, 13(6), 829. https://doi.org/10.3390/plants13060829

Chen, Y., et al. (2025). Microorganisms in macroalgae cultivation ecosystems: A systematic review and future prospects based on bibliometric analysis. Microorganisms, 13(5), 1110. https://doi.org/10.3390/microorganisms13051110

Errera, R. M., Yvon-Lewis, S., Kessler, J. D., & Campbell, L. (2014). Responses of the dinoflagellate Karenia brevis to climate change: pCO2 and sea surface temperatures. Harmful Algae, 37, 110–116.
https://doi.org/10.1016/j.hal.2014.05.012

Garel, M., et al. (2019). Pressure-retaining sampler and high-pressure systems to study deep-sea microbes under in situ conditions. Front. Microbiol., 10, 453. https://doi.org/10.3389/fmicb.2019.00453

Gordon, B. R., & Leggat, W. (2010). Symbiodinium-invertebrate symbioses and the role of metabolomics. Marine Drugs, 8(10), 2546–2568. https://doi.org/10.3390/md8102546

Goulitquer, S., et al. (2012). Mass spectrometry-based metabolomics to elucidate functions in marine organisms and ecosystems. Marine Drugs, 10(4), 849–880. https://doi.org/10.3390/md10040849

Gusmão, A. C. B., et al. (2023). Microbial communities in the deep-sea sediments of the South São Paulo Plateau. Int. Microbiol., 26, 1041–1051. https://doi.org/10.1007/s10123-023-00358-w

Hattenrath-Lehmann, T. K., Smith, J. L., Wallace, R. B., Merlo, L., Koch, F., Mittelsdorf, H., Goleski, J. A., Anderson, D. M., & Gobler, C. J. (2015). The effects of elevated CO(2) on the growth and toxicity of field populations and cultures of the saxitoxin-producing dinoflagellate, Alexandrium fundyense. Limnology and Oceanography, 60(1), 198–214. https://doi.org/10.1002/lno.10012

Inwongwan, S., et al. (2025). Metabolomic insights into the adaptations and biotechnological potential of Euglena gracilis under different trophic conditions. Plants, 14(11), 1580. https://doi.org/10.3390/plants14111580

IPCC. (2019). IPCC Special Report on the Ocean and Cryosphere in a Changing Climate. Cambridge University Press.

Kiruba, N. J. M., & Saeid, A. (2022). An insight into microbial inoculants for bioconversion of waste biomass into sustainable "bio-organic" fertilizers. International Journal of Molecular Sciences, 23(21), 13049. https://doi.org/10.3390/ijms232113049

Lauritano, C., et al. (2020). Physiological and molecular responses to main environmental stressors of microalgae and bacteria in polar marine environments. Microorganisms, 8(12), 1957. https://doi.org/10.3390/microorganisms8121957

Lian, Z., Li, F., He, X., Chen, J., & Yu, R.-C. (2022). Rising CO2 will increase toxicity of marine dinoflagellate Alexandrium minutum. Journal of Hazardous Materials, 431, 128627. https://doi.org/10.1016/j.jhazmat.2022.128627

Lyon, B. R., & Mock, T. (2014). Polar microalgae: New approaches towards understanding adaptations to an extreme and changing environment. Biology, 3(1), 56–80. https://doi.org/10.3390/biology3010056

Mazard, S., et al. (2016). Tiny microbes with a big impact: The role of cyanobacteria and their metabolites in shaping our future. Marine Drugs, 14(5), 97. https://doi.org/10.3390/md14050097

Moore, S. K., et al. (2021). An autonomous platform for near real-time surveillance of harmful algae and their toxins in dynamic coastal shelf environments. J. Mar. Sci. Eng., 9, 336. https://doi.org/10.3390/jmse9030336

Nouri, M. Z., et al. (2015). Abiotic stresses: Insight into gene regulation and protein expression in photosynthetic pathways of plants. International Journal of Molecular Sciences, 16(9), 20392–20416. https://doi.org/10.3390/ijms160920392

Novosel, N., et al. (2022). Temperature-induced response in algal cell surface properties and behaviour. J. Appl. Phycol., 34, 243–259. https://doi.org/10.1007/s10811-021-02591-0

Obata, T., et al. (2013a). Gas-chromatography mass-spectrometry (GC-MS) based metabolite profiling reveals mannitol as a major storage carbohydrate in the coccolithophorid alga Emiliania huxleyi. Metabolites, 3(1), 168–184. https://doi.org/10.3390/metabo3010168

Obata, T., et al. (2013b). The central carbon and energy metabolism of marine diatoms. Metabolites, 3(2), 325–346. https://doi.org/10.3390/metabo3020325

Rojas-Villalta, D., et al. (2023). Insights into co-cultivation of photosynthetic microorganisms for novel molecule discovery and enhanced production of specialized metabolites. Fermentation, 9(11), 941. https://doi.org/10.3390/fermentation9110941

Saini, D. K., et al. (2024). Microalgal metabolomes and recent biotechnological advances for their industrial application. Microbiol. Res., 15, 2056–2069. https://doi.org/10.3390/microbiolres15040138

Salman, I., et al. (2022). Multi-modal lake sampling for detecting harmful algal blooms. OCEANS 2022. https://doi.org/10.1109/OCEANS47191.2022.9977137

Sanchez-Arcos, C., et al. (2022). Responses of the macroalga Ulva prolifera Müller to ocean acidification revealed by complementary NMR- and MS-based omics approaches. Marine Drugs, 20(12), 743. https://doi.org/10.3390/md20120743

Schwarz, D., et al. (2013). Recent applications of metabolomics toward cyanobacteria. Metabolites, 3(1), 72–100. https://doi.org/10.3390/metabo3010072

Sellanes, J., et al. (2021). A new threat to local marine biodiversity: Filamentous mats proliferating at mesophotic depths off Rapa Nui. PeerJ, 9, e12052. https://doi.org/10.7717/peerj.12052

Sun, J., Hutchins, D. A., Feng, Y., Seubert, E. L., Caron, D. A., & Fu, F.-X. (2011). Effects of changing pCO2 and phosphate availability on domoic acid production and physiology of the marine harmful bloom diatom Pseudo-nitzschia multiseries. Limnology and Oceanography, 56(3), 829–840. https://doi.org/10.4319/lo.2011.56.3.0829

Tatters, A. O., Flewelling, L. J., Fu, F., Granholm, A. A., & Hutchins, D. A. (2013). High CO2 promotes the production of paralytic shellfish poisoning toxins by Alexandrium catenella from Southern California waters. Harmful Algae, 30, 37–43. https://doi.org/10.1016/j.hal.2013.08.007

Temkin, M. I., et al. (2019). High throughput co-culture assays for the investigation of microbial interactions. J. Vis. Exp., 152, e60275. https://doi.org/10.3791/60275

Thangaraj, S., et al. (2019). Quantitative proteomic analysis reveals novel insights into intracellular silicate stress-responsive mechanisms in the diatom Skeletonema dohrnii. International Journal of Molecular Sciences, 20(10), 2540. https://doi.org/10.3390/ijms20102540

Tsui, T.-K. V., & Kong, H.-K. (2023). Metabolomics approach to reveal the effects of ocean acidification on the toxicity of harmful microalgae: A review of the literature. AppliedChem, 3(1), 169–195. https://doi.org/10.3390/appliedchem3010012

Van de Waal, D. B., Eberlein, T., John, U., Wohlrab, S., & Rost, B. (2014). Impact of elevated pCO(2) on paralytic shellfish poisoning toxin content and composition in Alexandrium tamarense. Toxicon, 78, 58–67. https://doi.org/10.1016/j.toxicon.2013.11.011

Wingert, C. J., & Cochlan, W. P. (2021). Effects of ocean acidification on the growth, photosynthetic performance, and domoic acid production of the diatom Pseudo-nitzschia australis from the California Current System. Harmful Algae, 107, 102030.
https://doi.org/10.1016/j.hal.2021.102030

Wohlrab, S., John, U., Klemm, K., Eberlein, T., Forsberg Grivogiannis, A. M., Krock, B., Frickenhaus, S., Bach, L. T., Rost, B., Riebesell, U., et al. (2020). Ocean acidification increases domoic acid contents during a spring to summer succession of coastal phytoplankton. Harmful Algae, 92, 101697.
 https://doi.org/10.1016/j.hal.2019.101697

Yu, Y., et al. (2013). Development of Synechocystis sp. PCC 6803 as a phototrophic cell factory. Marine Drugs, 11(8), 2894–2916. https://doi.org/10.3390/md11082894

Zammit, G., Zammit, M. G., & Buttigieg, K. G. (2023). Emerging technologies for the discovery of novel diversity in cyanobacteria and algae and the elucidation of their valuable metabolites. Diversity, 15(11), 1142. https://doi.org/10.3390/d15111142