Latest Issue - Volume 9 Number 1 2025
Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health,
Integrative Biomedical Research
Volume 9 Number 1 2025
Table of Contents
Case Study
Biomedical sciences
Shanmathi R1, Rajprabha2, Prem kumar J3, Rajashree V 4*
This case determines the rare occurrence of thrombotic microangiopathy in dengue fever, emphasizing the need for awareness and early diagnosis.
Abstract | Full Text |PDF (129 KB) | Open Access Article
Ramesh T V1, Gopi Ayyaswamy2, Zioni Sangeetha3 and Vinod Kumar P 4*
This case determines the importance of early diagnosis and treatment of rare cold agglutinin-induced hemolytic anemia in systemic lupus erythematosus.
Abstract | Full Text |PDF (140 KB) | Open Access Article
Kannan N1, Prabhu K2, Jamunarani A3, Thatiparthi Stephen*4
This case determines the rare but critical progression from localized Bullous Impetigo to severe Staphylococcal Scalded Skin Syndrome, emphasizing the importance of vigilant diagnosis and timely treatment.
Abstract | Full Text |PDF (125 KB) | Open Access Article
Rare Case of Mature Teratoma in the Greater Omentum: Diagnostic and Surgical Challenges
Brigida S 1, Parijatham S 2, Lakshmi Prabha M 3, Saravanan K 4*
This rare case of greater omental teratoma determines diagnostic challenges and underscores the importance of surgical intervention for accurate diagnosis and treatment.
Abstract | Full Text |PDF (132 KB) | Open Access Article
Sushma1, Nandipatti2, Mary Chandrika3, Aljin V 4*
This case determines the importance of recognizing clinical and radiological features of RCDP for early diagnosis in limited-resource settings.
Abstract | Full Text |PDF (140 KB) | Open Access Article
The Complexities of Neuropsychiatric Lupus: Pathogenesis, Diagnosis, and Management
Ramesh T V1, Gopi Ayyaswamy2, Zioni Sangeetha3, Vinod Kumar P 4*
This case determines the critical need for early diagnosis and aggressive treatment of CNS vasculitis in SLE to achieve remission.
Abstract | Full Text |PDF (215 KB) | Open Access Article
Vidhya N1, Durga Devi G2, Shenbaga Lalitha S3, Swetha N B4
This study shows a rare co-infection of scrub typhus and CMV encephalitis in immunosuppressed patients, underscoring diagnostic challenges and treatment strategies.
Abstract | Full Text |PDF (384 KB) | Open Access Article
Yogarajan R 1, Jayakumari S 2, Sumathi K 3, Mohan Kumar P R 4*
This case showed the necessity of thorough diagnostic reevaluation in persistent asthma to uncover potential alternative diagnoses like carcinoid tumors.
Abstract | Full Text |PDF (127 KB) | Open Access Article
Early Diagnosis and Management of Neonatal Acute Hematogenous Osteomyelitis: A Case Report
Sushma1, Nandipatti2, Mary Chandrika3, Aljin V*4
This study determines the importance of early diagnosis and aggressive treatment in neonatal acute hematogenous osteomyelitis to prevent severe complications.
Abstract | Full Text |PDF (140 KB) | Open Access Article
Ramya Ravichandar1, Rajam Krishna S2, Priya Sivashankar3, and Sujai Anand*4
This case determines a rare co-occurrence of gastric adenocarcinoma in a TSC patient, urging consideration of malignancies in TSC management.
Abstract | Full Text |PDF (282 KB) | Open Access Article
Ramya Ravichandar1, Rajam Krishna S2, Priya Sivashankar3, Sujai Anand*4
This study shows rare spontaneous conception in mosaic Turner syndrome, emphasizing early fertility counseling and multidisciplinary pregnancy management.
Abstract | Full Text |PDF (132 KB) | Open Access Article
Cardiovascular Manifestations of Leptospirosis: A Case of Myopericarditis in an Endemic Region
Jayakanthan S 1, Manimaran R 1, Sathyanarayanan M 1*, Bharathi Raja K 1
This study showed the need for cardiovascular evaluation in leptospirosis patients, especially in endemic areas, to prevent severe cardiac complications.
Abstract | Full Text |PDF (130 KB) | Open Access Article
Vishnuvarthan R S 1, Valarmathy M 1, Suresh Babu P 1*, Karthikeyan C T 1
This case showed the critical need for differential diagnosis between acute aortic syndrome and myocardial ischemia to ensure timely and effective treatment.
Abstract | Full Text |PDF (127 KB) | Open Access Article
Nikath Nasreen N 1, Kaavya M 1, Logeswari B M 1, Blessy John 1*
This case showed the need for awareness of rare myocardial infarction causes, such as coronary artery dissection and heparin-induced thrombocytopenia, highlighting complex diagnostic and management challenges.
Abstract | Full Text |PDF (137 KB) | Open Access Article
Catastrophic Colorectal Injuries Due to Misuse of Compressed Air: A Case Report and Review
Pugazharasan M 1, Aluru Jayakrishna Reddy 1, Manikandan R S 1, Arul M 1*
This case describes the severe risks of using compressed air for sexual stimulation, highlighting the urgent need for improved safety awareness and preventive measures.
Abstract | Full Text |PDF (305 KB) | Open Access Article
Lakshmi K 1, Dinesh K 1, Bindu D 1*, Sharanya K 1
Early diagnosis and surgical management of Familial Adenomatous Polyposis (FAP) are crucial for preventing colorectal cancer, highlighting the need for vigilant surveillance and timely intervention.
Abstract | Full Text |PDF (135 KB) | Open Access Article
Pugazharasan M 1, Aluru Jayakrishna Reddy 1, Manikandan R S 1, Arul M 1*
Early diagnosis and surgical intervention in congenital glaucoma are crucial to preventing irreversible vision loss in pediatric patients.
Abstract | Full Text |PDF (687 KB) | Open Access Article
Lakshmi K 1, Dinesh K 1, Bindu D 1*, Sharanya K 1
This case report determined the complexity of diagnosing and managing GBS in immunocompromised patients, highlighting the critical role of parvovirus B19 in such cases and emphasizing the need for comprehensive viral investigations.
Abstract | Full Text |PDF (131 KB) | Open Access Article
Srivalsa Bhaskaran 1, Kamaal Mohideen Khan 1, Karthik V 1, Mani Shanthini 1*
This case showed the reversible nature of renal impairment in hypothyroidism, emphasizing the importance of timely thyroid hormone replacement therapy.
Abstract | Full Text |PDF (124 KB) | Open Access Article
Scurvy in a Pediatric Patient with Restrictive Eating for Dietary Management - Case Study
Sri vamsi krishna 1, Nabeel Nazeer 1, Bharath A S 1, Magesh C 1*
This case determined the importance of addressing restrictive eating patterns and dietary limitations in children, particularly those with special needs, to prevent vitamin C deficiency and support overall health.
Abstract | Full Text |PDF (131 KB) | Open Access Article
Research Article
Biomedical sciences
Antioxidant Effects of Ocimum tenuiflorum on Catalase and Glutathione Peroxidase In Vivo
Pande Ayu Naya Kasih Permatananda1,2*, I Wayan Sumardika2, I Wayan Putu Sutirta Yasa2, Made Ratna Saraswati2, I Gde Suranaya Pandit3, Sri Masyeni1
This study demonstrated Ocimum tenuiflorum’s antioxidant potential, enhancing catalase and glutathione peroxidase activities in diabetic mice to mitigate oxidative stress.
Abstract | Full Text |PDF (184 KB) | Open Access Article
S. Ariffa Begum1*, J. Raja2, N. Srinivas3, R. Nagendran4, G. Umamaheswari5, Srithar S6
PA-C-AI enhances angiogenesis prediction, enabling precise cancer therapies and personalized treatments, improving patient outcomes and survival rates.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Veera V Rama Rao M1*, Savitha. S2, Kumar Akuthota3, Pathan Firoze Khan4, Navyatha R5, Srithar S6
AI-driven models enhance cancer diagnostics, personalized treatment, and biomarker discovery, transforming precision oncology and patient care outcomes.
Abstract | Full Text |PDF (231 KB) | Open Access Article
Association of Serum Vitamin D Levels with Inflammatory Markers in Hospitalized COVID-19 Patients
Mohammad Esmaeil Hejazi 1*, Hoorieh Shojaan1, Niusha Kalami, Babak Alinejati1, Veghar Hejazi2, Akbar Javan Biparva3
This study determined no significant link between serum Vitamin D levels and COVID-19 mortality, except with LDH.
Abstract | Full Text |PDF (175 KB) | Open Access Article
S. Alagumuthukrishnan 1* , Ganga Sanuvala 1, Bibiana Jenifer J 2, M.J.D Ebinezer 3, B Veda Vidhya 4, Srithar S 5
This review discusses the understanding the interplay of angiogenesis and Aβ in Alzheimer’s could lead to innovative AI-driven diagnostics, enhancing early intervention strategies.
Abstract | Full Text |PDF (771 KB) | Open Access Article
Mario Hendri RW1*, Heroe Soebroto 1, Ito Puruhito 1
This study showed optimal decellularization methods for enhancing porosity and pore size in bovine pericardium scaffolds, crucial for pediatric heart surgery.
Abstract | Full Text |PDF (454 KB) | Open Access Article
Yuvaraja M 1*, R. Ramesh 2, R. Priya 3, J. Dhanasekar 4
This study enhances healthcare with WBSN-PHMS, enabling continuous, real-time monitoring and early detection while optimizing energy use.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Deep Learning, Particularly Convolutional Neural Network, Improves Melanoma Detection Accuracy
Adnan R. Ahmad 1*
This study demonstrated how deep learning, particularly CNNs, improves melanoma detection accuracy, supporting earlier diagnosis and better patient outcomes.
Abstract | Full Text |PDF (392 KB) | Open Access Article
Enhanced Cardiovascular Monitoring Using Radial Basis Function and Deep Belief Network Fusion
Srinivas Naveen Dolu Surabhi 1*, R.Saraswathi 2, S. Sugantha Priya 3, M. Indirani 4, Neeraj Kumar 5, S. Senthil Kumar 6
Combining RBF and DBN improves real-time cardiovascular monitoring by enhancing feature extraction and classification accuracy, addressing limitations of conventional methods.
Abstract | Full Text |PDF (427 KB) | Open Access Article
C V Keerthi Latha 1*, M Kezia Joseph 1*
Early seizure prediction via EEG signals might enable timely intervention, potentially improving patient outcomes and reducing clinical risks.
Abstract | Full Text |PDF (319 KB) | Open Access Article
Nameer Fadhel 1* Duraid Hameed AbidAlkadem 1* , Sahar Fawzi Abdulla 2
This study showed normative ranges for MMO and explored correlations with neck circumference in young Iraqi adults. It enhances mandibular health assessment precision and clinical outcomes.
Abstract | Full Text |PDF (196 KB) | Open Access Article
T. Sangeetha 1*, K. Manikandan 1, D. Victor Arokia Doss 2
This study determined an advanced deep learning model optimized for early and accurate cardiomyopathy classification, addressing issues like overfitting and high dimensionality in gene expression data.
Abstract | Full Text |PDF (603 KB) | Open Access Article
R. Shiva Kumar 1, Joseph Prakash Mosiganti 2*
This study determined leukemia diagnostics by leveraging EfficientNetB3's transfer learning, improving accuracy and efficiency in blast cell classification.
Abstract | Full Text |PDF (531 KB) | Open Access Article
spo0A Gene Determination in Spore-Forming Bacteria Infections
Shler Ali Khorsheed 1*
Understanding and identifying spore-forming bacteria in surgical wounds can enhance infection control and treatment in healthcare settings.
Abstract | Full Text |PDF (238 KB) | Open Access Article
Fitriana Fitriana 1, 5, Sri Sulistyowati 1, 2*, Dono Indarto 1, 3 , Soetrisno Soetrisno 1, 4
Kopyor Coconut Water showed potential in reducing preeclampsia symptoms by modulating autophagy and apoptosis, suggesting therapeutic benefits.
Abstract | Full Text |PDF (393 KB) | Open Access Article
Tanzil al Hair1*, Wachyu Hadisaputra2*, Soegiharto Soebijanto3*, Primariadewi Rustamadji4
Early laparoscopic cystectomy for endometriomas, especially before 4 cm diameter, preserves ovarian function, preventing significant AMH decline and reducing long-term fertility risks.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Ensemble Deep Learning based Lung Cancer Classification Model using Gene Expression Data
V. Yuvaraj 1*, D. Maheswari 2
Precision medicine, microarray analysis, ensemble learning, and deep neural networks revolutionize lung cancer diagnosis, enhancing accuracy and treatment efficacy.
Abstract | Full Text |PDF (633 KB) | Open Access Article
Elytrigia Repens Extracts Control Urban Mosquito Vectors with a Larvicidal Potential
Prakash D 1*, Mohideen Abdulkader M 1, Sakthivel D 1, Manju I 1, Sreenivasan K S 1, Manikandan S 2
This study demonstrated larvicidal activity to prevent mosquito disease and its spread, which might be due to insecticidal phytocompounds in the extract.
Abstract | Full Text |PDF (307 KB) | Open Access Article
Inflammatory Modulation of Interleukin-17 and -23 in Long COVID Diabetic Patients
Esra Hassan Abd Ali 1*
The global COVID-19 pandemic disrupted daily life. This study demonstrated Long COVID's severity, especially in diabetic individuals, highlighting inflammation's crucial role.
Abstract | Full Text |PDF (246 KB) | Open Access Article
Abdulah Y. Al-Mahdi 1, Alabed Ali A. Alabed 2, Hana W. Jun Chen1, Mohammed Faez Baobaid 1, Sakina Ruhi 1, Jegathambigai Rameshwar Naidu 1, Mukti Nor Ashikeen 1, Husni Ahmed Abdullah Al-Goshae 1, Imad I. Al-Sultan1, Mahfoud A.M. Abdulghani 1, Abusif Sonousi 3, Elan Selvi Anandan 4, Belqes Hamood Serag 5
This research showed that essential oils derived from medicinal plants are antibiotic-resistant by exhibiting strong antibacterial activity against multidrug-resistant pathogens, suggesting potential alternative options against antibiotic resistance.
Abstract | Full Text |PDF (480 KB) | Open Access Article
In vitro Cytotoxicity of Activated Carbon from Musa Acuminate Fruit Peel Against HepG-2 Cells
Shanmugasundaram M 1, Prasath S 2, Geetha N B 2, Manikandan S 2
Activated carbon from Musa Acuminate exhibits potent inhibitory effects on HepG-2 cells via ROS-mediated MTD pathway, suggesting therapeutic potential against cancer.
Abstract | Full Text |PDF (519 KB) | Open Access Article
Geetha N B 1, Priya R 1, Weslin D 1, Ashmi Christus A T 2
The study of anti-cancer properties of Actinidia deliciosa methanol extract in Colorectal cancer as effective treatments.
Abstract | Full Text |PDF (330 KB) | Open Access Article
Geetha N B 1*, Chintala Venkatesh 1, Suresh M 1, Manikandan S 2
Allium ascalonicum might be a safer, more effective alternative to toxic chemotherapy for combating cancer with targeted potency.
Abstract | Full Text |PDF (266 KB) | Open Access Article
Kartheeswari 1, Archana C 1, Anupreyaa K 1, Saranya M 2
Assessment of A. deliciosa extracts' anticancer potential on MCF-7 cells offers insights for natural cancer medication development
Abstract | Full Text |PDF (411 KB) | Open Access Article
Eman Salem Algariri 1,2, Rabiatul Basria S. M. N. Mydin 1*, Emmanuel Jairaj Moses 1, Nur Arzuar Abdul Rahim 3, Narazah Mohd Yusoff 3
STIM1's potential role in promoting AML-M2 cell survival by regulating calcium/ROS interactions, as well as KRAS/MAPK and Akt-related pathways
Abstract | Full Text |PDF (604 KB) | Open Access Article
Bootan A. Salih 1,*, Omer Q. Allela 2, Raad A Kaskoos 3, Javed Ahamad 4
The main goal of the study is to design an intervention program to increase knowledge attitude and practice of healthcare practitioners towards pharmacovigilance.
Abstract | Full Text |PDF (738 KB) | Open Access Article
Pomegranate Juice Attenuates Anti-ulcer in Indomethacin-induced Peptic Ulcer
Ali Omar Yaseen 1, Payam Jamal Muhamed 1, Hacer Haltas 1 , Subasini Uthirapathy 1*
Study on using pomegranate juice supplements to treat ulcers caused by pain medications.
Abstract | Full Text |PDF (489 KB) | Open Access Article
Lee Wei Zheng1,2, Rabiatul Basria S. M. N. Mydin1*, Adam Azlan1,5 and Muhamad Yusri Musa3,4
Abstract | Full Text |PDF (389 KB) | Open Access Article
Assessing Knowledge Gaps on Diabetes Prevention Among Biology Graduates: A Study in Pondicherry
Samyuktha P 1, Pugazharasan 1*, Kuberan 1
This study determined critical gaps in preventive diabetes knowledge among biology graduates, highlighting the need for improved educational strategies on root causes and prevention.
Abstract | Full Text |PDF (138 KB) | Open Access Article
Bharathwaj D K 1*, Indhumathi Krishnaswamy 1, Arun Shriram A 1, Shreevithya D 1
This study showed the superior functional recovery and reduced complications associated with bipolar hemiarthroplasty compared to Austin Moore prostheses in elderly patients.
Abstract | Full Text |PDF (265 KB) | Open Access Article
Umashankar R 1, Sundarrajan K 1, Anupama K A 1, Prathiba B 1*
This study showed insights into SSI rates, associated risk factors, and microbial profiles, informing targeted interventions to improve surgical outcomes and infection control.
Abstract | Full Text |PDF (168 KB) | Open Access Article
Nandini M S 1, Priya Santharam 1, Bindu D 1*, Priya V 1
GGT showed high sensitivity and specificity for diagnosing metabolic syndrome, aiding early detection and management to reduce cardiovascular risks.
Abstract | Full Text |PDF (147 KB) | Open Access Article
Dental Office Noise as Key Trigger of Anxiety in Children, Advocates Non-Invasive Solutions
Bhaskaran Sathyapriya1, Swamikannu Bhuminathan, 2 Jayesh S Raghavendra3*, Adugula Chandrakala 4, Geo Danny C5, Vignesh N R5
This study showed noise as a significant trigger of dental anxiety in children, suggesting non-invasive techniques to enhance pediatric dental care.
Abstract | Full Text |PDF (358 KB) | Open Access Article
Extract of Urgenia grandiflora inhibited breast cancer cell (MCF-7) proliferation and tumorgenesity
Ibrahim B. E. El Bashir A,B, Loiy Elsir Ahmed HassanC, Amin M. S. Abdul Majid D, Sakina Yagi A*
U. grandiflora could be a new source of chemotherapeutic for breast cancer.
Abstract | Full Text |PDF (3 MB) | Open Access Article
Li-xin XU A, Xiao-bo XIA B, Aman Shah Abdul Majid C, Dan Ji B
This study provides insight to EDHF-mediated vasomotor response, as well as various eye disorders caused by dysfunctional retinal arteries, like central retinal artery occlusion.
Abstract | Full Text |PDF (971 KB) | Open Access Article
Reviews
Biomedical sciences
Mohosin Kabir 1*, Md. Refayet Hossen Rana 2, Arnab Debnath 3
This study highlights the role of Quality Assurance in ensuring product integrity, patient safety, and driving pharmaceutical innovation.
Abstract | Full Text |PDF (334 KB) | Open Access Article
Ishita Singha1, Bani Kumar Jana1, Niva Rani Gogoi1, Hemanta Pathak1, Mohini Singh1, Bhaskar Mazumder1*
This review discusses the use of gelatin sponges for safer, more effective, and affordable wound dressings for improved clinical outcomes.
Abstract | Full Text |PDF (334 KB) | Open Access Article
P. Daniel Sundarraj 1*, J. Raja2, R. Usha3, Arul Kumar V P4, N Sirisha5, Srithar S6
AI-driven insights into angiogenesis and inflammation can revolutionize disease prediction, biomarker discovery, and personalized therapeutic interventions.
Abstract | Full Text |PDF (413 KB) | Open Access Article
Anastasia V. Poznyak 1*, Alexey V. Churov 2,3, Irina Alexandrovna Starodubtseva 4, Natalia V. Elizova 2, Tatiana Ivanovna Kovyanova 1,3, Vasily N. Sukhorukov 3, and Alexander N. Orekhov 3
This review describes the understanding of atherosclerosis through animal models aids in revealing disease mechanisms, testing treatments, and improving therapeutic strategies for humans.
Abstract | Full Text |PDF (968 KB) | Open Access Article
Anastasia V. Poznyak 1*, Nikolay A. Orekhov 3, Dmitry Felixovich Beloyartsev 5, Alexey V. Churov 3,6, Tatiana Ivanovna Kovyanova 1,3, Irina Alexandrovna Starodubtseva 4, Vasily N. Sukhorukov 3, Alexander N. Orekhov 3
Understanding how mitochondrial dysfunction contributes to immune dysregulation in Sjögren’s Syndrome may lead to new treatment strategies targeting mitochondrial function and immune responses.
Abstract | Full Text |PDF (228 KB) | Open Access Article
Ancient DNA studies: Common limitations and Genotyping
Anastasia V. Poznyak 1*, Nikolay A. Orekhov 2, Tatiana Ivanovna Kovyanova 1,3, Irina Alexandrovna Starodubtseva 4, Natalia V. Elizova 2, Vasily N. Sukhorukov 3, Alexander N. Orekhov 3
Mapping human genes transformed genomic research, revealing human evolution, disease susceptibility, and ethical challenges in ancient DNA studies.
Abstract | Full Text |PDF (188 KB) | Open Access Article
The cGAS–STING Pathway is A Source of Potential Therapeutic Targets for Atherosclerosis Treatment
Anastasia V. Poznyak 1*, Nikolay A. Orekhov 2, Tatiana Ivanovna Kovyanova 1,3, Irina Alexandrovna Starodubtseva 4, Natalia V. Elizova 2, Vasily N. Sukhorukov 3, Alexander N. Orekhov 3
cGAS-STING's role in DNA detection illuminates innate immunity's mechanisms, demonstraing novel antiviral and therapeutic strategies.
Abstract | Full Text |PDF (322 KB) | Open Access Article
Exploring the Complex Interactions Between COVID-19, Oxidative Stress, and Cancer Susceptibility
Nurhani Jamali1, Rabiatul Basria S. M. N. Mydin1,2*, Nur Hakimah Abu Mansor2
Oxidative stress in COVID-19 causes disease severity, induces inflammation, and may increase post-infection cancer risks through DNA damage.
Abstract | Full Text |PDF (193 KB) | Open Access Article
M. Lincy Jacquline 1*, N. Sudha 1
This study determined advanced AI techniques for accurate CKD diagnosis, enhancing medical decision-making through efficient data analysis methods.
Abstract | Full Text |PDF (626 KB) | Open Access Article
Tasbir Amin 1, Nusrat Jerin 1, Md Fakruddin 1, Jinath Sultana Jime 1, Nayeema Bulbul 1, Sadaf Saaz Siddiqi 2, S M Bakhtiar UL Islam 1*
Diffuse glioma, notably glioblastoma, poses immense treatment challenges due to its invasiveness, genetic variability, and resistance, necessitating innovative therapeutic strategies.
Abstract | Full Text |PDF (819 KB) | Open Access Article
Oluwafemi Shittu Bakare 1*, Alonge Oluwatominsin Mary 1
This review describes hops' traditional medicinal uses and their emerging biomedical applications, emphasizing their anti-inflammatory, antioxidant, and chemopreventive potential.
Abstract | Full Text |PDF (918 KB) | Open Access Article
Anastasia Vladimirovna Poznyak 1, Victoria A. Khotina 2,3, Mikhail ?lexandrovich Popov 2, Nikolay Alexandrovich Orekhov 2, Vasily Nikolaevich Sukhorukov 2,4, Dmitry Felixovich Beloyartsev 5, Alexander Nikolaevich Orekhov 2,3
This comprehensive review elucidates NAFLD's intricate link to atherosclerosis, highlighting shared pathogenic mechanisms and proposing innovative therapeutic strategies.
Abstract | Full Text |PDF (1 MB) | Open Access Article
HDL Cholesterol And Female Infertility: Lessons From Animal Models
Anastasia V. Poznyak 1*, Igor A. Sobenin 2, Victor Y Glanz 2, Victoria A. Khotina 2, Vasily N. Sukhorukov 1, and Alexander N. Orekhov 1
This review describes HDL metabolism's role in oocyte quality and female fertility offers insights for targeted interventions and personalized treatments in reproductive medicine.
Abstract | Full Text |PDF (821 KB) | Open Access Article
Mitochondria in Endothelial Dysfunction and The Relation to Cardiovascular Disease
Anastasia V Poznyak 1*, Victoria A. Khotina 2, Vasily N Sukhorukov 2, Igor A. Sobenin 2, Mikhail A. Popov 2, Anton Y. Postnov 2, and Alexander N. Orekhov 2,*
This review discusses the mitochondria's role in endothelial function informs strategies for preventing cardiovascular diseases through targeted interventions on mitochondrial health
Abstract | Full Text |PDF (577 KB) | Open Access Article
Anastasia V. Poznyak 1*, Victoria A. Khotina 2, Roghayyeh Vakili-Ghartavol 3, Alexander L Golovyuk 4, Dmitriy Yu Serdyukov 5, Victor Y Glanz 2, Vasily N. Sukhorukov 2, Alexander N. Orekhov 2*
Curcumin has various pharmacological effects on atherosclerosis. This review discussed the promising therapeutic potential, of curcumin as anti-inflammatory, lipid regulation, and endothelial function for cardiovascular disease.
Abstract | Full Text |PDF (863 KB) | Open Access Article
Radhika R. 1*, Rashima Mahajan 1
Enhancing medical image contrast improves diagnosis accuracy. COA-SCSO optimizes parameters efficiently, ensuring clearer images and better patient care outcomes.
Abstract | Full Text |PDF (676 KB) | Open Access Article
ALI Aalsaud 1*, Raghad Z. Yousif 2, 3
The novel ECG analysis method improves detection accuracy, is vital for early diagnosis of CVD, and potentially saves lives, especially in underserved regions.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Vishwanadham Mandala 1*, Srinivas Naveen Dolu Surabhi 2, V. R. Balaji 3, Dipak Raghunath Patil 4, Saiyed Faiayaz Waris 5, G. Shobana 6
Heart disease, responsible for millions of deaths annually, necessitates early detection. Machine Learning offers efficient, cost-effective diagnostic tools. The proposed Wild Horse Optimizer (WHO) and SVM classifier enhance heart disease forecasting, addressing critical healthcare needs.
Abstract | Full Text |PDF (489 KB) | Open Access Article
Neoatherosclerosis And Paleoatherosclerosis: Complications After Stenting
Anastasia V. Poznyak 1*, Victoria A. Khotina 2, Roghayyeh Vakili-Ghartavol 2,3, Victor Y Glanz 2, Vasily N. Sukhorukov 2, and Alexander N. Orekhov 2*
Enhanced imaging techniques help in the comprehension of neoatherosclerosis and paleoatherosclerosis, which are crucial for preventing stent failure and improving treatment approaches.
Abstract | Full Text |PDF (700 KB) | Open Access Article
Green Fungus Challenges in Post-COVID Health Landscape
Jeha J 1, Sudha S 1, Geetha N B 1, Benitta Sherine S 2
This review provides Green Fungus challenge in post-COVID situation. Early detection, hygiene, and research are imperative.
Abstract | Full Text |PDF (479 KB) | Open Access Article
Navigating COVID-19 Treatment: CT Scans, Steroids, and Medical Practice Challenges in India
Jayanthi E 1, C. Elayaraja 2, Priyadharshini S 2, Ashok kumar M 2
The review highlights India's struggle with COVID-19, emphasizing the need for tailored treatments amid rising cases, cautioning against unnecessary tests and misuse of medications.
Abstract | Full Text |PDF (173 KB) | Open Access Article
Concerning Fungal Coinfections in COVID-19: Risks, Types, and Prevention – A Review
Bala Krishnan A 1, Vinoth Kumar K K 1, Tharanikumar L 1, M. Shajini G Inbakani 1
The review highlights the alarming rise of fungal infections like Mucormycosis among COVID-19 patients, necessitating prompt diagnosis and care to prevent fatalities.
Abstract | Full Text |PDF (191 KB) | Open Access Article
Bala Krishnan A 1, Vigneshwaran V 1, Tharanikumar L 1, M. Shagar Banu 1
Timely analysis is crucial for understanding and combating global health crises like COVID-19 effectively
Abstract | Full Text |PDF (443 KB) | Open Access Article
Nithya A 1, Vinoth S V 1, Ashok Kumar M 1, Sindhu T 1
Mucormycosis in COVID-19 patients in India necessitates urgent updates in treatment protocols and public awareness
Abstract | Full Text |PDF (173 KB) | Open Access Article
Vitamin D Deficiency As A Contributor To Atherosclerosis Development – A Review
Anastasia V. Poznyak 1*, Victoria A. Khotina 2, Alexandra A. Melnichenko 2, Victor Y Glanz 2, Vasily N. Sukhorukov 2, and Alexander N. Orekhov 2*
Vitamin D deficiency and cardiovascular diseases, explores role in inflammation, oxidative stress, and vascular calcification
Abstract | Full Text |PDF (899 KB) | Open Access Article
Two Forms of C-Reactive Protein and Their Implication for Atherogenesis: Focus on Monomeric Form
Anastasia V. Poznyak 1*, Victoria A. Khotina 2, Anton Y Postnov 2, Vasily N. Sukhorukov 2, Nikolay Sadykhov 2, Alexander N. Orekhov 2*
A review on inflammatory protein in atherosclerosis progression.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Nadirah Yusof 1, Rabiatul Basria S. M. N. Mydin 1,2*, Chandrarohini Saravanan 2,3,4, Nor Hazliana Harun 2,5, Siti Salmah Noordin 5
The study aims to provide a detailed understanding of the microorganisms involved in different types of HAIs, such as surgical site infections, urinary tract infections, bloodstream infections, and respiratory tract infections.
Abstract | Full Text |PDF (212 KB) |Supplementary Material | Open Access Article
Rabiatul Basria S. M. N. Mydin1, Adam Azlan1, Eman Salem Saeed Algariri,1 Nur Azuar Abdul Rahim2,3, Emmanuel Jairaj Moses1, Narazah Mohd Yusoff1
Abstract | Full Text |PDF (199 KB) | Open Access Article
The way of cholesterol in atherogenesis: from the main enemy to complex biomarkers
Anastasia V. Poznyak 1*, Victoria A. Khotina 2, Mikhail A. Popov 3, Alexander D. Zhuravlev 2, Vasily N. Sukhorukov 2, Alexander N. Orekhov 2*
Abstract | Full Text |PDF (998 KB) | Open Access Article
Manuscript-In-Press
Md. Shohayeb Hossain Saif1*
This study demonstrated the need for robust surveillance, innovative therapeutics, and multidisciplinary approaches to combat infectious diseases and future pandemics.
Abstract | Full Text | Open Access Article
Moniruddin Chowdhury1,2, Syeda Humayra2, Sohel Mahmud3, Yukihito Higashi4, YD Singh1
PAD and its impact in physical impairment or mortality.
Abstract | Full Text |PDF (201 KB) | Open Access Article
Targeting Microtubules by Phytoestrogens for the Treatment of Cancer: An Overview
Fan Xu1, Nozlena Abdul Samad1, Nurhuda Mohamad Ansor1*
In this review, we summarize reported effects of some phytoestrogens that bind directly to tubulin at various binding site and disrupt the microtubule dynamics, either by promoting microtubule polymerization or enhancing microtubule depolymerization.
Abstract | Full Text |PDF (737 KB) | Open Access Article
Sasi Kumar S 1, Gopinath S 2, Kalaichezhian M 3, Harish M 4*
This study demonstrates the effectiveness of strict surgical protocols during COVID-19, ensuring patient and staff safety during emergency surgeries.
Abstract | Full Text |PDF (134 KB) | Open Access Article
Manimekalai P 1, Suresh Kanna S 1, Vijaykumar Edward 1 Anandan P 1*
This meta-analysis clarifies NLR's prognostic role in COPD, revealing its potential as a predictive marker for exacerbation and mortality.
Abstract | Full Text |PDF (143 KB) | Open Access Article
Lionel John J 1, Srinivasan N 1, Shiva P 1*, Radhakrishnan P 1
The NLR is a promising, cost-effective marker for predicting COPD exacerbations and mortality, with potential for routine clinical use.
Abstract | Full Text |PDF (150 KB) | Open Access Article
Immune Dysfunction linking hyperglycemia with periodontitis in Diabetes Management
Harini Venkata Subbiah1, Polani Ramesh Babu2, Usha Subbiah1*, Daniel Rajendran T3, Vinod Kumar P3
This review discusses the mechanisms linking hyperglycemia with periodontitis highlights the need for comprehensive management of diabetes to improve periodontal health.
Abstract | Full Text |PDF (232 KB) | Open Access Article
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The Role of Quality Assurance in Accelerating Pharmaceutical Research and Development: Strategies for Ensuring Regulatory Compliance and Product Integrity
This study highlights the role of Quality Assurance in ensuring product integrity, patient safety, and driving pharmaceutical innovation.
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Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
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Serum Albumin Levels as Predictors of Microvascular Health and Wound Healing Outcomes in Diabetic Foot Ulcers
This study deermines the critical role of serum albumin in improving vascularization and granulation tissue, reducing amputation risks in diabetic foot ulcers.
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Knowledge in Enhancing Antenatal Care Compliance and Improving Maternal and Neonatal Health Outcomes
This study provides the understanding how knowledge influences antenatal care compliance can enhance health education strategies and improve maternal and neonatal health outcomes.
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Prevalence and Risk Factors of Hypertension in Adolescents
This study determines hypertension prevalence and associated risk factors in Indonesian adolescents, crucial for targeted public health interventions.
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Biogeochemical Role of Mangroves: Carbon Sequestration, Oxygen Release, and Their Contribution to Ecosystem Sustainability
This study highlights mangroves' critical role in carbon sequestration and oxygen release, contributing significantly to ecosystem and climate regulation.
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Wastewater Treatment and Reuse: Preventive Measures for Chronic Infectious Diseases
This review discusses the significance of wastewater treatment in sustainability, water security, environmental preservation, human health safeguarding and resource recovery.
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Advancements in Virus Detection and Isolation: The Role of Chromatography in Virology Research and Health
This review discusses the viral infections, transmission, and morphology for developing effective diagnostics, treatments, and preventive strategies against future pandemics.
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Early Detection of Sickle Cell Anemia in Nilgiri Tribes Using a Hybrid Swin Transformer-Based RNN with Improved Weighted Quantum Monkey Optimization Algorithm Optimization
This model offers an accurate, timely SCA detection solution, improving healthcare outcomes for Nilgiri tribes and vulnerable populations.
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Machine Learning in Healthcare: From Diagnostics to Personalized Medicine and Predictive Analytics
Machine learning transforms healthcare through accurate diagnosis, tailored therapies, and predictive analytics, promoting a future of precision medicine.
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Sago and Katuk Leaf Combination Treatment Reduces The Blood Glucose Levels in Diabetes Mellitus Patients
This study demonstrates that sago and katuk leaves effectively reduce blood glucose levels, offering a cost-effective, culturally suitable diabetes management solution.
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In Silico Determination of Tinospora cordifolia Phytochemicals as Potential DPP-4 Inhibitors for Type 2 Diabetes Management
This study determined Tinospora cordifolia phytochemicals as potential DPP-4 inhibitors, offering promising therapeutic candidates for type 2 diabetes.
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A Cross-Sectional Study on Toxic Agents, Exposure Routes, and Healthcare Challenges on Pediatric Poisoning in the Al Jouf Region
This study emphasizes the need for preventive measures, caregiver education, and improved healthcare systems to reduce pediatric poisoning incidents.
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Investigating the Impact of Tablet Coatings on Gastrointestinal Tract Residence Time and Drug Bioavailability: A Comparative Study of Different Coating Materials
This review discusses the importance of tailored tablet coatings to optimize drug release, stability, bioavailability, and therapeutic efficacy.
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Lung-Targeted Solid Lipid Nanoparticles for Enhanced Pulmonary Delivery of Anti-Tubercular Drugs: A Novel Approach to Improve Bioavailability
Solid lipid nanoparticles improved anti-tubercular drug encapsulation, stability, and lung retention, offering a promising targeted pulmonary delivery approach for tuberculosis treatment.
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Biological Maturity in Youth Athletes: Comparing Upper-Lower Body Ratios and Second Molar Eruption
Our study assesses upper-lower body ratios and second molar eruption as indicators of biological maturity in young athletes.
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Antioxidant Potential of Curculigo pilosa Rhizome Extracts in Hydrogen Peroxide Induced Oxidation In Vivo
Curculigo pilosa extracts exhibit strong antioxidant properties, mitigating oxidative stress in Drosophila melanogaster, highlighting potential therapeutic applications.
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Impact of Hemodiafiltration and Hemodialysis on FGF-23 Levels and Cardiovascular Calcification in End-Stage Renal Disease
This study determines the effects of dialysis modalities on FGF-23 levels and cardiovascular calcification, offering insights into improving ESRD patient outcomes.
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Comparative Efficacy of Endovascular Versus Surgical Thrombectomy for Arteriovenous Graft Thrombosis in Hemodialysis Patients - A Systematic Review and Meta-Analysis
This study evaluates endovascular versus surgical thrombectomy in arteriovenous graft thrombosis, providing insights for optimizing hemodialysis vascular access management and patient outcomes.
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Analysis of Potential Biomarkers in Hypertension
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
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Hemoglobin N Seattle in a Bengali Child: Diagnostic Challenges and Insights into Genetic Diversity – A Case
This case highlights Hb N Seattle's first detection in a Bengali child, emphasizing diagnostic challenges and genetic diversity insights.
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Factors Influencing Pulmonary Tuberculosis Incidence in Banggai Laut
This study identifies factors influencing TB distribution in Banggai Laut, offering insights for targeted interventions to improve public health outcomes.
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Risk Factors for Knee Injuries in Sports and Intense Physical Exercise
This study highlights the importance of identifying risk factors for knee injuries to develop targeted prevention and rehabilitation strategies.
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Predicting Habitat Suitability and Climate Change Impact on Medicinal plant Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
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Exon 4 Mutations Determination in NOTCH3 Gene for Cryptogenic Ischemic Stroke
This study highlights the genetic and vascular risk factors for cryptogenic ischemic stroke in young adults, emphasizing prevention and personalized treatment strategies.
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Collaborative Governance in Combating Illegal Cosmetics: A Study of Multi-Stakeholder Dynamics in South Sulawesi, Indonesia
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
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Advances in Human Umbilical Vein Scaffolds for Vascular Tissue Engineering: Innovations, Challenges, and Future Directions
This review explores innovative human umbilical vein scaffolds, enhancing vascular tissue engineering for regenerative medicine and cardiovascular applications.
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A Review of Antipsychotic Medications on Hypercoagulability in Schizophrenia: Pathophysiology, Risks, and Management Strategies
Understanding antipsychotic-induced hypercoagulability in schizophrenia is crucial for reducing thromboembolic risks and improving patient outcomes.
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Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
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Effects of Physical Activity as A Treatment For Depression in the Elderly
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
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Smart Nutrition and Active Living in Hypertension Management: Assessing Lifestyle Behaviors, Barriers, and the Role of Digital Health Tools
This study is significant as it highlights the effectiveness of smart nutrition and active living in managing hypertension, promoting sustainable, non-pharmacological interventions for better cardiovascular health.
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High Viral Load is a Risk Factor for Hepatocellular Carcinoma: Clinical and Laboratory Insights from a Cross-Sectional Study
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
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A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
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Phytochemical Composition, Antioxidant, and Anti-Inflammatory Activities of Laurus nobilis Leaf Extracts Using Solvent Fractionation
Ethyl acetate extract of Laurus nobilis leaves showed potent antioxidant and anti-inflammatory activities, highlighting its therapeutic and pharmacological potential.Pages: 1-8
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Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
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Comparative Effects of Sodium Dodecyl Sulfate and Hydrogen Peroxide on Type I and III Collagen Preservation in Decellularized Bovine Pericardium Scaffolds
SDS significantly reduces type I and III collagen density in decellularized bovine pericardium, whereas H2O2 better preserves extracellular matrix integrity.
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Evaluation of Cardiac Biomarkers as Predictors of Short-Term Mortality Following Coronary Artery Bypass Grafting
This study evaluates the predictive value of biomarkers in short-term mortality after coronary artery bypass grafting to guide clinical decisions.
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Machine Learning for Cardiovascular Healthcare: Opportunities, Challenges, and the Path Forward
Machine learning improves healthcare efficiency; yet issues such as data privacy and bias must be resolved for ethical, scalable, and effective application.
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PEGylated Liposomal Teriflunomide: A Novel Approach of Targeted Breast Cancer Treatment to Advance Efficacy and Minimize Adverse Effects
Developing pegylated liposomal teriflunomide may enhance breast cancer treatment efficacy, reduce side effects, and improve patient outcomes.
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Enhancing Pharmacological Access and Health Outcomes in Rural Communities through Renewable Energy Integration: Implications for chronic inflammatory Disease Management
This study emphasises how renewable energy enhances pharmacological logistics, clinical service continuity, and health outcomes in rural, disadvantaged healthcare systems.
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Multidisciplinary Challenges in Managing a Ruptured Ascending Aortic Aneurysm with Concurrent Pulmonary Pathology: A Case Report
This case highlights the challenges of managing ruptured aortic aneurysms with comorbidities, emphasizing multidisciplinary care and TEVAR’s limitations in complex cases.
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The Importance of Autoimmunity and Chronic Inflammation in the Development of Atherosclerosis: New Treatment Strategies
Understanding immune mechanisms in atherosclerosis enables development of targeted anti-inflammatory therapies, improving cardiovascular outcomes and plaque stabilization strategies.
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Cardiovascular Complications in Patients with Hepatocellular Carcinoma
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
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Potential Role of Helicobacter pylori Infection in Hepatocellular Carcinoma: A Clinical and Laboratory-Based Study
The study is to determine the pervasiveness of H. pylori infection among patients with liver illness of HCC.
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Early Surgical Intervention in Congenital Pulmonary Airway Malformation: A Case Report
Early recognition and surgical intervention in symptomatic CPAM cases prevent complications, ensuring optimal respiratory function and long-term clinical outcomes in neonates.
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The Evolving Role of Hospital and Community Pharmacist in Post-COVID-19 Healthcare Delivery in Bangladesh: A Survey-Based Analysis
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
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Integrating Health Analytics tools to Enhance Pharmacological Management and Patient Outcomes in Hospital Settings
This study emphasises that the integration of business and HR analytics improves hospital efficiency, personnel management, and patient care outcomes.
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OR-PSGAN-CNN: An Occlusion-Robust Deep Learning Framework for Early Detection of Cerebral Palsy in Infants Using RGB-D Videos
Improves early cerebral palsy detection by resolving pose occlusions through enhanced skeleton generation and feature extraction from infant movement videos.
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Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
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Antidiabetic and Toxicological Evaluation of Ostodes Pauciflora merr. Seed (kop nut) Oil, A Potential Functional Food Alternative
This study evaluates Ostodes pauciflora Merr. seed oil for antidiabetic properties, providing insights into its potential as a functional food alternative.
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AI-driven Innovations in Cancer Research and Personalized Healthcare
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
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Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
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Global Burden, Risk Factors, and Evidence-Based Strategies for Cardiovascular Disease Prevention: A Comprehensive Systematic Review
This review highlights global CVD disparities, identifies major risk factors, and evaluates effective, cost-efficient prevention strategies for population health.
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An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
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