References
Afzali, B., Lombardi, G., Lechler, R. I., & Lord, G. M. (2007). The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clinical and experimental immunology, 148(1), 32–46. https://doi.org/10.1111/j.1365-2249.2007.03356.x
An, C., Li, Z., Chen, Y., Huang, S., Yang, F., Hu, Y., Xu, T., Zhang, C., & Ge, S. (2024). The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives. Cell & bioscience, 14(1), 58. https://doi.org/10.1186/s13578-024-01242-4
Bai, S., Wei, Y., Hou, W., Yao, Y., Zhu, J., Hu, X., Chen, W., Du, Y., He, W., Shen, B., & Du, J. (2020). Orai-IGFBP3 signaling complex regulates high-glucose exposure-induced increased proliferation, permeability, and migration of human coronary artery endothelial cells. BMJ open diabetes research & care, 8(1), e001400. https://doi.org/10.1136/bmjdrc-2020-001400
Bao, T., Liu, J., Leng, J., & Cai, L. (2021). The cGAS-STING pathway: more than fighting against viruses and cancer. Cell & bioscience, 11(1), 209. https://doi.org/10.1186/s13578-021-00724-z
Bekkering, S., Quintin, J., Joosten, L. A., van der Meer, J. W., Netea, M. G., & Riksen, N. P. (2014). Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes. Arteriosclerosis, thrombosis, and vascular biology, 34(8), 1731–1738. https://doi.org/10.1161/ATVBAHA.114.303887
Bobryshev, Y. V., Ivanova, E. A., Chistiakov, D. A., Nikiforov, N. G., & Orekhov, A. N. (2016). Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis. BioMed research international, 2016, 9582430. https://doi.org/10.1155/2016/9582430
Bryant, F. R., & Benkovic, S. J. (1982). Phosphorothioate substrates for T4 RNA ligase. Biochemistry, 21(23), 5877–5885. https://doi.org/10.1021/bi00266a023
Bu, L. L., Yuan, H. H., Xie, L. L., Guo, M. H., Liao, D. F., & Zheng, X. L. (2023). New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death. International journal of molecular sciences, 24(20), 15160. https://doi.org/10.3390/ijms242015160
Chathuranga, K., Weerawardhana, A., Dodantenna, N., & Lee, J. S. (2021). Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing. Experimental & molecular medicine, 53(11), 1647–1668. https://doi.org/10.1038/s12276-021-00691-y
Chen, C., & Khismatullin, D. B. (2015). Oxidized low-density lipoprotein contributes to atherogenesis via co-activation of macrophages and mast cells. PloS one, 10(3), e0123088. https://doi.org/10.1371/journal.pone.0123088
Coccia, E. M., & Battistini, A. (2015). Early IFN type I response: Learning from microbial evasion strategies. Seminars in immunology, 27(2), 85–101. https://doi.org/10.1016/j.smim.2015.03.005
Danziger, O., Patel, R. S., DeGrace, E. J., Rosen, M. R., & Rosenberg, B. R. (2022). Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor. PLoS pathogens, 18(4), e1010464. https://doi.org/10.1371/journal.ppat.1010464
David, C., & Frémond, M. L. (2022). Lung Inflammation in STING-Associated Vasculopathy with Onset in Infancy (SAVI). Cells, 11(3), 318. https://doi.org/10.3390/cells11030318
Decout, A., Katz, J. D., Venkatraman, S., & Ablasser, A. (2021). The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nature reviews. Immunology, 21(9), 548–569. https://doi.org/10.1038/s41577-021-00524-z
Deng, Z., Chong, Z., Law, C. S., Mukai, K., Ho, F. O., Martinu, T., Backes, B. J., Eckalbar, W. L., Taguchi, T., & Shum, A. K. (2020). A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome. The Journal of experimental medicine, 217(11), e20201045. https://doi.org/10.1084/jem.20201045
Ding, C., Song, Z., Shen, A., Chen, T., & Zhang, A. (2020). Small molecules targeting the innate immune cGAS?STING?TBK1 signaling pathway. Acta pharmaceutica Sinica. B, 10(12), 2272–2298. https://doi.org/10.1016/j.apsb.2020.03.001
Dubensky, T. W., Jr, Kanne, D. B., & Leong, M. L. (2013). Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants. Therapeutic advances in vaccines, 1(4), 131–143. https://doi.org/10.1177/2051013613501988
Esposito, M., Ruffini, F., Bergami, A., Garzetti, L., Borsellino, G., Battistini, L., Martino, G., & Furlan, R. (2010). IL-17- and IFN-γ-secreting Foxp3+ T cells infiltrate the target tissue in experimental autoimmunity. Journal of immunology (Baltimore, Md. : 1950), 185(12), 7467–7473. https://doi.org/10.4049/jimmunol.1001519
Fang, Q., Tian, M., Wang, F., Zhang, Z., Du, T., Wang, W., Yang, Y., Li, X., Chen, G., Xiao, L., Wei, H., Wang, Y., Chen, C., & Wang, D. W. (2019). Amlodipine induces vasodilation via Akt2/Sp1-activated miR-21 in smooth muscle cells. British journal of pharmacology, 176(13), 2306–2320. https://doi.org/10.1111/bph.14679
Frankowska, N., Lisowska, K., & Witkowski, J. M. (2022). Proteolysis dysfunction in the process of aging and age-related diseases. Frontiers in aging, 3, 927630. https://doi.org/10.3389/fragi.2022.927630
Gan, Y., Li, X., Han, S., Liang, Q., Ma, X., Rong, P., Wang, W., & Li, W. (2022). The cGAS/STING Pathway: A Novel Target for Cancer Therapy. Frontiers in immunology, 12, 795401. https://doi.org/10.3389/fimmu.2021.795401
Gomelsky M. (2011). cAMP, c-di-GMP, c-di-AMP and now cGMP: bacteria use them all!. Molecular microbiology, 79(3), 562–565. https://doi.org/10.1111/j.1365-2958.2010.07514.x
Guimarães, E. S., Marinho, F. V., de Queiroz, N. M. G. P., Antunes, M. M., & Oliveira, S. C. (2021). Impact of STING Inflammatory Signaling during Intracellular Bacterial Infections. Cells, 11(1), 74. https://doi.org/10.3390/cells11010074
Gulen, M. F., Samson, N., Keller, A., Schwabenland, M., Liu, C., Glück, S., Thacker, V. V., Favre, L., Mangeat, B., Kroese, L. J., Krimpenfort, P., Prinz, M., & Ablasser, A. (2023). cGAS-STING drives ageing-related inflammation and neurodegeneration. Nature, 620(7973), 374–380. https://doi.org/10.1038/s41586-023-06373-1
Hall, J., Ralph, E. C., Shanker, S., Wang, H., Byrnes, L. J., Horst, R., Wong, J., Brault, A., Dumlao, D., Smith, J. F., Dakin, L. A., Schmitt, D. C., Trujillo, J., Vincent, F., Griffor, M., & Aulabaugh, A. E. (2017). The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition. Protein science : a publication of the Protein Society, 26(12), 2367–2380. https://doi.org/10.1002/pro.3304
Hall, J., Ralph, E. C., Shanker, S., Wang, H., Byrnes, L. J., Horst, R., Wong, J., Brault, A., Dumlao, D., Smith, J. F., Dakin, L. A., Schmitt, D. C., Trujillo, J., Vincent, F., Griffor, M., & Aulabaugh, A. E. (2017). The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition. Protein science : a publication of the Protein Society, 26(12), 2367–2380. https://doi.org/10.1002/pro.3304
He, W., Mu, X., Wu, X., Liu, Y., Deng, J., Liu, Y., Han, F., & Nie, X. (2024). The cGAS-STING pathway: a therapeutic target in diabetes and its complications. Burns & trauma, 12, tkad050. https://doi.org/10.1093/burnst/tkad050
Hooy, R. M., & Sohn, J. (2018). The allosteric activation of cGAS underpins its dynamic signaling landscape. eLife, 7, e39984. https://doi.org/10.7554/eLife.39984
Hu, H., Zhao, R., He, Q., Cui, C., Song, J., Guo, X., Zang, N., Yang, M., Zou, Y., Yang, J., Li, J., Wang, L., Xia, L., Wang, L., He, F., Hou, X., Yan, F., & Chen, L. (2022). cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 36(5), e22266. https://doi.org/10.1096/fj.202101988R
Hu, T., Pan, M., Yin, Y., Wang, C., Cui, Y., & Wang, Q. (2021). The Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion. Frontiers in microbiology, 12, 790714. https://doi.org/10.3389/fmicb.2021.790714
Kang, Z. P., Wang, M. X., Wu, T. T., Liu, D. Y., Wang, H. Y., Long, J., Zhao, H. M., & Zhong, Y. B. (2021). Curcumin Alleviated Dextran Sulfate Sodium-Induced Colitis by Regulating M1/M2 Macrophage Polarization and TLRs Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM, 2021, 3334994. https://doi.org/10.1155/2021/3334994
Kato, T., Yamamoto, M., Honda, Y., Orimo, T., Sasaki, I., Murakami, K., Hemmi, H., Fukuda-Ohta, Y., Isono, K., Takayama, S., Nakamura, H., Otsuki, Y., Miyamoto, T., Takita, J., Yasumi, T., Nishikomori, R., Matsubayashi, T., Izawa, K., & Kaisho, T. (2021). Augmentation of Stimulator of Interferon Genes-Induced Type I Interferon Production in COPA Syndrome. Arthritis & rheumatology (Hoboken, N.J.), 73(11), 2105–2115. https://doi.org/10.1002/art.41790
Khalil, R., Diab-Assaf, M., & Lemaitre, J. M. (2023). Emerging Therapeutic Approaches to Target the Dark Side of Senescent Cells: New Hopes to Treat Aging as a Disease and to Delay Age-Related Pathologies. Cells, 12(6), 915. https://doi.org/10.3390/cells12060915
Kuchitsu, Y., Mukai, K., Uematsu, R., Takaada, Y., Shinojima, A., Shindo, R., Shoji, T., Hamano, S., Ogawa, E., Sato, R., Miyake, K., Kato, A., Kawaguchi, Y., Nishitani-Isa, M., Izawa, K., Nishikomori, R., Yasumi, T., Suzuki, T., Dohmae, N., Uemura, T., … Taguchi, T. (2023). STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes. Nature cell biology, 25(3), 453–466. https://doi.org/10.1038/s41556-023-01098-9
Lang, R., Li, H., Luo, X., Liu, C., Zhang, Y., Guo, S., Xu, J., Bao, C., Dong, W., & Yu, Y. (2022). Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases. Frontiers in immunology, 13, 1008072. https://doi.org/10.3389/fimmu.2022.1008072
Li, Q., Wu, P., Du, Q., Hanif, U., Hu, H., & Li, K. (2024). cGAS-STING, an important signaling pathway in diseases and their therapy. MedComm, 5(4), e511. https://doi.org/10.1002/mco2.511
Li, S., Qian, N., Jiang, C., Zu, W., Liang, A., Li, M., Elledge, S. J., & Tan, X. (2022). Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation. Nature communications, 13(1), 105. https://doi.org/10.1038/s41467-021-27670-1
Li, T., Li, X., Feng, Y., Dong, G., Wang, Y., & Yang, J. (2020). The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability. Mediators of inflammation, 2020, 3872367. https://doi.org/10.1155/2020/3872367
Li, X., Shu, C., Yi, G., Chaton, C. T., Shelton, C. L., Diao, J., Zuo, X., Kao, C. C., Herr, A. B., & Li, P. (2013). Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. Immunity, 39(6), 1019–1031. https://doi.org/10.1016/j.immuni.2013.10.019
Li, X., Zhu, Y., Zhang, X., An, X., Weng, M., Shi, J., Wang, S., Liu, C., Luo, S., & Zheng, T. (2022). An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP. The Journal of clinical investigation, 132(3), e144339. https://doi.org/10.1172/JCI144339
Liu, Y., & Pu, F. (2023). Updated roles of cGAS-STING signaling in autoimmune diseases. Frontiers in immunology, 14, 1254915. https://doi.org/10.3389/fimmu.2023.1254915
Lodola, F., Laforenza, U., Bonetti, E., Lim, D., Dragoni, S., Bottino, C., Ong, H. L., Guerra, G., Ganini, C., Massa, M., Manzoni, M., Ambudkar, I. S., Genazzani, A. A., Rosti, V., Pedrazzoli, P., Tanzi, F., Moccia, F., & Porta, C. (2012). Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. PloS one, 7(9), e42541. https://doi.org/10.1371/journal.pone.0042541
Lukhele, S., Boukhaled, G. M., & Brooks, D. G. (2019). Type I interferon signaling, regulation and gene stimulation in chronic virus infection. Seminars in immunology, 43, 101277. https://doi.org/10.1016/j.smim.2019.05.001
Luo, K., Li, N., Ye, W., Gao, H., Luo, X., & Cheng, B. (2022). Activation of Stimulation of Interferon Genes (STING) Signal and Cancer Immunotherapy. Molecules (Basel, Switzerland), 27(14), 4638. https://doi.org/10.3390/molecules27144638
Luo, X., Li, H., Ma, L., Zhou, J., Guo, X., Woo, S. L., Pei, Y., Knight, L. R., Deveau, M., Chen, Y., Qian, X., Xiao, X., Li, Q., Chen, X., Huo, Y., McDaniel, K., Francis, H., Glaser, S., Meng, F., Alpini, G., … Wu, C. (2018). Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice. Gastroenterology, 155(6), 1971–1984.e4. https://doi.org/10.1053/j.gastro.2018.09.010
Ma, G., Bi, S., & Zhang, P. (2021). Long non-coding RNA MIAT regulates ox-LDL-induced cell proliferation, migration and invasion by miR-641/STIM1 axis in human vascular smooth muscle cells. BMC cardiovascular disorders, 21(1), 248. https://doi.org/10.1186/s12872-021-02048-9
Ma, X., Xin, D., She, R., Liu, D., Ge, J., & Mei, Z. (2023). Novel insight into cGAS-STING pathway in ischemic stroke: from pre- to post-disease. Frontiers in immunology, 14, 1275408. https://doi.org/10.3389/fimmu.2023.1275408
Martin, G. R., Blomquist, C. M., Henare, K. L., & Jirik, F. R. (2019). Stimulator of interferon genes (STING) activation exacerbates experimental colitis in mice. Scientific reports, 9(1), 14281. https://doi.org/10.1038/s41598-019-50656-5
Matsumiya, T., & Stafforini, D. M. (2010). Function and regulation of retinoic acid-inducible gene-I. Critical reviews in immunology, 30(6), 489–513. https://doi.org/10.1615/critrevimmunol.v30.i6.10
Mbongue, J. C., Nicholas, D. A., Torrez, T. W., Kim, N. S., Firek, A. F., & Langridge, W. H. (2015). The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity. Vaccines, 3(3), 703–729. https://doi.org/10.3390/vaccines3030703
McHugh, D., & Gil, J. (2018). Senescence and aging: Causes, consequences, and therapeutic avenues. The Journal of cell biology, 217(1), 65–77. https://doi.org/10.1083/jcb.201708092
Mohseni, G., Li, J., Ariston Gabriel, A. N., Du, L., Wang, Y. S., & Wang, C. (2021). The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer. Frontiers in immunology, 12, 781032. https://doi.org/10.3389/fimmu.2021.781032
Motani, K., & Kosako, H. (2018). Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D. The Journal of biological chemistry, 293(20), 7717–7726. https://doi.org/10.1074/jbc.RA118.002175
Newman, A. A. C., Serbulea, V., Baylis, R. A., Shankman, L. S., Bradley, X., Alencar, G. F., Owsiany, K., Deaton, R. A., Karnewar, S., Shamsuzzaman, S., Salamon, A., Reddy, M. S., Guo, L., Finn, A., Virmani, R., Cherepanova, O. A., & Owens, G. K. (2021). Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms. Nature metabolism, 3(2), 166–181. https://doi.org/10.1038/s42255-020-00338-8
Oduro, P. K., Zheng, X., Wei, J., Yang, Y., Wang, Y., Zhang, H., Liu, E., Gao, X., Du, M., & Wang, Q. (2022). The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy. Acta pharmaceutica Sinica. B, 12(1), 50–75. https://doi.org/10.1016/j.apsb.2021.05.011
Ou, L., Zhang, A., Cheng, Y., & Chen, Y. (2021). The cGAS-STING Pathway: A Promising Immunotherapy Target. Frontiers in immunology, 12, 795048. https://doi.org/10.3389/fimmu.2021.795048
Pan, J., Fei, C. J., Hu, Y., Wu, X. Y., Nie, L., & Chen, J. (2023). Current understanding of the cGAS-STING signaling pathway: Structure, regulatory mechanisms, and related diseases. Zoological research, 44(1), 183–218. https://doi.org/10.24272/j.issn.2095-8137.2022.464
Papinska, J., Bagavant, H., Gmyrek, G. B., Sroka, M., Tummala, S., Fitzgerald, K. A., & Deshmukh, U. S. (2018). Activation of Stimulator of Interferon Genes (STING) and Sjögren Syndrome. Journal of dental research, 97(8), 893–900. https://doi.org/10.1177/0022034518760855
Paul, S. K., Oshima, M., Patil, A., Sone, M., Kato, H., Maezawa, Y., Kaneko, H., Fukuyo, M., Rahmutulla, B., Ouchi, Y., Tsujimura, K., Nakanishi, M., Kaneda, A., Iwama, A., Yokote, K., Eto, K., & Takayama, N. (2024). Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model. Nature communications, 15(1), 4772. https://doi.org/10.1038/s41467-024-48663-w
Piaszyk-Borychowska, A., Széles, L., Csermely, A., Chiang, H. C., Wesoly, J., Lee, C. K., Nagy, L., & Bluyssen, H. A. R. (2019). Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription. Frontiers in immunology, 10, 1253. https://doi.org/10.3389/fimmu.2019.01253
Prantner, D., Perkins, D. J., & Vogel, S. N. (2017). AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling. The Journal of biological chemistry, 292(1), 292–304. https://doi.org/10.1074/jbc.M116.763268
Pu, Z., Lu, J., & Yang, X. (2022). Emerging Roles of Circular RNAs in Vascular Smooth Muscle Cell Dysfunction. Frontiers in genetics, 12, 749296. https://doi.org/10.3389/fgene.2021.749296
Saito, Y., Yamamoto, S., & Chikenji, T. S. (2024). Role of cellular senescence in inflammation and regeneration. Inflammation and regeneration, 44(1), 28. https://doi.org/10.1186/s41232-024-00342-5
Saleh, A., Macia, A., & Muotri, A. R. (2019). Transposable Elements, Inflammation, and Neurological Disease. Frontiers in neurology, 10, 894. https://doi.org/10.3389/fneur.2019.00894
Schmitz, C. R. R., Maurmann, R. M., Guma, F. T. C. R., Bauer, M. E., & Barbé-Tuana, F. M. (2023). cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging. Frontiers in immunology, 14, 1132653. https://doi.org/10.3389/fimmu.2023.1132653
Seok, J. K., Kim, M., Kang, H. C., Cho, Y. Y., Lee, H. S., & Lee, J. Y. (2023). Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases. Archives of pharmacal research, 46(6), 500–534. https://doi.org/10.1007/s12272-023-01452-3
Siedel, H., Roers, A., Rösen-Wolff, A., & Luksch, H. (2020). Type I interferon-independent T cell impairment in a Tmem173 N153S/WT mouse model of STING associated vasculopathy with onset in infancy (SAVI). Clinical immunology (Orlando, Fla.), 216, 108466. https://doi.org/10.1016/j.clim.2020.108466
Slavik, K. M., Morehouse, B. R., Ragucci, A. E., Zhou, W., Ai, X., Chen, Y., Li, L., Wei, Z., Bähre, H., König, M., Seifert, R., Lee, A. S. Y., Cai, H., Imler, J. L., & Kranzusch, P. J. (2021). cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Nature, 597(7874), 109–113. https://doi.org/10.1038/s41586-021-03743-5
Smith J. A. (2021). STING, the Endoplasmic Reticulum, and Mitochondria: Is Three a Crowd or a Conversation?. Frontiers in immunology, 11, 611347. https://doi.org/10.3389/fimmu.2020.611347
Tan, H. Y., Yong, Y. K., Xue, Y. C., Liu, H., Furihata, T., Shankar, E. M., & Ng, C. S. (2022). cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model. iScience, 25(6), 104404. https://doi.org/10.1016/j.isci.2022.104404
Unterholzner L. (2019). Beyond sensing DNA: a role for cGAS in the detection of extracellular cyclic di-nucleotides. EMBO reports, 20(4), e47970. https://doi.org/10.15252/embr.201947970
Van Giesen, K. J. D., Thompson, M. J., Meng, Q., & Lovelock, S. L. (2022). Biocatalytic Synthesis of Antiviral Nucleosides, Cyclic Dinucleotides, and Oligonucleotide Therapies. JACS Au, 3(1), 13–24. https://doi.org/10.1021/jacsau.2c00481
Verrier, E. R., & Langevin, C. (2021). Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing. Frontiers in immunology, 12, 637399. https://doi.org/10.3389/fimmu.2021.637399
Verrier, E. R., & Langevin, C. (2021). Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS), a Multifaceted Platform of Intracellular DNA Sensing. Frontiers in immunology, 12, 637399. https://doi.org/10.3389/fimmu.2021.637399
Wan, D., Jiang, W., & Hao, J. (2020). Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response. Frontiers in immunology, 11, 615. https://doi.org/10.3389/fimmu.2020.00615
Wang, B., Zhang, L., Dai, T., Qin, Z., Lu, H., Zhang, L., & Zhou, F. (2021). Liquid-liquid phase separation in human health and diseases. Signal transduction and targeted therapy, 6(1), 290. https://doi.org/10.1038/s41392-021-00678-1
Wang, L. Y., Zhang, J. H., Yu, J., Yang, J., Deng, M. Y., Kang, H. L., & Huang, L. (2015). Reduction of Store-Operated Ca(2+) Entry Correlates with Endothelial Progenitor Cell Dysfunction in Atherosclerotic Mice. Stem cells and development, 24(13), 1582–1590. https://doi.org/10.1089/scd.2014.0538
Wang, X., Wang, Y., Cao, A., Luo, Q., Chen, D., Zhao, W., Xu, J., Li, Q., Bu, X., & Quan, J. (2023). Development of cyclopeptide inhibitors of cGAS targeting protein-DNA interaction and phase separation. Nature communications, 14(1), 6132. https://doi.org/10.1038/s41467-023-41892-5
Wang, Y., Wang, F., & Zhang, X. (2021). STING-associated vasculopathy with onset in infancy: a familial case series report and literature review. Annals of translational medicine, 9(2), 176. https://doi.org/10.21037/atm-20-6198
Warner, J. D., Irizarry-Caro, R. A., Bennion, B. G., Ai, T. L., Smith, A. M., Miner, C. A., Sakai, T., Gonugunta, V. K., Wu, J., Platt, D. J., Yan, N., & Miner, J. J. (2017). STING-associated vasculopathy develops independently of IRF3 in mice. The Journal of experimental medicine, 214(11), 3279–3292. https://doi.org/10.1084/jem.20171351
Whiteley, A. T., Eaglesham, J. B., de Oliveira Mann, C. C., Morehouse, B. R., Lowey, B., Nieminen, E. A., Danilchanka, O., King, D. S., Lee, A. S. Y., Mekalanos, J. J., & Kranzusch, P. J. (2019). Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature, 567(7747), 194–199. https://doi.org/10.1038/s41586-019-0953-5
Yang, Y., Wang, L., Peugnet-González, I., Parada-Venegas, D., Dijkstra, G., & Faber, K. N. (2023). cGAS-STING signaling pathway in intestinal homeostasis and diseases. Frontiers in immunology, 14, 1239142. https://doi.org/10.3389/fimmu.2023.1239142
Yu, L., & Liu, P. (2021). Cytosolic DNA sensing by cGAS: regulation, function, and human diseases. Signal transduction and targeted therapy, 6(1), 170. https://doi.org/10.1038/s41392-021-00554-y
Yu, Y., Liu, J., Liu, C., Liu, R., Liu, L., Yu, Z., Zhuang, J., & Sun, C. (2022). Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation. Cells, 11(19), 3043. https://doi.org/10.3390/cells11193043
Zevini, A., Olagnier, D., & Hiscott, J. (2017). Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways. Trends in immunology, 38(3), 194–205. https://doi.org/10.1016/j.it.2016.12.004
Zhai, H., Liu, H., Shang, B., & Zou, X. (2023). Sarsasapogenin blocks ox-LDL-stimulated vascular smooth muscle cell proliferation, migration, and invasion through suppressing STIM1 expression. Cardiovascular diagnosis and therapy, 13(3), 441–452. https://doi.org/10.21037/cdt-23-111
Zhang, Q., Shen, L., Ruan, H., & Huang, Z. (2024). cGAS-STING signaling in cardiovascular diseases. Frontiers in immunology, 15, 1402817. https://doi.org/10.3389/fimmu.2024.1402817
Zhang, X., Shi, H., Wu, J., Zhang, X., Sun, L., Chen, C., & Chen, Z. J. (2013). Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Molecular cell, 51(2), 226–235. https://doi.org/10.1016/j.molcel.2013.05.022
Zhang, Z., Zhou, H., Ouyang, X., Dong, Y., Sarapultsev, A., Luo, S., & Hu, D. (2022). Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy. Signal transduction and targeted therapy, 7(1), 394. https://doi.org/10.1038/s41392-022-01252-z
Zhao, Q., Manohar, M., Wei, Y., Pandol, S. J., & Habtezion, A. (2019). STING signalling protects against chronic pancreatitis by modulating Th17 response. Gut, 68(10), 1827–1837. https://doi.org/10.1136/gutjnl-2018-317098
Zheng, J., Mo, J., Zhu, T., Zhuo, W., Yi, Y., Hu, S., Yin, J., Zhang, W., Zhou, H., & Liu, Z. (2020). Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy. Molecular cancer, 19(1), 133. https://doi.org/10.1186/s12943-020-01250-1
Zheng, W., Liu, A., Xia, N., Chen, N., Meurens, F., & Zhu, J. (2023). How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Apoptosis. International journal of molecular sciences, 24(3), 3029. https://doi.org/10.3390/ijms24033029
Zhou, J., Zhuang, Z., Li, J., & Feng, Z. (2023). Significance of the cGAS-STING Pathway in Health and Disease. International journal of molecular sciences, 24(17), 13316. https://doi.org/10.3390/ijms241713316
Zhuang, H., Lv, Q., Zhong, C., Cui, Y., He, L., Zhang, C., & Yu, J. (2021). Tiliroside Ameliorates Ulcerative Colitis by Restoring the M1/M2 Macrophage Balance via the HIF-1α/glycolysis Pathway. Frontiers in immunology, 12, 649463. https://doi.org/10.3389/fimmu.2021.649463