Integrative Biomedical Research (Journal of Angiotherapy) | Online ISSN  3068-6326

Integrative Biomedical Research

Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health, 

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Editor-in-Chief: Fazlul Huq, Ph.D.

Integrative Biomedical Research

Volume 9 Number 1 2025

Table of Contents


Research Article

Biological Sciences

Published online 08 April 2025

Predicting Habitat Suitability and Climate Change Impact on Medicinal plant  Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling

Pragya Sourabh 1*, Reena Panwar 1, Rafia Khanam 1

pp. 1-10

This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Published online 11 September 2024

Transforming Applied Medical Sciences: The Impact of AI, VR, and AR on Research, Education Technology, and Clinical Practices

Wasib Bin Latif 1*, Ida Md Yasin 1, Mohammed Julfikar Ali 2, Md. Nazrul Islam 3, Md. Shak Forid 4

pp. 1-8

This study determined the transformative impact of EdTech innovations in revolutionizing research productivity, elevating educational engagement, and enhancing clinical precision within applied medical sciences.

Abstract | Full Text |PDF (203 KB) | Open Access Article


Published online 12 August 2024

Impact of Anadara granosa L. and Spirulina platensis on Sperm Morphology and Motility in Mus musculus

Netty Ino Ischak 1*, Loso Judijanto 2, Eddyman W Ferial 3

pp. 1-7

This study explored nutrient effects of Anadara granosa and Spirulina platensis on improving sperm quality in preclinical Mus musculus trials.

Abstract | Full Text |PDF (346 KB) | Open Access Article


Published online 20 July 2024

Antibiotic Resistance and Inflammatory Response in Urology Infections Caused by E. coli: A Molecular and Clinical Investigation

Amani Alhejely 1*

pp. 1-9

This study reveals the alarming antibiotic resistance of E. coli in urology infections, emphasizing the need for molecular diagnostics and targeted treatments to mitigate clinical risks.

Abstract | Full Text |PDF (305 KB) | Open Access Article


Published online 19 July 2024

Lipoproteins and Their Receptors Association in Cerebrovascular Disease Pathogenesis: A Comprehensive Analysis

Nargiza Maksudovna Vakhabova 1, Maksud Makhmudovich Asadullaev 2, Gulnara Sattarovna Raximbayeva 3, Nigina Akram qizi Botirova, 4 Aktamov Shohruhbek Ulug’bek ug’li 5

pp. 1-6

This study showed critical biomarkers' roles in cerebrovascular accidents, offering insights into therapeutic strategies for stroke prevention and management.

Abstract | Full Text |PDF (245 KB) | Open Access Article


Published online 01 July 2024

Comparative Analysis of Cemented vs. Uncemented Hip Prostheses in Elderly Bangladeshi Patients with Osteoarthritis

Mohammad Sazzad Hossain1*, Erfanul Huq Siddiqui2, Sharif Md. Musa1, Sheikh Forhad1

pp. 1-7

Cemented hip arthroplasty offers superior function and fewer complications, supporting its use in elderly Bangladeshi patients with osteoarthritis.

Abstract | Full Text |PDF (191 KB) | Open Access Article


Published online 24 June 2024

A Clinical Analysis of Measles Outbreak and Immunization Gaps

Gulnora A. Arashova 1*

pp. 1-6

This study showed the immunization gaps and clinical severity, and an urgent need for better vaccination strategy for measles cases.

Abstract | Full Text |PDF (229 KB) | Open Access Article


Published online 21 May 2024

Embryotoxicity, Teratogenicity, and Chronic Toxicity of a Medicinal Balm with Adaptogenic Effects

Z.T. Fayzieva 1*, M. M. Rakhmatullayeva 1, G.O. Rakhimova 1, A.J.Rajapov 1, D. M. Hashirbaeva 1

pp. 1-7

Investigates medicinal balm's safety, showing no embryotoxic, teratogenic effects, or chronic toxicity, supporting its use in complex therapy.

Abstract | Full Text |PDF (374 KB) | Open Access Article


Published online 15 May 2024

Emergence of Antibiotic-Resistant Infections in ICU Patients

Md. Tahsin Salam1, Kaniz Fatima Bari2, Md Mostafizur Rahman3, Dewan Muhammad Mahmudul Gafur1, Md. Omar Faruk4, Khurshida Akter5, Farhana Irin6, Md Rahatul Ashakin7, Tanim Ahmed shaikat8, Ashik Chandra Das9, Tufael10, Mahmudul Hasan Mithun11, Atiqur Rahman Sunny10

pp. 1-9

Resistance-strain infections in ICU patients significantly increase morbidity and mortality, necessitating revised antibiotic policies for effective treatment.

Abstract | Full Text |PDF (278 KB) | Open Access Article


Published online 13 May 2024

Avocado (Persea americana Mill.) Leaf Extract for Diabetic Ulcer Treatment In Vivo

Lita Retta 1, Endy Juli Anto 4,5, Jekson Martiar Siahaan 2,3*, Syafruddin Ilyas 6, Menang Bastanta 7,8

pp. 1-15

Avocado leaf extract demonstrated potential in reducing blood sugar, enhancing wound healing, and mitigating inflammation, offering a novel diabetic ulcer treatment.

Abstract | Full Text |PDF (497 KB) | Open Access Article


Published online 09 May 2024

Combined Biomarkers for Early Diagnosis of Hepatocellular Carcinoma

Tufael 1, Md Mostafizur Rahman 2, Vijay Jagdish Upadhye 3*, Md Faruk Hossain 2, Nasir Uddin 4

pp. 1-12

This retrospective study assessed AFP, CEA, and CA19-9 efficacy, highlighting AFP's importance in early hepatocellular carcinoma detection.

Abstract | Full Text |PDF (393 KB) | Open Access Article


Published online 15 April 2024

Modeling Multifocal Atherosclerosis in Rabbits for Gender Influence and Lipid Profile Effects

Maksud M. Asadullayev 1, Khilola T. Mirakhmedova.2, Nataliya  L.Vipova 3, Albina V.Filatova 3, Rustam N. Jalolov 5, Doston R. Jumanazarov.5 , Nargiza M.Vaxabova 2, Ixtiyor T.Aliqulov 2, Sardoriddin Sh.Srojidinov 2

pp. 1-8

This study demonstrated a rabbit models as drug development and understanding atherosclerosis dynamics, which is vital for combating cardiovascular diseases globally.

Abstract | Full Text |PDF (469 KB) | Open Access Article


Published online 09 April 2024

Impact of Bacterial Infections on Semen Parameters in Sub-Fertile Men

 Muzdalifa Mejbel Fadwi 1,3*, Sawsan Q.T. Al-Quhli 1, Ziad H. Abd 2

pp. 1-8

This study demonstrated a correlation between bacterial infections and semen parameters, providing insights for precise therapy strategies in male sub-fertility.

Abstract | Full Text |PDF (442 KB) | Open Access Article


Published online 07 April 2024

Immunomodulatory Effects of Moringa oleifera Seed Extract and Nano Zinc Oxide on Benzene-Induced Toxicity In-Vivo

Shirin Jazar Amin 1*, Ayyub J. Abdl-Rhmaan Al-Bayaty 1, Salah M. A. Alkubaisi 2

pp. 1-5

This study addressed the critical need for antidotes against benzene toxicity, highlighting Moringa oleifera's potential immunomodulatory effects.

Abstract | Full Text |PDF (210 KB) | Open Access Article


Published online 06 April 2024

Elevated Co-infection in Hepatitis C Virus and Toxoplasmosis Patients With IL-32, IL-33 and TNF-α

Amjad T. Hameed  1*, Nazar Sh. Mohammed 1, Amani M. Jasim 1

pp. 1-9

The co-occurrence of HCV and toxoplasmosis presents severe health risks, including liver damage and exacerbated symptoms. Understanding cytokine dynamics is crucial for targeted therapies.

Abstract | Full Text |PDF (558 KB) |Supplementary Material | Open Access Article


Published online 04 April 2024

Biological Effectiveness of Seed Extracts of Some Species From Brassicaceae Family Against Two Types of Pathogenic Bacteria

Afnan Esam Adnan 1*, Wisam Malik Dawood 1*

pp. 1-9

Cruciferous Plant-derived compounds showed diverse medicinal properties, combating antibiotic resistance, providing therapeutic alternatives, and inhibiting biofilm formation in pathogenic bacteria.

Abstract | Full Text |PDF (248 KB) | Open Access Article


Published online 04 April 2024

Copper Toxicity and Calcium Supplementation on nkx2.5 and mt2 Gene Expression in Zebrafish Embryos

Sahib Mohammad bakir 1*, Theodore B. Henry 2, Richard D. Handy 3

pp. 1-8

This study determined how copper toxicity and calcium supplementation affect gene expression in early zebrafish embryos to inform aquatic environmental health and developmental biology.

Abstract | Full Text |PDF (263 KB) | Open Access Article


Published online 31 March 2024

Predicting Functional Impacts of Amino Acid Substitutions in Exon 21 of the ATP7B Gene for Wilson Disease Diagnosis

Omar Qahtan Yaseen 1*, Asra’a Adnan Abdul-Jalil 2*

pp. 1-6

This study determined the SAASs' impact on protein function aids in diagnosing genetic diseases like Wilson disease using bioinformatics algorithms.

Abstract | Full Text |PDF (732 KB) | Open Access Article


Published online 31 March 2024

The Acanthamoeba and Sappinia inflammation Induction in Cancer Patients' Oral Cavity

Shaymm Abd al Hussein Khalaf 1*, Bassad A. AL-Aboody 1

pp. 1-7

This study showed the presence and prevalence of Free-living Amoebae (FLA), particularly Acanthamoeba and Sappinia, in immunocompromised cancer patients is crucial for disease management and prevention.

Abstract | Full Text |PDF (833 KB) | Open Access Article


Published online 23 March 2024

Nanoparticle-Mediated Plasmid Curing in Combating Antibiotic Resistance in Pathogenic Bacteria

Muntaha R. Ibraheem 1*, Dhafar N. Al-Ugaili 2

pp. 1-9

Novel approach fights antibiotic resistance. Enhances DNA extraction efficiency. Eliminates resistance plasmids, aiding biotechnology. Highlights research needs for nanoparticle optimization and mechanism understanding.

Abstract | Full Text |PDF (596 KB) | Open Access Article


Published online 22 March 2024

High Growth Differentiation Factor-15 (GDF-15) in Rheumatoid Arthritis Patients Potential Risk for Cardiovascular Disease

Ghufran Abd Omran Abdulridha 1,2*, Mustafa Abdulkadhim Hussein 3, Suhad Rasheed Majeed 3

 

pp. 1-8

This study showed the high levels GDF-15, a clinical marker in rheumatoid arthritis, signified disease progression and heightened cardiovascular risk, implicating inflammation and tissue damage.

Abstract | Full Text |PDF (441 KB) | Open Access Article


Published online 08 March 2024

Postmenopausal Hormone, Hematology and Immune Modulation in Rheumatoid Arthritis Patients

Luma Qasim Ali 1, Firas Salih Abdulhadi 1, Ban Talib El-Haboby 1, Jamela Jouda 1*

pp. 1-9

This research determined the significant hematological, hormonal, and immunological changes in postmenopausal women with RA or SLE in compared to controls. This investigation had a high potential for therapeutic intervention.

Abstract | Full Text |PDF (280 KB) | Open Access Article


Published online 06 March 2024

Determination of Health Service for Beneficiary Satisfaction: A Study of Maysan Child and Maternity Hospital

Saad Bader Abbas 1*, Rihab Al-Bedoui Bin Salem 2*

pp. 1-8

Research on health service satisfaction highlights vital insights for improving care, enhancing patient well-being, and optimizing resource utilization for better outcomes.

Abstract | Full Text |PDF (274 KB) | Open Access Article


Published online 06 March 2024

Prolonged Formalin Exposure on Liver and Kidney Function Associated with TP53 Gene Expression in Quail Birds (Coturnix coturnix)

Iman Ibrahim Al hacham 1, Abdulrazzaq B. kadhim 2*, Eman F. Albaghdady 3

pp. 1-9

This study demonstrated a prolonged formaldehyde exposure in quails. It caused liver and kidney damage and affected gene expression as potential cancer risks.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Published online 24 February 2024

The Effect of Brain Natriuretic Peptide, and Prothrombin Biomarkers in Pregnant Women With Gestational And Chronic Hypertension

Saif al deen M. Khatlan 1*, Wijdan I.A. Abd-alwahab 2

pp. 1-7

A study of gestational hypertension (GH) and chronic hypertension (HT) impact pregnancy, emphasizing the importance of monitoring brain peptide and biomarkers.

Abstract | Full Text |PDF (247 KB) | Open Access Article


Published online 20 February 2024

Cumin Extract Alters The Histology of Kidney and Duodenum in Adult Rabbit

Hussein B. Mahmood 1*,  Naseer  A. Al-Arubaye 1, Walaa F. Obead 1

pp. 1-6

This study showed the histological alterations of the kidney and duodenum due to excessive use of cumin.

Abstract | Full Text |PDF (480 KB) | Open Access Article


Published online 19 February 2024

Determination of Demographic Liver Health with Giardia lambila Infection Analysis in Diyala

Noora Dhyaaldain Abed 1*, Shahad Abdul Jabbar Mohammed 2*

pp. 1-5

This study analyzed the Giardia infection as early detection for liver health intervention.

Abstract | Full Text |PDF (189 KB) | Open Access Article


Published online 18 February 2024

Diagnosis of Chronic Brucellosis with Interferon-Gamma Quantification

Sarah Yahya Abdullah 1, Yasir Mufeed Abdulateef 2*, Sawsan Qahtan Taha Al-Quhli 3

pp. 1-8

This study showed the improvement of brucellosis diagnosis using interferon-gamma for better detection in chronic cases

Abstract | Full Text |PDF (402 KB) | Open Access Article


Published online 17 February 2024

The Analysis of Hematological Parameters CBC, ABO, NLR, and APTT and Its Implications on Haemophilic Patients with Low Bone Mineral Density

Rasha Ibrahim Salman 1* , Khalid Mahdi Salih 1, Nidal Karim Al-Rahal 2

pp. 1-7

The study determined a high prevalence of low bone mineral density in hemophilic patients, associated with elevated NLR and prolonged APTT.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Published online 15 February 2024

Association Between Low Bone Mineral Density in Hemophilia Patients and Musculoskeletal Function Impairments

Rasha Ibrahim Salman 1* , Khalid Mahdi Salih 1*, Nidal Karim Al-Rahal 2*

pp. 1-8

Hemophilia patients with low bone density (BMD) face higher risk with severe limitation of movement (LOM) and viral infections.

Abstract | Full Text |PDF (1007 KB) | Open Access Article


Published online 12 February 2024

A Double-blind, Randomized Clinical Trial Study of Plantago major l. Syrup on Menorrhagia

Sajedeh Ghasempour 1, Mohsen Naseri 2, Fatemeh Alijaniha 2, Yasin Karimi 3, Anoushirvan Kazemnejad 4, Shahrzad Hadavand 5 , Seyedeh Fatemeh Jafari 2, 6

pp. 1-8

The study highlights Plantago major's potential to reduce menorrhagia severity and duration, offering a promising complementary treatment with minimal side effects.

Abstract | Full Text |PDF (326 KB) | Open Access Article


Published online 23 January 2024

In vitro Antibacterial Activity of Seribu kuman Leaf (Rhinacanthus nasutus (l.) Kurz) Extracts Against Staphylococcus aureus and Pseudomonas aeruginosa

Betty Fitriyasti 1*, Siska Ferilda 2, Widia Sari 3, Muhammad Rizki Saputra 4, Heng Yen Khong 5*

pp. 1-7

Rhinacanthus nasutus extract inhibits the growth of Staphylococcus aureus and could serve as an alternative in treating infections caused by S. aureus.

 

Abstract | Full Text |PDF (396 KB) | Open Access Article


Published online 05 December 2023

Gymnemagenin a Promising Drug Candidate for Management of Hyperglycemia: In-Vitro and In-Vivo Study

Javed Ahamad1, Saima Amin2, Kamran J Naquvi1, Showkat R Mir3*

pp. 1-6

Study of Gymnema sylvestre plant for the treatment and management of diabetes.

Abstract | Full Text |PDF (349 KB) | Open Access Article


Published online 27 November 2023

Characterization of Essential Oil Composition of Syzygium aromaticum Linn. (Clove) by GC-MS and Evaluation of its Antioxidant Activity

Javed Ahamad 1*

pp. 1-5

The study of Clove essential oil as an antioxidant drug.

Abstract | Full Text |PDF (470 KB) | Open Access Article


Published online 29 July 2023

Design, Synthesis, And Characterization Of New Schiff Bases For 3-Amino-1,2,4-Triazole-5-Thiolate Salt, Bearing Morpholine Ring And Biological Evaluation As Antibacterial Agents

Abeer Hussein Alia, and Mukhlif Mohsin Slaihimb*.

pp. 1-9

Antibacterial efficacy of new chemical compounds named benzaldehyde derivatives.

Abstract | Full Text |PDF (532 KB) | Open Access Article


Published online 18 December 2021

Leptin Levels, Lipid Profiles, and Central Fat Distribution in Atherosclerosis: Implications for Cardiovascular Disease Risk

Mathangi R1, Selvaraj J2, Reji M3, Jaideep M4, Ponnulakshmi R5, Nalini D4*, Samyuktha. P6, Pugazharasan6

pp. 1-6

Understanding leptin's role in atherosclerosis and its link with metabolic and anthropometric factors can aid in cardiovascular risk management.

Abstract | Full Text |PDF (197 KB) | Open Access Article


Published online 18 December 2021

Resistin as a Potential Biomarker for Chronic Periodontitis in Patients with Type 2 Diabetes Mellitus

Keerthidaa Govindaraj1, Jayamathi Govindaraj2*, S.Bhuminathan 3, Vidyarekha U4 and Kesavaram Padmavathy5, Gowtham S6 and Nivetha V6

pp. 1-6

This study showed resistin's potential as a biomarker for periodontitis and its association with type 2 diabetes, emphasizing systemic inflammation's role.

Abstract | Full Text |PDF (245 KB) | Open Access Article


Published online 15 December 2021

In Vitro Anti-Inflammatory Potential of Mangifera Indica Peels

Bhaskaran Sathyapriya1, Jayesh S Raghavendra2, Swamikannu Bhuminathan3, Adugula Chandrakala4, Kesavaram Padmavathy5*, Bharathwaj D K6, Indhumathi Krishnaswamy6

pp. 1-5

This study determined Mangifera indica peels' significant anti-inflammatory effects, supporting their use in natural remedies and sustainable practices.

Abstract | Full Text |PDF (163 KB) | Open Access Article


Published online 08 December 2021

Chemo-Preventive Effect of 1-Piperoyl Piperidine (Piperine) is Mediated Through Intrinsic Signaling Mechanisms in Human Prostate Cancer Cells (Pc-3) In Vitro

Mathangi1, Nalini D2, Ponnulakshmi R3, Monisha Prasad4, Lakshmi Priya5, Selvaraj J6*, Prasannakumar M7, Naveen Chander K7

pp. 234-240

Piperine can be considered a potential phototherapeutic drug for the treatment of prostate cancer.

Abstract | Full Text |PDF (400 KB) | Open Access Article


Published online 12 September 2020

Dose Dependent Synergism from Combination of Platinum Drugs with Curcumin against Colorectal Cancer Cell Lines

Hana Bali1, Jun Qing Yu1, Philip Beale2, and Fazlul Huq3

pp. 176-193

Ox in combination Cur demonstrated very high synergism against HT-29 and Caco-2 cell lines.

Abstract | Full Text |PDF (1002 KB) | Open Access Article


Reviews

Biological Sciences

Published online 16 July 2025

Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration

Mohammad Lutfor Rahman1*

pp. 1-15

Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.

Abstract | Full Text |PDF (729 KB) | Open Access Article


Published online 23 June 2024

Efficacy and Toxicity of Nanoencapsulation of Peronema canescens Extract in Reducing ARDS Inflammation In-vivo

Tonny Cortis Maigoda1*, Judiono Judiono2, Felix Zulhendri3,4, Meriwati Meriwati1, Rustam Aji1

pp. 1-10

This study demonstrated nanoencapsulation for effective delivery of Peronema canescens extract to reduce ARDS-related inflammation offers potential advancements in respiratory disease management.

Abstract | Full Text |PDF (795 KB) | Open Access Article


Published online 06 March 2024

An intra-oral infection Halitosis and its Causes, Diagnosis, and Treatment Strategies – A Systematic Review

Noora Abdulrazzaq Naji 1*, Safa Ali Hamad 2, Samar Khalid Al-Adel 2, Hamsa Thabet Musa 2, Saja Sami Malik 2 

pp. 1-9

Halitosis, a prevalent issue, often remains untreated, causing social discomfort. Oral causes, especially bacterial buildup, necessitate effective dental management strategies.

Abstract | Full Text |PDF (265 KB) | Open Access Article


Published online 04 March 2024

Modified VGG-19 Deep Learning Strategies for Parkinson's Disease Diagnosis - A Comprehensive Review and Novel Approach

Aruna Kokkula 1*, P. Chandra Sekhar 2, T. M. Praneeth Naidu 3

pp. 1-11

This study showed VGG-19 model with superior training speed, accuracy, and iteration efficiency, significantly enhancing Parkinson’s disease diagnosis from MRI images.

Abstract | Full Text |PDF (976 KB) | Open Access Article


Published online 27 February 2024

Interplay And Causative Relationship Between Frailty And Atherosclerosis

Anastasia V. Poznyak 1*, Victoria A. Khotina 2, Roghayyeh Vakili-Ghartavol 2,3, Victor Y Glanz 2, Vasily N. Sukhorukov 2, Alexander N. Orekhov 2*

pp. 1-11

Frailty syndrome (FS) and cardiovascular diseases have a significant interaction, which impacts both the patient experience and how they are managed. Knowledge about the intricate associations between the two could provide a meaningful way towards developing targeted interventions.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Published online 08 December 2023

Current Perspective on Pesticides: Their Classification, Behaviour, Potential Use and Toxic Effects

Adil Ahamad1*, Javed Ahamad2, Mohd. Javed Naim2

pp. 1-12

Monitoring the use of pesticide and analyzing their acceptable levels for human health.

Abstract | Full Text |PDF (442 KB) | Open Access Article


Published online 12 August 2023

A review of the effects of Calophyllum spp. on cancer cells

Melissa Kilus1, Nozlena Abdul Samad1*, Shaari Daud2

pp. 1-6

Abstract | Full Text |PDF (225 KB) | Open Access Article


Published online 18 December 2021

Saliva as a Diagnostic Medium: Biomarker Identification, Genetic Analysis, and Disease Association

Usha Subbiah1*, Harini Venkata Subbiah1, Sumathi K2, Shenbaga Lalitha S2

pp. 1-8

Saliva acts as a non-invasive, cost-effective medium for diagnosing diseases, enabling biomarker identification, genetic analysis, and monitoring systemic health.

Abstract | Full Text |PDF (245 KB) | Open Access Article


Published online 15 December 2021

Signaling Pathway Genetic Variations in Apical Periodontitis

Athira Ajith1, Usha Subbiah1*, Deepika. P2, Minthami Sharon P2

pp. 1-6

The purpose of this review is to provide information on host response and genetic variations in major apical periodontitis signaling pathways.

Abstract | Full Text |PDF (316 KB) | Open Access Article


Published online 11 November 2021

Phytochemicals with Direct and/or Indirect Anti-angiogenic Properties Against Various Cancer Types Focusing on Their Mechanism of Action

Ibrahim Al-deeb1,2,3, Julia Joseph1, Amin Malik Shah Abdul Majid2, Nozlena Abdul Samad1

pp. 226-233

Abstract | Full Text |PDF (289 KB) | Open Access Article


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