A Clinical Analysis of Measles Outbreak and Immunization Gaps

Gulnora A. Arashova

doi:10.25163/angiotherapy.869754

Angiogenesis, Inflammation & Therapeutics | Online ISSN 2207-872X

RESEARCH ARTICLE (Open Access)

Previous Next Contents Vol 8 (6)

A Clinical Analysis of Measles Outbreak and Immunization Gaps

Gulnora A. Arashova ^1*

+ Author Affiliations

Journal of Angiotherapy 8 (6) 1-6 https://doi.org/10.25163/angiotherapy.869754

Submitted: 21 April 2024 Revised: 23 June 2024 Published: 24 June 2024

Abstract

Background: Measles remains one of the most highly contagious infectious diseases globally, despite extensive vaccination efforts. Its high transmissibility and lack of specific treatment highlight the critical need for preventive measures. Recent outbreaks across Europe have underscored the persistent presence of non-immune populations, exacerbating the spread of the virus. This study aims to examine the clinical features and age distribution of measles cases in Bukhara amidst widespread immunization efforts. Methods: This observational study analyzed 369 measles patients admitted to the regional Bukhara infectious diseases hospital from January 2023 to January 2024. Diagnoses were based on clinical symptoms and confirmed through enzyme-linked immunosorbent assays detecting IgM antibodies. Detailed epidemiological and clinical histories were recorded and analyzed to identify disease patterns and severity. Results: The patient cohort included children and adults aged 6 months to 51 years. The highest incidence was among children under one year (41%) and those aged 1-5 years (27%). A significant portion of the patients (58%) were unvaccinated, while vaccination status was unknown for 42%. Clinical severity varied, with 72.2% experiencing moderate symptoms and 6.4% mild symptoms. Notably, 97% developed acute symptoms, and 81.1% exhibited Belsky-Filatov-Koplik spots. Complications such as pneumonia and bronchopneumonia were more common in children under one year (42%) and adults with chronic conditions (11%). Conclusion: The age distribution of measles cases highlights the vulnerability of children under one year and those between 1-5 years. The findings suggest a potential decline in post-vaccination immunity, stressing the need for comprehensive immunization and booster programs. Measles continues to manifest with moderate severity and significant complications in specific age groups, emphasizing the importance of sustained vaccination efforts to mitigate outbreaks.

Keywords: Measles, Outbreak, Immunization, Clinical Features, Complications

References

Amirkulovna, A. G. (2022). Observation of the Immuno-Pathogenetic State of Measles in Adults. International Journal of Health Systems and Medical Sciences, 1(5), 154-158.

Amiruzzaman, M., Islam, M. R., Islam, M. R., & Nor, R. M. (2022). Analysis of COVID-19: An infectious disease spread. Journal of Internet Services and Information Security, 12(3), 1-15.

Arashova, G. A. (2021). Pecularties of the disease chickenpox in adults. World Medicine Journal, 1(1), 100-104.

Arashova, G. A. (2022). Clinical and epidemiological features of measles in adults. Journal of Infection, Immunity and Pharmacology, 1(2), 12-17.

Arashova, G. A. (2022). Measles in adults. Journal New Day in Medicine, 2(40), 556-559.

Dementyev, A. S. (2016). Airborne infections. Standards of Medical Care. M.: GEOTAR-Media, pp. 448.

Esaulenko, E. V. (2012). Clinical and epidemiological characteristics of measles in adults. Treatment and prevention, (3), 90–92.

Kutlu, Y., & Camgözlü, Y. (2021). Detection of coronavirus disease (COVID-19) from X-ray images using deep convolutional neural networks. Natural and Engineering Sciences, 6(1), 60-74.

Lobzin, YV. (2015). Clinical recommendations (treatment protocol) for providing medical care to children with measles. St. Petersburg, Paragraphs.

Measles. World Health Organization. http://www.who.int/ru/news-room/fact-sheets/detail/measles.

Nizam, M., Zaneta, S., & Basri, F. (2023). Machine Learning based Human eye disease interpretation. International Journal of Communication and Computer Technologies (IJCCTS), 11(2), 42-52.

Pokrovsky, V. I. (2007). Infectious diseases and epidemiology: textbook. 2nd ed., M.: GEOTAR-Media.

Ponezheva, Z. B., Arakelyan, A. K., Kozlova, M. S., Vdovina, E. T. (2018). Measles in adults. Epidemiology and infectious diseases, 50–55.

Pozdnyakov, A. A. (2018). Manifestations of the epidemic process of measles and rubella at the present stage. Epidemiology and vaccine prevention, 17(5), 45–53.

Timchenko, V.N. (2017). Current problems of measles infection. Pediatrician, (3), 120–129.

Venugopal, R.M. (2023). Efficient Hybrid CNN Method to Classify the Liver Diseases. Journal of Wireless Mobile Networks, Ubiquitous Computing, and Dependable Applications, 14(3), 36-47.

WHO Plan, (2019). Elimination of measles and rubella in the European Region. www.euro.who.int › pdf_file › e 96153-Rus-final-version

Yunasova, T. N. (2017). Analysis of measles incidence in Russia and problems of measles prevention at the elimination stage. Scientific Center for Expertise of Medical Products of the Ministry of Health of the Russian Federation.

Yushchuk, N. D. (2016). Viral diseases. Tutorial. M.: GEOTAR-Media, pp. 640.

PDF
Abstract
Export Citation

View Dimensions

View Plumx

View Altmetric

Save

0
Citation

404
View

Share