Interplay And Causative Relationship Between Frailty And Atherosclerosis
Anastasia V. Poznyak 1*, Victoria A. Khotina 2, Roghayyeh Vakili-Ghartavol 2,3, Victor Y Glanz 2, Vasily N. Sukhorukov 2, Alexander N. Orekhov 2*
Journal of Angiotherapy 8(2) 1-11 https://doi.org/10.25163/angiotherapy.829449
Submitted: 01 January 2024 Revised: 20 February 2024 Published: 27 February 2024
Abstract
Frailty syndrome is a complex condition with numerous contributing factors. It is characterized by a decline in physiological reserves and increased susceptibility to stress due to multi-system impairments. Commonly associated with aging, frailty can lead to adverse outcomes such as hospitalization, falls, and mortality. Cardiovascular diseases are recognized as a significant risk factor for frailty syndrome and frequently coexist in the elderly population. This review aims to explore the relationship between cardiovascular diseases and frailty syndrome. Research demonstrates that both acute and chronic cardiac conditions are prevalent among the risk factors for frailty. Cardiovascular diseases often manifest against the backdrop of atherosclerosis (AS) and are a leading cause of death in older adults. This review seeks to examine potential pathways through which cardiovascular events contribute to the development of frailty syndrome. Frail individuals often experience impaired physical function, significantly impacting their quality of life. Understanding the link between subclinical cardiovascular events and the pathogenesis of frailty syndrome is crucial for developing effective therapeutic interventions. Investigating how cardiovascular events influence the progression of frailty can provide valuable insights into improving clinical outcomes for frail patients.
Keywords: Frailty, Atherosclerosis, Cardiovascular disease
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