Journal of Angiotherapy
Angiogenesis, Inflammation & Therapeutics | Online ISSN  2207-872X
  1. You are here:
  2. Home
  3. Journals
  4. Biological Sciences
RESEARCH ARTICLE   (Open Access)
Contents Vol 8 (4)

Modeling Multifocal Atherosclerosis in Rabbits for Gender Influence and Lipid Profile Effects

Maksud M. Asadullayev 1, Khilola T. Mirakhmedova.2, Nataliya  L.Vipova 3, Albina V.Filatova 3, Rustam N. Jalolov 5, Doston R. Jumanazarov.5 , Nargiza M.Vaxabova 2, Ixtiyor T.Aliqulov 2, Sardoriddin Sh.Srojidinov 2

+ Author Affiliations

Journal of Angiotherapy 8 (4) 1-8 https://doi.org/10.25163/angiotherapy.849662

Submitted: 26 February 2024 Revised: 04 April 2024  Published: 15 April 2024 

Abstract

Background: Circulatory diseases (CD) show a significant health risk globally, particularly in countries like Uzbekistan, where mortality rates from non-infectious diseases, including CD, are alarmingly high. Despite advancements in treatment methods, mortality from CD continues to rise. It emphasizes the need for deeper understanding and effective treatment strategies for multifocal atherosclerosis. Method: A study was conducted using Chinchilla rabbits to simulate multifocal atherosclerosis. The influence of gender and diet on atherosclerosis was studied, along with the impact of blood lipid composition on the coagulation system. Ultrasound examinations of the aorta and its large branches were performed to monitor the dynamics of atherogenesis. Result: The study revealed that a cholesterol-enriched diet led to significant increases in blood lipid parameters, indicating hyperlipidemia. Coagulogram parameters shifted towards hypercoagulation, accompanied by increased platelet count and signs of systemic inflammation. Ultrasound examinations identified early manifestations of atherosclerosis, with male rabbits exhibiting higher lipid profile indicators and inflammatory markers compared to females. Conclusion: The study showed the pronounced effects of a cholesterol-enriched diet on blood lipid parameters and coagulogram parameters in rabbits, particularly in males, highlighting their susceptibility to atherosclerosis. Ultrasound monitoring proved valuable in detecting early signs of atherosclerosis. These findings underscore the importance of developing interventions targeting multifocal atherosclerosis, with rabbit models providing a platform for future drug development and treatment strategies, including potential therapies for atherosclerosis.

Keywords: Atherosclerosis, Rabbits, Gender, Lipid Profile, Multifocal Atherosclerosis

References

Anastasia V. Poznyak, Ludmila V Nedosugova, Vasily N. Sukhorukov. (2023). Hepatitis C and atherosclerosis: inflammatory interplay, Journal of Angiotherpay, 7(1), 1-10, 9361

Anastasia V. Poznyak, Varvara A. Orekhova, Vasily N. Sukhorukov. (2024a). Platelet Implication in Atherosclerosis Pathogenesis, Journal of Angiotherapy, 8(1), 1-8, 9385

Anastasia V. Poznyak, Vasily N. Sukhorukov, Igor A. Sobenin et al. (2024f). Exploring the Link between Chronic Inflammation and Atherosclerosis-Endometriosis Association, Journa of Angiotherapy, 8(3), 1-8, 9556

Anastasia V. Poznyak, Victoria A. Khotina, Alexandra A. Melnichenko et al., (2024b). Vitamin D Deficiency As A Contributor To Atherosclerosis Development – A Review, Journal of Angiotherapy, 8(2), 1-11, 9389

Anastasia V. Poznyak, Victoria A. Khotina, Roghayyeh Vakili-Ghartavol. (2024c). Interplay And Causative Relationship Between Frailty And Atherosclerosis, Journal of Angiotherapy, 8(2), 1-11, 9449

Anastasia V. Poznyak, Victoria A. Khotina, Roghayyeh Vakili-Ghartavo. (2024d). Neoatherosclerosis And Paleoatherosclerosis: Complications After Stenting, Journal of Angiotherapy, 8(2), 1-9, 9450

Anastasia V. Poznyak, Victoria A. Khotina, Roghayyeh Vakili-Ghartavol et al. (2024e). The Role of Natural Compounds for Atherosclerosis Treatment: Lessons Learned from The Use of Curcumin, Journal of Angiotherapy, 8(3), 1-8, 9555

Anastasia V. Poznyak, Victoria A. Khotina, Victor Y Glanz et al. (2024g). Advances in Cellular Models of Atherosclerosis, Journal of Angiotherapy, 8(3), 1-8, 9503

Anichkov, N. N. (1913). Proceedings of the Society of Russian doctors in St. Petersburg (Vol. 1, 90 p.).

Hu, Z., Gong, H., Yang, M., Niu, Y., et al. (2011). The granulocyte colony-stimulating factor promotes atherosclerosis in high-fat diet rabbits. Heart, 97(A27).

Instructions for the use of Sepid 10% fat emulsion.

Klimov, A. N. (1977). Causes and conditions of atherosclerosis development. In G. I. Kositsky (Ed.), Preventive cardiology (pp. 260-321). Medicine.

Leiderman, I. N. (2016). Fat emulsions in the clinical practice of parenteral nutrition in the intensive care unit. Spring of emergency medicine, (4), 75-78.

Luczak, M., Formanowicz, D., Pawliczak, E., Wanic-Kossowska, M., et al. (2011). Chronic kidney disease-related atherosclerosis – proteomic studies of blood plasma. Proteome Science, 9, 25.

Mathangi R, Selvaraj J, Reji M, Jaideep M, Ponnulakshmi R, Nalini D, Samyuktha. P, Pugazharasan. (2021). Relationship Between Ob Gene Product and Lipid Profile in The Pathogenesis of Atherosclerosis, Journal of Angiotherapy, 5(2)

Nepomnyashchikh, L. M., Filyushina, E. E., Mishina, S. V., Semenova, L. A., & Martynyuk, R. A. (1976). Morphological characteristics of rabbit myocardium in experimental atherosclerosis. Arch. pathologies, (5), 42-47.

Nizamov, U. I. (2021). Improvement of diagnostic and treatment methods in patients with coronary heart disease based on the assessment of risk factors for aging of the main vessels (pp. 19-35). Tashkent.

Protasov, E. A. (2018). Etiology of atherosclerosis: Dietary cholesterol (opinion on the problem). Cardiology: News, opinions, training, 6(2), 91-93. https://doi.org/10.24411/2309-1908-2018-1202

Ragino, Yu. I., Chernyavsky, A. M., Volkov, A. M., Volkova, I. I., & Voevoda, M. I. (2011). Factors and mechanisms of development of coronary atherosclerosis. Novosibirsk: Nauka.

Rekhter, M. D., Hicks, G. W., Brammer, D. W., et al. (2000). Hypercholesterolemia causes mechanical weakening of rabbit atheroma: local collagen loss as a prerequisite of plaque rupture. Circulation Research, 86, 101–108.

Santos, M. J., & Fonseca, J. E. (2009). Metabolic syndrome, inflammation and atherosclerosis – the role of adipokines in health and in systemic inflammatory rheumatic diseases. Acta Reumatol. Port., 34, 590–598.

State Committee of the Republic of Uzbekistan on Statistics. (2022). Analytical materials.

Voronkova, N. A., Kuspanalieva, D. S., & Maslova, M. V. (2021, November 3). Ways of reproducing experimental atherosclerosis in laboratory animals. Scientific and practical conference "Actual problems of pathophysiology," Chita.

World Health Organization. (2021). World Health Statistics, 2021: Health monitoring for achieving the SDGs.

Xiangdong, L., Yuanwu, L., Hua, Z., Liming, R., et al. (2011). Animal models for the atherosclerosis research: a review. Protein Cell, 2, 189–201.

Zainab Abdlkadhim Aboshnin, Safa Azhar Razzaq, Zahraa Ibraheim Jawad Shubber, (2024). Impact of Dapagliflozin on Atherosclerosis through Inflammation and Oxidative Pathways, Journal of Angiotherapy, 8(2), 1-7, 9478

PDF
Abstract
Export Citation

View Dimensions


View Plumx


View Altmetric




Save
0
Citation
384
View

Share