Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health,
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Integrative Biomedical Research
Volume 9 Number 1 2025
Table of Contents
Case Study
Cell and Developmental Biology
Daud Yudhistira Sukanto 1, Danang Himawan Limanto 1*
This case highlights the challenges of managing ruptured aortic aneurysms with comorbidities, emphasizing multidisciplinary care and TEVAR’s limitations in complex cases.
Abstract | Full Text |PDF (796 KB) | Open Access Article
Health Sciences
Early Surgical Intervention in Congenital Pulmonary Airway Malformation: A Case Report
Ryan Prasdinar Pratama Putra1,2, Mohamad Rizki1,2, I Gusti Bagus Chandogya Giriastawa1,2, Dhihintia Jiwangga Suta Winarno1,2
Early recognition and surgical intervention in symptomatic CPAM cases prevent complications, ensuring optimal respiratory function and long-term clinical outcomes in neonates.
Abstract | Full Text |PDF (282 KB) | Open Access Article
Research Article
Biological Sciences
Pragya Sourabh 1*, Reena Panwar 1, Rafia Khanam 1
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Biomedical Image Analysis
Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
Moin Uddin Patwary1*, Tanjila Hasan Tulon1, Shamim Al Mamun1, Md. Mortuza Galib1, Ezaz Ahmad Shah1, Antu Das2, Rudro kumar Saha1, Sabrina Sultana Sneha1, Arobi Akter Mim1, Jinia1
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
Abstract | Full Text |PDF (878 KB) | Open Access Article
Cardiovascular Medicine
Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
Md. Maruf-Ur-Rahman1,2*¶, Md. Rafiqul Islam2*¶, Wazeda Begum3, Md. Fakhrul Islam Khaled4
¶equal author contribution
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
Abstract | Full Text |PDF (555 KB) | Open Access Article
Cell and Developmental Biology
Zulfayandi Pawanis1, Heroe Soebroto2, Dhihintia Jiwangga2, Yan Efrata Sembiring, Puruhito2
SDS significantly reduces type I and III collagen density in decellularized bovine pericardium, whereas H2O2 better preserves extracellular matrix integrity.
Abstract | Full Text |PDF (344 KB) | Open Access Article
Chemistry
Mohammed Abbas Al-Silaykhee1 , Saif Ddin Kadhoum Al-Zamili2 , Ahmed Ghdhban Al-Ziaydi1*
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
Abstract | Full Text |PDF (519 KB) | Open Access Article
Damilola A. Omoboyowa1*, Elijah A. Agboola 1, Damilola S. Bodun 1, Simbo T. Akinsulure 1, Samia Belahcene 2, Dhurgham Al-Fahad 3
Curculigo pilosa extracts exhibit strong antioxidant properties, mitigating oxidative stress in Drosophila melanogaster, highlighting potential therapeutic applications.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
Sakina Ruhi1, Nur Alyssya Binti Yusoff 2*, Sohayla M. Attalla3, Jiyauddin Khan3, Norshafarina Shari Kamaruddin3, Indang Ariati2, Husni Ahmed Al-Gosha1, Subramanian Rammohan1, Ayesha Syed 1, Rajesh Thangarajan1
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
Abstract | Full Text |PDF (220 KB) | Open Access Article
Clinical Biochemistry
Nusrat Chowdhury1*, Nirmal Chandra Mahat2, Tufael3, Md Abu Bakar Siddique4
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Health Sciences
Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
Abla Hannachi-Hecini 1,4*, Aya Mekimah 2, Soundous Gharbi 2, Houcine Laouar 3,4, Chafia Bentchouala 3,4
Abstract | Full Text |PDF (687 KB) | Open Access Article
Wiwi Hasmita1, Muhammad Alwy Arifin 1, Muhammada Yusran 1, Darmawansyah Darmawansyah1, Nurhaedar Jafar2, Hariani Hariani 3
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
Abstract | Full Text |PDF (427 KB) | Open Access Article
Fatma A. Ahmed 1, Hesham M. Elsayed 1, Waleed A. Bichari 1, Kaled R. Elsisi 1, Mustafa A. Aboalkhair 1*
This study determines the effects of dialysis modalities on FGF-23 levels and cardiovascular calcification, offering insights into improving ESRD patient outcomes.
Abstract | Full Text |PDF (217 KB) | Open Access Article
Naima Layachi 1, 2*, Amel Berrezeg 3, 4
Ethyl acetate extract of Laurus nobilis leaves showed potent antioxidant and anti-inflammatory activities, highlighting its therapeutic and pharmacological potential.Pages: 1-8
Abstract | Full Text |PDF (331 KB) | Open Access Article
Natural Products
Shahrina Shah Jahan1, Wan Amir Nizam Wan Ahmad 2, Rafidah Husen1
This study evaluates Ostodes pauciflora Merr. seed oil for antidiabetic properties, providing insights into its potential as a functional food alternative.
Abstract | Full Text |PDF (407 KB) | Open Access Article
Public Health
Md Samiul Bashir1*, Md. Abu Sayem 2, Shib Shankar Das3, Nishita Das4, Afrin Sultana5, Md. Moshiur Rahman6, Md Shamsuzzaman7, Pravas Paul8, Moazzam Hossian9, Md. Khaja Mohi Uddin 10
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
Abstract | Full Text |PDF (688 KB) | Open Access Article
Cardiovascular Complications in Patients with Hepatocellular Carcinoma
Md. Khaja Mohi Uddin1, Afrin Sultana 2, Md. Moshiur Rahman3, Md Shamsuzzaman4, Pravas Paul 5, Md Mahmudul Hasan 6, Md. Abu Sayem 7, Md Samiul Bashir 8*, Shib Shankar Das 9, Moazzam Hossian 10
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
Abstract | Full Text |PDF (409 KB) | Open Access Article
Reviews
(Unspecified)
Sama Attiyah 1*
This review discusses the viral infections, transmission, and morphology for developing effective diagnostics, treatments, and preventive strategies against future pandemics.
Abstract | Full Text |PDF (663 KB) | Open Access Article
AI in Biomedical Research
Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
Yue Li¹*, Shunqi Liu2 *, Ran Tong³, Pengfei Zhang4, Jiang Bian5, Tong Wang6, Panpan Gu7
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
Abstract | Full Text | Open Access Article
Biological Sciences
Mohammad Lutfor Rahman1*
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
Abstract | Full Text |PDF (729 KB) | Open Access Article
Cell and Developmental Biology
Alexander V. Blagov1*, Vladislav A. Kalmykov1, Olga N. Maltseva2, Alikhan Z. Asoyan1, Anastasia O. Maksaeva1,3, Alexander N. Orekhov1,4*
Understanding immune mechanisms in atherosclerosis enables development of targeted anti-inflammatory therapies, improving cardiovascular outcomes and plaque stabilization strategies.
Abstract | Full Text |PDF (239 KB) | Open Access Article
Drug Delivery
Mohammad Lutfor Rahman1*, Md Al Mamun2, Ahad Ahamed3, Mohosin Kabir4, Faranak Nadarkhani Dinehkaboudi4, Marziyeh Zangeneh4, Md. Nezab Uddin5, AHM Quamruzzaman6
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
Abstract | Full Text |PDF (565 KB) | Open Access Article
Dipanjan Koley1, Vaibhav Walia2, Mohammed. Aslam3, Manvi Singh4*
Developing pegylated liposomal teriflunomide may enhance breast cancer treatment efficacy, reduce side effects, and improve patient outcomes.
Abstract | Full Text |PDF (426 KB) | Open Access Article
Drug Synthesis and Characterization
Nazmun Nahar 1, 2*
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
Abstract | Full Text |PDF (296 KB) | Open Access Article
Health Sciences
AI-driven Innovations in Cancer Research and Personalized Healthcare
Rabi Sankar Mondal1*, Md Nazmul Alam Bhuiyan1, Lamia Akter2
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
Abstract | Full Text |PDF (683 KB) | Open Access Article
Md. Maniruzzaman1, Md. Rakib Rased Rana2, Md Mizan3, Md. Sakibul Hasan4, Md. Nasim 4, Saiful Islam3, Jannatul Ferdush Easha mony3, Farjana Akter Shimo3, Miss Nuzhat Tasnim2, Md Nahid Hasan2
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
Abstract | Full Text |PDF (272 KB) | Open Access Article
Effects of Physical Activity as A Treatment For Depression in the Elderly
José Vinicius Bulhões da Silva 1, Weslley Barbosa Sales 2, Natália Herculano Paz 3, Annicia Lins Freitas1, Natália Mota da Silva Borges 1, Andrea Carla Brandão da Costa Santos 3, Eduardo Eriko Tenório de França1, Pollyana Soares de Abreu Morais 3, José Heriston de Morais Lima 1
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
Abstract | Full Text |PDF (399 KB) | Open Access Article
Sanad Shujaaa Alanzi 1, Sulaiman Mohammed Abdullah Almayouf 1, Khaled Mohamed Nahil Alotaibi 2, Amer Obelk Attya Alanazi 2, Alsahli, Hassan Ghuwayzi 3, Omar Nashmi Alharbi 1, Obaid Hamlan Obaid Aldajani 1
This review highlights global CVD disparities, identifies major risk factors, and evaluates effective, cost-efficient prevention strategies for population health.
Abstract | Full Text |PDF (358 KB) | Open Access Article
Immunology
Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
Alexander V. Blagov1*, Marina D. Sazonova 1, Anastasia I. Ryzhkova1, Vasily P. Karagodin5, Mikhail A. Popov6, Egor Yu. Budnikov1, Alessio Luigi Ravani4, Alexander N. Orekhov1,4, Margarita A. Sazonova1,2, Yuri V. Arkhipenko1,3
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Metabolism and Biochemistry
Analysis of Potential Biomarkers in Hypertension
Alexander V. Blagov1*, Margarita A. Sazonova 1,2, Anastasia I. Ryzhkova1, Marina D. Sazonova1, Mikhail A. Popov6, Egor Yu. Budnikov1, Paolo Poggio7, Donato Moschetta7, Yuri V. Arkhipenko1,3, Vasily P. Karagodin5, Alexander N. Orekhov1,4
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Public Health
An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
K M Sadat Samin1*, Soraya Sadek2
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
Abstract | Full Text |PDF (347 KB) | Open Access Article
Systematic Review
Health Sciences
Sree Shib Shankar Devnath Debu1, Israt Jahan Eti2, Subrata Sarker Shubho3, Md. Manjurul Islam4, Mamata Mostari5, Umme Sadia6
This study is significant as it highlights the effectiveness of smart nutrition and active living in managing hypertension, promoting sustainable, non-pharmacological interventions for better cardiovascular health.
Abstract | Full Text |PDF (917 KB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
The Most Read ranking is based on the number of downloads in the last 60 days from papers published on the Journal of Angiotherapy within the last 12 months. Usage statistics are updated daily.
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Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
-
Advancements in Virus Detection and Isolation: The Role of Chromatography in Virology Research and Health
This review discusses the viral infections, transmission, and morphology for developing effective diagnostics, treatments, and preventive strategies against future pandemics.
-
Lung-Targeted Solid Lipid Nanoparticles for Enhanced Pulmonary Delivery of Anti-Tubercular Drugs: A Novel Approach to Improve Bioavailability
Solid lipid nanoparticles improved anti-tubercular drug encapsulation, stability, and lung retention, offering a promising targeted pulmonary delivery approach for tuberculosis treatment.
-
Analysis of Potential Biomarkers in Hypertension
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
-
Impact of Hemodiafiltration and Hemodialysis on FGF-23 Levels and Cardiovascular Calcification in End-Stage Renal Disease
This study determines the effects of dialysis modalities on FGF-23 levels and cardiovascular calcification, offering insights into improving ESRD patient outcomes.
-
Predicting Habitat Suitability and Climate Change Impact on Medicinal plant Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
-
Antioxidant Potential of Curculigo pilosa Rhizome Extracts in Hydrogen Peroxide Induced Oxidation In Vivo
Curculigo pilosa extracts exhibit strong antioxidant properties, mitigating oxidative stress in Drosophila melanogaster, highlighting potential therapeutic applications.
-
A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
-
Effects of Physical Activity as A Treatment For Depression in the Elderly
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
-
Collaborative Governance in Combating Illegal Cosmetics: A Study of Multi-Stakeholder Dynamics in South Sulawesi, Indonesia
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
-
Smart Nutrition and Active Living in Hypertension Management: Assessing Lifestyle Behaviors, Barriers, and the Role of Digital Health Tools
This study is significant as it highlights the effectiveness of smart nutrition and active living in managing hypertension, promoting sustainable, non-pharmacological interventions for better cardiovascular health.
-
Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
-
Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
-
High Viral Load is a Risk Factor for Hepatocellular Carcinoma: Clinical and Laboratory Insights from a Cross-Sectional Study
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
-
Phytochemical Composition, Antioxidant, and Anti-Inflammatory Activities of Laurus nobilis Leaf Extracts Using Solvent Fractionation
Ethyl acetate extract of Laurus nobilis leaves showed potent antioxidant and anti-inflammatory activities, highlighting its therapeutic and pharmacological potential.Pages: 1-8
-
PEGylated Liposomal Teriflunomide: A Novel Approach of Targeted Breast Cancer Treatment to Advance Efficacy and Minimize Adverse Effects
Developing pegylated liposomal teriflunomide may enhance breast cancer treatment efficacy, reduce side effects, and improve patient outcomes.
-
Comparative Effects of Sodium Dodecyl Sulfate and Hydrogen Peroxide on Type I and III Collagen Preservation in Decellularized Bovine Pericardium Scaffolds
SDS significantly reduces type I and III collagen density in decellularized bovine pericardium, whereas H2O2 better preserves extracellular matrix integrity.
-
Multidisciplinary Challenges in Managing a Ruptured Ascending Aortic Aneurysm with Concurrent Pulmonary Pathology: A Case Report
This case highlights the challenges of managing ruptured aortic aneurysms with comorbidities, emphasizing multidisciplinary care and TEVAR’s limitations in complex cases.
-
The Importance of Autoimmunity and Chronic Inflammation in the Development of Atherosclerosis: New Treatment Strategies
Understanding immune mechanisms in atherosclerosis enables development of targeted anti-inflammatory therapies, improving cardiovascular outcomes and plaque stabilization strategies.
-
Cardiovascular Complications in Patients with Hepatocellular Carcinoma
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
-
Early Surgical Intervention in Congenital Pulmonary Airway Malformation: A Case Report
Early recognition and surgical intervention in symptomatic CPAM cases prevent complications, ensuring optimal respiratory function and long-term clinical outcomes in neonates.
-
The Evolving Role of Hospital and Community Pharmacist in Post-COVID-19 Healthcare Delivery in Bangladesh: A Survey-Based Analysis
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
-
OR-PSGAN-CNN: An Occlusion-Robust Deep Learning Framework for Early Detection of Cerebral Palsy in Infants Using RGB-D Videos
Improves early cerebral palsy detection by resolving pose occlusions through enhanced skeleton generation and feature extraction from infant movement videos.
-
Global Burden, Risk Factors, and Evidence-Based Strategies for Cardiovascular Disease Prevention: A Comprehensive Systematic Review
This review highlights global CVD disparities, identifies major risk factors, and evaluates effective, cost-efficient prevention strategies for population health.
-
AI-driven Innovations in Cancer Research and Personalized Healthcare
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
-
Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
-
Antidiabetic and Toxicological Evaluation of Ostodes Pauciflora merr. Seed (kop nut) Oil, A Potential Functional Food Alternative
This study evaluates Ostodes pauciflora Merr. seed oil for antidiabetic properties, providing insights into its potential as a functional food alternative.
-
Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
-
An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
-
Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
-
Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
-
Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
-
TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
-
Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
-
Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.