Analysis of Potential Biomarkers in Hypertension
Alexander V. Blagov1*, Margarita A. Sazonova 1,2, Anastasia I. Ryzhkova1, Marina D. Sazonova1, Mikhail A. Popov6, Egor Yu. Budnikov1, Paolo Poggio7, Donato Moschetta7, Yuri V. Arkhipenko1,3, Vasily P. Karagodin5, Alexander N. Orekhov1,4
Integrative Biomedical Research (Former Journal of Angiotherapy) 9(1) 1-8 https://doi.org/10.25163/biomedical.9110267
Submitted: 11 March 2025 Revised: 28 May 2025 Published: 31 May 2025
Abstract
Hypertension is a leading global health issue associated with significant morbidity and mortality. Early and accurate detection is crucial to prevent cardiovascular and renal complications. This article reviews both currently used and emerging biomarkers for hypertension. Current biomarkers include renin, aldosterone, and natriuretic peptides, which aid in diagnosing secondary hypertension but have limitations. Novel biomarkers—such as microRNAs, DNA methylation profiles, and metabolomics—are showing potential for early detection and personalized care. We compare the strengths and weaknesses of these biomarkers and emphasize the need for further validation in clinical settings. The goal is to enhance diagnostic precision and therapeutic strategies for hypertension through biomarker innovation.
Keywords: inflammation, biomarkers, hypertension, vascular, CRP
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