Natural Polyphenol-Rich Inhibitors of Pancreatic Lipase for Obesity Management – A Systematic Review

Kamran Javed Naquvi ¹*

This review discusses the plant-derived pancreatic lipase inhibitors as potential for natural, effective obesity management, reducing fat absorption and promoting metabolic health.

Abstract

Background: Obesity, a critical public health challenge, is associated with an increased risk of chronic diseases such as cardiovascular disease, diabetes, and cancer. Body mass index (BMI) categorizes obesity levels, with trends indicating a growing prevalence worldwide. Dietary choices and sedentary lifestyles contribute significantly to this condition, yet treatments remain limited by side effects. Pancreatic lipase, the primary enzyme in dietary fat digestion, presents a promising target for obesity management. Inhibitors of pancreatic lipase reduce fat absorption, lowering caloric intake and aiding in weight management. Synthetic inhibitors like orlistat are effective but lead to adverse gastrointestinal and systemic effects, creating a demand for safer alternatives. Methods: A thorough literature review was conducted using PubMed, Elsevier, ScienceDirect, and Google Scholar databases, employing search terms such as "herbal drugs," "polyphenols," "pancreatic lipase inhibitors," "antilipase," "natural products," and "antiobesity herbal drugs." Discussion and Conclusion: Polyphenol-rich plants such as Camellia sinensis (tea), Coffea (coffee), Punica granatum (pomegranate), Vitis vinifera (grape), and Curcuma longa (turmeric) exhibit natural pancreatic lipase inhibitory properties, offering therapeutic potential for obesity management. This review explores the bioactive compounds in these plants, emphasizing their efficacy and minimal side effects compared to synthetic drugs, and underscores the importance of further research in developing natural, polyphenol-based treatments for obesity.

Keywords: Polyphenols, Pancreatic lipase inhibitors, Obesity, Fat absorption, Plant-based therapy

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