Journal of Angiotherapy
Angiogenesis, Inflammation & Therapeutics | Online ISSN  2207-872X
  1. You are here:
  2. Home
  3. Journals
  4. Biological Sciences
RESEARCH ARTICLE   (Open Access)
Contents Vol 9 (1)

Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo

Sakina Ruhi1, Nur Alyssya Binti Yusoff 2*, Sohayla M. Attalla3, Jiyauddin Khan3, Norshafarina Shari Kamaruddin3, Indang Ariati2, Husni Ahmed Al-Gosha1, Subramanian Rammohan1, Ayesha Syed 1, Rajesh Thangarajan1

+ Author Affiliations

Journal of Angiotherapy 9 (1) 1-7 https://doi.org/10.25163/angiotherapy.81210101

Submitted: 11 November 2024 Revised: 04 January 2025  Published: 05 January 2025 

Abstract

Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, leading to severe complications such as cardiovascular diseases, neuropathy, and nephropathy. While pharmacological interventions like atorvastatin are effective in managing hyperlipidemia, concerns regarding their adverse effects necessitate alternative or adjunctive therapies. Cinnamomum zeylanicum (CZ) has shown promise in diabetes management due to its bioactive compounds, which enhance insulin sensitivity and regulate lipid metabolism. Objective: This study investigates the anti-hyperglycemic and anti-hyperlipidemic effects of Cinnamomum zeylanicum in combination with atorvastatin in streptozotocin (STZ)-induced diabetic rats, assessing glucose levels, lipid profiles, liver function, and renal parameters. Methods: Thirty-five male Sprague-Dawley rats were divided into seven groups, including control, diabetic, CZ (250 mg/kg and 500 mg/kg), atorvastatin (10 mg/kg), and combination therapy groups. Diabetes and hyperlipidemia were induced using STZ and Triton X-100, respectively. Biochemical parameters were analyzed using enzymatic assays, and statistical significance was determined via ANOVA. Results: CZ at 500 mg/kg significantly reduced blood glucose (8.3 ± 14.4 mg/dL) and improved lipid profiles by lowering total cholesterol, triglycerides, and LDL levels. Combination therapy showed moderate improvements but was less effective than CZ alone. Liver function markers indicated hepatoprotective effects, while renal parameters remained stable, confirming CZ's safety. Conclusion: Cinnamomum zeylanicum demonstrates potent anti-diabetic and lipid-lowering effects, with a favorable safety profile. These findings support its potential as a complementary therapy for diabetes management, warranting further clinical investigations.

Keywords: Cinnamomum zeylanicum, Diabetes, Atorvastatin, Lipid Metabolism, Streptozotocin

References

Ahmad, I., Hussain, N., & Amjad, M. (2015). Therapeutic potential of cinnamon in diabetes management. Phytotherapy Research, 29(6), 871-881.

Alsoodeeri, F. N., Alqabbani, H. M., & Aldossari, N. M. (2020). Effects of cinnamon (Cinnamomum cassia) consumption on serum lipid profiles in albino rats. Journal of Lipids.

American Heart Association. (2020). Treatment of high blood cholesterol. Clinician Pocket Guide. Retrieved from https://www.heart.org/-/media/Files/Health-Topics/Cholesterol/AHA20PrimaryPocketGuideFinal.pdf

Beheshti, A. S., Qazvini, M. M., Abeq, M., Abedi, E., Fadaei, M. S., Fadaei, M. R., Rahimi, V. B., & Askari, V. R. (2024). Molecular, cellular, and metabolic insights of cinnamon (Cinnamomum zeylanicum) advantages in diabetes and related complications: Condiment or medication? Naunyn-Schmiedeberg's Archives of Pharmacology. Retrieved from https://link.springer.com/article/10.1007/s00210-024-03644-0

Cortez-Navarrete, M., Pérez-Rubio, K. G., & Escobedo-Gutiérrez, M. de J. (2023). Role of cinnamon in type 2 diabetes treatment. Pharmaceuticals, 16(4), 515.

Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., … & Wilson, P. W. (2018). 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. Retrieved from https://www.ahajournals.org/doi/10.1161/CIR.0000000000000625

Lee, J.-J., Yi, H.-Y., Yang, J.-W., Shin, J.-S., Kwon, J.-H., & Kim, C.-W. (2003). Characterization of streptozotocin-induced diabetic rats and pharmacodynamics of insulin formulations. Bioscience, Biotechnology, and Biochemistry, 67(11), 2396-2401. Retrieved from https://www.jstage.jst.go.jp/article/bbb/67/11/67112396/_pdf

Li, R., Zhang, X., & Wang, Y. (2013). Induction of hyperglycemia and hyperlipidemia in rats using streptozotocin: Methodological considerations. Diabetes Research and Clinical Practice, 100(2), 218-225.

Nawrocki, J. W., Weiss, S. R., Davidson, M. H., Sprecher, D. L., Schwartz, S. L., Lupien, P., Jones, P. H., Haber, H. E., & Black, D. M. (1995). Reduction of LDL cholesterol by 25% to 60% in patients with primary hypercholesterolemia by atorvastatin, a new HMG-CoA reductase inhibitor. Arteriosclerosis Thrombosis and Vascular Biology, 15(5), 678–682.

Nurinda, E., et al. (2022). Antidiabetic activity of cinnamon bark and ginger extract. Open Access Macedonian Journal of Medical Sciences, 10(8), 1-6.

Padugupati, S., Ramamoorthy, S., Thangavelu, K., Sarma, D. S., & Jamadar, D. (2021). Effective dose of streptozotocin to induce diabetes mellitus and variation of biophysical and biochemical parameters in albino Wistar rats. Journal of Clinical and Diagnostic Research, 15(6), 1-5. Retrieved from https://www.jcdr.net/article_fulltext.asp?issn=0973-709x&year=2021&volume=15&issue=6&page=1&issn=0973-709x&id=15567

Pezzani, R., Salehi, B., Vitalini, S., Iriti, M., Zuñiga, F. A., Sharifi-Rad, J., Martorell, M., & Martins, N. (2019). Synergistic effects of plant derivatives and conventional chemotherapeutic agents: An update on the cancer perspective. Medicina (Kaunas), 55(4), 110.

Qamar, F., Sultana, S., & Sharma, M. (2023). Animal models for induction of diabetes and its complications. Journal of Diabetes & Metabolic Disorders, 22, 1021-1028. Retrieved from https://link.springer.com/article/10.1007/s40200-023-01277-3

Ranasinghe, P., Perera, S., Gunatilake, M., Abeywardene, E., Gunapala, N., Premakumara, S., Perera, K., Lokuhetty, D., & Katulanda, P. (2012). Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. Pharmacognosy Research, 4(2), 73-79.

Zari, M. A., & Al-Logmani, A. S. (2009). Effects of cinnamon on oxidative stress and lipid peroxidation. Journal of Medical Plants Research, 3(5), 246-249.

PDF
Abstract
Export Citation

View Dimensions


View Plumx


View Altmetric



1
Save
0
Citation
27
View
0
Share