Impact of Pharmacist-Led Interventions on Hypertension Management in Cancer Patients Undergoing Chemotherapy

Prachi Gurudiwan ¹*, Ritesh Patel ¹

This study determines the pharmacists' essential role in managing hypertension, enhancing cancer patient care, and improving overall health outcomes through targeted interventions.

Abstract

Background: Hypertension (HT) is a common cardiovascular condition, particularly prevalent among cancer patients, with approximately 40% exhibiting concurrent diseases. This study aimed to investigate the relationship between hypertension and cancer, focusing on how anticancer treatments contribute to hypertension and its cardiovascular complications. Methods: A retrospective analysis was conducted at a specialized pharmacy involving adults receiving oral chemotherapy. Participants were divided into control (n=50) and intervention (n=29) groups, based on their enrollment in a pharmacist-led hypertension management program. Data were collected on blood pressure (BP) measurements and interventions, with statistical analyses employed to assess differences between groups. Results: The intervention group demonstrated significant improvement in BP management, with 19 out of 29 patients achieving controlled BP by February 2023 (p=0.04), compared to 21 out of 50 in the control group. Continuous monitoring led to a gradual decline in average BP measurements in the intervention group, indicating effective management. Pharmacists made recommendations to physicians, achieving a 100% acceptance rate for medication adjustments. Conclusion: Integrating pharmacist-led interventions in managing hypertension among cancer patients significantly improves BP control and patient outcomes. Given the rising prevalence of hypertension in this population, further research is necessary to explore the long-term effects of such interventions and their broader implementation in clinical practice.

Keywords: Hypertension, Cancer, Pharmacist-led interventions, Chemotherapy, Patient outcomes

References

Alamer, L., Alqahtani, I. M., & Shadadi, E. (2023). Intelligent Health Risk and Disease Prediction Using Optimized Naive Bayes Classifier. Journal of Internet Services and Information Security, 13(1), 01-10.

Battineni, G., Sagaro, G. G., Chintalapudi, N., Amenta, F., Tomassoni, D., & Tayebati, S. K. (2021). Impact of obesity-induced inflammation on cardiovascular diseases (CVD). International Journal of Molecular Sciences, 22(9), 4798.

Bendor, C. D., Bardugo, A., Pinhas-Hamiel, O., Afek, A., & Twig, G. (2020). Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity. Cardiovascular diabetology, 19, 1-14.

Bukowski, K., Kciuk, M., & Kontek, R. (2020). Mechanisms of multidrug resistance in cancer chemotherapy. International journal of molecular sciences, 21(9), 3233.

Chatterjee, P., Siddiqui, S., Granata, G., Dey, P., & Abdul Kareem, R. S. (2024). Performance Analysis of Five U-Nets on Cervical Cancer Datasets. Indian Journal of Information Sources and Services, 14(1), 17–28.

Christakoudi, S., Kakourou, A., Markozannes, G., Tzoulaki, I., Weiderpass, E., Brennan, P., ... & Tsilidis, K. K. (2020). Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition. International journal of cancer, 146(10), 2680-2693.

Dieffenbach, B. V., Liu, Q., Murphy, A. J., Stein, D. R., Wu, N., Madenci, A. L., ... & Weil, B. R. (2021). Late-onset kidney failure in survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. European Journal of Cancer, 155, 216-226.

Elnaem, M. H., Rosley, N. F. F., Alhifany, A. A., Elrggal, M. E., & Cheema, E. (2020). Impact of pharmacist-led interventions on medication adherence and clinical outcomes in patients with hypertension and hyperlipidemia: a scoping review of published literature. Journal of Multidisciplinary Healthcare, 635-645.

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Ramakrishnan, J., Ravi Sankar, G., & Thavamani, K. (2019). Publication Growth and Research in India on Lung Cancer Literature: A Bibliometric Study. Indian Journal of Information Sources and Services, 9(S1), 44–47.

Ramana, R.H.V., & Ravisankar, V. (2024). Precision in Prostate Cancer Diagnosis: A Comprehensive Study on Neural Networks. Journal of Wireless Mobile Networks, Ubiquitous Computing, and Dependable Applications (JoWUA), 15(2), 109-122. https://doi.org/10.58346/JOWUA.2024.I2.008 

Staplin, N., de la Sierra, A., Ruilope, L. M., Emberson, J. R., Vinyoles, E., Gorostidi, M., ... & Williams, B. (2023). Relationship between clinic and ambulatory blood pressure and mortality: an observational cohort study in 59 124 patients. The Lancet, 401(10393), 2041-2050.

Surendar, A., Veerappan, S., Sadulla, S., & Arvinth, N. (2024). Lung cancer segmentation and detection using KMP algorithm. Onkologia i Radioterapia, 18(4).

Tam, H. L., Wong, E. M. L., & Cheung, K. (2020). Effectiveness of educational interventions on adherence to lifestyle modifications among hypertensive patients: an integrative review. International journal of environmental research and public health, 17(7), 2513.

Zhou, B., Perel, P., Mensah, G. A., & Ezzati, M. (2021). Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension. Nature Reviews Cardiology, 18(11), 785-802.