Journal of Angiotherapy
Integrative Biomedical Research | Online ISSN  2207-872X
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CASE STUDY   (Open Access)
Contents Vol 9 (1)

Early Surgical Intervention in Congenital Pulmonary Airway Malformation: A Case Report

Ryan Prasdinar Pratama Putra1,2, Mohamad Rizki1,2, I Gusti Bagus Chandogya Giriastawa1,2, Dhihintia Jiwangga Suta Winarno1,2

+ Author Affiliations

Journal of Angiotherapy 9 (1) 1-8 https://doi.org/10.25163/angiotherapy.9110164

Submitted: 09 December 2025 Revised: 14 January 2025  Published: 18 January 2025 

Abstract

Congenital Pulmonary Airway Malformation (CPAM) is a rare developmental anomaly of the bronchial tree, characterized by cystic or solid lung lesions. Early diagnosis has improved with advanced prenatal imaging, but symptomatic cases often require surgical intervention. This report presents a 2-month-old girl with respiratory distress, increased respiratory effort, and diminished breath sounds on the left side. Chest X-ray and high-resolution computed tomography (HRCT) revealed a large air-filled lesion in the left lung, causing a significant mediastinal shift. The patient underwent thoracotomy with bullectomy and wedge resection, leading to full lung expansion and symptom resolution. Postoperative recovery was uneventful, with excellent clinical improvement at follow-up. CPAM is classified into five types based on histopathologic and imaging characteristics, with Type 1 being the most common and having a favorable prognosis. Early infancy presentation often includes respiratory distress due to airway obstruction and cystic mass effect. Surgical excision remains the definitive treatment for symptomatic cases to prevent complications such as infection or malignant transformation. This case underscores the importance of early recognition, timely surgical intervention, and a multidisciplinary approach in optimizing outcomes for congenital lung anomalies.

Keywords: Bullectomy; Congenital Pulmonary Airway Malformation (CPAM); High-resolution computed tomography (HRCT); Neonatal respiratory distress; Thoracotomy.

References

Aryal, K., Regmi, P. R., Adhikari, G., et al. (2023). Congenital pulmonary airway malformation (CPAM): A case report and review of the literature. Radiology Case Reports, 18(10), 3483–3486.

Bertolino, A., Bertolo, S., Lago, P., et al. (2024). Congenital pulmonary airway malformation in preterm infants: A case report and review of the literature. Life, 14(8), 990.

Bhende, V. V., Sharma, T. S., Krishnakumar, M., et al. (2024). Surgical management of congenital pulmonary airway malformations (CPAM) in an infant and a toddler: Case report depicting two distinct surgical techniques with successful outcomes. Cureus.

Bolde, S. (2015). Congenital pulmonary airway malformation: A report of two cases. World Journal of Clinical Cases, 3(5), 470.

Cayonu Kahraman, N., Vanli Tonyali, N., Orgul, G., et al. (2024). Prenatal diagnosis of congenital pulmonary airway malformation (CPAM) types: Case series. Eastern Journal of Medicine, 29(4), 440–445.

Dasteh Goli, Y., & Datta, H. (2024). Early detection and management of congenital pulmonary airway malformation in a newborn with stable clinical course. Journal of Case Reports and Images in Pediatrics, 6(2), 5–10.

Downard, C. D., Calkins, C. M., Williams, R. F., et al. (2017). Treatment of congenital pulmonary airway malformations: A systematic review from the APSA outcomes and evidence-based practice committee. Pediatric Surgery International, 33(9), 939–953.

Habtamu Sime, G., Abera, A., Mengistu, A., et al. (2021). Congenital pulmonary airway malformation (CPAM): A case report, Jimma University Medical Center, Southwest Ethiopia. Ethiopian Journal of Health Sciences, 31(4).

Huang, M., & Gong, Y.-H. (2023). Treatment of congenital pulmonary airway malformation with rare high cystic volume ratio: A case report and literature review. Medicine, 102(47), e36249.

Jiang, Y., Luo, Y., Tang, Y., et al. (2019). Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. Scientific Reports, 9(1), 5296.

Jimoh, A., Gbobie, D., Ikwuagwu, E., et al. (2024). Congenital pulmonary airway malformation in a term female neonate with prune belly syndrome in Calabar Cross Rivers State, Southern Nigeria: A case report. Journal of Pediatrics & Neonatology, 5(2), 21–24.

Leblanc, C., Baron, M., Desselas, E., et al. (2017). Congenital pulmonary airway malformations: State-of-the-art review for pediatricians’ use. European Journal of Pediatrics, 176(12), 1559–1571.

Liao, J. (2024). Prognosis of infants with congenital pulmonary airway malformations after surgery: A short- and mid-term evaluation. American Journal of Translational Research, 16(1), 208–215.

Seear, M., Townsend, J., Hoepker, A., et al. (2017). A review of congenital lung malformations with a simplified classification system for clinical and research use. Pediatric Surgery International, 33(6), 657–664.

Ursini, W. P., & Ponce, C. C. (2018). Congenital pulmonary airway malformation. Autopsy & Case Reports, 8(2).

Yadav, A. P., Rai, B. K., Shah, P. K., et al. (2023). 19-day-old neonate with congenital pulmonary airway malformation: A case report. Medical Phoenix, 7(2), 53–55.

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