Shatadhauta Ghrita and Panchavalkala Prevent Wound Healing In Vivo

Tripti Dewangan ¹*, Kishor Kumar Sahu ¹

This study determined the potential of ancient Ayurvedic formulations for modern wound care, promoting effective healing while reducing treatment costs.

Abstract

Background: Wounds disrupt the integrity of skin or mucosa, causing significant cellular and vascular damage. Historical and modern research aims to improve wound healing through effective management strategies and therapeutic applications, particularly within traditional systems like Ayurveda. This study evaluates the efficacy of Shatadhauta Ghrita (SDG) combined with Panchavalkala Siddha Ghrita (PSSG) for wound healing, assessing their potential as modern treatments. Methods: Thirty mature Wistar strain albino rats were divided into five groups, including a control and treatment groups receiving SDG, Go-Ghrita (GH), and PSSG. Standardized excision wounds were created, and healing was monitored through wound contraction measurements over 21 days. Results: The control group showed a wound contraction of 91.53% after 15 days, increasing to 95.23% by day 21. The GH group exhibited 93.67%, while the SDG group had 87.95%. Notably, the SDG group demonstrated a contraction of 98.67% by day 21, outperforming both control and GH groups. Conclusion: SDG’s superior wound healing efficacy suggests it may serve as an effective topical treatment, supported by traditional Ayurvedic practices. This research emphasizes the importance of integrating traditional knowledge with scientific validation, advocating for further studies on SDG's biological properties and potential applications in modern medicine.

Keywords: Wound healing, Shatadhauta Ghrita, Panchavalkala, Ayurveda, SDG, rat model.

References

Bajaj, K. K., Chavhan, V., Raut, N. A., & Gurav, S. (2022). Panchgavya: A precious gift to humankind. Journal of Ayurveda and Integrative Medicine, 13(2), 100525.

Biswas, A., Maiti, P., & Sahu, M. (2022). Polymeric vehicles for controlled delivery of Ayurvedic drugs for wound management. In Biomedical Translational Research: Drug Design and Discovery (pp. 585-599). Singapore: Springer Nature Singapore.

Dhurve, V. A., & Dudhamal, T. S. (2020). Formulations of Panchavalkala as Vrana Shodhana and Vrana Ropana: A brief review. Indian Journal of Ancient Medicine and Yoga, 13(1), 17-22.

Dudhamal, T. S. (2023). Review of grey literature on Ayurveda wound healing formulations and procedures—A systematic review. Journal of Ayurveda and Integrative Medicine, 14(4), 100779.

Fazil, M., & Nikhat, S. (2020). Topical medicines for wound healing: A systematic review of Unani literature with recent advances. Journal of Ethnopharmacology, 257, 112878.

Mansouri, S. (2023). Application of neural networks in the medical field. Journal of Wireless Mobile Networks, Ubiquitous Computing, and Dependable Applications, 14(1), 69-81.

Monika, P., Chandraprabha, M. N., Rangarajan, A., Waiker, P. V., & Chidambara Murthy, K. N. (2022). Challenges in healing wounds: Role of complementary and alternative medicine. Frontiers in Nutrition, 8, 791899.

Nabeesab Mamdapur, G. M., Hadimani, M. B., Sheik, A. K., & Senel, E. (2019). The Journal of Horticultural Science and Biotechnology (2008-2017): A scientometric study. Indian Journal of Information Sources and Services, 9(1), 76–84.

Roja, L. D., & Ramlingh, H. (2022). Shashti Upakrama in the management of geriatric wound care. International Journal of Trend in Scientific Research and Development, 6(3), 852-856.

Rokohl, A. C., Loreck, N., Matos, P. A. W., Zwingelberg, S., Augustin, M., Dewald, F., ... & Heindl, L. M. (2020). More than loss of taste and smell: Burning watering eyes in coronavirus disease 2019. Clinical Microbiology and Infection, 26(11), 1560-e5.

Sen, C. K. (2021). Human wound and its burden: Updated 2020 compendium of estimates. Advances in Wound Care, 10(5), 281-292.

Sharma, P., & Kajaria, D. (2022). Ayurvedic management of Hirayama disease: A case report. Journal of Ayurveda Case Reports, 5(3), 130-134.

Süt, B. B., Keles, A. I., & Kankiliç, T. (2020). Comparative analysis of the different regions of skin tissue in Nannospalax xanthodon. Natural and Engineering Sciences, 5(2), 92-100.

Tu, Z., Zhong, Y., Hu, H., Shao, D., Haag, R., Schirner, M., ... & Leong, K. W. (2022). Design of therapeutic biomaterials to control inflammation. Nature Reviews Materials, 7(7), 557-574.

Uyan, A. (2022). A review on the potential usage of lionfishes (Pterois spp.) in biomedical and bioinspired applications. Natural and Engineering Sciences, 7(2), 214-227.

Wayal, S. R., & Gurav, S. S. (2020). Bhallatakadi Ghrita: Development and evaluation with reference to Murcchana and Shata-Dhauta process. Journal of Ayurveda and Integrative Medicine, 11(3), 261-269.