Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health,
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Integrative Biomedical Research
Volume 9 Number 1 2025
Table of Contents
Research Article
Pharmaceuticals and Drug Delivery
Paulami Pal1, Subhabrata Ray2, Anup Kumar Das3, Manjir Sarma Kataki1, Saurav Dey4, Partha Pratim Dutta5, Tumpa Sarkar1, Mohini Singh1, Niva Rani Gogoi1, Bhaskar Mazumder1*
Solid lipid nanoparticles improved anti-tubercular drug encapsulation, stability, and lung retention, offering a promising targeted pulmonary delivery approach for tuberculosis treatment.
Abstract | Full Text |PDF (832 KB) | Open Access Article
Ammar Adil Fahad 1*
This study showed phacoemulsification outcomes with/without OVDs, demonstrating cost-effectiveness and safety without increased intraocular pressure.
Abstract | Full Text |PDF (306 KB) | Open Access Article
Ladi Alik Kumar 1, Gurudutta Pattnaik 1, Bhabani Sankar Satapathy2,*, Himansu Bhusan Samal 1, *
Glioma's high mortality and treatment challenges necessitate innovative strategies like nanoparticle-based drug delivery, enhancing therapy efficiency and prognosis.
Abstract | Full Text |PDF (912 KB) | Open Access Article
Natural Colorants Induce the Drug Release from Fast Dissolving Tablets
Esra Tariq Bayrakdar 1, Sharad Visht 1*, Duran Kala 2, Saya Ameer 1, Ahmed Hamdy 1, Sawsan S. Al-Rawi 3, Samir Bhargava 4, Abhijeet Ojha 5
This study showed the impact of hydrophilic and hydrophobic colorants on drug release, crucial for improving palatability and therapeutic efficacy of fast dissolving tablets.
Abstract | Full Text |PDF (617 KB) |Supplementary Material | Open Access Article
Resveratrol Mitigates Acrylonitrile-induced Thyroid and Adrenal Toxicity in Rats
Samer I. Sabeeh 1*, Ahmed Q. Al-Awadi 1
Resveratrol counters acrylonitrile's adverse effects, preserving thyroid and adrenal function, evidenced hormonally and histologically, suggesting therapeutic potential.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Green Synthesis, Lead Toxicity and Pharmacokinetic Evaluation of Sumac Silver Nanoparticles In Vivo
Ammar H. Salman 1*, Mohammed Mosleh Shwaish 1
Sumac-synthesized silver nanoparticles (SAgNP) showed an eco-friendly approach to reduce blood lead levels, promising safer, cost-effective lead detoxification.
Abstract | Full Text |PDF (412 KB) | Open Access Article
Ghaida Fahad S Mubki 1, Mohmad Saad M Al Karani 1, Ahmed Saeed Abdullah 1, Tahani Mahmoud M Riyahi 1, Reem Abdulaziz Abdullah 1, Maha Mubarak Hamas Alotaibi 1, Amal Abdullah Faraj Hassan 2, Ahmed awad ali Zahrani 3, Nada Abdulrahman Hamad Altooq 1, Anfal Khalid Zain Bajamal 1, Nada saleh mohammad aldahaiman 1, Sajeda Qasim Abdulaziz Binjumaiah 1, Afaf Eesa Alsaggar Alenizi 1
Abstract | Full Text |PDF (341 KB) | Open Access Article
Effect of Steroid Treatment on Tissue Damage Markers in Diabetic Patients
Mohammed Shakir Ali 1*, Ali Al-Shammari 1, Qutaiba A. Ismael 1, Obaida Amer Imran 1, Mohammed H. Al-Bayati 1
This research showed how diabetes and steroids worsen effects, providing a better understanding of the pathophysiology processes.
Abstract | Full Text |PDF (348 KB) | Open Access Article
Rozhan Arif 1, Sharad Visht 1*, Ali Omar Yassen 1, Sana Sirwan Salih 1
Formulating ketotifen fast-dissolving tablets (FDT) tackled poor bioavailability challenges, emphasizing sodium bicarbonate's pivotal role for rapid tablet disintegration, highlighting FDT viability for asthmatic treatment.
Abstract | Full Text |PDF (556 KB) | Open Access Article
Menopause-Related Insomnia, Cognitive, Behavioral, and Mindfulness-Based Treatments
Venu Anand Das 1, Jitendra Sinha 2
The study explores challenges in treating menopausal symptoms, introducing the Menopause-based Treatment Study Framework (MTSF) for more effective and enduring resolution.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Reviews
Pharmaceuticals and Drug Delivery
Balisa Mosisa Ejeta1*, Malay K Das 1, Sanjoy Das 1
This analysis is crucial for identifying barriers to oral contraceptive use, enhancing effectiveness, and improving reproductive health outcomes for diverse populations.
Abstract | Full Text |PDF (158 KB) | Open Access Article
Balisa Mosisa Ejeta1*, Malay K Das1, Sanjoy Das1
This study showed advanced nanotechnology-based paclitaxel delivery systems, offering enhanced cancer targeting, reduced side effects, and potential solutions to drug resistance.
Abstract | Full Text |PDF (174 KB) | Open Access Article
Recent Advances in Paclitaxel Drug Delivery: Challenges, Innovations, and Future Directions
Balisa Mosisa Ejeta 1*, Malay K Das 1*, Sanjoy Das 1
This review addresses advancements in paclitaxel drug delivery, emphasizing innovative methods to enhance efficacy and combat resistance.
Abstract | Full Text |PDF (700 KB) | Open Access Article
Suryakanta Swain1, Ashirbaad Nanda2, Rudra Narayan Sahu3, Bikash Ranjan Jena2*, Rabisankar Dash4, Amaresh Prusty5, Prasanna Parida2, Abhisek Sahu2, Bhisma Narayan Ratha2
Biomaterials significantly enhance tissue repair and regeneration, offering innovative solutions in modern medicine and improving patient outcomes.
Abstract | Full Text |PDF (376 KB) | Open Access Article
Advances in Periodontal Drug Delivery Systems and the Role of Probiotics in Periodontitis Treatment
Pratikshya Mohanty 1, Kalpita Bhatta 1*, Itishree Jogamaya Das 2, Himansu Bhusan Samal 3*
This review discussed the periodontitis and its prevalence in gum inflammation and bone loss. Local drug delivery systems offer effective treatment, enhancing patient care.
Abstract | Full Text |PDF (543 KB) | Open Access Article
A Review of 3d Printing Model of New Blood Vessel Formation For Pharmaceutical Applications
Nidhi Mishra 1*, Priya Vij 1, Akanksha Mishra 1
Innovative synthetic blood vessels offer promising solutions for cardiovascular diseases, providing safer, more accessible treatments for aging populations
Abstract | Full Text |PDF (530 KB) | Open Access Article
A Pharmacy System Integrated with A Machine Learning Algorithm for Cardiovascular Disease Prediction
Kumar Shwetabh 1*, F Rahman 1, Sushree Sasmita Dash 1
The review explores an inclusive ML structure, vital for efficient CVD forecasting. The proposed model showcases superior accuracy, emphasizing the need for comprehensive predictive algorithms in cardiovascular health research.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Priya Vij 1, Sushree Sasmita Dash 1, Akanksha Mishra 1
Advanced integration of deep learning (AlexNet) and SVM-RBF for breast cancer diagnosis surpasses existing models, ensuring precise and reliable early detection.
Abstract | Full Text |PDF (899 KB) | Open Access Article
Advances of AI-driven Drug Design and Discovery in Pharmaceuticals - Review
Dev Ras Pandey 1*, Sushree Sasmita Dash 1, Akanksha Mishra 1
The application of AI in pharmaceuticals holds the promise of personalized therapies, streamlined production, and improved market strategies, making it an indispensable tool for the future of drug development.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Abhijeet Madhukar Haval 1*, Akanksha Mishra 1, Sushree Sasmita Dash 1
Wound features impact healing; indicators like temperature, oxygen levels, and moisture influence the process. This review shows and effective at-home wound monitoring with biosensors.
Abstract | Full Text |PDF (962 KB) | Open Access Article
Vijay Kumar Jaiswal 1*, Monika Barsagade 1, Jitendra Sinha 1
Contribution to advancing diagnostic methods, proposing innovative treatment approaches, and demonstrating the effectiveness of pharmacist-led preventive strategies for improving population health, reducing the economic burden of cardiovascular diseases, and showing more personalized and mechanism-based approaches in healthcare.
Abstract | Full Text |PDF (834 KB) | Open Access Article
Advancements in Ocular Vascularization Analysis Using Deep Learning Techniques – A Systematic Review
F Rahman 1*, Akanksha Mishra 1, Sushree Sasmita Dash 1
This review shows an advanced machine learning method for efficient segmentation and classification of blood vessels in medical images, revolutionizing diagnostic precision.
Abstract | Full Text |PDF (873 KB) | Open Access Article
Prachi Gurudiwan 1*, Ragini Patel 1, Urvashi Jain 1
Quantitative Systems Pharmacology models immune processes in breast cancer, aiding personalized treatment by identifying biomarkers, resistance mechanisms, and therapeutic options
Abstract | Full Text |PDF (1 MB) | Open Access Article
Chandrapratap Dhimar 1*, Krishna Sahu 1, Moniza Nurez Khan 1
Utilizing innovative postbiotics and Simvastatin Polymeric Nanoparticles, wound research accelerates healing, promising improved treatment with minimal inflammation.
Abstract | Full Text |PDF (652 KB) | Open Access Article
Evolution of Genes and Transcripts Modifies Drug Sensitivity in Cancer Cell Lines - A Review
Krishna Sahu 1, Urvashi Jain 2
Dynamic genomic and transcriptomic evolutionary modeling guides cancer genetics, transforming treatment by predicting drug sensitivity in genomics.
Abstract | Full Text |PDF (196 KB) | Open Access Article
Moniza Nurez Khan 1, Naresh Chandravanshi 2
The critical impact of Food-Borne Mycotoxins (FBM) and Artificial Light At Night (ALAN) on DNA methylation, influencing cancer risk and disease outcomes.
Abstract | Full Text |PDF (325 KB) | Open Access Article
Identifying Thyroid Dysfunction Using Standard Laboratory Testings – A Systematic Review
Vinay Jaiswal 1, Prachi Gurudiwan 2
A ML-TDI model for thyroid dysfunction identification, addressing underdiagnosis challenges and emphasizing the importance of comprehensive assessment in care.
Abstract | Full Text |PDF (616 KB) | Open Access Article
Lakhan Lal Kashyap 1, Harish Jaiswal 2
A targeted drug delivery approach, using double-imprinted nanoparticles and EGFR-SVM, to enhance anticancer drug effectiveness selectively in tumor cells.
Abstract | Full Text |PDF (446 KB) | Open Access Article
Hydrophobin-Coated Noisomes as Drug Carriers in Lung Cancer Cells - A Review
Srishti Namdeo 1, Chandrapratap Dhimar 2
Targeted nanoparticle delivery to Lung Cancer Cells, using hydrophobin-coated niosomes, addressing multidrug resistance, and enhancing treatment efficacy.
Abstract | Full Text |PDF (880 KB) | Open Access Article
Poorti Sharma 1*, Lukeshwari Sahu 1
Study explores Cannabis use by metastatic tumor patients, analyzing active components, addressing gaps in research, and promoting informed medical guidance.
Abstract | Full Text |PDF (769 KB) | Open Access Article
Vijay Kumar Jaiswal 1, Mahendra Kumar Verma 2
Evolutionary Computation Network for Drug Repositioning reveals oral cancer stem cells, informing targeted therapies for treatment.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Bhuneshwari Dewangan 1, Naina Bhoyar 2
A review of polydopamine sensor in breast cancer diagnosis.
Abstract | Full Text |PDF (882 KB) | Open Access Article
Sanjay Kumar Mire 1, Deepak Kumar Sahu 2
Echocardiography-based strain imaging offers early detection of cardiac abnormalities, treatment, and research strategy.
Abstract | Full Text |PDF (951 KB) | Open Access Article
A Review of Potential Roles for Micro RNAs as Drugs Sensitivity Biomarkers in Breast Cancer
Monika Barsagade 1*, Ravi kishore Agrawal 2*
The role of miR-202's in discovering biomarkers for early diagnosis and improving therapeutic strategies for breast cancer.
Abstract | Full Text |PDF (393 KB) | Open Access Article
Aman Chandrakar 1, Chetan Kumar Sonkar 2
The cancer treatment will be accelerated through drug repositioning.
Abstract | Full Text |PDF (1 MB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
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Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
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Analysis of Potential Biomarkers in Hypertension
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
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Predicting Habitat Suitability and Climate Change Impact on Medicinal plant Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
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A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
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Effects of Physical Activity as A Treatment For Depression in the Elderly
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
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Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
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Collaborative Governance in Combating Illegal Cosmetics: A Study of Multi-Stakeholder Dynamics in South Sulawesi, Indonesia
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
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High Viral Load is a Risk Factor for Hepatocellular Carcinoma: Clinical and Laboratory Insights from a Cross-Sectional Study
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
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Cardiovascular Complications in Patients with Hepatocellular Carcinoma
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
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AI-driven Innovations in Cancer Research and Personalized Healthcare
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
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The Evolving Role of Hospital and Community Pharmacist in Post-COVID-19 Healthcare Delivery in Bangladesh: A Survey-Based Analysis
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
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Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
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An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
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Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.