Integrative Biomedical Research (Journal of Angiotherapy) | Online ISSN  3068-6326

Integrative Biomedical Research

Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health, 

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Editor-in-Chief: Fazlul Huq, Ph.D.

Integrative Biomedical Research

Volume 9 Number 1 2025

Table of Contents


Research Article

Pharmaceuticals and Drug Delivery

Published online 31 December 2024

Lung-Targeted Solid Lipid Nanoparticles for Enhanced Pulmonary Delivery of Anti-Tubercular Drugs: A Novel Approach to Improve Bioavailability

Paulami Pal1, Subhabrata Ray2, Anup Kumar Das3, Manjir Sarma Kataki1, Saurav Dey4, Partha Pratim Dutta5, Tumpa Sarkar1, Mohini Singh1, Niva Rani Gogoi1, Bhaskar Mazumder1*

pp. 1-13

Solid lipid nanoparticles improved anti-tubercular drug encapsulation, stability, and lung retention, offering a promising targeted pulmonary delivery approach for tuberculosis treatment.

Abstract | Full Text |PDF (832 KB) | Open Access Article


Published online 14 June 2024

Phacoemulsification Cataract Surgery without Ophthalmic Viscoelastic Devices: A Randomized Controlled Trial

Ammar Adil Fahad 1*

pp. 1-6

This study showed phacoemulsification outcomes with/without OVDs, demonstrating cost-effectiveness and safety without increased intraocular pressure.

Abstract | Full Text |PDF (306 KB) | Open Access Article


Published online 14 May 2024

Advances in Targeted Glioma Therapy with Transferrin-Conjugated Gemcitabine-Loaded PLGA Nanoparticles

Ladi Alik Kumar 1, Gurudutta Pattnaik 1, Bhabani Sankar Satapathy2,*, Himansu Bhusan Samal 1, *

pp. 1-12

Glioma's high mortality and treatment challenges necessitate innovative strategies like nanoparticle-based drug delivery, enhancing therapy efficiency and prognosis.

Abstract | Full Text |PDF (912 KB) | Open Access Article


Published online 12 April 2024

Natural Colorants Induce the Drug Release from Fast Dissolving Tablets

Esra Tariq Bayrakdar 1, Sharad Visht 1*, Duran Kala 2, Saya Ameer 1, Ahmed Hamdy 1, Sawsan S. Al-Rawi 3, Samir Bhargava 4, Abhijeet Ojha 5

pp. 1-12

This study showed the impact of hydrophilic and hydrophobic colorants on drug release, crucial for improving palatability and therapeutic efficacy of fast dissolving tablets.

Abstract | Full Text |PDF (617 KB) |Supplementary Material | Open Access Article


Published online 09 April 2024

Resveratrol Mitigates Acrylonitrile-induced Thyroid and Adrenal Toxicity in Rats

Samer I. Sabeeh 1*, Ahmed Q. Al-Awadi 1

pp. 1-8

Resveratrol counters acrylonitrile's adverse effects, preserving thyroid and adrenal function, evidenced hormonally and histologically, suggesting therapeutic potential.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Published online 08 April 2024

Green Synthesis, Lead Toxicity and Pharmacokinetic Evaluation of Sumac Silver Nanoparticles In Vivo

Ammar H. Salman 1*, Mohammed Mosleh Shwaish 1

pp. 1-7

Sumac-synthesized silver nanoparticles (SAgNP) showed an eco-friendly approach to reduce blood lead levels, promising safer, cost-effective lead detoxification.

Abstract | Full Text |PDF (412 KB) | Open Access Article


Published online 02 April 2024

Comparing Apixaban vs Rivaroxaban for Atrial Fibrillation Patients: An Effectiveness and Safety Analysis

Ghaida Fahad S Mubki 1, Mohmad Saad M Al Karani 1, Ahmed Saeed Abdullah 1, Tahani Mahmoud M Riyahi 1, Reem Abdulaziz Abdullah 1, Maha Mubarak Hamas Alotaibi 1, Amal Abdullah Faraj Hassan 2, Ahmed awad ali Zahrani 3, Nada Abdulrahman Hamad Altooq 1, Anfal Khalid Zain Bajamal 1, Nada saleh mohammad aldahaiman 1, Sajeda Qasim Abdulaziz Binjumaiah 1, Afaf Eesa Alsaggar Alenizi 1

pp. 1-13

Abstract | Full Text |PDF (341 KB) | Open Access Article


Published online 22 January 2024

Effect of Steroid Treatment on Tissue Damage Markers in Diabetic Patients

Mohammed Shakir Ali 1*, Ali Al-Shammari 1, Qutaiba A. Ismael 1, Obaida Amer Imran 1, Mohammed H. Al-Bayati 1

pp. 1-10

This research showed how diabetes and steroids worsen effects, providing a better understanding of the pathophysiology processes.

Abstract | Full Text |PDF (348 KB) | Open Access Article


Published online 19 January 2024

Optimizing Fast-Dissolving Tablets of Ketotifen: Impact of Sodium Bicarbonate and Citric Acid in Formulation and Evaluation

Rozhan Arif 1, Sharad Visht 1*, Ali Omar Yassen 1, Sana Sirwan Salih 1

pp. 1-11

Formulating ketotifen fast-dissolving tablets (FDT) tackled poor bioavailability challenges, emphasizing sodium bicarbonate's pivotal role for rapid tablet disintegration, highlighting FDT viability for asthmatic treatment.

Abstract | Full Text |PDF (556 KB) | Open Access Article


Published online 17 December 2023

Menopause-Related Insomnia, Cognitive, Behavioral, and Mindfulness-Based Treatments

Venu Anand Das 1, Jitendra Sinha 2

pp. 1-11

The study explores challenges in treating menopausal symptoms, introducing the Menopause-based Treatment Study Framework (MTSF) for more effective and enduring resolution.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Reviews

Pharmaceuticals and Drug Delivery

Published online 19 October 2024

Oral Contraceptives: Analyzing Effectiveness and Utilization Challenges to Improve Reproductive Health Outcomes

Balisa Mosisa Ejeta1*, Malay K Das 1, Sanjoy Das 1

pp. 1-6

This analysis is crucial for identifying barriers to oral contraceptive use, enhancing effectiveness, and improving reproductive health outcomes for diverse populations.

Abstract | Full Text |PDF (158 KB) | Open Access Article


Published online 18 October 2024

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Advancements in Nanotechnology-Based Paclitaxel Delivery Systems: Systematic Review on Overcoming Solubility, Toxicity, and Drug Resistance Challenges in Cancer Therapy

Balisa Mosisa Ejeta1*, Malay K Das1, Sanjoy Das1

pp. 1-7

This study showed advanced nanotechnology-based paclitaxel delivery systems, offering enhanced cancer targeting, reduced side effects, and potential solutions to drug resistance.

Abstract | Full Text |PDF (174 KB) | Open Access Article


Published online 09 August 2024

Recent Advances in Paclitaxel Drug Delivery: Challenges, Innovations, and Future Directions

Balisa Mosisa Ejeta 1*, Malay K Das 1*, Sanjoy Das 1

pp. 1-13

This review addresses advancements in paclitaxel drug delivery, emphasizing innovative methods to enhance efficacy and combat resistance.

Abstract | Full Text |PDF (700 KB) | Open Access Article


Published online 25 May 2024

Advancements in Biomaterials for Envisioning Healing and Function Restoration in Modern Medicine – A Review

Suryakanta Swain1, Ashirbaad Nanda2, Rudra Narayan Sahu3, Bikash Ranjan Jena2*, Rabisankar Dash4, Amaresh Prusty5, Prasanna Parida2, Abhisek Sahu2, Bhisma Narayan Ratha2

pp. 1-7

Biomaterials significantly enhance tissue repair and regeneration, offering innovative solutions in modern medicine and improving patient outcomes.

Abstract | Full Text |PDF (376 KB) | Open Access Article


Published online 07 March 2024

Advances in Periodontal Drug Delivery Systems and the Role of Probiotics in Periodontitis Treatment

Pratikshya Mohanty 1, Kalpita Bhatta 1*, Itishree Jogamaya Das 2,  Himansu Bhusan Samal 3*

pp. 1-12

This review discussed the periodontitis and its prevalence in gum inflammation and bone loss. Local drug delivery systems offer effective treatment, enhancing patient care.

Abstract | Full Text |PDF (543 KB) | Open Access Article


Published online 09 February 2024

A Review of 3d Printing Model of New Blood Vessel Formation For Pharmaceutical Applications

Nidhi Mishra 1*, Priya Vij 1, Akanksha Mishra 1

pp. 1-6

Innovative synthetic blood vessels offer promising solutions for cardiovascular diseases, providing safer, more accessible treatments for aging populations

Abstract | Full Text |PDF (530 KB) | Open Access Article


Published online 26 January 2024

A Pharmacy System Integrated with A Machine Learning Algorithm for Cardiovascular Disease Prediction

Kumar Shwetabh 1*, F Rahman 1, Sushree Sasmita Dash 1

pp. 1-9

The review explores an inclusive ML structure, vital for efficient CVD forecasting. The proposed model showcases superior accuracy, emphasizing the need for comprehensive predictive algorithms in cardiovascular health research.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Published online 26 January 2024

Advances in Image Processing Methods for Breast Cancer Diagnosis and Classification Using A Hybrid Machine Learning – A Systematic Review

Priya Vij 1, Sushree Sasmita Dash 1, Akanksha Mishra 1

pp. 1-9

Advanced integration of deep learning (AlexNet) and SVM-RBF for breast cancer diagnosis surpasses existing models, ensuring precise and reliable early detection.

Abstract | Full Text |PDF (899 KB) | Open Access Article


Published online 25 January 2024

Advances of AI-driven Drug Design and Discovery in Pharmaceuticals - Review

Dev Ras Pandey 1*, Sushree Sasmita Dash 1, Akanksha Mishra 1

pp. 1-10

The application of AI in pharmaceuticals holds the promise of personalized therapies, streamlined production, and improved market strategies, making it an indispensable tool for the future of drug development.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Published online 25 January 2024

Smart Wound Monitoring and Healing Assessment System With Deep Learning Methods - A Systematic Review

Abhijeet  Madhukar Haval 1*, Akanksha Mishra 1, Sushree Sasmita Dash 1

pp. 1-9

Wound features impact healing; indicators like temperature, oxygen levels, and moisture influence the process. This review shows and effective at-home wound monitoring with biosensors.

Abstract | Full Text |PDF (962 KB) | Open Access Article


Published online 24 January 2024

A Comprehensive Review on Cardiovascular Disease Detection, Risk Assessment, And Treatment Using A Network Pharmacology Model

Vijay Kumar Jaiswal 1*, Monika Barsagade 1, Jitendra Sinha 1

pp. 1-9

Contribution to advancing diagnostic methods, proposing innovative treatment approaches, and demonstrating the effectiveness of pharmacist-led preventive strategies for improving population health, reducing the economic burden of cardiovascular diseases, and showing more personalized and mechanism-based approaches in healthcare.

Abstract | Full Text |PDF (834 KB) | Open Access Article


Published online 24 January 2024

Advancements in Ocular Vascularization Analysis Using Deep Learning Techniques – A Systematic Review

F Rahman 1*, Akanksha Mishra 1, Sushree Sasmita Dash 1

pp. 1-9

This review shows an advanced machine learning method for efficient segmentation and classification of blood vessels in medical images, revolutionizing diagnostic precision.

Abstract | Full Text |PDF (873 KB) | Open Access Article


Published online 23 January 2024

A Review of Modeling Checkpoint Blockade Therapy and Therapeutic Strategies in Integrative Pharmacological Approach for Metastatic Breast Cancer

Prachi Gurudiwan 1*, Ragini Patel 1, Urvashi Jain 1

pp. 1-8

Quantitative Systems Pharmacology models immune processes in breast cancer, aiding personalized treatment by identifying biomarkers, resistance mechanisms, and therapeutic options

Abstract | Full Text |PDF (1 MB) | Open Access Article


Published online 23 January 2024

A Systematic Review of Advanced Approaches in Wound Healing: Simvastatin Polymeric Nanoparticles and Postbiotics Innovation

Chandrapratap Dhimar 1*, Krishna Sahu 1, Moniza Nurez Khan 1

pp. 1-10

Utilizing innovative postbiotics and Simvastatin Polymeric Nanoparticles, wound research accelerates healing, promising improved treatment with minimal inflammation.

Abstract | Full Text |PDF (652 KB) | Open Access Article


Published online 07 January 2024

Evolution of Genes and Transcripts Modifies Drug Sensitivity in Cancer Cell Lines - A Review

Krishna Sahu 1, Urvashi Jain 2

pp. 1-5

Dynamic genomic and transcriptomic evolutionary modeling guides cancer genetics, transforming treatment by predicting drug sensitivity in genomics.

Abstract | Full Text |PDF (196 KB) | Open Access Article


Published online 21 December 2023

The Effect of Naturally Occurring Dietary Chemicals and Food-Borne Mycotoxins on DNA Methylation and Cancer - A Review

Moniza Nurez Khan 1, Naresh Chandravanshi 2

pp. 1-6

The critical impact of Food-Borne Mycotoxins (FBM) and Artificial Light At Night (ALAN) on DNA methylation, influencing cancer risk and disease outcomes.

Abstract | Full Text |PDF (325 KB) | Open Access Article


Published online 19 December 2023

Identifying Thyroid Dysfunction Using Standard Laboratory Testings – A Systematic Review

Vinay Jaiswal 1, Prachi Gurudiwan 2

pp. 1-8

A ML-TDI model for thyroid dysfunction identification, addressing underdiagnosis challenges and emphasizing the importance of comprehensive assessment in care.

Abstract | Full Text |PDF (616 KB) | Open Access Article


Published online 17 December 2023

Epidermal Growth Factor Receptor and Double-Imprinted Nanoparticles for Targeted Cancer Drug Delivery - A Review

Lakhan Lal Kashyap 1, Harish Jaiswal 2

pp. 1-8

A targeted drug delivery approach, using double-imprinted nanoparticles and EGFR-SVM, to enhance anticancer drug effectiveness selectively in tumor cells.

Abstract | Full Text |PDF (446 KB) | Open Access Article


Published online 12 December 2023

Hydrophobin-Coated Noisomes as Drug Carriers in Lung Cancer Cells - A Review

Srishti Namdeo 1, Chandrapratap Dhimar 2

pp. 1-8

Targeted nanoparticle delivery to Lung Cancer Cells, using hydrophobin-coated niosomes, addressing multidrug resistance, and enhancing treatment efficacy.

Abstract | Full Text |PDF (880 KB) | Open Access Article


Published online 08 December 2023

Analyzing The Risks, Benefits, and Therapeutic Potential of Cannabis And Cannabinoids in Tumor Therapy - A Review

Poorti Sharma 1*, Lukeshwari Sahu 1

pp. 1-11

Study explores Cannabis use by metastatic tumor patients, analyzing active components, addressing gaps in research, and promoting informed medical guidance.

Abstract | Full Text |PDF (769 KB) | Open Access Article


Published online 07 December 2023

Discovering Novel and Old Drug Targets in Oral Cancer Stem Cells Using bio-inspired methods - A Review

Vijay Kumar Jaiswal 1, Mahendra Kumar Verma 2

pp. 1-9

Evolutionary Computation Network for Drug Repositioning reveals oral cancer stem cells, informing targeted therapies for treatment.

Abstract | Full Text |PDF (1 MB) | Open Access Article


Published online 07 December 2023

Impedimetric Sensor Aided by Polydopamine Nanoparticles for Label-Free Detection of Breast Cancer Cells - A Review

Bhuneshwari Dewangan 1, Naina Bhoyar 2

 

pp. 1-12

A review of polydopamine sensor in breast cancer diagnosis.

Abstract | Full Text |PDF (882 KB) | Open Access Article


Published online 06 December 2023

Evaluation of Cardiac Reserve Using Echocardiography for The Detection of Mild Cardiac Dysfunction in Mice - A Review

Sanjay Kumar Mire 1, Deepak Kumar Sahu 2

pp. 1-11

Echocardiography-based strain imaging offers early detection of cardiac abnormalities, treatment, and research strategy. 

Abstract | Full Text |PDF (951 KB) | Open Access Article


Published online 05 December 2023

A Review of Potential Roles for Micro RNAs as Drugs Sensitivity Biomarkers in Breast Cancer

Monika Barsagade 1*, Ravi kishore Agrawal 2*

pp. 1-7

The role of miR-202's in discovering biomarkers for early diagnosis and improving therapeutic strategies for breast cancer.

Abstract | Full Text |PDF (393 KB) | Open Access Article


Published online 04 December 2023

Drug Repositioning and Response Detection Based on Randomized Control Trials for Cancer Treatment - A Review

Aman Chandrakar 1, Chetan Kumar Sonkar 2

pp. 1-13

The cancer treatment will be accelerated through drug repositioning.

Abstract | Full Text |PDF (1 MB) | Open Access Article


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These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.

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