Journal of Angiotherapy
Angiogenesis, Inflammation & Therapeutics | Online ISSN  2207-872X
  1. You are here:
  2. Home
  3. Journals
  4. Biological Sciences
REVIEWS   (Open Access)
Contents Vol 8 (1)

A Systematic Review of Advanced Approaches in Wound Healing: Simvastatin Polymeric Nanoparticles and Postbiotics Innovation

Chandrapratap Dhimar 1*, Krishna Sahu 1, Moniza Nurez Khan 1

+ Author Affiliations

Journal of Angiotherapy 8 (1) 1-10 https://doi.org/10.25163/angiotherapy.819483

Submitted: 08 November 2023 Revised: 17 January 2024  Published: 23 January 2024 

Abstract

A wound is a disruption in the continuity of the skin caused by accident, disease, or surgery. Wound treatment is a vital, ongoing biologically and physiologically method that reacts to cell injury. Regarding health, economy, and social aspects, the significant impact of wounds on individuals and society underscores the need for research to identify innovative therapeutic actors that might improve the treatment of wounds.  Postbiotics, a recent addition to the biotics category, are bioactive compounds of great value generated by probiotics via metabolic processes. These substances possess various advantageous properties, such as immunomodulatory, antimicrobial, and anti-inflammatory, and promote faster wound healing. The Simvastatin Polymeric Nanoparticles (S-PNP) were synthesized utilizing the nanoprecipitation technique to enhance the solubility of the medicine and its capacity to grow the skin. The drug data, dissolution, particle dimension, charged surface, and broadcasting electron microscope of the produced S-PNP are assessed. S-PNP was applied to the hydrogel, and the physical properties, release behavior in a controlled environment, and penetration across a biological membrane of the hydrogel were assessed. The gel that had been made was administered to the wounds of rats, and a histological examination was conducted. The findings demonstrated notable effectiveness in expediting the rat wound recovery process, resulting in full epithelialization and little invasion of inflammatory cells.

Keywords: Bioactive Compounds, Wound Healing, Nanoparticles, Analysis

References

Ahmed, L.M., Hassanein, K.M., Mohamed, F.A., Elfaham, T.H. (2023). Formulation and evaluation of simvastatin cubosomal nanoparticles for assessing its wound healing effect. Sci. Rep. 13(1), 17941.

https://doi.org/10.1038/s41598-023-44304-2

 

Andjic, M., Božin, B., Draginic, N., Kocovic, A., Jeremic, J. N., Tomovic, M., ... & Bradic, J. V. (2021). Formulation and evaluation of Helichrysum italicum essential oil-based topical formulations for wound healing in diabetic rats. Pharmaceuticals, 14(8), 813.

https://doi.org/10.3390/ph14080813

 

Baptista-Silva, S., Borges, S., Costa-Pinto, A.R., Costa, R., Amorim, M., Dias, J.R., Oliveira, A.L. (2021). In situ forming silk sericin-based hydrogel: A novel wound healing biomaterial. ACS Biomater. Sci. Eng. 7(4), 1573-1586.

https://doi.org/10.1021/acsbiomaterials.0c01745

 

Bovone, G., Guzzi, E.A., Bernhard, S., Weber, T., Dranseikiene, D., Tibbitt, M.W. (2022). Supramolecular reinforcement of polymer-nanoparticle hydrogels for modular materials design. Adv Mater. 34(9), 2106941.

https://doi.org/10.1002/adma.202106941

 

Cho, Y.D., Kim, K.H., Lee, Y.M., Ku, Y., Seol, Y.J. (2021). Periodontal wound healing and tissue regeneration: A narrative review. Pharm. 14(5), 456.

https://doi.org/10.3390/ph14050456

 

Dong, R., Guo, B. (2021). Smart wound dressings for wound healing. Nano Today. 41, 101290.

https://doi.org/10.1016/j.nantod.2021.101290

 

Duarte, J.A., de Barros, A.L.B., Leite, E.A. (2021). The potential use of simvastatin for cancer treatment: A review. Biomed. Pharmacother. 141, 111858.

https://doi.org/10.1016/j.biopha.2021.111858

 

Farahani, M., Shafiee, A. (2021). Wound healing: From passive to smart dressings. Adv. Healthc. Mater. 10(16), 2100477.

https://doi.org/10.1002/adhm.202100477

 

Gaspar-Pintiliescu, A., Stanciuc, A. M., & Craciunescu, O. (2019). Natural composite dressings based on collagen, gelatin and plant bioactive compounds for wound healing: A review. International journal of biological macromolecules, 138, 854-865.

https://doi.org/10.1016/j.ijbiomac.2019.07.155

 

Geana, E. I., Ciucure, C. T., Tamaian, R., Marinas, I. C., Gaboreanu, D. M., Stan, M., & Chitescu, C. L. (2023). Antioxidant and Wound Healing Bioactive Potential of Extracts Obtained from Bark and Needles of Softwood Species. Antioxidants, 12(7), 1383.

https://doi.org/10.3390/antiox12071383

 

Grada, A., Phillips, T.J. (2022). Nutrition and cutaneous wound healing. Clin. Dermatol. 40(2), 103-113.

https://doi.org/10.1016/j.clindermatol.2021.10.002

 

Guo, Z., Zhang, Z., Zhang, N., Gao, W., Li, J., Pu, Y., Xie, J. (2022). A Mg2+/polydopamine composite hydrogel for the acceleration of infected wound healing. Bioact. Mater. 15, 203-213.

https://doi.org/10.1016/j.bioactmat.2021.11.036

 

Hu, W., Chen, Z., Chen, X., Feng, K., Hu, T., Huang, B., Wang, Z. (2023). Double-network cellulose-based hybrid hydrogels with favorable biocompatibility and antibacterial activity for wound healing. Carbohydr. Polym. 319, 121193.

https://doi.org/10.1016/j.carbpol.2023.121193

 

Ikram Ullah Khan (2022). Synthesis and Characterization Gold Nanoparticles using polymeric micelles to Induce Block Copolymer Composition, Biosensors and Nanotheranostics, 1(1), 1-6, 9837

 

Isopencu, G. O., Covaliu-Mierla, C. I., & Deleanu, I. M. (2023). From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds. Plants, 12(14), 2661.

https://doi.org/10.3390/plants12142661

 

Kant, V., Kumari, P., Jitendra, D. K., Ahuja, M., & Kumar, V. (2021). Nanomaterials of natural bioactive compounds for wound healing: Novel drug delivery approach. Current Drug Delivery, 18(10), 1406-1425.

https://doi.org/10.2174/1567201818666210729103712

 

Koshak, A.E., Algandaby, M.M., Mujallid, M.I., Abdel-Naim, A.B., Alhakamy, N.A., Fahmy, U.A., Esmat, A. (2021). Wound healing activity of Opuntia ficus-indica fixed oil formulated in a self-nano emulsifying formulation. Int J Nanomedicine. 3889-3905.

https://doi.org/10.2147/IJN.S299696

 

Li, S., Zhang, Y., Ma, X., Qiu, S., Chen, J., Lu, G., Wei, Y. (2022). Antimicrobial lignin-based Polyurethane/Ag composite foams for improving wound healing. Biomacromolecules. 23(4), 1622-1632.

https://doi.org/10.1021/acs.biomac.1c01465

 

Liang, Y., Liang, Y., Zhang, H., Guo, B. (2022). Antibacterial biomaterials for skin wound dressing. Asian J. Pharm. Sci. 17(3), 353-384.

https://doi.org/10.1016/j.ajps.2022.01.001

 

Luo, R., Dai, J., Zhang, J., Li, Z. (2021). Accelerated skin wound healing by electrical stimulation. Adv. Healthc. Mater. 10(16), 2100557.

https://doi.org/10.1002/adhm.202100557

 

Lyu, W., Ma, Y., Chen, S., Li, H., Wang, P., Chen, Y., Feng, X. (2021). Flexible ultrasonic patch for accelerating chronic wound healing. Adv. Healthc. Mater. 10(19), 2100785.

https://doi.org/10.1002/adhm.202100785

 

Meng, Y., Chen, L., Chen, Y., Shi, J., Zhang, Z., Wang, Y., Bu, W. (2022). Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing. Nat. Commun. 13(1), 7353.

https://doi.org/10.1038/s41467-022-35050-6

 

Sofrona, E., Tziveleka, L. A., Harizani, M., Koroli, P., Sfiniadakis, I., Roussis, V., ... & Ioannou, E. (2020). In vivo evaluation of the wound healing activity of extracts and bioactive constituents of the marine isopod Ceratothoa oestroides. Marine Drugs, 18(4), 219.

https://doi.org/10.3390/md18040219

 

Vendrame, S., Alaba, T., Marchi, N., Tsakiroglou, P., & Klimis-Zacas, D. (2024). In vitro and in vivo evaluation of bioactive compounds from berries for wound healing. Current Developments in Nutrition, 102078.

https://doi.org/10.1016/j.cdnut.2024.102078

 

Zhang, W., Mehta, A., Tong, Z., Esser, L., Voelcker, N.H. (2021). Development of polymeric nanoparticles for blood-brain barrier transfer-strategies and challenges. Adv. Sci. 8(10), 2003937.

https://doi.org/10.1002/advs.202003937

 

Zhang, X., Li, Y., He, D., Ma, Z., Liu, K., Xue, K., Li, H. (2021). An effective strategy for preparing macroporous and self-healing bioactive hydrogels for cell delivery and wound healing. J. Chem. Eng. 425, 130677.

https://doi.org/10.1016/j.cej.2021.130677

PDF
Abstract
Export Citation

View Dimensions


View Plumx


View Altmetric




Save
0
Citation
396
View

Share