A Review of Potential Roles for Micro RNAs as Drugs Sensitivity Biomarkers&nbsp;in Breast Cancer

Monika Barsagade; Ravi kishore Agrawal

doi:10.25163/angiotherapy.729395

Angiogenesis, Inflammation & Therapeutics | Online ISSN 2207-872X

REVIEWS (Open Access)

Previous Next Contents Vol 7 (2)

A Review of Potential Roles for Micro RNAs as Drugs Sensitivity Biomarkers in Breast Cancer

Monika Barsagade ^1*, Ravi kishore Agrawal ^2*

+ Author Affiliations

Journal of Angiotherapy 7 (2) 1-7 https://doi.org/10.25163/angiotherapy.729395

Submitted: 31 October 2023 Revised: 01 December 2023 Published: 05 December 2023

Abstract

MiR-202, part of the let-7 family, plays a role in cell division and tumor development, especially in breast cancer (BC) among females. We have conducted a detailed review on new biomarkers to enhance BC screening and enable early diagnosis, particularly in younger women. Early detection and monitoring drug responses are crucial for optimal BC therapy, prompting the need for new biomarkers in diagnosis and prognosis. This review discusses recent findings on microRNAs in detecting, analyzing, and treating breast cancer (miRNA-BC). Although breast cancer patients often start treatment with radiotherapy, its effectiveness may decline with radiation resistance. This review study compares docetaxel-resistant breast cancer (DRBC) and docetaxel-sensitive cell lines, exploring the role of non-coding RNAs, especially circular RNAs (circRNAs), in DRBC development and identifying predictive biomarkers for taxane-containing therapies. MicroRNA sequencing and bioinformatics predict differences in microRNA expression, genes, and pathways between breast cancer cell types. Current evidence suggests that miR-202 dysregulation is linked to signaling pathways, influencing its anti- or pro-tumorigenic effects, showcasing its potential as a diagnostic biomarker.

Keywords: microRNA, breast cancer, biomarkers, drug, radio therapy

References

Abdalla, F., Singh, B., & Bhat, H. K. (2020). MicroRNAs and gene regulation in breast cancer. Journal of biochemical and molecular toxicology, 34(11), e22567.

Aggarwal, T., Wadhwa, R., Gupta, R., Paudel, K. R., Collet, T., Chellappan, D. K., ... & Maurya, P. K. (2020). MicroRNAs as biomarker for breast cancer. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 20(10), 1597-1610.

Ahmed, E. A., Rajendran, P., & Scherthan, H. (2022). The microRNA-202 as a diagnostic biomarker and a potential tumor suppressor. International Journal of Molecular Sciences, 23(11), 5870.

Allen, K. E., & Weiss, G. J. (2010). Resistance may not be futile: microRNA biomarkers for chemoresistance and potential therapeutics. Molecular cancer therapeutics, 9(12), 3126-3136.

Andrikopoulou, A., Shalit, A., Zografos, E., Koutsoukos, K., Korakiti, A. M., Liontos, M., ... & Zagouri, F. (2021). MicroRNAs as potential predictors of response to CDK4/6 inhibitor treatment. Cancers, 13(16), 4114.

Angius, A., Cossu-Rocca, P., Arru, C., Muroni, M. R., Rallo, V., Carru, C., ... & De Miglio, M. R. (2020). Modulatory role of microRNAs in triple negative breast cancer with basal-like phenotype. Cancers, 12(11), 3298.

Ashekyan, O., Abdallah, S., Shoukari, A. A., Chamandi, G., Choubassy, H., Itani, A. R. S., ... & Nasr, R. (2022). Spotlight on exosomal non-coding RNAs in breast cancer: An in silico analysis to identify potential lncRNA/circRNA-miRNA-Target Axis. International Journal of Molecular Sciences, 23(15), 8351.

Bertoli, G., Cava, C., & Castiglioni, I. (2015). MicroRNAs: new biomarkers for diagnosis, prognosis, therapy prediction and therapeutic tools for breast cancer. Theranostics, 5(10), 1122.

Campos-Parra, A. D., Cuamani Mitznahuatl, G., Pedroza-Torres, A., Vazquez Romo, R., Porras Reyes, F. I., López-Urrutia, E., & Pérez-Plasencia, C. (2017). Micro-RNAs as potential predictors of response to breast cancer systemic therapy: future clinical implications. International journal of molecular sciences, 18(6), 1182.

Davey, M. G., Davies, M., Lowery, A. J., Miller, N., & Kerin, M. J. (2021). The role of microRNA as clinical biomarkers for breast cancer surgery and treatment. International Journal of Molecular Sciences, 22(15), 8290.

Fogazzi, V., Kapahnke, M., Cataldo, A., Plantamura, I., Tagliabue, E., Di Cosimo, S., ... & Iorio, M. V. (2022). The role of MicroRNAs in HER2-Positive breast Cancer: where we are and future prospective. Cancers, 14(21), 5326.

Hamam, R., Hamam, D., Alsaleh, K. A., Kassem, M., Zaher, W., Alfayez, M., ... & Alajez, N. M. (2017). Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers. Cell death & disease, 8(9), e3045-e3045.

Huang, P., Li, F., Mo, Z., Geng, C., Wen, F., Zhang, C., ... & Stenvang, J. (2021). A comprehensive RNA study to identify circRNA and miRNA biomarkers for docetaxel resistance in breast cancer. Frontiers in oncology, 11, 669270.

Itani, M. M., Nassar, F. J., Tfayli, A. H., Talhouk, R. S., Chamandi, G. K., Itani, A. R. S., ... & Nasr, R. R. (2021). A signature of four circulating microRNAs as potential biomarkers for diagnosing early-stage breast cancer. International journal of molecular sciences, 22(11), 6121.

Jahani, S., Nazeri, E., Majidzadeh-A, K., Jahani, M., & Esmaeili, R. (2020). Circular RNA; a new biomarker for breast cancer: A systematic review. Journal of Cellular Physiology, 235(7-8), 5501-5510.

Kutanzi, K. R., Yurchenko, O. V., Beland, F. A., Checkhun, V. F., & Pogribny, I. P. (2011). MicroRNA-mediated drug resistance in breast cancer. Clinical epigenetics, 2, 171-185.

Lakshmi, S., Hughes, T. A., & Priya, S. (2021). Exosomes and exosomal RNAs in breast cancer: A status update. European Journal of Cancer, 144, 252-268.

Liu, D., Li, B., Shi, X., Zhang, J., Chen, A. M., Xu, J., ... & Xu, J. (2021). Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers. Aging (Albany NY), 13(3), 4258.

Lv, Z., Wang, S., Zhao, W., & He, N. (2020). MicroRNA analysis of NCI-60 human cancer cells indicates that miR-720 and miR-887 are potential therapeutic biomarkers for breast cancer. Drug Discoveries & Therapeutics, 14(4), 197-203.

Masoudi-Khoram, N., Abdolmaleki, P., Hosseinkhan, N., Nikoofar, A., Mowla, S. J., Monfared, H., & Baldassarre, G. (2020). Differential miRNAs expression pattern of irradiated breast cancer cell lines is correlated with radiation sensitivity. Scientific reports, 10(1), 9054.

Nassar, F. J., Nasr, R., & Talhouk, R. (2017). MicroRNAs as biomarkers for early breast cancer diagnosis, prognosis and therapy prediction. Pharmacology & therapeutics, 172, 34-49.

Piva, R., Spandidos, D. A., & Gambari, R. (2013). From microRNA functions to microRNA therapeutics: novel targets and novel drugs in breast cancer research and treatment. International journal of oncology, 43(4), 985-994.

Takahashi, R. U., Miyazaki, H., & Ochiya, T. (2015). The roles of microRNAs in breast cancer. Cancers, 7(2), 598-616.

Yang, Z., & Liu, Z. (2020). The emerging role of microRNAs in breast cancer. Journal of Oncology, 2020.

Ye, Q., Raese, R. A., Luo, D., Feng, J., Xin, W., Dong, C., ... & Guo, N. L. (2023). MicroRNA-based discovery of biomarkers, therapeutic targets, and repositioning drugs for breast cancer. Cells, 12(14), 1917.

PDF
Abstract
Export Citation

View Dimensions

View Plumx

View Altmetric

Save

0
Citation

518
View

Share