Discovering Novel and Old Drug Targets in Oral Cancer Stem Cells Using bio-inspired methods - A Review

Vijay Kumar Jaiswal; Mahendra Kumar Verma

doi:10.25163/angiotherapy.729398

Angiogenesis, Inflammation & Therapeutics | Online ISSN 2207-872X

REVIEWS (Open Access)

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Discovering Novel and Old Drug Targets in Oral Cancer Stem Cells Using bio-inspired methods - A Review

Vijay Kumar Jaiswal ¹, Mahendra Kumar Verma ²

+ Author Affiliations

Journal of Angiotherapy 7 (2) 1-9 https://doi.org/10.25163/angiotherapy.729398

Submitted: 07 November 2023 Revised: 04 December 2023 Published: 07 December 2023

Abstract

Addressing the high mortality rate and limited treatment options for oral cancer is a global public health challenge. To enhance therapeutic approaches, a comprehensive understanding of oral cancer stem cells (OCSCs) is essential. This review employs advanced bio-inspired methods to identify unique pharmacological targets within OCSCs, considering their heterogeneity and resistance to conventional treatments. The Evolutionary Computation Network for Drug Repositioning (ECN-DR) dissects the intricate signaling pathways and molecular networks within OCSCs using bio-inspired techniques. By integrating machine learning, network analysis, and molecular dynamics simulations, this approach identifies potential targets for both new and existing anticancer drugs. Recognizing the key molecular players in OCSCs enables the design of tailored medicines to disrupt these cells, offering more potent and targeted therapy options with fewer side effects. Molecular dynamics simulations, protein-ligand docking studies, and in silico drug screening predict the binding affinity and therapeutic potential of prospective medications against selected OCSC targets. These simulations contribute to a better understanding of targeting specific proteins in oral cancer therapy. Utilizing bio-inspired methods and computational simulations enhances our knowledge of OCSC biology, advancing the prospects of personalized cancer treatment.

Keywords: Oral Cancer, Stem Cells, Bio-Inspired Methods, Evolutionary Computation, Drug Repositioning

References

Abudurexiti, M., Zhao, Y., Wang, X., Han, L., Liu, T., Wang, C., & Yuan, Z. (2023). Bio-Inspired Nanocarriers Derived from Stem Cells and Their Extracellular Vesicles for Targeted Drug Delivery. Pharmaceutics, 15(7), 2011.

Amiri, A., Bagherifar, R., Ansari Dezfouli, E., Kiaie, S. H., Jafari, R., & Ramezani, R. (2022). Exosomes as bio-inspired nanocarriers for RNA delivery: Preparation and applications. Journal of Translational Medicine, 20(1), 1-16.

Brogi, S., Tabanelli, R., & Calderone, V. (2022). Combinatorial approaches for novel cardiovascular drug discovery: a review of the literature. Expert Opinion on Drug Discovery, 17(10), 1111-1129.

Catania, M., Colombo, L., Sorrentino, S., Cagnotto, A., Lucchetti, J., Barbagallo, M. C., ... & Di Fede, G. (2022). A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer’s disease. Molecular Psychiatry, 27(12), 5227-5234.

Chen, S., Guo, Q., & Yu, J. (2022). Bio-inspired functional coacervates: Special Issue: Emerging Investigators. Aggregate, 3(6), e293.

De Matteis, V., & Rizzello, L. (2020). Noble metals and soft bio-inspired nanoparticles in retinal diseases treatment: A perspective. Cells, 9(3), 679.

Gao, P., Chang, X., Zhang, D., Cai, Y., Chen, G., Wang, H., & Wang, T. (2021). Synergistic integration of metal nanoclusters and biomolecules as hybrid systems for therapeutic applications. Acta Pharmaceutica Sinica B, 11(5), 1175-1199.

Gulia, K., James, A., Pandey, S., Dev, K., Kumar, D., & Sourirajan, A. (2022). Bio-inspired smart nanoparticles in enhanced cancer theranostics and targeted drug delivery. Journal of Functional Biomaterials, 13(4), 207.

Haring, A. P., Thompson, E. G., Tong, Y., Laheri, S., Cesewski, E., Sontheimer, H., & Johnson, B. N. (2019). Process-and bio-inspired hydrogels for 3D bioprinting of soft free-standing neural and glial tissues. Biofabrication, 11(2), 025009.

Harun-Ur-Rashid, M., Jahan, I., Foyez, T., & Imran, A. B. (2023). Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications. Micromachines, 14(9), 1786.

Huo, Y., Hu, J., Yin, Y., Liu, P., Cai, K., & Ji, W. (2023). Self-Assembling Peptide-Based Functional Biomaterials. ChemBioChem, 24(2), e202200582.

Koch, C., Dreava, D. M., Todea, A., Péter, F., Medeleanu, M., Pau?escu, I., ... & Sîrbu, I. O. (2023). Synthesis, Characterization, and Antiproliferative Properties of New Bio-Inspired Xanthylium Derivatives. Molecules, 28(3), 1102.

Lutz, T. M., Kimna, C., Casini, A., & Lieleg, O. (2022). Bio-based and bio-inspired adhesives from animals and plants for biomedical applications. Materials Today Bio, 13, 100203.

Mukherjee, A., Madamsetty, V. S., Paul, M. K., & Mukherjee, S. (2020). Recent advancements of nanomedicine towards antiangiogenic therapy in cancer. International Journal of Molecular Sciences, 21(2), 455.

Neubi, G. M. N., Opoku-Damoah, Y., Gu, X., Han, Y., Zhou, J., & Ding, Y. (2018). Bio-inspired drug delivery systems: an emerging platform for targeted cancer therapy. Biomaterials science, 6(5), 958-973.

Rezaie, J., Nejati, V., Mahmoodi, M., & Ahmadi, M. (2022). Mesenchymal stem cells derived extracellular vesicles: a promising nanomedicine for drug delivery system. Biochemical Pharmacology, 115167

Sang, S., Yang, C., Chai, H., Yuan, X., Liu, W., & Zhang, X. (2021). The sulfonated polyetheretherketone with 3D structure modified by two bio-inspired methods shows osteogenic and antibacterial functions. Chemical Engineering Journal, 420, 130059.

Schuh, C. M., Benso, B., & Aguayo, S. (2019). Potential novel strategies for the treatment of dental pulp-derived pain: pharmacological approaches and beyond. Frontiers in Pharmacology, 10, 1068.

Tampieri, A., Sandri, M., Iafisco, M., Panseri, S., Montesi, M., Adamiano, A., ... & Sprio, S. (2021). Nanotechnological approach and bio-inspired materials to face degenerative diseases in aging. Aging Clinical and Experimental Research, 33, 805-821.

Tong, Q., Qiu, N., Ji, J., Ye, L., & Zhai, G. (2020). Research progress in bioinspired drug delivery systems. Expert Opinion on Drug Delivery, 17(9), 1269-1288.

Tripathi, D., Hajra, K., & Maity, D. (2023). Recent Advancement of Bio-Inspired Nanoparticles in Cancer Theragnostic. Journal of Nanotheranostics, 4(3), 299-322.

Wang, L., Li, Z., Xu, C., & Qin, J. (2019). Bioinspired engineering of organ-on-chip devices. Biological and Bio-inspired Nanomaterials: Properties and Assembly Mechanisms, 401-440.

Zaszczynska, A., Niemczyk-Soczynska, B., & Sajkiewicz, P. (2022). A Comprehensive Review of Electrospun Fibers, 3D-Printed Scaffolds, and Hydrogels for Cancer Therapies. Polymers, 14(23), 5278.

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