Impedimetric Sensor Aided by Polydopamine Nanoparticles for Label-Free Detection of Breast Cancer Cells - A Review

Bhuneshwari Dewangan; Naina Bhoyar

doi:10.25163/angiotherapy.729400

Angiogenesis, Inflammation & Therapeutics | Online ISSN 2207-872X

REVIEWS (Open Access)

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Impedimetric Sensor Aided by Polydopamine Nanoparticles for Label-Free Detection of Breast Cancer Cells - A Review

Bhuneshwari Dewangan ¹, Naina Bhoyar ²

+ Author Affiliations

Journal of Angiotherapy 7 (2) 1-12 https://doi.org/10.25163/angiotherapy.729400

Submitted: 07 November 2023 Revised: 04 December 2023 Published: 07 December 2023

Abstract

Integrating an impedimetric sensor with polydopamine nanoparticles presents a novel approach for detecting breast cancer cells without labels. This innovative technique is significant for painless and sensitive early identification of cancerous cells. However, challenges, such as precise characterization and functionalization of polydopamine nanoparticles, may impact the sensor's sensitivity. This review paper suggests Real-Time Enhanced Surface Functionalization (R-TESF), utilizing polydopamine nanoparticles to enhance the sensor's specificity. Impedance data is processed with machine learning and analytical models to accurately distinguish cancer cell signatures from background noise. The method leverages polydopamine's specificity to proteins associated with breast cancer, making it a powerful tool for early detection. Simulation analysis validates and refines the proposed method, providing insights into its performance across various variables and scenarios. Beyond breast cancer diagnostics, the integration of experimental and computational methods showcased in this study has the potential to transform cancer research.

Keywords: Impedimetric Sensor, Polydopamine, Nanoparticles, Label-Free Detection Breast Cancer Cells

References

Abedi, R., Raoof, J. B., Mohseni, M., & Hashkavayi, A. B. (2023). Development of a label-free impedimetric aptasensor for the detection of Acinetobacter baumannii bacteria. Analytical Biochemistry, 679, 115288.

Bolat, G., Vural, O. A., Yaman, Y. T., & Abaci, S. (2021). Polydopamine nanoparticles-assisted impedimetric sensor towards label-free lung cancer cell detection. Materials Science and Engineering: C, 119, 111549.

Chen, F., Wu, Q., Song, D., Wang, X., Ma, P., & Sun, Y. (2019). Fe3O4@ PDA immune probe-based signal amplification in surface plasmon resonance (SPR) biosensing of human cardiac troponin I. Colloids and Surfaces B: Biointerfaces, 177, 105-111.

Chen, L., Liu, X., & Chen, C. (2017). Impedimetric biosensor modified with hydrophilic material of tannic acid/polyethylene glycol and dopamine-assisted deposition for detection of breast cancer-related BRCA1 gene. Journal of Electroanalytical Chemistry, 791, 204-210.

Esfandiari, M., Khodayari, M., Shojaee, M., Kamankesh, M., Esfandiari, B., & Mohajerzadeh, S. (2023). A laser-assisted electrochemical biosensor based on folic acid-functionalized tungsten disulfide nanosheets for label-free cancer cell detection. Sensors and Actuators B: Chemical, 381, 133443.

Fan, T., Mao, Y., Liu, F., Zhang, W., Lin, J. S., Yin, J., ... & Jiang, Y. (2019). Label-free fluorescence detection of circulating microRNAs based on duplex-specific nuclease-assisted target recycling coupled with rolling circle amplification. Talanta, 200, 480-486.

Feng, Y. G., Wang, X. Y., Wang, Z. W., Wang, A. J., Mei, L. P., Luo, X., & Feng, J. J. (2021). A label-free electrochemical immunosensor based on encapsulated signal molecules in mesoporous silica-coated gold nanorods for ultrasensitive assay of procalcitonin. Bioelectrochemistry, 140, 107753.

Gajdosova, V., Lorencova, L., Kasak, P., & Tkac, J. (2020). Electrochemical nanobiosensors for detection of breast cancer biomarkers. Sensors, 20(14), 4022.

Hassanpour, S., & Hasanzadeh, M. (2021). Label-free electrochemical-immunoassay of cancer biomarkers: Recent progress and challenges in the efficient diagnosis of cancer employing electroanalysis and based on point of care (POC). Microchemical Journal, 168, 106424.

Li, Y., Hu, M., Huang, X., Wang, M., He, L., Song, Y., ... & Du, M. (2020). Multicomponent zirconium-based metal-organic frameworks for impedimetric aptasensing of living cancer cells. Sensors and Actuators B: Chemical, 306, 127608.

Li, Y., Wang, C., Li, Z., Wang, M., He, L., & Zhang, Z. (2020). Zirconium-porphyrin complex as novel nanocarrier for label-free impedimetric biosensing neuron-specific enolase. Sensors and Actuators B: Chemical, 314, 128090.

Linh, N. D., Huyen, N. T. T., Dang, N. H., Piro, B., & Thu, V. T. (2023). Electrochemical interface based on polydopamine and gold nanoparticles/reduced graphene oxide for impedimetric detection of lung cancer cells. RSC advances, 13(15), 10082-10089.

Malla, P., Chen, G. C., Liao, H. P., Liu, C. H., & Wu, W. C. (2021). Label-free parathyroid hormone immunosensor using nanocomposite modified carbon electrode. Journal of Electroanalytical Chemistry, 880, 114917.

Mujica, M. L., Rubianes, M. D., & Rivas, G. (2022). A multipurpose biocapture nanoplatform based on multiwalled-carbon nanotubes non-covalently functionalized with avidin: Analytical applications for the non-amplified and label-free impedimetric quantification of BRCA1. Sensors and Actuators B: Chemical, 357, 131304.

Rahmati, Z., Roushani, M., & Hosseini, H. (2021). Thionine functionalized hollow N-doped carbon nanoboxes: as a high-performance substrate for fabrication of label-free electrochemical aptasensor toward ultrasensitive detection of carcinoembryonic antigen. Journal of Electroanalytical Chemistry, 903, 115858.

Sahraei, N., Mazloum-Ardakani, M., Khoshroo, A., Hoseynidokht, F., Mohiti, J., & Moradi, A. (2022). Electrochemical system designed on a paper platform as a label-free immunosensor for cancer derived exosomes based on a mesoporous carbon foam-ternary nanocomposite. Journal of Electroanalytical Chemistry, 920, 116590.

Sanko, V., & Kuralay, F. (2023). Label-Free Electrochemical Biosensor Platforms for Cancer Diagnosis: Recent Achievements and Challenges. Biosensors, 13(3), 333.

Suthar, J., Prieto-Simon, B., Williams, G. R., & Guldin, S. (2022). Dual-mode and label-free detection of exosomes from plasma using an electrochemical quartz crystal microbalance with dissipation monitoring. Analytical Chemistry, 94(5), 2465-2475.

Won, H. J., Robby, A. I., Jhon, H. S., In, I., Ryu, J. H., & Park, S. Y. (2020). Wireless label-free electrochemical detection of cancer cells by MnO2-Decorated polymer dots. Sensors and Actuators B: Chemical, 320, 128391.

Yadav, A. K., Verma, D., Kumar, A., Bhatt, A. N., & Solanki, P. R. (2023). Biocompatible epoxysilane substituted polymer-based nano biosensing platform for label-free detection of cancer biomarker SP17 in patient serum samples. International Journal of Biological Macromolecules, 239, 124325.

Yaman, Y. T., Vural, O. A., Bolat, G., & Abaci, S. (2023). Fabrication of trastuzumab conjugated curcumin nanoparticles based impedimetric cytosensor for the cancer cell detection. Microchemical Journal, 191, 108773.

Zhang, F., Fan, L., Liu, Z., Han, Y., & Guo, Y. (2022). A label-free electrochemical aptasensor for the detection of cancer antigen 125 based on nickel hexacyanoferrate nanocubes/polydopamine functionalized graphene. Journal of Electroanalytical Chemistry, 918, 116424.

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