Journal of Angiotherapy
Angiogenesis, Inflammation & Therapeutics | Online ISSN  2207-872X
  1. You are here:
  2. Home
  3. Journals
  4. Biological Sciences
REVIEWS   (Open Access)
Contents Vol 8 (2)

A Review of 3d Printing Model of New Blood Vessel Formation For Pharmaceutical Applications

Nidhi Mishra 1*, Priya Vij 1, Akanksha Mishra 1

+ Author Affiliations

Journal of Angiotherapy 8 (2) 1-6 https://doi.org/10.25163/angiotherapy.829486

Submitted: 30 November 2023 Revised: 22 January 2024  Published: 09 February 2024 

Abstract

Cardiovascular diseases (CVDs) are the primary cause of death in older individuals. An established medical approach for treating CVDs involves replacing blocked or restricted arteries. This surgery, known as vascular transplant, is now considered the most effective method and uses the patient's tissue for transplanting.  Artificial Blood Vessels (ABVs) are often not utilized for numerous cardiac individuals due to an individual's advanced age, narrow veins, prior medical history, and aberrant conditions. Hence, it is essential to consider the necessity of vascular substitutes, particularly in vascular transplanting involving extremely narrow dimensions and the presence of suitable alternatives. This work aimed to create a new type of synthetic blood vessel by combining polymer-reinforced materials with bioceramic nanomaterials.  Research has been conducted on the biomechanical and chemical characteristics of artificial blood arteries for their potential application in bypass surgery of the coronary arteries for atherosclerosis as part of biological development.  The work involved the preparation of thermoplastic polyurethane (TPU) by combining nanocrystalline hydroxyapatite (HA) tiny particles utilizing the extrusion process to create the ABVs. The ideal sample was examined using X-ray diffraction (XRD) and Scanned Electron Microscopy (SEM). The ABVs had a significant capability to determine the elasticity modulus, wetting, and permeability of the veins. These characteristics were evaluated using fused lamination modeling and 3D printing. The findings indicate that the constricted arteries, made of TPU composites with nanocrystalline HA small particles, had superior chemical resistance and structural properties.

Keywords: Cardiovascular diseases, pharmaceutical applications, blood vessel formation, 3D printing

References

Achmad, H., Djais, A. I., Petrenko, E. G., Alexander, M., Iarisa, V., & Putra, A. P. (2020). 3-D Printing as A Tool for Applying Biotechnologies in Modern Medicine. International Journal of Pharmaceutical Research (09752366), 12(4).

Arifvianto, B., Iman, T.N., Prayoga, B.T., Dharmastiti, R., Salim, U.A., Mahardika, M., Suyitno. (2021). Tensile properties of the FFF-processed thermoplastic polyurethane (TPU) elastomer. Int. J. Adv. Manuf. Technol. 117(5-6), 1709-1719.

Ben-Zvi, A., Liebner, S. (2022). Developmental regulation of barrier-and non-barrier blood vessels in the CNS. J. Intern. Med. 292(1), 31-46.

Boucherat, O., Yokokawa, T., Krishna, V., Kalyana-Sundaram, S., Martineau, S., Breuils-Bonnet, S., Bonnet, S. (2022). Identification of LTBP-2 as a plasma biomarker for right ventricular dysfunction in human pulmonary arterial hypertension. Nat Cardiovasc Res. 1(8), 748-760.

Cailleaux, S., Sanchez-Ballester, N.M., Gueche, Y.A., Bataille, B., Soulairol, I. (2021). Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines. J Control Release 330, 821-841.

Capel, A. J., Rimington, R. P., Lewis, M. P., & Christie, S. D. (2018). 3D printing for chemical, pharmaceutical and biological applications. Nature Reviews Chemistry, 2(12), 422-436.

De Santis, M.M., Alsafadi, H.N., Tas, S., Bölükbas, D.A., Prithiviraj, S., Da Silva, I. A., Wagner, D.E. (2021). Extracellular-matrix-reinforced bioinks for 3D bioprinting human tissue. Adv Mater. 33(3), 2005476.

Domínguez-Robles, J., Diaz-Gomez, L., Utomo, E., Shen, T., Picco, C. J., Alvarez-Lorenzo, C., ... & Larrañeta, E. (2021). Use of 3D printing for the development of biodegradable antiplatelet materials for cardiovascular applications. Pharmaceuticals, 14(9), 921.

Elebiyo, T.C., Rotimi, D., Evbuomwan, I.O., Maimako, R.F., Iyobhebhe, M., Ojo, O.A., Adeyemi, O.S. (2022). Reassessing vascular endothelial growth factor (VEGF) in anti-angiogenic cancer therapy. Cancer Treat. Res. Commun. 32, 100620.

Esmaeili, S., Shahali, M., Kordjamshidi, A., Torkpoor, Z., Namdari, F., Saber-Samandari, S., ... & Khandan, A. (2019). An artificial blood vessel fabricated by 3D printing for pharmaceutical application. Nanomedicine Journal, 6(3), 183-194.

Fico, D., Rizzo, D., Casciaro, R., Esposito Corcione, C. (2022). A review of polymer-based materials for fused filament fabrication (FFF): focus on sustainability and recycled materials. Polymers. 14(3), 465.

Fiume, E., Magnaterra, G., Rahdar, A., Verné, E., Baino, F. (2021). Hydroxyapatite for biomedical applications: A short overview. Ceram. 4(4), 542-563.

Gao, G., Ahn, M., Cho, W. W., Kim, B. S., & Cho, D. W. (2021). 3D printing of pharmaceutical application: drug screening and drug delivery. Pharmaceutics, 13(9), 1373.

Gardin, C., Ferroni, L., Latremouille, C., Chachques, J. C., Mitrecic, D., & Zavan, B. (2020). Recent applications of three dimensional printing in cardiovascular medicine. Cells, 9(3), 742.

Gu, Z., Fu, J., Lin, H., & He, Y. (2020). Development of 3D bioprinting: From printing methods to biomedical applications. Asian Journal of Pharmaceutical Sciences, 15(5), 529-557.

Jamróz, W., Szafraniec, J., Kurek, M., & Jachowicz, R. (2018). 3D printing in pharmaceutical and medical applications–recent achievements and challenges. Pharmaceutical research, 35, 1-22.

Jenndahl, L., Österberg, K., Bogestål, Y., Simsa, R., Gustafsson-Hedberg, T., Stenlund, P., Håkansson, J. (2022). Personalized tissue-engineered arteries as vascular graft transplants: A safety study in sheep. Regen. Ther. 21, 331-341.

Liu, X., Chai, Y., Liu, G., Su, W., Guo, Q., Lv, X., Wan, M. (2021). Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis. Nat. Commun. 12(1), 1832.

Liu, Z., Zhao, Q., Zheng, Z., Liu, S., Meng, L., Dong, L., Jiang, X. (2021). Vascular normalization in immunotherapy: A promising mechanisms combined with radiotherapy. Biomed. Pharmacother. 139, 111607.

Moore, M.J., Tan, R.P., Yang, N., Rnjak-Kovacina, J., Wise, S.G. (2022). Bioengineering artificial blood vessels from natural materials. Trends Biotechnol. 40(6), 693-707.

Schmelzer, C.E., Duca, L. (2022). Elastic fibers: Formation, function, and fate during aging and disease. FEBS J. 289(13), 3704-3730.

Tiemensma, M., Rutherford, J.D., Scott, T., Karch, S. (2021). Emergence of cumyl-PEGACLONE-related fatalities in the Northern Territory of Australia. Forensic Sci Med Pathol. 17, 3-9.

Townsend, N., Kazakiewicz, D., Lucy Wright, F., Timmis, A., Huculeci, R., Torbica, A., Vardas, P. (2022). Epidemiology of cardiovascular disease in Europe. Nat. Rev. Cardiol. 19(2), 133-143.

Wang, Y., Wu, H., Deng, R. (2021). Angiogenesis as a potential treatment strategy for rheumatoid arthritis. Eur. J. Pharmacol. 910, 174500.

Yamada, A., Yonemichi, W., Inatomi, O., Andoh, A., Tani, T. (2023). Steerable catheter based on wire-driven seamless artificial blood vessel tube for endoscopic retrograde transpapillary interventions. Int J Comput Assist Radiol Surg. 18(3), 433-447.

PDF
Abstract
Export Citation

View Dimensions


View Plumx


View Altmetric




Save
0
Citation
492
View

Share