The Effect of Naturally Occurring Dietary Chemicals and Food-Borne Mycotoxins on DNA Methylation and Cancer - A Review

Moniza Nurez Khan; Naresh Chandravanshi

doi:10.25163/angiotherapy.729411

Angiogenesis, Inflammation & Therapeutics | Online ISSN 2207-872X

REVIEWS (Open Access)

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The Effect of Naturally Occurring Dietary Chemicals and Food-Borne Mycotoxins on DNA Methylation and Cancer - A Review

Moniza Nurez Khan ¹, Naresh Chandravanshi ²

+ Author Affiliations

Journal of Angiotherapy 7 (2) 1-6 https://doi.org/10.25163/angiotherapy.729411

Submitted: 20 November 2023 Revised: 18 December 2023 Published: 21 December 2023

Abstract

Food-borne mycotoxins (FBM) can have severe effects, causing sickness or even death shortly after consuming contaminated food. Chronic exposure to mycotoxins is linked to cancer development and immune deficiencies. DNA methylation plays a role in diseases like cancer, influencing the expression of genes that regulate tumor growth. Mycotoxins can lead to crop loss, chemical production, and uncontrolled fungi growth. Aflatoxins, a type of mycotoxin, increase cancer risk and cause severe illnesses. Artificial Light At Night (ALAN) affects melatonin secretion, influencing global DNA methylation in cancer cells. FBM-ALAN shows promise against cancers by restoring normal expression of critical tumor suppressor genes and correcting abnormal DNA methylation. Abnormal DNA methylation can lead to diseases like cancer by silencing tumor suppressors and overexpressing oncogenes. Understanding DNA methylation is crucial for regulating gene expression and preventing illness in eukaryotic cells.

Keywords: Food-Borne Mycotoxins, Artificial Light at Night, Cancer, DNA methylation.

References

Barsouk, A., Thandra, K. C., Saginala, K., Rawla, P., & Barsouk, A. (2021). Chemical risk factors of primary liver cancer: an update. Hepatic Medicine: Evidence and Research, 179-188.

Davoodvandi, A., Nikfar, B., Reiter, R. J., & Asemi, Z. (2022). Melatonin and cancer suppression: insights into its effects on DNA methylation. Cellular & Molecular Biology Letters, 27(1), 1-11.

Dos Santos, P. W. D. S., Machado, A. R. T., De Grandis, R. A., Ribeiro, D. L., Tuttis, K., Morselli, M., ... & Antunes, L. M. G. (2020). Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food and Chemical Toxicology, 136, 111047.

Erichsen, L., Thimm, C., & Santourlidis, S. (2022). Methyl group metabolism in differentiation, aging, and cancer. International Journal of Molecular Sciences, 23(15), 8378.

Eskola, M., Elliott, C. T., Hajšlová, J., Steiner, D., & Krska, R. (2020). Towards a dietary-exposome assessment of chemicals in food: An update on the chronic health risks for the European consumer. Critical Reviews in Food Science and Nutrition, 60(11), 1890-1911.

Fujii, R., Sato, S., Tsuboi, Y., Cardenas, A., & Suzuki, K. (2022). DNA methylation as a mediator of associations between the environment and chronic diseases: a scoping review on application of mediation analysis. Epigenetics, 17(7), 759-785.

Ghazi, T., Arumugam, T., Foolchand, A., & Chuturgoon, A. A. (2020). The impact of natural dietary compounds and food-borne mycotoxins on DNA methylation and cancer. Cells, 9(9), 2004.

https://datasetsearch.research.google.com/search?src=0&query=%20DNA%20methylation%20in%20cancer%20&docid=L2cvMTF2YnBwajljdg%3D%3D

Hyun, J., & Jung, Y. (2020). DNA methylation in nonalcoholic fatty liver disease. International journal of molecular sciences, 21(21), 8138.

Janik, E., Niemcewicz, M., Ceremuga, M., Stela, M., Saluk-Bijak, J., Siadkowski, A., & Bijak, M. (2020). Molecular aspects of mycotoxins—A serious problem for human health. International journal of molecular sciences, 21(21), 8187.

Jasek, K., Kubatka, P., Samec, M., Liskova, A., Smejkal, K., Vybohova, D., ... & Büsselberg, D. (2019). DNA methylation status in cancer disease: modulations by plant-derived natural compounds and dietary interventions. Biomolecules, 9(7), 289.

Jin, J., Beekmann, K., Ringø, E., Rietjens, I. M., & Xing, F. (2021). Interaction between food-borne mycotoxins and gut microbiota: A review. Food Control, 126, 107998.

Kobets, T., Smith, B. P., & Williams, G. M. (2022). Food-borne chemical carcinogens and the evidence for human cancer risk. Foods, 11(18), 2828.

Malvandi, A. M., Shahba, S., Mehrzad, J., & Lombardi, G. (2022). Metabolic disruption by naturally occurring mycotoxins in circulation: a focus on vascular and bone homeostasis dysfunction. Frontiers in nutrition, 9, 915681.

Nasir, A., Bullo, M. M. H., Ahmed, Z., Imtiaz, A., Yaqoob, E., Safdar, M., & Yaqoob, S. (2022). Nutrigenomics: Epigenetics and cancer prevention: A comprehensive review. Critical reviews in food science and nutrition, 60(8), 1375-1387.

Patra, S., Nayak, R., Patro, S., Pradhan, B., Sahu, B., Behera, C., & Jena, M. (2021). Chemical diversity of dietary phytochemicals and their mode of chemoprevention. Biotechnology Reports, 30, e00633.

Ruan, H., Lu, Q., Wu, J., Qin, J., Sui, M., Sun, X., & Yang, M. (2022). Hepatotoxicity of food-borne mycotoxins: Molecular mechanism, anti-hepatotoxic medicines and target prediction. Critical Reviews in Food Science and Nutrition, 62(9), 2281-2308.

Ruan, H., Lu, Q., Wu, J., Qin, J., Sui, M., Sun, X., ... & Yang, M. (2022). Hepatotoxicity of food-borne mycotoxins: Molecular mechanism, anti-hepatotoxic medicines and target prediction. Critical Reviews in Food Science and Nutrition, 62(9), 2281-2308.

Shahba, S., Mehrzad, J., & Malvandi, A. M. (2021). Neuroimmune disruptions from naturally occurring levels of mycotoxins. Environmental science and pollution research, 28(25), 32156-32176.

Yin, S., Liu, X., Fan, L., & Hu, H. (2018). Mechanisms of cell death induction by food-borne mycotoxins. Critical reviews in food science and nutrition, 58(8), 1406-1417.

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