Latest Issue - Volume 9 Number 1 2025
Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health,
Integrative Biomedical Research
Volume 9 Number 1 2025
Table of Contents
Research Article
Metabolism and Biochemistry
Bandr Fakiha 1*
This study emphasizes the need for preventive measures, caregiver education, and improved healthcare systems to reduce pediatric poisoning incidents.
Abstract | Full Text |PDF (288 KB) | Open Access Article
Toxicological Assessment of Azo Dye Brown HT In Vivo
T M Tawabul Islam1, Nirmal Chandra Mahat2, Ivvala Anand Shaker3, Abul Kashem Tang2, Sheikh Arafat Rahman2, Mustakin Ahmed Shohel1, Inampudi Sailaja4*
This study demonstrated the adverse effects of azo dye Brown HT on juvenile health, underscoring the need for safer food practices to protect vulnerable populations.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Tissue Factor Levels Used as Coagulation Biomarkers in Diabetic and Hypertensive Patients
Waleed Haji Saeed 1*, Zikri Mahmood Mirza 1, Mohammed Rashid Ameen 1, Sarkaft Ghareeb Omer 2
This study dtermined elevated Tissue Factor levels as a potential biomarker for thrombotic risk in diabetic and hypertensive patients.
Abstract | Full Text |PDF (221 KB) | Open Access Article
Chronic Toxic Effects of Chocolate Brown HT Dye on Hepatorenal Functions In Vivo
T M Tawabul Islam 1, Abul Kashem Tang 2, Inampudi Sailaja 3, Mustakin Ahmed Shohel 1, Sheikh Arafat Rahman 2, Nirmal Chandra Mahat 2, Ivvala Anand Shaker 4*
This study showed the gender-specific toxicological impacts of Chocolate Brown HT as safer food colorant practices and regulatory guidelines.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Natural Diabetes Treatment with Litchi Seeds Extract In Vivo
Mustakin Ahmed Shohel 1, Abul Kashem Tang 2, Inampudi Sailaja 3, T M Tawabul Islam 1, Md. Humayan Kabir 2, Nirmal Chandra Mahat 2, Ivvala Anand Shaker 4*
This study demonstrated the therapeutic potential of litchi seeds for diabetes as safer, effective alternatives to synthetic drugs.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Fouad Ziedan Hamza Al-Quraishi 1*, Bassam Abdulameer Mohammed Al-Madany 1*, Mohammed Abdaljaleel 1, Fadhel Al-Kraawi 1, Zainab Mohammed Kadhim Hirzuldeen 1, Karrar Talib Salman Al-Ibrahimi 1
The study showed fenugreek’s potential to improve male fertility by enhancing sperm characteristics in hypothyroid conditions.
Abstract | Full Text |PDF (225 KB) | Open Access Article
Osama Abdel-Hameed Majeed 1*, Makarim Qassim Al-Lami 1, Gheyath AlGawwam 2
This study showed the biochemical and immunological links between Parkinson's Disease and gastrointestinal disorders, highlighting shared pathophysiological markers.
Abstract | Full Text |PDF (420 KB) | Open Access Article
Fenugreek Induces The Sperm Characteristics in Hypothyroid Male Rats
Fouad Ziedan Hamza Al-Quraishi 1*, Bassam Abdulameer Mohammed Al-Madany 1*, Mohammed Abdaljaleel Fadhel Al-Kraawi 1, Zainab Mohammed Kadhim Hirzuldeen 1, Karrar Talib Salman Al-Ibrahimi 1
This study demonstrated fenugreek's potential to improve sperm quality and hormone levels in hypothyroid male rats, suggesting therapeutic benefits.
Abstract | Full Text |PDF (270 KB) | Open Access Article
Diagnostic Efficacy of Tumor Markers AFP, CA19-9, and CEA in Hepatocellular Carcinoma Patients
Tufael 1*, Auditi Kar 2, Md Haroon Or Rashid 3, Atiqur Rahman Sunny 4*, António Raposo 5, Md. Saidul Islam 6, Md. Anower Hussain 7, Mohammad Anowar Hussen 8, Heesup Han 9, Henrique Douglas Melo Coutinho 10, Md. Sefaut Ullah 11, Md. Mizanur Rahman12
Early detection of hepatocellular carcinoma (HCC) is vital for improving patient outcomes. Chemiluminescence assays showed enhanced diagnostic accuracy, providing timely intervention and treatment.
Abstract | Full Text |PDF (418 KB) | Open Access Article
Lymphocyte, IL-10, IL-6, and IFN-g Cytokines Modulation in SARS-CoV-2 Patients
Inaam Ali Abid 1*, Ismail Ibrahim Latif 2, Namer Fadhil Ghaab 3, Saad Ahmed Ali Jadoo 4
The study showed gender disparities in COVID-19 severity, revealing elevated cytokine levels of IL-10, IL-6, and IFN-g in males, as a potential immune response variations.
Abstract | Full Text |PDF (308 KB) | Open Access Article
Khamees M. Al-Dulaimy 1, Zaynab Hameed Ibrahim 1, Bassim Mohammed Salman 1*
Understanding the genetic basis of cystinosis aids in early diagnosis, genetic counseling, and potential gene therapy approaches for disease management.
Abstract | Full Text |PDF (271 KB) | Open Access Article
Nutritional Evaluation of Cassava Meal Components and Maize in Securing Feed and Food
Shahabuddin Ahmed1,2, Mrityunjoy Biswas2*, Atiqur Rahman Sunny3, Farhana Irin4, Md Faruk Hossain5, Md Mostafizur Rahman5, Md Abu Bakar Siddique5, Md. Alauddin 6, Mrinal Kanti Debnath2, Md. Pallo Hossain2, Tufael3, 7
This study determined the nutritional composition of cassava and maize, pivotal crops for food and animal feed production globally, offering insights into dietary recommendations, agricultural practices, and food security measures in regions reliant on these staples.
Abstract | Full Text |PDF (305 KB) | Open Access Article
Tufael 1, Auditi Kar 2, Vijay Jagdish Upadhye 3*, Amith Dutta 4, Md Royhanur Islam 5, Abdus Sattar 6, Md. Eunus Ali 7, Julakha Akter 8, Kaniz Fatima Bari 9, Md. Tahsin Salam 10, Palash Chandra Banik 11, Md Shamsuddin Sultan Khan 12, Atiqur Rahman Sunny 6*
The research addresses a crucial gap by linking the unique lifestyle and stressors in fisher groups to hepatocellular carcinoma.
Abstract | Full Text |PDF (410 KB) | Open Access Article
Mohamed Sadeq Al-Ibrahim *1, Ahmad Hamdy Ibrahim 2, Sawsan S. Al- Rawi *3, Bayram Dawod Ahmed 4, Nalan Linda Fraim 5
Chronic stress affects many physiological processes including immunity and angiogenesis. IBS impacts anxiety, quality of life, and academic performance of undergraduate students.
Abstract | Full Text |PDF (305 KB) | Open Access Article
Reviews
Metabolism and Biochemistry
Analysis of Potential Biomarkers in Hypertension
Alexander V. Blagov1*, Margarita A. Sazonova 1,2, Anastasia I. Ryzhkova1, Marina D. Sazonova1, Mikhail A. Popov6, Egor Yu. Budnikov1, Paolo Poggio7, Donato Moschetta7, Yuri V. Arkhipenko1,3, Vasily P. Karagodin5, Alexander N. Orekhov1,4
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Two Sides of Triglycerides in Atherogenesis: An Essential Contributor
Anastasia V. Poznyak 1*, Tatyana Vladimirovna Kirichenko 2,5, Tatiana Ivanovna Kovyanova 1,2, Irina Alexandrovna Starodubtseva 3, Dmitry Felixovich Beloyartsev 4, Vasily N. Sukhorukov 2, Alexander N. Orekhov 2
This review discusses the role of triglycerides in atherogenesis and their potential as biomarkers in cardiovascular disease development.
Abstract | Full Text |PDF (388 KB) | Open Access Article
The Strength in Breakdown: Understanding Mitophagy and Its Implications in Cardiovascular Diseases
Anastasia V. Poznyak 1*, Alexey V. Churov 2,3, Natalia V. Elizova 2, Tatiana Ivanovna Kovyanova 1,2, Vasily N. Sukhorukov 3,4, Alexander N. Orekhov 3,4*
Understanding mitophagy's role in cardiovascular health offers potential therapeutic insights for related disorders.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Ancient DNA: Cardiovascular Disease Prediction from Mummies
Anastasia V. Poznyak 1*, Tatyana Vladimirovna Kirichenko 2,5, Natalia V. Elizova 2, Alexey V. Churov 2,6, Tatiana Ivanovna Kovyanova 1,2, Irina Alexandrovna Starodubtseva 3, Vasily N. Sukhorukov 2,5, and Alexander N. Orekhov 2,5
Understanding CVD's genetic roots through ancient mummies reveals its historical prevalence and informs contemporary health.
Abstract | Full Text |PDF (201 KB) | Open Access Article
Iza Safany Che Hanafi 1, Chandrarohini Saravanan 2, Rabiatul Basria S. M. N. Mydin 2*
This review discusses how oxidative stress affects our bodies due to factors like diet, stress, and environment, and how antioxidants help. Understanding this is crucial for fighting diseases like cancer and staying healthy.
Abstract | Full Text |PDF (219 KB) | Open Access Article
Repurposing Drugs for Overcoming Therapy Resistance in Colon Cancer – A Review
Mahdi Darvishi 1, Amir Mohammad Chekeni 2, Mohammad Fazelhosseini 1, Zeenat Iqbal 3*, Mohd Aamir Mirza 3*, Mohammed Aslam 4, Esra Tariq Anwer Bayrakdar 4
Oncology research seeks new therapies for aggressive CRC, utilizing repurposed drugs for accelerated and safer treatment approaches.
Abstract | Full Text |PDF (842 KB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
The Most Read ranking is based on the number of downloads in the last 60 days from papers published on the Journal of Angiotherapy within the last 12 months. Usage statistics are updated daily.
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The Role of Quality Assurance in Accelerating Pharmaceutical Research and Development: Strategies for Ensuring Regulatory Compliance and Product Integrity
This study highlights the role of Quality Assurance in ensuring product integrity, patient safety, and driving pharmaceutical innovation.
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Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
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Serum Albumin Levels as Predictors of Microvascular Health and Wound Healing Outcomes in Diabetic Foot Ulcers
This study deermines the critical role of serum albumin in improving vascularization and granulation tissue, reducing amputation risks in diabetic foot ulcers.
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Knowledge in Enhancing Antenatal Care Compliance and Improving Maternal and Neonatal Health Outcomes
This study provides the understanding how knowledge influences antenatal care compliance can enhance health education strategies and improve maternal and neonatal health outcomes.
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Prevalence and Risk Factors of Hypertension in Adolescents
This study determines hypertension prevalence and associated risk factors in Indonesian adolescents, crucial for targeted public health interventions.
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Biogeochemical Role of Mangroves: Carbon Sequestration, Oxygen Release, and Their Contribution to Ecosystem Sustainability
This study highlights mangroves' critical role in carbon sequestration and oxygen release, contributing significantly to ecosystem and climate regulation.
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Wastewater Treatment and Reuse: Preventive Measures for Chronic Infectious Diseases
This review discusses the significance of wastewater treatment in sustainability, water security, environmental preservation, human health safeguarding and resource recovery.
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Advancements in Virus Detection and Isolation: The Role of Chromatography in Virology Research and Health
This review discusses the viral infections, transmission, and morphology for developing effective diagnostics, treatments, and preventive strategies against future pandemics.
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Early Detection of Sickle Cell Anemia in Nilgiri Tribes Using a Hybrid Swin Transformer-Based RNN with Improved Weighted Quantum Monkey Optimization Algorithm Optimization
This model offers an accurate, timely SCA detection solution, improving healthcare outcomes for Nilgiri tribes and vulnerable populations.
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Machine Learning in Healthcare: From Diagnostics to Personalized Medicine and Predictive Analytics
Machine learning transforms healthcare through accurate diagnosis, tailored therapies, and predictive analytics, promoting a future of precision medicine.
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Sago and Katuk Leaf Combination Treatment Reduces The Blood Glucose Levels in Diabetes Mellitus Patients
This study demonstrates that sago and katuk leaves effectively reduce blood glucose levels, offering a cost-effective, culturally suitable diabetes management solution.
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In Silico Determination of Tinospora cordifolia Phytochemicals as Potential DPP-4 Inhibitors for Type 2 Diabetes Management
This study determined Tinospora cordifolia phytochemicals as potential DPP-4 inhibitors, offering promising therapeutic candidates for type 2 diabetes.
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A Cross-Sectional Study on Toxic Agents, Exposure Routes, and Healthcare Challenges on Pediatric Poisoning in the Al Jouf Region
This study emphasizes the need for preventive measures, caregiver education, and improved healthcare systems to reduce pediatric poisoning incidents.
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Investigating the Impact of Tablet Coatings on Gastrointestinal Tract Residence Time and Drug Bioavailability: A Comparative Study of Different Coating Materials
This review discusses the importance of tailored tablet coatings to optimize drug release, stability, bioavailability, and therapeutic efficacy.
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Lung-Targeted Solid Lipid Nanoparticles for Enhanced Pulmonary Delivery of Anti-Tubercular Drugs: A Novel Approach to Improve Bioavailability
Solid lipid nanoparticles improved anti-tubercular drug encapsulation, stability, and lung retention, offering a promising targeted pulmonary delivery approach for tuberculosis treatment.
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Biological Maturity in Youth Athletes: Comparing Upper-Lower Body Ratios and Second Molar Eruption
Our study assesses upper-lower body ratios and second molar eruption as indicators of biological maturity in young athletes.
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Antioxidant Potential of Curculigo pilosa Rhizome Extracts in Hydrogen Peroxide Induced Oxidation In Vivo
Curculigo pilosa extracts exhibit strong antioxidant properties, mitigating oxidative stress in Drosophila melanogaster, highlighting potential therapeutic applications.
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Impact of Hemodiafiltration and Hemodialysis on FGF-23 Levels and Cardiovascular Calcification in End-Stage Renal Disease
This study determines the effects of dialysis modalities on FGF-23 levels and cardiovascular calcification, offering insights into improving ESRD patient outcomes.
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Comparative Efficacy of Endovascular Versus Surgical Thrombectomy for Arteriovenous Graft Thrombosis in Hemodialysis Patients - A Systematic Review and Meta-Analysis
This study evaluates endovascular versus surgical thrombectomy in arteriovenous graft thrombosis, providing insights for optimizing hemodialysis vascular access management and patient outcomes.
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Analysis of Potential Biomarkers in Hypertension
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
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Hemoglobin N Seattle in a Bengali Child: Diagnostic Challenges and Insights into Genetic Diversity – A Case
This case highlights Hb N Seattle's first detection in a Bengali child, emphasizing diagnostic challenges and genetic diversity insights.
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Factors Influencing Pulmonary Tuberculosis Incidence in Banggai Laut
This study identifies factors influencing TB distribution in Banggai Laut, offering insights for targeted interventions to improve public health outcomes.
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Risk Factors for Knee Injuries in Sports and Intense Physical Exercise
This study highlights the importance of identifying risk factors for knee injuries to develop targeted prevention and rehabilitation strategies.
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Predicting Habitat Suitability and Climate Change Impact on Medicinal plant Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
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Exon 4 Mutations Determination in NOTCH3 Gene for Cryptogenic Ischemic Stroke
This study highlights the genetic and vascular risk factors for cryptogenic ischemic stroke in young adults, emphasizing prevention and personalized treatment strategies.
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Collaborative Governance in Combating Illegal Cosmetics: A Study of Multi-Stakeholder Dynamics in South Sulawesi, Indonesia
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
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Advances in Human Umbilical Vein Scaffolds for Vascular Tissue Engineering: Innovations, Challenges, and Future Directions
This review explores innovative human umbilical vein scaffolds, enhancing vascular tissue engineering for regenerative medicine and cardiovascular applications.
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A Review of Antipsychotic Medications on Hypercoagulability in Schizophrenia: Pathophysiology, Risks, and Management Strategies
Understanding antipsychotic-induced hypercoagulability in schizophrenia is crucial for reducing thromboembolic risks and improving patient outcomes.
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Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
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Effects of Physical Activity as A Treatment For Depression in the Elderly
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
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Smart Nutrition and Active Living in Hypertension Management: Assessing Lifestyle Behaviors, Barriers, and the Role of Digital Health Tools
This study is significant as it highlights the effectiveness of smart nutrition and active living in managing hypertension, promoting sustainable, non-pharmacological interventions for better cardiovascular health.
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High Viral Load is a Risk Factor for Hepatocellular Carcinoma: Clinical and Laboratory Insights from a Cross-Sectional Study
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
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A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
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Phytochemical Composition, Antioxidant, and Anti-Inflammatory Activities of Laurus nobilis Leaf Extracts Using Solvent Fractionation
Ethyl acetate extract of Laurus nobilis leaves showed potent antioxidant and anti-inflammatory activities, highlighting its therapeutic and pharmacological potential.Pages: 1-8
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Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
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Comparative Effects of Sodium Dodecyl Sulfate and Hydrogen Peroxide on Type I and III Collagen Preservation in Decellularized Bovine Pericardium Scaffolds
SDS significantly reduces type I and III collagen density in decellularized bovine pericardium, whereas H2O2 better preserves extracellular matrix integrity.
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Evaluation of Cardiac Biomarkers as Predictors of Short-Term Mortality Following Coronary Artery Bypass Grafting
This study evaluates the predictive value of biomarkers in short-term mortality after coronary artery bypass grafting to guide clinical decisions.
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Machine Learning for Cardiovascular Healthcare: Opportunities, Challenges, and the Path Forward
Machine learning improves healthcare efficiency; yet issues such as data privacy and bias must be resolved for ethical, scalable, and effective application.
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PEGylated Liposomal Teriflunomide: A Novel Approach of Targeted Breast Cancer Treatment to Advance Efficacy and Minimize Adverse Effects
Developing pegylated liposomal teriflunomide may enhance breast cancer treatment efficacy, reduce side effects, and improve patient outcomes.
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Enhancing Pharmacological Access and Health Outcomes in Rural Communities through Renewable Energy Integration: Implications for chronic inflammatory Disease Management
This study emphasises how renewable energy enhances pharmacological logistics, clinical service continuity, and health outcomes in rural, disadvantaged healthcare systems.
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Multidisciplinary Challenges in Managing a Ruptured Ascending Aortic Aneurysm with Concurrent Pulmonary Pathology: A Case Report
This case highlights the challenges of managing ruptured aortic aneurysms with comorbidities, emphasizing multidisciplinary care and TEVAR’s limitations in complex cases.
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The Importance of Autoimmunity and Chronic Inflammation in the Development of Atherosclerosis: New Treatment Strategies
Understanding immune mechanisms in atherosclerosis enables development of targeted anti-inflammatory therapies, improving cardiovascular outcomes and plaque stabilization strategies.
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Cardiovascular Complications in Patients with Hepatocellular Carcinoma
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
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Potential Role of Helicobacter pylori Infection in Hepatocellular Carcinoma: A Clinical and Laboratory-Based Study
The study is to determine the pervasiveness of H. pylori infection among patients with liver illness of HCC.
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Early Surgical Intervention in Congenital Pulmonary Airway Malformation: A Case Report
Early recognition and surgical intervention in symptomatic CPAM cases prevent complications, ensuring optimal respiratory function and long-term clinical outcomes in neonates.
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The Evolving Role of Hospital and Community Pharmacist in Post-COVID-19 Healthcare Delivery in Bangladesh: A Survey-Based Analysis
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
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Integrating Health Analytics tools to Enhance Pharmacological Management and Patient Outcomes in Hospital Settings
This study emphasises that the integration of business and HR analytics improves hospital efficiency, personnel management, and patient care outcomes.
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OR-PSGAN-CNN: An Occlusion-Robust Deep Learning Framework for Early Detection of Cerebral Palsy in Infants Using RGB-D Videos
Improves early cerebral palsy detection by resolving pose occlusions through enhanced skeleton generation and feature extraction from infant movement videos.
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Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
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Antidiabetic and Toxicological Evaluation of Ostodes Pauciflora merr. Seed (kop nut) Oil, A Potential Functional Food Alternative
This study evaluates Ostodes pauciflora Merr. seed oil for antidiabetic properties, providing insights into its potential as a functional food alternative.
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AI-driven Innovations in Cancer Research and Personalized Healthcare
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
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Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
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Global Burden, Risk Factors, and Evidence-Based Strategies for Cardiovascular Disease Prevention: A Comprehensive Systematic Review
This review highlights global CVD disparities, identifies major risk factors, and evaluates effective, cost-efficient prevention strategies for population health.
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An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
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