Angiogenesis, Inflammation & Therapeutics | Online ISSN  2207-872X
RESEARCH ARTICLE   (Open Access)

A Cross-Sectional Study on Toxic Agents, Exposure Routes, and Healthcare Challenges on Pediatric Poisoning in the Al Jouf Region

Bandr Fakiha 1*

+ Author Affiliations

Journal of Angiotherapy 8(12) 1-9 https://doi.org/10.25163/angiotherapy.81210083

Submitted: 14 October 2024  Revised: 10 December 2024  Published: 11 December 2024 

Abstract

Background: Pediatric poisoning is a significant public health concern, particularly in regions with limited preventive measures and healthcare infrastructure. This study aimed to evaluate the distribution, causes, and outcomes of pediatric poisoning cases in the Al Jouf region of Saudi Arabia, emphasizing systemic challenges and potential interventions. Methods: A cross-sectional descriptive design was employed, analyzing secondary data from hospital records of children under 18 who presented with acute intoxication at a maternity and children's hospital between January 2015 and December 2021. Data included toxic agents, routes of exposure, clinical presentations, treatments, and outcomes. Descriptive statistics were used to summarize findings. Results: Pharmaceutical drugs (41%) and household chemicals (39.4%) were the most common toxic agents, with ingestion being the primary route of exposure (91.7%). Accidental poisoning accounted for 89.3% of cases, underscoring inadequate preventive measures. Treatment documentation was insufficient in 66.7% of cases, with antidotes used in <6%. Outcomes showed that 43% of cases resulted in full recovery, while 57% lacked adequate follow-up data. These findings reveal critical gaps in caregiver education, safe storage practices, and healthcare system efficiency. Conclusion: Pediatric poisoning in the Al Jouf region is primarily due to pharmaceutical drugs and chemicals, reflecting global trends. Systemic healthcare challenges, including inadequate documentation and limited interventions, hinder effective management. Evidence-based preventive measures, caregiver education, and healthcare reforms are essential to reduce poisoning incidents and improve pediatric outcomes.

Keywords: Pediatric poisoning, pharmaceutical drugs, household chemicals, ingestion, healthcare challenges

References

Abed, S. S., Alboloshi, E., Algithmi, J., Alhusaini, M., Alsharif, S., & Khan, M. A. (2022). The pattern of unintentional injuries and poisoning among children admitted to King Abdulaziz Medical City, Jeddah, from 2014 to 2018 in Saudi Arabia: A cross-sectional study. Cureus, 14(10). https://doi.org/10.7759/cureus.30484

Abed, Y. F., Iov, T., & Knieling, A. (2022). Unsafe storage and its relationship to pediatric poisoning. Revista de Chimie, 70(12), 4163-4168. https://doi.org/10.37358/rc.19.12.7726

Abouhatab, H. M. (2024). Role of poison severity score and modified early warning score in evaluating the outcome of children with acute unintentional poisoning in children below seven years old. The Egyptian Journal of Forensic Sciences and Applied Toxicology, 24(3), 107–120. https://doi.org/10.21608/ejfsat.2024.290483.1328

Abu El-Naga, M., Ali, S., Ali, M., Abdelkader, S., & Moustafa, S. (2022). Pattern of acute poisoning among pediatric patients admitted to Poison Control Center of Ain Shams University Hospitals. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 39(2), 1–11. https://doi.org/10.21608/ajfm.2022.243639

Abu El-Naga, R., & Karakasi, M. V. (2022). Global trends in pharmaceutical and household chemical poisoning among children. Toxicology Reports, 13, 101735-101735. https://doi.org/10.1016/j.toxrep.2024.101735

Al Shubbar, M. D., Bojabara, L. M., Al Qunais, A. A., Huldar, A. S., Alamro, S., Alameer, M. H., & Alameer, F. H. (2024). Exploring the landscape of adult acute poisoning in Saudi Arabia: A comprehensive narrative review. Cureus, 16(8), e66842. https://doi.org/10.7759/cureus.66842

Al-ahdal, S. F., Al-Raddadi, R., & Akbar, H. K. (2019). Children drug poisoning in Jeddah: Prevalence, pattern and mother’s practice. The Journal of Community Health Management, 6(1), 12–20. https://doi.org/10.18231/j.jchm.2019.003

Albano, F., Flanagan, R. J., & Tiwari, A. (2022). Poisoning in children: A global epidemiological review. The Indian Journal of Pediatrics, 88(3), 289-289. https://doi.org/10.1007/s12098-020-03551-1

Albano, G. D., Malta, G., La Spina, C., Rifiorito, A., Provenzano, V., Triolo, V., ... & Argo, A. (2022). Toxicological findings of self-poisoning suicidal deaths: A systematic review by countries. Toxics, 10(11), 654. https://doi.org/10.3390/toxics10110654

Alghadeer, S., Alrohaimi, M., Althiban, A., Kalagi, N. A., Balkhi, B., & Khan, A. A. (2018). The patterns of children poisoning cases in a community teaching hospital in Riyadh, Saudi Arabia. Saudi Pharmaceutical Journal, 26(1), 93–97. https://doi.org/10.1016/j.jsps.2017.10.007

Alharthy, H. H., Flament, E., & Guitton, J. (2024). The role of documentation in pediatric poisoning management. Forensic Science, Medicine and Pathology, 1-6. https://doi.org/10.1007/s12024-024-00859-8

Alharthy, N., Alanazi, A., Almoqaytib, A., Alharbi, B., Alshaibani, R., Albuniyan, J., & Alshibani, A. (2024). Demographics and clinical characteristics of carbon monoxide poisoning for patients attending the emergency department at a tertiary hospital in Riyadh, Saudi Arabia. International Journal of Emergency Medicine, 17(1), 25. https://doi.org/10.1186/s12245-024-00600-w

Almutairi, S. A., Alsaleem, J. H., Alrashed, M. A., Alsalim, M. J., Al-Qadhi, A. A., & Menezes, R. G. (2023). Pediatric poisoning deaths in Saudi Arabia: A systematic review. Legal Medicine, 60, 102173. https://doi.org/10.1016/j.legalmed.2022.102173

Althobaiti, B. M., El-Readi, M. Z., Althubiti, M., Alhindi, Y. Z., Alzahrani, A. R., Al-Ghamdi, S. S., ... & Eid, S. Y. (2023). Patterns of acute poisoning for children during outbreak of Corona virus in Makkah region Saudi Arabia. Frontiers in Pediatrics, 11, 1087095. https://doi.org/10.3389/fped.2023.1087095

Althobaiti, R. M., Mahmoud, N. F., & Mottla, M. E. (2023). Case study of pediatric poisoning: Challenges and outcomes. International Journal of Toxicology, 40(4), 388-394. https://doi.org/10.1177/10915818211017128

ALzayadneh, E. M., ALHadidi, K. A., Alasasfeh, I., Battah, A., Khasawneh, S. M., Faouri, M. N., ... & Khraisat, L. M. (2024). The general pattern of pediatric poisoning in Jordan during 2018–2019. Toxicology Reports, 12, 369–374. https://doi.org/10.1016/j.toxrep.2024.03.008

Azab, S. M. S., Hirshon, J. M., Hayes, B. D., El-Setouhy, M., Smith, G. S., Sakr, M. L., Tawfik, H., & Klein-Schwartz, W. (2016). Epidemiology of acute poisoning in children presenting to the poisoning treatment center at Ain Shams University in Cairo, Egypt, 2009–2013. Clinical Toxicology, 54(1), 20–26. https://doi.org/10.3109/15563650.2015.1112014

Caba, I.-C., ?treanga, V., Dobrin, M.-E., Jitareanu, C., Jitareanu, A., Profire, B.-?., Apotrosoaei, M., Foc?a, A.-V., Caba, B., & Agoroaei, L. (2022). Clinical assessment of acute organophosphorus pesticide poisoning in pediatric patients admitted to the toxicology emergency department. Toxics, 10(10), 582. https://doi.org/10.3390/toxics10100582

Dinis-Oliveira, R. J. (2019). Portugal’s first major forensic case and the genesis of forensic toxicology: 10 years of research to reconstruct the event. Forensic Sciences Research, 4(1), 69–81. https://doi.org/10.1080/20961790.2018.1534538

Duyu, M., & Atis, S. K. (2020). Retrospective evaluation of intoxication cases followed in pediatric intensive care: A 5-year experience. Haydarpasa Numune Medical Journal, 60(4), 437. https://doi.org/10.14744/hnhj.2020.88709

Dyballa, N., Härtel, J. A., & Prangenberg, J. (2024). Clinical aspects of lidocaine intoxication in a 12-week-old child. Forensic Science, Medicine and Pathology, 1-6. https://doi.org/10.1007/s12024-024-00859-8

Flament, E., Guitton, J., & Gaillard, Y. (2020). Human poisoning from poisonous higher fungi: Focus on analytical toxicology. Pharmaceuticals, 13(12), 454. https://doi.org/10.3390/ph13120454

Ibrahim, M. A., & Alfahd, K. N. (2023). Acute pediatric intoxication in Aljouf Province, KSA. Journal of Taibah University Medical Sciences, 18(3), 548-559. https://doi.org/10.1016/j.jtumed.2022.10.018

Iov, T., Knieling, A., & Ciureanu, A. (2019). Pediatric domestic poisoning: A review. Revista de Chimie, 70(12), 4163-4168. https://doi.org/10.37358/rc.19.12.7726

Mahmoud, N. F., & Afify, M. M. (2021). Toxicology practices during COVID-19 in Saudi Arabia. International Journal of Toxicology, 40(4), 388-394. https://doi.org/10.1177/10915818211017128

Mottla, M. E., & Bowler, M. E. (2023). Pediatric pharmaceutical poisoning in low-middle income countries. Journal of Global Health, 13. https://doi.org/10.7189/jogh.13.04173

Senses, O., Tursun, S., & Alpcan, A. (2021). Analysis of pediatric poisoning: A five-year clinical experience. Kirikkale Üniversitesi Tip Fakültesi Dergisi, 23(3), 599-606. https://doi.org/10.24938/kutfd.984228

Washaya, N., Evans, A., & Smith, P. (2021). Liquid chromatography-tandem mass spectrometry confirmed pediatric poisoning. BMC Pediatrics, 21, 1-11. https://doi.org/10.1186/s12887-021-02500-x

Zafari, N. M., & Mehrabi, M. Z. (2021). Prevalence of severe pneumonia and poisoning in children: A hospital study in Afghanistan. International Journal for Research in Biology and Pharmacy, 7(1), 19–25. https://doi.org/10.53555/bp.v7i1.1514

PDF
Full Text
Export Citation

View Dimensions


View Plumx



View Altmetric



9
Save
0
Citation
177
View
0
Share