Journal of Angiotherapy
Angiogenesis, Inflammation & Therapeutics | Online ISSN  2207-872X
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RESEARCH ARTICLE   (Open Access)
Contents Vol 8 (1)

Significance of Serum Biomarkers in Early Diagnosis of Hepatocellular Carcinoma in Patients with Fisher Groups

Tufael 1, Auditi Kar 2, Vijay Jagdish Upadhye 3*, Amith Dutta 4, Md Royhanur Islam 5, Abdus Sattar 6, Md. Eunus Ali 7, Julakha Akter 8, Kaniz Fatima Bari 9, Md. Tahsin Salam 10, Palash Chandra Banik 11, Md Shamsuddin Sultan Khan 12, Atiqur Rahman Sunny 6*

+ Author Affiliations

Journal of Angiotherapy 8 (1) 1-9 https://doi.org/10.25163/angiotherapy.819440

Submitted: 12 December 2023 Revised: 18 January 2024  Published: 20 January 2024 

Abstract

Introduction: This study investigates the relationship between serum biomarkers and the detection of hepatocellular carcinoma (HCC) in different fisher groups in Bangladesh. The research adopts a descriptive and experimental approach to demonstrate the health risks faced by fishermen, including tobacco consumption, polluted drinking water, and insufficient sunlight exposure. Method: We used serum biomarkers such as vitamin D, alpha-fetoprotein (AFP), creatinine (Cr), and hemoglobin A1C (HbA1c) to evaluate their significance in distinguishing between different categories and sexes. Result: We determined a strong and direct correlation between insufficient vitamin D levels and an increased risk of liver cancer. The combination of AFP, vitamin D, and Cr (AFP+Vit-D+Cr) emerges as a highly predictive tool, enhancing diagnostic accuracy and providing a reliable means of identifying hepatocellular carcinoma. Conclusion: The identified correlation showed the significance of addressing lifestyle factors and promoting nutritional support to mitigate the risk of liver cancer among fisher groups. The AFP+Vit-D+Cr combination is a promising diagnostic tool for hepatocellular carcinoma, offering an improved early detection and intervention approach.

Keywords: Liver Cancer Detection, Fisher groups, Serum Biomarkers, Vitamin D Insufficiency, Health Risk Factors

References

Adelani, I.B.; Rotimi, O.A.; Maduagwu, E.N. and Rotimi, S.O. (2021). Vitamin D: possible therapeutic roles in hepatocellular carcinoma. Frontiers in Oncology, 11, 642653.

Alpha Fetoprotein. (2023). National Library of Medicine. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK430750/ (Accessed on: August 6, 2023)

Amarapurkar, D.N.; Patel, N.D. and Kamani, P.M. (2008). Impact of diabetes mellitus on outcome of HCC. Annals of hepatology, 7(2), 148-151.

Banal, K.A.; Paz-Pacheco, E. and de Villa, V. (2017). Diabetes mellitus and prediabetes in patients with hepatocellular carcinoma in a tertiary Philippine hospital. Journal of the ASEAN Federation of Endocrine Societies, 32(1), 32.

Bari, K.F.; Salam, M.T.; Hasan, S.E. and Sunny, A.R. (2023). Serum zinc and calcium level in patients with psoriasis. Journal of Knowledge Learning and Science Technology ISSN: 2959-6386 (online), 2(3), 7-14.

Chakma, S.; Paul, A.K.; Rahman, M.A.; Hasan, M.M.; Sazzad, S.A. and Sunny, A.R. (2022). Climate Change Impacts and Ongoing Adaptation Measures in the Bangladesh Sundarbans. Egyptian Journal of Aquatic Biology and Fisheries. 1;26(2):329-48.

Creatinin Blood. (2023). University of Rochester. Retrived from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=creatinine_serum (Accessed on: August 6, 2023)

Diabetes overview. (2023). American Diabetes Association. Retrieved from: https://www.diabetes.org/a1c/diagnosis (Accessed on: August 6, 2023)

Edoo, M.I.A.; Chutturghoon, V.K.; Wusu-Ansah, G.K.; Zhu, H.; Zhen, T.Y.; Xie, H.Y. and Zheng, S. S. (2019). Serum Biomarkers AFP, CEA and CA19-9 Combined Detection for Early Diagnosis of Hepatocellular Carcinoma. Iranian journal of public health, 48(2), 314–322.

Fabrizi, F.; Cerutti, R.; Alfieri, C.M. and Ridruejo, E. (2021). An Update on Hepatocellular Carcinoma in Chronic Kidney Disease. Cancers, 13(14), 3617.

Faruk, O.; Hasan, S. E.; Jubayer, A.; Akter, K.; Al Shiam, S.A.; Rahman, K. and Ali, M.Y. (2023). Microbial Isolates from Urinary Tract Infection and their Antibiotic Resistance Pattern in Dhaka city of Bangladesh. Journal of Knowledge Learning and Science Technology ISSN: 2959-6386 (online), 2(3), 76-87.

Hasan, M.R.; Hossain, M.M.; Islam, M.S.; Sunny, A.R.; Ferdous, J.; Chowdhury, M.Z.A.; Maria, A.M.; Sarder, A.A.H... and Sultana, A. (2023). Seasonal Variation of Quality and the Total Viable Count of Lean and Fatty Fish. Egyptian Journal of Aquatic Biology & Fisheries, 27(5), DOI: 10.21608/EJABF.2023.324732

Henriques, C.U.; Damm, P.; Tabor, A.; Pedersen, J.F. and Mølsted-Pedersen, L.A.R.S. (1993). Decreased alpha-fetoprotein in amniotic fluid and maternal serum in diabetic pregnancy. Obstetrics & Gynecology, 82(6), 960-964.

Huo, T.I; Wu, J.C.; Lee, P.C.; Chang, F.Y. and Lee, S.D. (2004). Incidence and risk factors for acute renal failure in patients with hepatocellular carcinoma undergoing transarterial chemoembolization: a prospective study. Liver Int 24:210–215

Islam, M.M.; Cansse, T.; Islam, M.S. and Sunny, A.R. (2018). Climate change and its impacts: The case of coastal fisher groups of the Meghna River in south central Bangladesh. International Journal of Marine and Environmental Sciences. doi: 10.5281/zendo.1474924.

 

Islam, R.; Sunny, A.R.; Sazzad, S.A.;  Amith, D.; Nazmul, H.; Koushikur, R.; Faruque, M.M.; Ashrafuzzaman, M. and Prodhan, S.H. (2023). Environmental Jeopardy and Coping Strategies of the Small-scale Fishers in the Bangladesh Sundarbans: The Precedent of the World’s Largest Mangrove. Egyptian Journal of Aquatic Biology & Fisheries, 27(6).

Kennel, K.A.; Drake, M.T. and Hurley, D.L. (2010). Vitamin D deficiency in adults: when to test and how to treat. Mayo Clinic proceedings, 85(8), 752–758. https://doi.org/10.4065/mcp.2010.0138

Kuddus, M.A.; Alam, M.J.; Datta, G.C.; Miah, M.A.; Sarker, A.K. and Sunny, M.A.R. (2021). Climate resilience technology for year round vegetable production in northeastern Bangladesh. Int. J. Agril. Res. Innov. Tech., 11(1): 29-36. https://doi.org/10.3329/ijarit.v11i1.54464

Kuddus, M.A.; Datta, G.C.; Miah, M.A.; Sarker, A.K.; Hamid, S.M.A. and Sunny, A.R. (2020). Performance study of selected orange fleshed sweet potato varieties in North Eastern Bangladesh. International Journal of Environment, Agriculture and Biotechnology, 5(3): 673-682.

Kuddus, M.A.; Sunny, A.R.; Sazzad, S.A.; Hossain, M.; Rahman, M.; Mithun, M.H.; Ifat, S.E.H.; Ahmed, K.J.; Zandonadi, R.P.; Han, H., Montes, A.A.; Vega, A.A. and Raposo, A. (2022). Sense and Manner of WASH and Their Coalition with Disease and Nutritional Status of Under-five Children in Rural Bangladesh: A Cross-Sectional Study. Frontiers in Public Health, 10.

Kumar, R.; Priyadarshi, R.N. and Anand, U. (2021). Chronic renal dysfunction in cirrhosis: A new frontier in hepatology. World journal of gastroenterology, 27(11), 990–1005. https://doi.org/10.3748/wjg.v27.i11.990

Lai, G.Y.; Wang, J.B.; Weinstein, S.J.; Parisi, D.; Horst, R.L.; McGlynn, K.A. ... and Freedman, N.D. (2018). Association of 25-hydroxyvitamin D with liver cancer incidence and chronic liver disease mortality in Finnish male smokers of the ATBC study. Cancer Epidemiology, Biomarkers & Prevention, 27(9), 1075-1082.

Lange, C.M.; Miki, D.; Ochi, H.; Nischalke, H.D.; Bojunga, J.; Bibert, S. ... and Swiss Hepatitis C Cohort Study Group. (2013). Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development. PLoS One, 8(5), e64053.

Lee, C.H.; Hsieh, S.Y.; Lin, J.L.; Liu, M.S. and Yen, T.H. (2013). Hepatocellular carcinoma in patients with chronic kidney disease. World journal of gastroenterology, 19(16), 2466–2472. https://doi.org/10.3748/wjg.v19.i16.2466

Lee, C.W.; Tsai, H.I.; Lee, W.C.; Huang, S.W.; Lin, C.Y.; Hsieh, Y.C.; Kuo, T.; Chen, C.W. and Yu, M.C. (2019). Normal Alpha-Fetoprotein Hepatocellular Carcinoma: Are They Really Normal?. Journal of clinical medicine, 8(10), 1736. https://doi.org/10.3390/jcm8101736.

Li, C.I.; Chen, H.J.; Lai, H.C.; Liu, C.S.; Lin, W.Y.; Li, T.C. and Lin, C.C. (2015). Hyperglycemia and chronic liver diseases on risk of hepatocellular carcinoma in Chinese patients with type 2 diabetes––National cohort of Taiwan Diabetes Study. International journal of cancer, 136(11), 2668-2679.

Lim, T.S.; Kim, D.Y.; Han, K.H.; Kim, H.S.; Shin, S.H.; Jung, K.S. ... and Ahn, S.H. (2016). Combined use of AFP, PIVKA-II, and AFP-L3 as tumor markers enhances diagnostic accuracy for hepatocellular carcinoma in cirrhotic patients. Scandinavian journal of gastroenterology, 51(3), 344-353.

Lin, W.C.; Chang, C.W.; Chang, C.W.; Wang, T.E.; Chen, M.J. and Wang, H.Y. (2019). Challenges of transarterial therapy for hepatocellular carcinoma in patients with chronic kidney disease. Medicine, 98(35), e17007. https://doi.org/10.1097/MD.0000000000017007

Louka, M.L.; Fawzy, A.M.; Naiem, A.M.; Elseknedy, M.F.; Abdelhalim, A.E. and Abdelghany, M.A. (2017). Vitamin D and K signaling pathways in hepatocellular carcinoma. Gene, 629, 108-116.

Markotic, A.; Kelava, T.; Markotic, H.; Silovski, H. and Mrzljak, A. (2022). Vitamin D in liver cancer: novel insights and future perspectives. Croatian medical journal, 63(2), 187–196. https://doi.org/10.3325/cmj.2022.63.187

Rohlfing, C. L.; Hanson, S.; Tennill, A.L. and Little, R.R. (2012). Effects of whole blood storage on hemoglobin a1c measurements with five current assay methods. Diabetes technology & therapeutics, 14(3), 271–275. https://doi.org/10.1089/dia.2011.0136

Sazzad, S.A.; Billah, M.; Sunny, A.R.; Anowar, S.; Pavel, J.H.; Rakhi, M.S.; ... and Al-Mamun, M.A. (2023). Sketching Livelihoods and Coping Strategies of Climate Vulnerable Fishers. Egyptian Journal of Aquatic Biology & Fisheries, 27(4).

Sunny, A.R.; Prodhan, S.H.; Ashrafuzzaman, M.; Mithun, M.H.; Hussain, M.; Alam, M.T.; Rashid, A. and Hossain, M.M. (2021a). Fisheries in the context of attaining sustainable development goals (sdgs) in Bangladesh: COVID-19 impacts and future prospects. Preprints, 2021040549 (doi: 10.20944/preprints202104.0549.v1).

Sunny, A.R.; Reza, J.; Anas, M.; Hassan, M.N.; Baten, M.A.; Hasan, R.; Monwar, M.M.; Solaimoan, H. and Hossain, M.M. (2020). Biodiversity assemblages and conservation necessities of ecologically sensitive natural wetlands of north eastern Bangladesh. Indian Journal of Geo-Marine Sciences, 49(1): 135-148.

Sunny, A.R.; Sazzad, S.A.; Datta, G.C.; Sarker, A.K.; Ashrafuzzaman, M. and Prodhan, S.H. (2021b). Assessing impacts of COVID-19 on aquatic food system and small-scale fisheries in Bangladesh. Marine Policy, 126: 104422, doi: 10.1016/j.marpol.2021.104422

 

Tufael; Hasan, S.E.; Jubayer, A.; Akter, K.; Akter, A.; Akter, F.; Shiam, S.A.A. and Sunny, A.R. (2023). Effects of Nigella Sativa and Syzygium Cumini Seed Extracts on Blood Glucose Levels in Swiss Albino Mice. Journal of Knowledge Learning and Science Technology ISSN: 2959-6386 (online), 2(3), 53-62. https://doi.org/10.60087/jklst.vol2.n3.p62

Weng, P.H.; Hung, K.Y.; Huang, H.L.; Chen, J.H.; Sung, P.K. and Huang, K.C. (2011). Cancer-specific mortality in chronic kidney disease: longitudinal follow-up of a large cohort. Clinical journal of the American Society of Nephrology: CJASN, 6(5), 1121.

Yi, Z.; Wang, L. and Tu, X. (2021). Effect of Vitamin D Deficiency on Liver Cancer Risk: A Systematic Review and Meta-Analysis. Asian Pacific journal of cancer prevention : APJCP, 22(4), 991–997. https://doi.org/10.31557/ APJCP.2021.22.4.991.

Zhang, Y.; Jiang, X.; Li, X.; Gaman, M.A.; Kord-Varkaneh, H.; Rahmani, J. ... and Xu, Y. (2021). Serum vitamin D levels and risk of liver cancer: a systematic review and dose-response meta-analysis of cohort studies. Nutrition and cancer, 73(8), 1-9.

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