Impact of Bacterial Infections on Semen Parameters in Sub-Fertile Men
Muzdalifa Mejbel Fadwi 1,3*, Sawsan Q.T. Al-Quhli 1, Ziad H. Abd 2
Journal of Angiotherapy 8(4) 1-8 https://doi.org/10.25163/angiotherapy.849603
Submitted: 05 February 2024 Revised: 03 April 2024 Published: 09 April 2024
Abstract
The male reproductive system is a complex structure crucial for sperm generation, transportation, and release. This study aimed to investigate the correlation between bacterial infections and male fertility by evaluating sperm parameters. A prospective observational study was conducted on 100 sub-fertile men and 30 fertile controls in western Iraq from October 2022 to October 2023. Semen samples were collected and analyzed for bacterial infections and sperm parameters. Results showed prevalent bacteria in seminal fluid, including E. coli, Enterococcus faecalis, and Streptococcus agalactiae. No significant differences in age (p = 0.813) or BMI (p = 0.609) were seen between the control group and the sub-fertile males group. Compared to fertile and sub-fertile males, bacteriospermia altered sperm concentration, motility, and morphology, affecting male fertility. Bacterial infections correlated with decreased semen volume, sperm count, motility, and morphology. Healthy fertile men exhibited superior sperm parameters compared to sub-fertile groups, emphasizing the clinical significance of bacteriospermia on male fertility. This study provides insights into the relationship between bacterial infections and male reproductive outcomes, informing potential therapeutic interventions for male sub-fertility.
Keywords: Male sub-fertility, Bacterial infections, Semen parameters, Sperm characteristics, Fertility assessment, Bacteriospermia
References
Agarwal, A., Sharma, R., Gupta, S., Finelli, R., Parekh, N., Selvam, M. K. P., . . . Darbandi, M. (2022). Standardized laboratory procedures, quality control and quality assurance are key requirements for accurate semen analysis in the evaluation of infertile male. The world journal of men's health, 40(1), 52.
Agyepong, E., & Bedu-Addo, K. (2019). Semen parameters and the incidence and effects of bacteriospermia in male partners of infertile couples attending a fertility clinic in the Kumasi Metropolis, Ghana. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 8(1), 99-108.
Alahmar, A. T., Calogero, A. E., Sengupta, P., & Dutta, S. (2021). Coenzyme Q10 improves sperm parameters, oxidative stress markers and sperm DNA fragmentation in infertile patients with idiopathic oligoasthenozoospermia. The world journal of men's health, 39(2), 346.
Al-Janabi, A., Jubair, A., Pemmaraju, S., Pruthi, P., & Pruthi, V. (2014). The role of bacterial infections on male infertility in Al-Anbar province of Iraq. Int J Med Sci Public Health, 3(2), 177-180.
Al-Saadi, B. Q. H., & Abd, A. S. (2019). The effect of bacterial infection on male infertility. Iraqi journal of biotechnology, 18(3).
Auger, J., Jouannet, P., & Eustache, F. (2016). Another look at human sperm morphology. Human Reproduction, 31(1), 10-23.
Beltran, L., & Berney, D. M. (2020). The urinary tract and male reproductive system. In Muir's Textbook of Pathology (pp. 447-462): CRC Press.
Bonner, M., Sheele, J. M., Cantillo-Campos, S., & Elkins, J. M. (2021). A descriptive analysis of men diagnosed with epididymitis, orchitis, or both in the emergency department. Cureus, 13(6).
Chamkori, A., Shariati, M., Moshtaghi, D., & Farzadinia, P. (2016). Effect of noise pollution on the hormonal and semen analysis parameters in industrial workers of Bushehr, Iran. Crescent Journal of Medical & Biological Sciences, 3(2).
Chillon, T. S., Demircan, K., Weiss, G., Minich, W. B., Schenk, M., & Schomburg, L. (2023). Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters. International Journal of Infectious Diseases, 130, 161-165.
Darbandi, M., Darbandi, S., Agarwal, A., Sengupta, P., Durairajanayagam, D., Henkel, R., & Sadeghi, M. R. (2018). Reactive oxygen species and male reproductive hormones. Reproductive Biology and Endocrinology, 16(1), 1-14.
Eini, F., Kutenaei, M. A., Zareei, F., Dastjerdi, Z. S., Shirzeyli, M. H., & Salehi, E. (2021). Effect of bacterial infection on sperm quality and DNA fragmentation in subfertile men with Leukocytospermia. BMC Molecular and Cell Biology, 22(1), 1-10.
Emokpae, M., Obialor, J., & Emokpae, L. (2023). Seminal Plasma Bisphenol A Concentrations Among Men with Secondary and Primary Infertility. Journal of Basic and Applied Research in Biomedicine, 9(1), 13-16.
Fraczek, M., Hryhorowicz, M., Gill, K., Zarzycka, M., Gaczarzewicz, D., Jedrzejczak, P., . . . Kurpisz, M. (2016). The effect of bacteriospermia and leukocytospermia on conventional and nonconventional semen parameters in healthy young normozoospermic males. Journal of Reproductive Immunology, 118, 18-27.
Gacem, S., Castello-Ruiz, M., Hidalgo, C. O., Tamargo, C., Santolaria, P., Soler, C., . . . Silvestre, M. A. (2023). Bull Sperm SWATH-MS-Based Proteomics Reveals Link between High Fertility and Energy Production, Motility Structures, and Sperm–Oocyte Interaction. Journal of Proteome Research, 22(11), 3607-3624.
Guiton, R., & Drevet, J. R. (2023). Viruses, bacteria and parasites: infection of the male genital tract and fertility. Basic and Clinical Andrology, 33(1), 19.
Henkel, R., Offor, U., & Fisher, D. (2021). The role of infections and leukocytes in male infertility. Andrologia, 53(1), e13743.
Ivanov, R., Pavlova, E., & Atanassova, N. (2023). Spermatozoa under Oxidative Stress: Risk or Benefit? Acta Morphologica et Anthropologica, 30, 1-2.
Lincoln Bastos Farias, J., da Cunha Barreto-Vianna, A. R., de Mello, M. D., Dos Santos, A. L., da Fonte Ramos, C., & Fontoura, P. (2023). Comparison of Diff-Quick and Spermac Staining Methods for Sperm Morphology Evaluation. Journal of Reproduction & Infertility, 24(3), 166.
Lundy, S. D., Sangwan, N., Parekh, N. V., Selvam, M. K. P., Gupta, S., McCaffrey, P., . . . Sabanegh, E. S. (2021). Functional and taxonomic dysbiosis of the gut, urine, and semen microbiomes in male infertility. European Urology, 79(6), 826-836.
Mändar, R., Punab, M., Korrovits, P., Türk, S., Ausmees, K., Lapp, E., . . . Truu, J. (2017). Seminal microbiome in men with and without prostatitis. International Journal of Urology, 24(3), 211-216.
Martins, A. D., Panner Selvam, M. K., Agarwal, A., Alves, M. G., & Baskaran, S. (2020). Alterations in seminal plasma proteomic profile in men with primary and secondary infertility. Scientific reports, 10(1), 7539.
Mateus, F. G., Moreira, S., Martins, A. D., Oliveira, P. F., Alves, M. G., & Pereira, M. d. L. (2023). L-carnitine and male fertility: is supplementation beneficial? Journal of Clinical Medicine, 12(18), 5796.
McGowan, M., Burger, H., Baker, H., De Kretser, D., & Kovacs, G. (1981). The incidence of non-specific infection in the semen in fertile and sub-fertile males. International journal of andrology, 4(1-6), 657-662.
Mohammadi, F., Mehdinia, Z., Ghasemi, S., Zolfaghari, Z., Amjadi, F. S., Ashrafi, M., & Zandieh, Z. (2021). Relationship between sperm parameters and clinical outcomes of Intra Uterine Insemination (IUI). Caspian journal of internal medicine, 12(1), 70.
Moretti, E., Capitani, S., Figura, N., Pammolli, A., Federico, M. G., Giannerini, V., & Collodel, G. (2009). The presence of bacteria species in semen and sperm quality. Journal of assisted reproduction and genetics, 26, 47-56.
Obukohwo, O. M., Kingsley, N. E., Rume, R. A., & Victor, E. (2021). The concept of Male reproductive anatomy. Male Reproductive anatomy.
Oehninger, S., & Ombelet, W. (2019). Limits of current male fertility testing. Fertility and Sterility, 111(5), 835-841.
Opheelia, M. K., Moungala, L. W., Minkobame, U., Assoumou, P., Boulende, A., & Meye, J. F. (2023). The Effect of Age on Male Infertility in Gabon. Advances in Reproductive Sciences, 11(4), 127-139.
Pebdeni, P. H., Saffari, F., Mirshekari, T. R., Ashourzadeh, S., Soodejani, M. T., & Ahmadrajabi, R. (2022). Bacteriospermia and its association with seminal fluid parameters and infertility in infertile men, Kerman, Iran: A cross-sectional study. International journal of reproductive biomedicine, 20(3), 202.
Shash, R. Y. M., Mohamed, G. A. A., Shebl, S. E., Shokr, M., & Soliman, S. A. (2023). The Impact of Bacteriospermia on Semen Parameters Among Infertile Egyptian Men: A Case–Control Study. American Journal of Men's Health, 17(3), 15579883231181861.
Shrestha, A., Joshi, D. R., Vaidya, D., Shrestha, S. M., & Singh, A. (2023). Bacteriospermia in Men Among Infertile Couples in Nepalese Population.
Suede, S. H., Malik, A., & Sapra, A. (2020). Histology, spermatogenesis.
Tamessar, C. T., Trigg, N. A., Nixon, B., Skerrett-Byrne, D. A., Sharkey, D. J., Robertson, S. A., . . . Schjenken, J. E. (2021). Roles of male reproductive tract extracellular vesicles in reproduction. American Journal of Reproductive Immunology, 85(2), e13338.
Vilvanathan, S., Kandasamy, B., Jayachandran, A. L., Sathiyanarayanan, S., Tanjore Singaravelu, V., Krishnamurthy, V., & Elangovan, V. (2016). Bacteriospermia and its impact on basic semen parameters among infertile men. Interdisciplinary perspectives on infectious diseases, 2016.
Wang, C., Mbizvo, M., Festin, M. P., Björndahl, L., & Toskin, I. (2022). Evolution of the WHO “Semen” processing manual from the first (1980) to the sixth edition (2021). Fertility and Sterility, 117(2), 237-245.
Wang, F., Chen, R., & Han, D. (2019). Innate immune defense in the male reproductive system and male fertility. Innate Immunity in Health and Disease.
Zeyad, A., Hamad, M., & Hammadeh, M. (2018). The effects of bacterial infection on human sperm nuclear protamine P1/P2 ratio and DNA integrity. Andrologia, 50(2), e12841.
Zhao, J.-Q., Lv, J.-L., Wang, X.-B., Wei, Y.-F., Guo, R.-H., Leng, X., . . . Pan, B.-C. (2023). Phytochemical consumption and the risk of teratozoospermia: findings from a hospital-based case-control study in China. Human Reproduction Open, hoad025.
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