Integrative Biomedical Research
Integrative Biomedical Research (Journal of Angiotherapy) | Online ISSN 3068-6326
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Volume 10 Number 2 2026
CASE STUDY (Open Access)
Long-Term Clinical Course of Metastatic Colorectal Cancer Following Sequential Hepatic and Pulmonary Metastasectomy With Adjunctive Standardized Orthosiphon stamineus Extract (Nuvastatic™): A Case Report
Amin Malik Shah Abdul Majid 1,2*, Adam Shah Abdul Majid 2, Muhammad Asyraf Abduraman 2*
Integrative Biomedical Research 10 (2) 1-13 https://doi.org/10.25163/biomedical.10210912
Submitted: 05 August 2026 Revised: 22 September 2026 Accepted: 28 September 2026 Published: 29 September 2026
Abstract
Background: Selected patients with oligometastatic colorectal cancer (CRC) may achieve prolonged survival following complete resection of metastatic disease, although recurrence remains common. Nuvastatic™ is a standardized Orthosiphon stamineus botanical formulation under clinical development in oncology with preclinical anti-angiogenic and other biologically relevant activities. We describe the longitudinal course of metastatic CRC during conventional curative-intent management and adjunctive Nuvastatic™ use.Case presentation: A 47-year-old woman underwent high anterior resection for pT2N0 sigmoid adenocarcinoma in November 2020. By March–April 2021, carcinoembryonic antigen increased to 29 µg/L, and imaging revealed a large right-lobe hepatic metastasis with small pulmonary nodules. Nuvastatic™ was initiated at 4,000 mg/day approximately one month before right hepatectomy in May 2021. Following R0 hepatic resection, the patient completed six months of FOLFOX, using Nuvastatic™ between chemotherapy cycles. According to patient-reported treatment history, the dose was reduced to 2,000 mg/day approximately three months before enlargement of pre-existing pulmonary lesions was detected in March 2022, after which 4,000 mg/day was resumed. Pulmonary metastasectomy confirmed metastatic colorectal adenocarcinoma. A further 7-mm pulmonary metastasis was resected in August 2024. Genomic profiling demonstrated KRAS G12V, APC and TP53 alterations, microsatellite-stable disease, and low tumour mutational burden. CT imaging on 4 August 2026 showed no evidence of recurrence or new metastatic disease. The patient remained clinically well (ECOG 0) while continuing Nuvastatic™ 2,000 mg/day.Conclusion: This case describes prolonged survival and repeated periods of disease control during multimodal treatment and long-term adjunctive Nuvastatic™ exposure. Although causality cannot be established from a single case, the temporal relationship between dose reduction and pulmonary progression, together with the preclinical biological rationale for O. stamineus, warrants prospective investigation of Nuvastatic™ using pharmacokinetic, biomarker, and oncological endpoints.
Keywords: colorectal cancer; liver metastasis; pulmonary metastasis; KRAS G12V; metastasectomy; Orthosiphon stamineus; Nuvastatic™; CEA; botanical drug; case report
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