Lanctos 75™ is A Novel Retino-Protective and Neovascular Inhibitor for Diabetic Retinopathy
Fouad Saleih Resq Al-Suede 1, Muhammad Asyraf Abduraman 1, Indumathi Ashok 2, Gnanasekaran Ashok 3, Khadeer Ahamed basheer 1, Amin Malik Shah Abdul Majid 4,5*, Aman Shah Abdul Majid 2*
Journal of Angiotherapy 8(7) 1-6 https://doi.org/10.25163/angiotherapy.879827
Submitted: 28 July 2024 Revised: 28 July 2024 Published: 28 July 2024
Abstract
Diabetic retinopathy (DR) is a prominent angiogenesis-dependent neurovascular complication. The present study aimed to evaluate the efficacy and safety of Lanctos 75™ extract code name C5OSEW5050ESA, which is a proprietry standardized extract of Orthosiphon stamineus leaves, as a retino-protective and neovascular inhibitory agent against streptozotocin-induced diabetic retinopathy in rats and other related models. This study investigated the safety profile and neuroprotective properties of Lanctos 75™ in various in vitro and in vivo models of neuronal injury induced by ischemia. The in vivo inhibitory effect of was investigated using a streptozotocin-induced diabetic retinopathy in rats. Results of in vitro neuroprotective studies using RGC-5 cells showed that Lanctos 75™ demonstrated significant cytoprotection by suppressing apoptosis induction in the cells. PanOptic ophthalmoscopic imaging of the fundus of the eyes in streptozotocin-induced diabetic rats revealed that Lanctos 75™ protected the animals against diabetes-induced retinal damage and inhibited the formation of microaneurysms, hemorrhages, vascular leakage, retinal venous beading, and inflammation in the retina. Similarly, fluorescence molecular tomography (FMT) imaging provided further supportive information towards the protective effect of Lanctos 75™ against ischemia-reperfusion injury inflammatory response. From the overall results, it can be concluded that Lanctos 75™ containing an effective dose of O. stamineus demonstrates promising potential as an adjunctive therapeutic agent for the treatment and management of diabetic retinopathy and other neovascularization-related ophthalmic complications.
Keywords: Oxidative Stress, Angiogenesis Inhibition, Ocular Drug Delivery Orthosiphon Stamineus, Lanctos 75™, C5OSEW5050ESA, Neovascularization, Diabetic Retinopathy
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