Abstract

Background: Cushing's syndrome is a rare endocrine disorder characterized by excessive cortisol production, presenting significant challenges in diagnosis and treatment, particularly in recurrent cases during pregnancy. The COVID-19 pandemic has exacerbated these challenges, introducing new complications for patients with cortisol disorders and amplifying socioeconomic disparities in access to medical care. Methods: This study conducted an integrative literature review to explore the impact of Cushing's syndrome and its complications, with a specific focus on the additional challenges posed by the COVID-19 pandemic. The review included studies published in the last five years, examining clinical complications and implications for patient management and treatment. The PICO strategy and PRISMA method were employed for article selection and analysis, resulting in the inclusion of 10 relevant studies. Results: The review revealed that Cushing's syndrome significantly impacts the current medical context, leading to a range of complications, including metabolic, cardiovascular, and psychological issues. The findings emphasized the necessity of a multidisciplinary treatment approach to optimize clinical outcomes, particularly during the COVID-19 pandemic. Effective disease management was highlighted as crucial for preventing metabolic complications and improving patients' quality of life. The review also underscored the need for preventive measures and adaptive management strategies to protect patients with Cushing's syndrome during the pandemic. Conclusion: Cushing's syndrome presents substantial management challenges, which have been further intensified by the COVID-19 pandemic. A multidisciplinary and patient-centered approach is essential for effective management, requiring collaboration among various medical specialties. Promoting awareness, implementing evidence-based strategies, and ensuring continuous access to medical care are vital for improving clinical outcomes and the quality of life for patients with Cushing's syndrome.

Keywords: Cushing's syndrome, Multidisciplinary treatment, COVID-19 complications, Endocrine disorders, Patient management