Integrative Biomedical Research (Journal of Angiotherapy) | Online ISSN 3068-6326
Volume 8 Number 4 2024
RESEARCH ARTICLE (Open Access)
Green Synthesis, Lead Toxicity and Pharmacokinetic Evaluation of Sumac Silver Nanoparticles In Vivo
Ammar H. Salman 1*, Mohammed Mosleh Shwaish 1
Journal of Angiotherapy 8 (4) 1-7 https://doi.org/10.25163/angiotherapy.849586
Submitted: 03 February 2024 Revised: 04 April 2024 Published: 08 April 2024
Abstract
Sumac (Rhuscoriaria L., family Anacardiaceae) is rich in bio-active substances such as tannins and phenolic compounds, exhibiting an antioxidant activity. The green synthesis of silver nanoparticles (SAgNP) is an eco-friendly and cost-effective method of synthesis. In the present study the effect of Sumac Nano Silver particles on lead pharmacokinetics was studied. The green synthesis of silver nanoparticles was achieved by the addition of 25 ml of sumac extract to 200 ml of 1mM silver nitrate solution under hot stirring. The male albino rats (21 no.) were taken for the experiment and divided randomly in to 3 groups, each containing 7 rats, lead group (60 mg/kg of lead acetate orally), crude group (100 mg/kg of crude sumac extract orally) and nano group (100 mg/kg of nano sumac extract orally followed by lead acetate). In the present study it was exhibited that the SAgNP were formed successfully with number of advantages and there was found significant reduction (p≤0.05) in the blood lead concentration, after 6 hours suggesting the possibility of using SAgNP to reduce the lead concentration of the body. The SAgNP were more effective rather than the crude extract to reduce the blood lead concentration. Green synthesis of silver nanoparticles offers a safe, cost-effective, and environmentally friendly approach with promising applications in mitigating lead toxicity. Importance of miRNAs in male infertility diagnostics and lays the groundwork for future research in this area. Developing non-invasive diagnostic techniques is crucial for effective management of male infertility.
Keywords: Sumac, Silver nanoparticles, Green synthesis, Pharmacokinetics, Lead toxicity
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