Green Synthesis, Lead Toxicity and Pharmacokinetic Evaluation of Sumac Silver Nanoparticles In Vivo
Ammar H. Salman 1*, Mohammed Mosleh Shwaish 1
Journal of Angiotherapy 8(4) 1-7 https://doi.org/10.25163/angiotherapy.849586
Submitted: 03 February 2024 Revised: 04 April 2024 Published: 08 April 2024
Abstract
Sumac (Rhuscoriaria L., family Anacardiaceae) is rich in bioactive components like tannins and phenolic compounds, exhibiting antioxidant properties. Green synthesis of silver nanoparticles (SAgNP) offers eco-friendly and cost-effective production methods. In this study, the effect of Sumac nano silver particles (SAgNP) on lead pharmacokinetics was assessed. Green synthesis of silver nanoparticles involved adding 25 ml of sumac extract to 200 ml of 1 mM silver nitrate solution under hot stirring. Twenty-one male albino rats were randomly divided into three groups: lead group (60 mg/kg of lead acetate orally), crude group (100 mg/kg of crude sumac extract orally), and nano group (100 mg/kg of SAgNP orally followed by lead acetate). Results demonstrated successful SAgNP formation and significant reduction (p≤0.05) in blood lead concentration after 6 hours, suggesting SAgNP's potential in lowering lead levels. SAgNP exhibited stronger efficacy than crude extract in reducing blood lead concentrations. Green synthesis of silver nanoparticles offers a safe, cost-effective, and environmentally friendly approach with promising applications in mitigating lead toxicity.
Keywords: Sumac, Silver nanoparticles, Green synthesis, Pharmacokinetics, Lead toxicity
References
Agency for Toxic Substances and Disease Registry. (2020). Toxicological Profile for Lead.Atlanta.USA.
Ahn, EY. and Park, Y. (2020). Anticancer prospects of silver nanoparticles green-synthesized by plant extracts. Materials Science and Engineering: C. Nov 1;116:111253.
Al-Modhefer, A. J., Bradbury, M. W., & Simons, T. J. (1991). Observations on the chemical nature of lead in human blood serum. Clinical Science (London, England: 1979), 81(6), 823-829.
Alonso-Villar, EM., Rivas, T. and Pozo-Antonio, JS. (2021). Resistance to artificial daylight of paints used in urban artworks. Influence of paint composition and substrate. Progress in Organic Coatings. May 1;154:106180.
Bergdahl, I. A., Grubb, A., Schütz, A., Desnick, R. J., Wetmur, J. G., Sassa, S., & Skerfving, S. (1997). Lead binding to δ-aminolevulinic acid dehydratase (ALAD) in human erythrocytes. Pharmacology & toxicology, 81(4), 153-158.
Bhuneshwari Dewangan, Naina Bhoyar. (2023). Impedimetric Sensor Aided by Polydopamine Nanoparticles for Label-Free Detection of Breast Cancer Cells - A Review, Journal of Angiotherapy, 7(2), 1-12, 9400
Chandrapratap Dhimar, Krishna Sahu, Moniza Nurez Khan, (2024). A Systematic Review of Advanced Approaches in Wound Healing: Simvastatin Polymeric Nanoparticles and Postbiotics Innovation, Journal of Angiotherapy, 8(1), 1-10, 9483
Dubey, S. P., Lahtinen, M., & Sillanpää, M. (2010). Tansy fruit mediated greener synthesis of silver and gold nanoparticles. Process Biochemistry, 45(7), 1065-1071.
Flecknell, P. (2015). Laboratory animal anaesthesia. Academic press; Sep 21.
Gulbagça, F., Aygun, A., Altuner, E. E., Bekmezci, M., Gur, T., Sen, F., ... & Vasseghian, Y. (2022). Facile bio-fabrication of Pd-Ag bimetallic nanoparticles and its performance in catalytic and pharmaceutical applications: Hydrogen production and in-vitro antibacterial, anticancer activities, and model development. Chemical Engineering Research and Design, 180, 254-264.
Guo, M., He, L., Strong, P. J., & Wang, H. (2014). Binding between lead ions and the high-abundance serum proteins. Chemosphere, 112, 472-480.
Gur, T. (2022). Green synthesis, characterizations of silver nanoparticles using sumac (Rhus coriaria L.) plant extract and their antimicrobial and DNA damage protective effects. Frontiers in Chemistry. Aug 25;10:968280.
Haleem, A., Javaid, M., Singh, R. P., Rab, S., & Suman, R. (2023). Applications of nanotechnology in medical field: a brief review. Global Health Journal, 7(2), 70-77.
Hasan, K. F., Xiaoyi, L., Shaoqin, Z., Horváth, P. G., Bak, M., Bejó, L., ... & Alpár, T. (2022). Functional silver nanoparticles synthesis from sustainable point of view: 2000 to 2023?A review on game changing materials. Heliyon, 8(12).
Huang, B., Chen, F., Shen, Y., Qian, K., Wang, Y., Sun, C., ... & Cui, H. (2018). Advances in targeted pesticides with environmentally responsive controlled release by nanotechnology. Nanomaterials, 8(2), 102.
Ibrahim, M., Krejcík, M., Havlícek, K., Petrík, S., & Eldessouki, M. (2020). Evaluation of chemical and physical properties of biodegradable gum Arabic/PVA/Ag nanofibrous membranes as a potential wrapping material. Journal of Engineered Fibers and Fabrics, 15, 1558925020946451.
Jebril, S., Jenana, R. K. B., & Dridi, C. (2020). Green synthesis of silver nanoparticles using Melia azedarach leaf extract and their antifungal activities: In vitro and in vivo. Materials Chemistry and Physics, 248, 122898.
Kapoor, LD. (2018). CRC handbook of Ayurvedic medicinal plants. CRC press; Jan 18.
Kim, H. S., Seo, Y. S., Kim, K., Han, J. W., Park, Y., & Cho, S. (2016). Concentration effect of reducing agents on green synthesis of gold nanoparticles: size, morphology, and growth mechanism. Nanoscale research letters, 11, 1-9.
Lakhan Lal Kashyap, Harish Jaiswal. (2023). Epidermal Growth Factor ReceptoraAnd Double-Imprinted Nanoparticles for Targeted Cancer Drug Delivery, Journal of Angiotherpay, 7(2), 1-8, 9408
Mavlyanov, S. M., Islambekov, S. Y., Karimdzhanov, A. K., & Ismailov, A. I. (1997). Polyphenols of the fruits of some varieties of pomegranate growing in Uzbekistan. Chemistry of natural compounds, 33(1), 98-99.
MSD MANUAL. (2023). Veterinary Manual. animals Merck & Co., Inc. USA. https://www.msdvetmanual.com/toxicology/lead-poisoning/lead-poisoning-in.
Nasar-Abbas, S. M., & Halkman, A. K. (2004). Antimicrobial effect of water extract of sumac (Rhus coriaria L.) on the growth of some food borne bacteria including pathogens. International journal of food microbiology, 97(1), 63-69.
Ovais, M., Khalil, A. T., Raza, A., Khan, M. A., Ahmad, I., Islam, N. U., ... & Shinwari, Z. K. (2016). Green synthesis of silver nanoparticles via plant extracts: beginning a new era in cancer theranostics. Nanomedicine, 12(23), 3157-3177.
Periasamy, S., Joo, H. S., Duong, A. C., Bach, T. H. L., Tan, V. Y., Chatterjee, S. S., ... & Otto, M. (2012). How Staphylococcus aureus biofilms develop their characteristic structure. Proceedings of the National Academy of Sciences, 109(4), 1281-1286.
Rai, M., Kon, K., Ingle, A., Duran, N., Galdiero, S., & Galdiero, M. (2014). Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects. Applied microbiology and biotechnology, 98, 1951-1961.
Ren, C., Wang, Z., Zhang, X., Gao, J., Gao, Y., Zhang, Y., ... & Liu, J. (2021). Construction of all-in-one peptide nanomedicine with photoacoustic imaging guided mild hyperthermia for enhanced cancer chemotherapy. Chemical Engineering Journal, 405, 127008.
Sajadi, S. M., Nasrollahzadeh, M., & Akbari, R. (2019). Cyanation of Aryl and Heteroaryl Aldehydes Using In-Situ-Synthesized Ag Nanoparticles in Crocus sativus L. Extract. ChemistrySelect, 4(4), 1127-1130.
Shukla, AK. and Iravani S. (2018). Green synthesis, characterization and applications of nanoparticles. Elsevier; Nov 26.
Subramanian, R., Subbramaniyan, P., Raj, V. (2013). Antioxidant activity of the stem bark of Shorea roxburghii and its silver reducing power. SpringerPlus. Dec;2(1):1-1.
Uddin, A. H., Khalid, R. S., Alaama, M., Abdualkader, A. M., Kasmuri, A., & Abbas, S. A. (2016). Comparative study of three digestion methods for elemental analysis in traditional medicine products using atomic absorption spectrometry. Journal of analytical science and technology, 7, 1-7.
Umar, H. O., Hamman, W. O., Adebisi, S. S., Muhammad, A. S., Usman, K., & Salisu, R. of Lead Acetate on Hematological Indices of Male and Female Adult Wistar Rats. Dutse Journal of Pure and Applied Sciences (DUJOPAS)., 5: 2b.
Who. (2008). Children's Health and the Environment.WHO Training Package for the Health Sector.
Zheng, M., Wang, C., Wang, Y., Wei, W., Ma, S., Sun, X., & He, J. (2018). Green synthesis of carbon dots functionalized silver nanoparticles for the colorimetric detection of phoxim. Talanta, 185, 309-315.
View Dimensions
View Altmetric
Save
Citation
View
Share