Impact of Toxoplasmosis on Liver and Kidney Function in Women

Doaa A. Abdulwahab ^1*, Dina A. A. Abdullah ²

This study determined the relationship between Toxoplasma infection and liver and kidney dysfunction, aiding in early diagnosis and treatment.

Abstract

Background: Toxoplasma gondii infection shows significant health risks, particularly in women of childbearing age. Understanding its impact on liver and kidney function is crucial. This study aimed to investigate the prevalence of Toxoplasma gondii IgG and IgM antibodies in a cohort of women and assess their liver and kidney function through biochemical markers. Method: Blood samples from 88 women (aged 14-43 years) were analyzed for IgG and IgM antibodies against T. gondii. Liver and kidney function markers were assessed using biochemical tests. Result: Out of the specimens, 14 (16%) tested positive for IgG and 9 (10%) for IgM antibodies. Notably, the highest antibody rates were observed in the second age group (20-29 years), with 52%, followed by the first and third age groups (<20 / 30-39 years) with 24% each. Significant elevations in creatinine and urea concentrations were observed in patients (P < 0.05), along with elevated levels of Aspartate amino-transferase, Alanine transaminase, and Alkaline Phosphatase (P < 0.001). Conclusion: The study highlights a significant association between Toxoplasma gondii IgG and IgM antibodies and altered liver and kidney function markers. These findings underscore the importance of screening and managing Toxoplasma infections, especially in women of reproductive age, to mitigate potential health complications.

Keywords: Toxoplasmosis, liver function, kidney function, IgG, IgM

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