The Analysis of Hematological Parameters CBC, ABO, NLR, and APTT and Its Implications on Haemophilic Patients with Low Bone Mineral Density

Rasha Ibrahim Salman ^1* , Khalid Mahdi Salih ¹, Nidal Karim Al-Rahal ²

The study determined a high prevalence of low bone mineral density in hemophilic patients, associated with elevated NLR and prolonged APTT.

Abstract

Background: Haemophilia is a rare X-linked recessive genetic disorder characterized by the absence or deficiency of factor VIII (haemophilia A) or factor IX (haemophilia B). The current study aimed to assess some hematological factors in hemophilic patients with low bone mineral density (BMD). Objective: The study was carried out on Iraqi patients with hemophilia at the National Center of Hematology, Mustansiriyah University. Method: Sixty-eight male patients were involved in this study, with ages ranging from (14 to 53) years. Along with the patient group, 18 healthy subjects with matched age and gender were involved as the control group. Various hematological parameters were determined in the samples of healthy and patient subjects. Results: The results found that; only  39.7% of patients have positive DEXA scan characterized by low BMD (abbreviated as DX+) and 60.3 % with normal BMD (abbreviated as DX0), and reveal non-significant in ABO system distribution; all RBCs indices, WBC, prothrombin time, and platelets count (PLT) in patients (DX+, DX0) and control groups, higher NLR ratio was greater in patients in the DX+ group than in the DX0 and control groups; furthermore Activated-partial thromboplastin time (APTT) in DX+ and DX0 groups of patients are significantly (P ? 0.0001) higher than in control group. Conclusion: the increase in neutrophils-lymphocytes ratio (NLR) and prolonged of APTT may be a marker that increases the risk of low bone density development in hemophilic patients.

Keywords: Hemophilia, DEXA scan, BMD, NLR, APTT

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