Effect of Steroid Treatment on Tissue Damage Markers in Diabetic Patients

Mohammed Shakir Ali ^1*, Ali Al-Shammari ¹, Qutaiba A. Ismael ¹, Obaida Amer Imran ¹, Mohammed H. Al-Bayati ¹

This research showed how diabetes and steroids worsen effects, providing a better understanding of the pathophysiology processes.

Abstract

Steroid-induced hyperglycemia challenges primary care providers. Understanding and managing these effects are insufficient despite widespread glucocorticoid use. Our study aimed to investigate the impact of steroid treatment on tissue damage markers in diabetic patients. We determined the liver enzymes, blood biochemistry, and interleukins (IL-12, IL-17A, IL-6, and IL1B) before and after steroid treatment. The results revealed a significant increase in creatinine levels among the active patients compared to the control group. The mean concentrations of ALT and ALP in the active patients (on steroids) were 43 ± 3.1 and 112 ± 10.2 U/L, respectively, significantly higher than the active control (24 ± 5.1). Our study also found that IL-12, IL-17A, IL-6, and IL-10 were upregulated 5.2, 16.2, 2.13, and 5.11 times, respectively, compared to the control. The blood sugar levels (RBS) showed positive correlations with Neutrophils (r = 0.81, P = 0.012), IL-12 (r = 0.68, P = 0.028), and IL-6 (r = 0.51, P = 0.03). In conclusion, our research demonstrated the significance of inflammation and tissue damage in the expression patterns associated with type 2 diabetes and its effects.

Keywords: Steroid-induced hyperglycemia, Glucocorticoid, Tissue damage markers, Interleukins (IL-12, IL-17A, IL-6, IL-1B), Type 2 diabetes

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