Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health,
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Integrative Biomedical Research
Volume 9 Number 1 2025
Table of Contents
Research Article
Traditional and Herbal Medicine
Sa’adiah Mohd. Yusoff a*, Mohd Zaini Asmawi a, Amin Malik Shah Abdul Majid a, b, Mohamed Khadeer A. Basheer c, Shazmin Kithur Mohamed a, Muhammad Asif a, Seyedeh Fatemeh Jafari a, Hussein Mahfoudh Baharetha a, d
Crinum asiaticum is used traditionally to treat inflammations and tumours. The aim of this work is to ascertain the scientific viability of its use in traditional medicine as an anti-tumour (potential anti-cancer) agent.
Abstract | Full Text |PDF (1 MB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
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Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
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Advancements in Virus Detection and Isolation: The Role of Chromatography in Virology Research and Health
This review discusses the viral infections, transmission, and morphology for developing effective diagnostics, treatments, and preventive strategies against future pandemics.
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Wastewater Treatment and Reuse: Preventive Measures for Chronic Infectious Diseases
This review discusses the significance of wastewater treatment in sustainability, water security, environmental preservation, human health safeguarding and resource recovery.
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In Silico Determination of Tinospora cordifolia Phytochemicals as Potential DPP-4 Inhibitors for Type 2 Diabetes Management
This study determined Tinospora cordifolia phytochemicals as potential DPP-4 inhibitors, offering promising therapeutic candidates for type 2 diabetes.
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Lung-Targeted Solid Lipid Nanoparticles for Enhanced Pulmonary Delivery of Anti-Tubercular Drugs: A Novel Approach to Improve Bioavailability
Solid lipid nanoparticles improved anti-tubercular drug encapsulation, stability, and lung retention, offering a promising targeted pulmonary delivery approach for tuberculosis treatment.
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Biological Maturity in Youth Athletes: Comparing Upper-Lower Body Ratios and Second Molar Eruption
Our study assesses upper-lower body ratios and second molar eruption as indicators of biological maturity in young athletes.
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Analysis of Potential Biomarkers in Hypertension
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
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Comparative Efficacy of Endovascular Versus Surgical Thrombectomy for Arteriovenous Graft Thrombosis in Hemodialysis Patients - A Systematic Review and Meta-Analysis
This study evaluates endovascular versus surgical thrombectomy in arteriovenous graft thrombosis, providing insights for optimizing hemodialysis vascular access management and patient outcomes.
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Antioxidant Potential of Curculigo pilosa Rhizome Extracts in Hydrogen Peroxide Induced Oxidation In Vivo
Curculigo pilosa extracts exhibit strong antioxidant properties, mitigating oxidative stress in Drosophila melanogaster, highlighting potential therapeutic applications.
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Impact of Hemodiafiltration and Hemodialysis on FGF-23 Levels and Cardiovascular Calcification in End-Stage Renal Disease
This study determines the effects of dialysis modalities on FGF-23 levels and cardiovascular calcification, offering insights into improving ESRD patient outcomes.
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Predicting Habitat Suitability and Climate Change Impact on Medicinal plant Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
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Advances in Human Umbilical Vein Scaffolds for Vascular Tissue Engineering: Innovations, Challenges, and Future Directions
This review explores innovative human umbilical vein scaffolds, enhancing vascular tissue engineering for regenerative medicine and cardiovascular applications.
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Collaborative Governance in Combating Illegal Cosmetics: A Study of Multi-Stakeholder Dynamics in South Sulawesi, Indonesia
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
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A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
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Effects of Physical Activity as A Treatment For Depression in the Elderly
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
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Smart Nutrition and Active Living in Hypertension Management: Assessing Lifestyle Behaviors, Barriers, and the Role of Digital Health Tools
This study is significant as it highlights the effectiveness of smart nutrition and active living in managing hypertension, promoting sustainable, non-pharmacological interventions for better cardiovascular health.
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Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
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Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
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High Viral Load is a Risk Factor for Hepatocellular Carcinoma: Clinical and Laboratory Insights from a Cross-Sectional Study
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
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Phytochemical Composition, Antioxidant, and Anti-Inflammatory Activities of Laurus nobilis Leaf Extracts Using Solvent Fractionation
Ethyl acetate extract of Laurus nobilis leaves showed potent antioxidant and anti-inflammatory activities, highlighting its therapeutic and pharmacological potential.Pages: 1-8
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PEGylated Liposomal Teriflunomide: A Novel Approach of Targeted Breast Cancer Treatment to Advance Efficacy and Minimize Adverse Effects
Developing pegylated liposomal teriflunomide may enhance breast cancer treatment efficacy, reduce side effects, and improve patient outcomes.
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Comparative Effects of Sodium Dodecyl Sulfate and Hydrogen Peroxide on Type I and III Collagen Preservation in Decellularized Bovine Pericardium Scaffolds
SDS significantly reduces type I and III collagen density in decellularized bovine pericardium, whereas H2O2 better preserves extracellular matrix integrity.
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Evaluation of Cardiac Biomarkers as Predictors of Short-Term Mortality Following Coronary Artery Bypass Grafting
This study evaluates the predictive value of biomarkers in short-term mortality after coronary artery bypass grafting to guide clinical decisions.
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Enhancing Pharmacological Access and Health Outcomes in Rural Communities through Renewable Energy Integration: Implications for chronic inflammatory Disease Management
This study emphasises how renewable energy enhances pharmacological logistics, clinical service continuity, and health outcomes in rural, disadvantaged healthcare systems.
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Multidisciplinary Challenges in Managing a Ruptured Ascending Aortic Aneurysm with Concurrent Pulmonary Pathology: A Case Report
This case highlights the challenges of managing ruptured aortic aneurysms with comorbidities, emphasizing multidisciplinary care and TEVAR’s limitations in complex cases.
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The Importance of Autoimmunity and Chronic Inflammation in the Development of Atherosclerosis: New Treatment Strategies
Understanding immune mechanisms in atherosclerosis enables development of targeted anti-inflammatory therapies, improving cardiovascular outcomes and plaque stabilization strategies.
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Cardiovascular Complications in Patients with Hepatocellular Carcinoma
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
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Early Surgical Intervention in Congenital Pulmonary Airway Malformation: A Case Report
Early recognition and surgical intervention in symptomatic CPAM cases prevent complications, ensuring optimal respiratory function and long-term clinical outcomes in neonates.
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The Evolving Role of Hospital and Community Pharmacist in Post-COVID-19 Healthcare Delivery in Bangladesh: A Survey-Based Analysis
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
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OR-PSGAN-CNN: An Occlusion-Robust Deep Learning Framework for Early Detection of Cerebral Palsy in Infants Using RGB-D Videos
Improves early cerebral palsy detection by resolving pose occlusions through enhanced skeleton generation and feature extraction from infant movement videos.
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Global Burden, Risk Factors, and Evidence-Based Strategies for Cardiovascular Disease Prevention: A Comprehensive Systematic Review
This review highlights global CVD disparities, identifies major risk factors, and evaluates effective, cost-efficient prevention strategies for population health.
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AI-driven Innovations in Cancer Research and Personalized Healthcare
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
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Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
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Antidiabetic and Toxicological Evaluation of Ostodes Pauciflora merr. Seed (kop nut) Oil, A Potential Functional Food Alternative
This study evaluates Ostodes pauciflora Merr. seed oil for antidiabetic properties, providing insights into its potential as a functional food alternative.
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Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
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An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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Synergistic Effects of Cinnamomum zeylanicum and Atorvastatin in streptozotocin-Induced In Vivo
This study assesses the combined effects of Cinnamomum zeylanicum and atorvastatin on glucose regulation, lipid metabolism, and organ function in diabetic models.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.