Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles in following topics:
- Molecular & Cellular Biomedicine
- Pharmacology & Drug Discovery
- Clinical & Translational Medic
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Integrative Biomedical Research
Table of Contents
Reviews
Emergency Medicine
Turki Awad Alharbi 1*, Shaima Abdullah Bukhamsin 2, Auwaidh Bijad Albaqami 3, Saud Mani Hamed Al-Qahtani 4, Nawaf Rezeq Awad Al-Sulami 5, Abdullah Saleh Mohammed Alotaibi 6
Reframes acute illness as cumulative exposure outcome, enabling smarter emergency care, targeted prevention, and improved health equity across vulnerable populations.
Abstract | Full Text |PDF (308 KB) | Open Access Article
Habib Farah Awwad Alanazi 1, Abdullah Rashed Tami Alzuabi 2, Ali Mohammed Abdullah Alshehri 1, Amin Saleha Ali Alshehri 2, Ghareeb Mohammed Ghareeb Alruwaili 2, Mohmmed Abulhedie Alamri 2, Faleh Mohammed Lafi Alshalawi 3, Ali Naif Ali Alotaibi 4, Ahmad Mohammed Alharbi 2, Adel Mohammed AlJabri 2, Mohammed Daleem Alotaibi 2, Majed Abdulrahman Al-Shehri 4 Habib Farah Awwad Alanazi 1, Abdullah Rashed Tami Alzuabi 2, Ali Mohammed Abdullah Alshehri 1, Amin Saleha Ali Alshehri 2, Ghareeb Mohammed Ghareeb Alruwaili 2, Mohmmed Abulhedie Alamri 2, Faleh Mohammed Lafi Alshalawi 3, Ali Naif Ali Alotaibi 4, Ahmad Mohammed Alharbi 2, Adel Mohammed AlJabri 2, Mohammed Daleem Alotaibi 2, Majed Abdulrahman Al-Shehri 4, Fahad Ayidh H Alotaibi 4, Faisal Bunayyan Binyah Alrashdi 4, Faisal Bunyan Binyah Al-Rashidi 4, Fahad Ayed Hamdan Al-Otaibi 4, Mohammed Muqham Matar Al-Adhyani 4
Provides integrated anatomical, clinical, and management insights to improve early diagnosis, guide interventions, reduce complications, and strengthen prevention strategies globally.
Abstract | Full Text |PDF (576 KB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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RETRACTED ARTICLE: Predicting Parkinson’s Disease Progression Using Statistical And Neural Mixed Effects Models: Comparative Study On Longitudinal Biomarkers
This study demonstrates interpretable, robust modeling for Parkinson’s telemonitoring, guiding reliable disease progression prediction under small-sample longitudinal data constraints.
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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An Integrated AI-Driven Framework for Maternal Resource Intelligence Shortages Across U.S. Hospital
Integrating predictive analytics, reinforcement learning, and causal inference improves maternal outcomes by aligning risk prediction with real-time, equity-aware resource allocation decisions.
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Serum Uric Acid Reduction Following Use of Canssu5®, a Standardized Orthosiphon stamineus Extract, in Adults with Hyperuricemia: A Retrospective Case Study
This study provides preliminary clinical evidence that standardized Orthosiphon stamineus extract may meaningfully reduce serum uric acid in hyperuricemic adults.
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Comprehensive Review of Foundation Toxicity Models Integrating In Vivo, In Vitro, and Chemical Knowledge for Unified Risk Prediction
Bridges experimental and computational toxicology to enable predictive, human-relevant risk assessment frameworks for safer and faster chemical evaluation
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Integrative Perspectives on Complex Biological Systems: Linking Liver Fibrosis, Cancer Biology, Microbial Ecology, and Agricultural Symbiosis
This study integrates biomedical and ecological research, revealing shared biological mechanisms that inform therapeutic innovation, sustainable agriculture, and systems-level understanding of complex biological interactions.
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Dietary Bioactive Compounds in Cancer and Cardiovascular Health: A Systematic Review of Methylxanthines, Polyphenols, and Flavonoids
This study demonstrates that dietary bioactive compounds play a significant role in reducing the risk of chronic diseases, improving cardiovascular health, and offering protective effects against certain types of cancer.
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Therapeutic Angiogenesis: From Single-Factor Failures to Precision Vascular Regeneration
Multimodal, precision-guided angiogenic therapies—gene, cell, extracellular vesicle, and biomaterial-based—offer transformative potential for treating ischemic diseases where revascularization remains unfeasible.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.
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Organoid-on-Chip Platforms as Predictive Models of Human Disease: Promise and Pitfalls
Organoid-on-chip systems merge biological fidelity with engineering precision, offering AI-augmented, human-relevant platforms positioned to reshape preclinical drug development.
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Senescent Cell Heterogeneity and Precision Clearance Strategies: From Molecular Mechanism to Clinical Translation
Mapping senescent-cell heterogeneity to precision senotherapies could transform multimorbid, age-related disease treatment safely
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Mitochondrial Transfer Between Cells: Physiological Roles and Therapeutic Potential
Intercellular mitochondrial transfer sustains tissue bioenergetics and immunity, offering a transformative, biologically grounded therapeutic strategy for degenerative and ischemic disease.
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Epigenetic Clocks and Biological Ageing: From Biomarker to Intervention Target
Epigenetic clocks convert DNA methylation into a modifiable biomarker, repositioning ageing as a treatable clinical target.
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The Gut–Brain–Immune Axis in Chronic Disease: Mechanisms and Therapeutic Opportunities — A Narrative Synthesis
This review reframes chronic neurodegenerative and autoimmune disease through a reproducible, microbiome-centered mechanistic and therapeutic lens.
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Mapping the Invisible Architecture of Disease: Spatial Multi-Omics Technologies, Computational Integration, and the Path Toward Clinical Translation
Spatial multi-omics repositions tissue context as a first-class clinical variable, but equitable, standardized translation remains unfinished business.
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Tissue-Resident Memory T Cells in Health and Disease: Emerging Regulators of Immunity
Tissue-resident memory T cells permanently guard peripheral organs, but their dysregulation drives chronic autoimmune disease, making them a precise emerging therapeutic target.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.
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Single-Cell and Spatial Transcriptomics in Precision Diagnostics: A Roadmap for Clinical Adoption
Spatial transcriptomics reveals disease architecture at cellular resolution, but cost, FFPE limits, and complexity keep it from routine clinical diagnostics.
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Extracellular Vesicles as Diagnostic and Therapeutic Tools: Closing the Translational Gap
Extracellular vesicles promise cell-free precision diagnostics and therapeutics, but standardization, scalability, and regulatory gaps still block routine clinical adoption.