Epidemiological Characteristics of Hydatid Cyst Disease Crucial for Targeted Public Health Interventions in Endemic Areas

Abdulsalam Harfash Hassan; Abeer Th.kadhim

doi:10.25163/angiotherapy.869731

Angiogenesis, Inflammation & Therapeutics | Online ISSN 2207-872X

RESEARCH ARTICLE (Open Access)

Previous Next Contents Vol 8 (6)

Epidemiological Characteristics of Hydatid Cyst Disease Crucial for Targeted Public Health Interventions in Endemic Areas

Abdulsalam Harfash Hassan ^1*, Abeer Th.kadhim ¹

+ Author Affiliations

Journal of Angiotherapy 8 (6) 1-6 https://doi.org/10.25163/angiotherapy.869731

Submitted: 11 April 2024 Revised: 03 June 2024 Published: 09 June 2024

Abstract

Background: Echinococcosis, caused by Echinococcus granulosus larvae, remains a significant public health challenge globally due to its complex life cycle and impact on human health and economy. The disease primarily affects intermediate hosts, including humans, through the formation of hydatid cysts in various organs, notably the liver and lungs. Despite advancements in treatment with albendazole and surgical interventions, recurrence rates and morbidity remain considerable, particularly in endemic regions. Methods: This retrospective hospital-based study analyzed 66 cases of hydatid cyst disease admitted to Baquba Teaching Hospital in Diyala Governorate, Iraq, between January 2019 and December 2022. Data on patient demographics, including age, gender, residency, occupation, and cyst location, were extracted from medical records and analyzed using descriptive statistics. Results: Females constituted 61% of the cases, with the highest incidence observed among individuals aged 21-40 years (44%). Rural residents accounted for 65% of cases, reflecting the disease's association with agricultural activities. Housewives (51.5%) and primary school students (55.5% among students) were disproportionately affected. The liver was the most common site of cyst development (74.2%), followed by the lung (24.2%). Conclusion: This study provides crucial insights into the epidemiological profile of hydatid cyst disease in Diyala Governorate, Iraq. The findings underscore the demographic patterns, occupational risks, and anatomical distributions associated with the disease, highlighting the need for targeted public health interventions. Strategies focusing on rural communities, particularly women and school-age children, are essential for effective prevention and management of hydatid disease in endemic regions.

Keywords: Echinococcus granulosus, Hydatid cyst disease, Epidemiology, Intermediate hosts, Public health interventions

References

Abdulhameed, M. F., Habib, I., Al-Azizz, S. A., & Robertson, I. (2018). A retrospective study of human cystic echinococcosis in Basrah province, Iraq. Acta Tropica, 178, 130-133. https://doi.org/10.1016/j.actatropica.2017.11.019

Abdulhameed, M. F., Robertson, I. D., Al-Azizz, S. A., & Habib, I. (2019). Neglected zoonosis and the missing opportunities for one health education: The case of cystic echinococcosis among surgically operated patients in Basrah, Southern Iraq. Diseases, 7(4), 1-10. https://doi.org/10.3390/diseases7010004

Ahmadi, N. A., & Badi, F. (2011). Human hydatidosis in Tehran, Iran: A retrospective epidemiological study of surgical cases between 1999 and 2009 at two university medical centers. Tropical Biomedicine, 28(2), 450-456.

Alonso, C. O., Moreno, G. E., Loinaz, S. C., Gimeno, C. A., González, P. I., Pérez, S. B., et al. (2000). Results of 22 years of experience in radical surgical treatment of hepatic hydatid cysts. Hepato-Gastroenterology, 48(37), 235-243.

Al-Qaadhi, B. A. (2005). Study of some immunological and biochemical aspects of patients infected with hydatidosis. PhD thesis, College of Science, University of Baghdad.

Al-Qaoud, K. M., Craig, P. S., & Abdel-Hafez, S. K. (Year). Retrospective surgical incidence and case distribution of cystic echinococcosis in Jordan between 1994 and 2000. (Source).

Amali, M., Yousef, I. F., Mohammadi, M. J., Alavi, S. M., Salman Zadeh, S., Geravandi, S., & Kamali, A. (2018). Hydatid cyst epidemiology in Khuzestan, Iran: A 15-year evaluation. Archives of Clinical Infectious Diseases, 13(1), e13765. https://doi.org/10.5812/archcid.13765

Amini, M., Bahador, M., & Malekhoseyni, M. (2008). Evaluation of hydatid cyst manifestations in patients admitted to Shaheed Modarres Hospital, 1984-2004. Archives of Clinical Infectious Diseases, 2(4), 177-180.

Anonymous. (2020). International Journal of One Health, 6(1), 17-22.

Asgarim, Mohebali, M., Kia, E. B., Farahnak, A. M., & Asadian, S. (2013). Seroepidemiology of human hydatidosis using Ag B-ELISA test in Arak, central Iran. Iranian Journal of Public Health, 42(4), 391-396.

Aziz, A., Zhang, W., Li, J., Loukas, A., McManus, D. P., & Mulvenna, J. (2011). Proteomic characterisation of Echinococcus granulosus hydatid cyst fluid from sheep, cattle, and humans. Journal of Proteomics, 74(9), 1560-1572. https://doi.org/10.1016/j.jprot.2011.04.017

Bennett, J. E., Dolin, R., & Blaser, M. J. (Eds.). (2014). Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Health Sciences.

Bingham, G. M., Larrieu, E., Uchiumi, L., Mercapide, C. H., Mujica, G., Del Carpio, M., ... Budke, C. M. (2016). The economic impact of cystic echinococcosis in Rio Negro province, Argentina. American Journal of Tropical Medicine and Hygiene, 94(3), 615-625. https://doi.org/10.4269/ajtmh.15-0602

Budke, C. M., Deplazes, P., & Torgerson, P. R. (2006). Global socioeconomic impact of cystic echinococcosis. Emerging Infectious Diseases, 12(2), 296-303. https://doi.org/10.3201/eid1202.050499

Chalechale, A., Hashemnia, M., Rezaei, F., & Sayadpour, M. (Year). Echinococcus granulosus in humans associated with disease incidence in domestic animals in Kermanshah, west of Iran. (Source).

Conchedda, M., Antonelli, A., Caddori, A., & Gabriele, F. (2010). A retrospective analysis of human cystic echinococcosis in Sardinia (Italy), an endemic Mediterranean region from 2001-2005. Parasitology International, 59(3), 454-459. https://doi.org/10.1016/j.parint.2010.04.002

Dybicz, M., Borkowski, P. K., Jonas, M., Wasiak, D., & Malkowski, P. (2019). First report of Echinococcus ortleppi in human cases of cystic echinococcosis in Poland. BioMed Research International, 2019. https://doi.org/10.1155/2019/3695304

Falagas, M. E., & Bliziotis, I. A. (2007). Albendazole for the treatment of human echinococcosis: A review of comparative clinical trials. The American Journal of the Medical Sciences, 334(3), 171-177.

Gollackner, B., Längle, F., Auer, H., Maier, A., Mittlböck, M., Agstner, I., et al. (2000). Radical surgical therapy of abdominal cystic hydatid disease: Factors of recurrence. World Journal of Surgery, 24(6), 717-721. https://doi.org/10.1007/s002689910115

Hama, A. A., Hassan, Z. I., Mero, W. M., Interisano, M., Boufana, B., & Casulli, A. (2015). Epidemiology/ : Open Access a Morphologically Unusual Echinococcus granulosus (G1 Genotype) Cyst in a Cow from Kurdistan - Iraq. Medicine, 16th ed. McGraw-Hill Professional Publisher, USA. https://doi.org/10.4172/2161-1165.S2-005

Ibrahim, B. B., Haridy, F. M., Hegazi, M. M., & Morsy, T. A. (2007). Human hydatidosis granulosis in Greater Cairo, Egypt: With general review. Journal of the Egyptian Society of Parasitology, 937(2), 681-688.

Islami Parkoohi, P., Jahani, M., Hossein Zadeh, H. Z., Taghian, F., Rostami, M., Mousavi, A., & Rezai, M. S. (2018). Epidemiology and clinical features of hydatid cyst in Northern Iran from 2005 to 2015. Iranian Journal of Parasitology, 13(2), 310-316.

Jaira Jpuri, Z. S., Jetley, S., Hassan, M. J., & Hussain, M. (2012). Hydatid disease in childhood: Revisited report of an interesting case. Journal of Parasitic Diseases, 36(2), 265-268.

Kalin, A. S., Kutluss, S., Caylak, S. D., Onal, O., Kayas, S., & Bozkut, A. L. (2014). Seroprevalence of human cystic echinococcosis and risk factors in animal breeders in rural communities in Denizli, Turkey. Journal of Infection in Developing Countries, 8(09), 1188–1194. https://doi.org/10.3855/jidc.4437

Kayal, A., & Hussain, A. (2014). A comprehensive prospective clinical study of hydatid disease. SRN Gastroenterology, 2014, Article ID 514757, 5 pages. https://doi.org/10.1155/2014/514757

Kern, P. (2003). Echinococcus granulosus infection: Clinical presentation, medical treatment, and outcome. Langenbeck's Archives of Surgery, 388(6), 413-420. https://doi.org/10.1007/s00423-003-0405-1

Kohansal, M. H., Nourian, A., & Bafandeh, S. (2015). Human cystic echinococcosis in Zanjan area, Northwest Iran: A retrospective hospital-based survey between 2007 and 2013. Iranian Journal of Public Health, 44(9), 1277-1282.

Mahmoudi, S., Mamishi, S., Banar, M., Pourakbari, B., & Keshavarz, H. (2019). Epidemiology of echinococcosis in Iran: A systematic review and meta-analysis. BMC Infectious Diseases, 19, 929. https://doi.org/10.1186/s12879-019-4458-0

Marquardt, W. C., Demaree, R. S., & Grieve, R. B. (2000). Parasitology and Vector Biology. Harcourt Academic Press, New York.

Molan, A. L. (1993). Epidemiology of hydatidosis and Echinococcus in the Qar province, Southern Iraq. Japanese Journal of Medical Science & Biology, 46, 29-35.

Moro, P. L., & Schantz, P. M. (2009). Echinococcosis: A review. International Journal of Infectious Diseases, 13(2), 125-133. https://doi.org/10.1016/j.ijid.2008.03.037

Mousavi, S. R., Samsami, M., Fallah, M., & Zirakzadeh, H. (2012). A retrospective survey of human hydatidosis based on hospital records during the period of layers. Journal of Parasitic Diseases, 36(1), 7-9.

Niger, J., & Clin. Pract. (2013). 16(2), 221-225.

Pierangeli, N. B., Soriano, S. V., Roccia, L., Gimenez, J., Lazzarini, L. E., Grenovero, M. S., et al. (2007). Heterogeneous distribution of human cystic echinococcosis after a long-term program control in Neuquen, Patagonia Argentina. Parasitology International, 56(2), 149-155. https://doi.org/10.1016/j.parint.2007.01.001

Raja Jawad, M., Alyaa Neamh, N. Alsaedi, & Jasim Hameed, T. (2021). Epidemiology of hydatid disease in Najaf provincial, Iraq. Journal of Physics: Conference Series, 1879. https://doi.org/10.1088/1742-6596/1879/2/022037

Rampal, K., Prajapati, D. K., & Sharma, M. (2016). Hydatid Disease-A clinical perspective with a review of primary hydatidosis of spleen. International Journal of Integrative Medical Sciences, 3(7), 337-340.

Romig, T., Deplazes, P., Jenkins, D., Giraudoux, P., Massolo, A., Craig, P. S., et al. (2017). Ecology and life cycle patterns of Echinococcus species. In Advances in Parasitology, 95, 213-314. https://doi.org/10.1016/bs.apar.2016.09.002

Saeed, I., Kapel, C. M. O., Saida, L. A., Willingham, A. L., & Nansen, P. (2000). Epidemiology of Echinococcus granulosus in Erbil province, northern Iraq, 1990-1998. Journal of Helminthology, 74(1), 83-88.

Saghafipour, A., Divband, M., ZanJiran Farahani, L., HamidiParsa, H., & Golabchi Fard, H. (2003). Epidemiology, burden, and geographical distribution of cystic echinococcosis in central Iran. Acta Tropica, 85(1), 51-61. https://doi.org/10.1016/S0001-706X(02)00237-3

Saimot, M., & Adrien, G. (2001). Medical treatment of liver hydatidosis. World Journal of Surgery, 25(1), 15-20.

Sastry, A. S., & Bhat, S. (2014). Essentials of Medical Parasitology. Jaypee Brothers, Medical Publishers Pvt. Limited.

Stamatakos, M., Sargedi, C., Stefanaki, C., Safioleas, C., Matthaiopoulou, I., & Safioleas, M. (2009). Anthelminthic treatment: An adjuvant therapeutic strategy against Echinococcus granulosus. Parasitology International, 58(2), 115-120. https://doi.org/10.1016/j.parint.2008.12.003

Thompson, R. C. A. (2017). Biology and systematics of Echinococcus. In Advances in Parasitology, 95, 65-109. https://doi.org/10.1016/bs.apar.2016.09.001

Xiu-Min, H., Qi-Gang, C., Wei, W., Hu, W., Qiang, Z., & Yong, W. (2018). Childhood suffering: Hyperendemic echinococcosis in Qinghai-Tibetan primary school students, China. Infectious Diseases of Poverty, 7, 71. https://doi.org/10.1186/s40249-018-0452-0

Yaghan, R. J., Bani-Hani, K. E., & Heis, H. A. (2004). The clinical and epidemiological features of hydatid disease in northern Jordan. Saudi Medical Journal, 25(7), 886-889.

Zibaei, M., Azargoon, A., Ataie-Khorasgani, M., Ghanadi, K., & Sadjjadi, S. M. (Year). The serological study of cystic echinococcus and assessment of surgical cases during 5 years (2007-2011) in Khorramabad, Iran.

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