Aborziza, M., Amalia, R., Zuhrotun, A., Ikram, N. K. K., Novitasari, D., & Muchtaridi, M. (2024). Coffee bean and its chemical constituent caffeine and chlorogenic acid as promising chemoprevention agents: Updated biological studies against cancer cells. Molecules, 29(14), 3302. https://doi.org/10.3390/molecules29143302
Abrahão, F. R., Rocha, L. C. R., Santos, T. A., Carmo, E. L. d., Pereira, L. A. S., Borges, S. V., & Pereira, R. G. F. A. (2019). Microencapsulation of bioactive compounds from espresso spent coffee by spray drying. LWT, 103, 116–124.
https://doi.org/10.1016/j.lwt.2018.12.061
Adamczyk, P., Wolski, Z., Butkiewicz, R., Nussbeutel, J., & Drewa, T. (2014). Significance of atypical small acinar proliferation and extensive high-grade prostatic intraepithelial neoplasm in clinical practice. Central European Journal of Urology, 67(2), 136–141. https://doi.org/10.5173/ceju.2014.02.art4
Ademowo, O. S., Dias, H. K. I., Pararasa, C., & Griffiths, H. R. (2019). Nutritional hormesis in a modern environment. In S. I. S. Rattan & M. Kyriazis (Eds.), The science of hormesis in health and longevity (pp. 75–86). Academic Press.
https://doi.org/10.1016/B978-0-12-814253-0.00006-1
Adhami, V. M., Siddiqui, I. A., Sarfaraz, S., Khwaja, S. I., Hafeez, B. B., Ahmad, N., et al. (2009). Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease. Clinical Cancer Research, 15(6), 1947–1953. https://doi.org/10.1158/1078-0432.CCR-08-2332
Ahmad, N., Gupta, S., & Mukhtar, H. (2000). Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor kappaB in cancer cells versus normal cells. Archives of Biochemistry and Biophysics, 376(2), 338–346.
https://doi.org/10.1006/abbi.2000.1742
Ahmed, J. U., Waziri, M., Dauda, A., & Bida, K. M. (2021). A short review of medicinal plants extract accompanied by potential antidepressant activity. Journal of Chemical Review, 3(3), 307–319.
Ahmed, M., Rahman, M. W., Rahman, M. T., & Hossain, C. (2002). Analgesic principle from the bark of Careya arborea. Pharmazie, 57(10), 698–701.
Akinmoladun, A. C., Adetuyi, A. R., Komolafe, K., & Oguntibeju, O. O. (2020). Nutritional benefits, phytochemical constituents, ethnomedicinal uses and biological properties of miracle fruit plant (Synsepalum dulcificum Shumach. & Thonn. Daniell). Heliyon, 6(12), e05837. https://doi.org/10.1016/j.heliyon.2020.e05837
Akkol, E. K., Tatli Çankaya, I., Seker Karatoprak, G., Carpar, E., Sobarzo-Sánchez, E., & Capasso, R. (2021). Natural compounds as medical strategies in the prevention and treatment of psychiatric disorders seen in neurological diseases. Frontiers in Pharmacology, 12, 669638. https://doi.org/10.3389/fphar.2021.669638
Alawadi, A. A., Benedito, V. A., Skinner, R. C., Warren, D. C., Showman, C., & Tou, J. C. (2022). RNA-sequencing revealed apple pomace ameliorates expression of genes in the hypothalamus associated with neurodegeneration in female rats fed a western diet during adolescence to adulthood. Nutritional Neuroscience, 25(11), 1–13.
Ali, A., Zahid, H. F., Cottrell, J. J., & Dunshea, F. R. (2022). A comparative study for nutritional and phytochemical profiling of Coffea arabica from different origins and their antioxidant potential and molecular docking. Molecules, 27(15), 5126. https://doi.org/10.3390/molecules27165126
Almasi, F., Dang, W., Mohammadipanah, F., & Li, N. (2022). Neurological disorders of COVID-19: Insights to applications of natural products from plants and microorganisms. Archives of Pharmacal Research.
https://doi.org/10.1007/s12272-022-01420-3
Alves, R. C., Rodrigues, F., Nunes, M. A., Vinha, A. F., & Oliveira, M. B. P. P. (2017). Chapter 1—State of the art in coffee processing by-products. In Handbook of coffee processing by-products (pp. 1–26). Academic Press.
https://doi.org/10.1016/B978-0-12-811290-8.00001-3
American Society for Nutrition. (2023, April). How to boost mental health through better nutrition. American Psychiatric Association.
Angeloni, C., Malaguti, M., Prata, C., Freschi, M., Barbalace, M. C., & Hrelia, S. (2022). Mechanisms underlying neurodegenerative disorders and potential neuroprotective activity of agrifood by-products. Antioxidants, 12(1), 94.
https://doi.org/10.3390/antiox12010094
Angeloni, S., Freschi, M., Marrazzo, P., Hrelia, S., Beghelli, D., Juan-García, A., Juan, C., Caprioli, G., Sagratini, G., & Angeloni, C. (2021). Antioxidant and anti-inflammatory profiles of spent coffee ground extracts for the treatment of neurodegeneration. Oxidative Medicine and Cellular Longevity, 2021, 6620913.
https://doi.org/10.1155/2021/6620913
Ayaz, M., Sadiq, A., Junaid, M., Ullah, F., Ovais, M., Ullah, I., Ahmed, J., & Shahid, M. (2019). Flavonoids as prospective neuroprotectants and their therapeutic propensity in aging associated neurological disorders. Frontiers in Aging Neuroscience, 11, 155. https://doi.org/10.3389/fnagi.2019.00155
Baig, S., Seevasant, I., Mohamad, J., Mukheem, A., Huri, H. Z., & Kamarul, T. (2015). Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand? Cell Death & Disease, 6(10), e1498.
Bakrim, S., El Omari, N., El Hachlafi, N., Bakri, Y., Lee, L. H., & Bouyahya, A. (2022). Dietary phenolic compounds as anticancer natural drugs: Recent update on molecular mechanisms and clinical trials. Foods, 11(21), 3323.
https://doi.org/10.3390/foods11213323
Barcz, E., Sommer, E., Sokolnicka, I., Gawrychowski, K., Roszkowska-Purska, K., Janik, P., & Skopinska-Rózewska, E. (1998). The influence of theobromine on angiogenic activity and proangiogenic cytokines production of human ovarian cancer cells. Oncology Reports, 5(2), 517–520. https://doi.org/10.3892/or.5.2.517
Bastianetto, S., Yao, Z. X., Papadopoulos, V., & Quirion, R. (2006). Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. European Journal of Neuroscience, 23(1), 55–64.
https://doi.org/10.1111/j.1460-9568.2005.04532.x
Bhaskaragoud, G., Rajath, S., Mahendra, V. P., Kumar, G. S., Gopala Krishna, A. G., & Kumar, G. S. (2016). Hypolipidemic mechanism of oryzanol components—Ferulic acid and phytosterols. Biochemical and Biophysical Research Communications, 476(2), 82–89. https://doi.org/10.1016/j.bbrc.2016.05.053
Chen, Y., Chou, W. C., Ding, Y. M., & Wu, Y. C. (2014). Caffeine inhibits migration in glioma cells through the ROCK-FAK pathway. Cellular Physiology and Biochemistry, 33(6), 1888–1898.
https://doi.org/10.1159/000362966
Cinausero, M., Aprile, G., Ermacora, P., Basile, D., Vitale, M. G., Fanotto, V., Parisi, G., Calvetti, L., & Sonis, S. T. (2017). New frontiers in the pathobiology and treatment of cancer regimen-related mucosal injury. Frontiers in Pharmacology, 8, 354. https://doi.org/10.3389/fphar.2017.00354
Cova, I., Leta, V., Mariani, C., Pantoni, L., & Pomati, S. (2019). Exploring cocoa properties: Is theobromine a cognitive modulator? Psychopharmacology, 236(2), 561–572. https://doi.org/10.1007/s00213-019-5172-0
D’Arcy, M. S. (2019). Cell death: A review of the major forms of apoptosis, necrosis and autophagy. Cell Biology International, 43(6), 582–592. https://doi.org/10.1002/cbin.11137
Drion, C. M., van Scheppingen, J., Arena, A., Geijtenbeek, K. W., Kooijman, L., van Vliet, E. A., Aronica, E., & Gorter, J. A. (2018). Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo-In search of potential anti-epileptogenic strategies for temporal lobe epilepsy. Journal of Neuroinflammation, 15(1), 212.
https://doi.org/10.1186/s12974-018-1247-9
Dutta, S., Mahalanobish, S., Saha, S., Ghosh, S., & Sil, P. C. (2019). Natural products: An upcoming therapeutic approach to cancer. Food and Chemical Toxicology, 128, 240–255. https://doi.org/10.1016/j.fct.2019.04.012
Eini, H., Frishman, V., Yulzari, R., Kachko, L., Lewis, E. C., Chaimovitz, C., & Douvdevani, A. (2015). Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor. Biochemical Pharmacology, 98(1), 110–118. https://doi.org/10.1016/j.bcp.2015.08.092
Epstein, R. S., Aapro, M. S., Basu Roy, U. K., Salimi, T., Krenitsky, J. A., Leone-Perkins, M. L., Girman, C., Schlusser, C., & Crawford, J. (2020). Patient burden and real-world management of chemotherapy-induced myelosuppression: Results from an online survey of patients with solid tumors. Advances in Therapy, 37(8), 3606–3618.
https://doi.org/10.1007/s12325-020-01419-6
Febriyanti, R. M., Rafif, S. N., Mikdar, N. N., Hikmatiana, B. N., Maisyarah, I. T., Khatib, A., & Muhaimin, M. (2025). Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: A review of in vitro evidence. Cancer Management and Research. https://doi.org/10.2147/CMAR.S516204
Figueira, I., Menezes, R., Macedo, D., Costa, I., & dos Santos, C. N. (2017). Polyphenols beyond barriers: A glimpse into the brain. Current Neuropharmacology, 15(4), 562–594. https://doi.org/10.2174/1570159X14666161026151545
Franco, R., Oñatibia-Astibia, A., & Martínez-Pinilla, E. (2013). Health benefits of methylxanthines in cacao and chocolate. Nutrients, 5(10), 4159–4173.https://doi.org/10.3390/nu5104159
Gao, J. L., & Chen, Y. G. (2015). Natural compounds regulate glycolysis in hypoxic tumor microenvironment. BioMed Research International, 2015, 354143. https://doi.org/10.1155/2015/354143
Gil, M., Skopinska-Rózewska, E., Radomska, D., Demkow, U., Skurzak, H., Rochowska, M., Beuth, J., & Roszkowski, K. (1993). Effect of purinergic receptor antagonists suramin and theobromine on tumor-induced angiogenesis in BALB/c mice. Folia Biologica (Praha), 39(2), 63–68.
Guruvayoorappan, C., & Kuttan, G. (2008). (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages. Innate Immunity, 14(3), 160–174.
https://doi.org/10.1177/1753425908093295
Nandakumar, V., Vaid, M., & Katiyar, S. K. (2011). (−)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells. Carcinogenesis, 32(4), 537–544. https://doi.org/10.1093/carcin/bgq285
Prasad, R., & Katiyar, S. K. (2015). Polyphenols from green tea inhibit the growth of melanoma cells through inhibition of class I histone deacetylases and induction of DNA damage. Genes & Cancer, 6(1–2), 49–61.
https://doi.org/10.18632/genesandcancer.52
Pratheeshkumar, P., & Kuttan, G. (2012). Piperine inhibits tumor angiogenesis and metastasis in B16F-10 melanoma cells in vitro and in vivo. Anticancer Agents in Medicinal Chemistry, 12(10), 1159–1184.
Rossi, A., Fortuna, M. C., Caro, G., Pranteda, G., Garelli, V., Pompili, U., & Carlesimo, M. (2017). Chemotherapy-induced alopecia management: Clinical experience and practical advice. Journal of Cosmetic Dermatology, 16(4), 537–541. https://doi.org/10.1111/jocd.12308
Saiki, S., Sasazawa, Y., Imamichi, Y., Kawajiri, S., Fujimaki, T., Tanida, I., Kobayashi, H., Sato, F., Sato, S., Ishikawa, K., et al. (2011). Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy, 7(2), 176–187. https://doi.org/10.4161/auto.7.2.14074
Skopinska-Rózewska, E., Janik, P., Przybyszewska, M., Sommer, E., & Bialas-Chromiec, B. (1998). Inhibitory effect of theobromine on induction of angiogenesis and VEGF mRNA expression in V-Raf transfectants of human urothelial cells HCV-29. International Journal of Molecular Medicine, 2(6), 649–652. https://doi.org/10.3892/ijmm.2.6.649
Talib, W. H., Abed, I., Raad, D., Alomari, R. K., Jamal, A., Jabbar, R., Alhasan, E. O. A., Alshaeri, H. K., Alasmari, M. M., & Law, D. (2024). Targeting cancer hallmarks using selected food bioactive compounds: Potentials for preventive and therapeutic strategies. Foods, 13(18), 2687. https://doi.org/10.3390/foods13172687
Vella, T., Iacobucci, D., Marino, V. N., Perilli, E., & Milia, A. M. (2023). Caffeine as a neuroprotective and weight-loss natural compound: Focus on the cardiovascular system. Pharmaceuticals, 16(5), 730.
Vicinanza, R., Zhang, Y., Henning, S. M., & Heber, D. (2013). Pomegranate juice metabolites, ellagic acid and urolithin A, synergistically inhibit androgen-independent prostate cancer cell growth via distinct effects on cell cycle control and apoptosis. Evidence-Based Complementary and Alternative Medicine, 2013, 247504.
https://doi.org/10.1155/2013/247504
Wang, H., Khor, T. O., Shu, L. M., Su, Z. Y., Fuentes, F., Lee, J. H., & Kong, A. N. T. (2012). Plants vs. cancer: A review on natural phytochemicals in preventing and treating cancers and their druggability. Anti-Cancer Agents in Medicinal Chemistry, 12(10), 1281–1305. https://doi.org/10.2174/187152012803833026
Wang, Z., Dabrosin, C., Yin, X., Fuster, M. M., Arreola, A., Rathmell, W. K., Generali, D., Nagaraju, G. P., El-Rayes, B., Ribatti, D., et al. (2015). Broad targeting of angiogenesis for cancer prevention and therapy. Seminars in Cancer Biology, 35, S224–S243. https://doi.org/10.1016/j.semcancer.2015.01.001
Wang, Z., Gu, C., Wang, X., Lang, Y., Wu, Y., Wu, X., Zhu, X., Wang, K., & Yang, H. (2019). Caffeine enhances the anti-tumor effect of 5-fluorouracil via increasing the production of reactive oxygen species in hepatocellular carcinoma. Medical Oncology, 36(12), 97. https://doi.org/10.1007/s12032-019-1323-8
Xu, H., Wang, L., Shi, B., Hu, L., Gan, C., Wang, Y., Xiang, Z., Wang, X., & Sheng, J. (2020). Caffeine inhibits the anticancer activity of paclitaxel via down-regulation of β-tubulin acetylation. Biomedicine & Pharmacotherapy, 129, 110441. https://doi.org/10.1016/j.biopha.2020.110441
Yan, R., Zhang, J., Park, H.-J., Park, E. S., Oh, S., Zheng, H., Junn, E., Voronkov, M., Stock, J. B., & Mouradian, M. M. (2018). Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB. Proceedings of the National Academy of Sciences, 115(49), E12053–E12062. https://doi.org/10.1073/pnas.1813365115
Yang, H., Jiang, J., Lv, S., & Li, R. (2019). Chlorogenic acid: A comprehensive review of its multiple health benefits. Food & Function, 10(12), 8560–8580.
Yoneda, M., Sugimoto, N., Katakura, M., Matsuzaki, K., Tanigami, H., Yachie, A., & Shido, O. (2017). Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice. The Journal of Nutritional Biochemistry, 39, 110–116. https://doi.org/10.1016/j.jnutbio.2016.10.002