Resveratrol in Wound Healing Application: Cellular Effects, Mechanisms, and Dressing Innovations
Nurfatin Mutalib1, Rabiatul Basria S. M. N. Mydin1, 2**
Journal of Angiotherapy 8(6) 1-5 https://doi.org/10.25163/angiotherapy.869627
Submitted: 06 April 2024 Revised: 11 June 2024 Published: 16 June 2024
Abstract
Resveratrol (RSV), a polyphenolic compound found in various plants and fruits, has garnered significant attention for its therapeutic potential in wound healing. Known for its anti-inflammatory, antioxidant, antimicrobial, and anti-aging properties, RSV plays a pivotal role in regulating cellular and molecular processes essential for wound repair. This review explores RSV's effects on different skin cells involved in wound healing, including fibroblasts, keratinocytes, and macrophages. Mechanisms underlying RSV's benefits, such as its modulation of inflammation, promotion of angiogenesis, and enhancement of tissue regeneration, are discussed. Despite challenges like low bioavailability, innovative RSV-loaded wound dressings like hydrogels and nanovesicles show promise in enhancing its efficacy by ensuring sustained release and tissue compatibility. Further research is crucial to optimize RSV delivery systems and establish standardized treatment protocols to maximize its therapeutic benefits in wound care.
Keywords: Resveratrol, Wound Dressing, Infectious Disease, Health, Wound Healing, Open Wound
References
Abdallah, F., Mijouin, L., & Pichon, C. (2017). Skin immune landscape: inside and outside the organism. Mediators of inflammation, 2017.
Abedini, E., Khodadadi, E., Zeinalzadeh, E., Moaddab, S.R., Asgharzadeh, M., Mehramouz, B., Dao, S. and Samadi Kafil, H., 2021. A comprehensive study on the antimicrobial properties of resveratrol as an alternative therapy. Evidence-Based Complementary and Alternative Medicine, 2021.
Arslaner, A., & Türkoglu, Z. (2020). A potential antiviral and food-derived healthy ingredient: Resveratrol. Food and Health, 7(1), 54-63.
Augustine, R., Rehman, S.R.U., Ahmed, R., Zahid, A.A., Sharifi, M., Falahati, M. and Hasan, A., 2020. Electrospun chitosan membranes containing bioactive and therapeutic agents for enhanced wound healing. International journal of biological macromolecules, 156, pp.153-170.
Ávila-Salas, F. et al. (2019) ‘Film dressings based on Hydrogels: Simultaneous and sustained-release of bioactive compounds with wound healing properties’, Pharmaceutics, 11(9), p. 447. doi:10.3390/pharmaceutics11090447.
Bártolo, I., Reis, R.L., Marques, A.P. and Cerqueira, M.T., 2022. Keratinocyte growth factor-based strategies for wound re-epithelialization. Tissue Engineering Part B: Reviews, 28(3), pp.665-676.
Boominathan, T. and Sivaramakrishna, A. (2021) ‘Recent advances in the synthesis, properties, and applications of modified chitosan derivatives: Challenges and opportunities’, Topics in Current Chemistry, 379(3). doi:10.1007/s41061-021-00331-z.
Cano Sanchez, M., Lancel, S., Boulanger, E. and Neviere, R., 2018. Targeting oxidative stress and mitochondrial dysfunction in the treatment of impaired wound healing: a systematic review. Antioxidants, 7(8), p.98.
Chen, K. et al. (2022) ‘pullulan-collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings’, Wound Repair and Regeneration, 30(3), pp. 397–408. doi:10.1111/wrr.13012.
Christovam, A.C., Theodoro, V., Mendonça, F.A.S., Esquisatto, M.A.M., Dos Santos, G.M.T. and do Amaral, M.E.C., 2019. Activators of SIRT1 in wound repair: an animal model study. Archives of dermatological research, 311(3), pp.193-201.
Dickmeis, C., Kauth, L. and Commandeur, U. (2020) ‘From infection to healing: The use of plant viruses in bioactive hydrogels’, WIREs Nanomedicine and Nanobiotechnology, 13(1). doi:10.1002/wnan.1662.
Ding, Y., Yang, P., Li, S., Zhang, H., Ding, X. and Tan, Q., 2022. Resveratrol accelerates wound healing by inducing M2 macrophage polarisation in diabetic mice. Pharmaceutical Biology, 60(1), pp.2328-2337.
Dunnill, C., Patton, T., Brennan, J., Barrett, J., Dryden, M., Cooke, J., Leaper, D. and Georgopoulos, N.T., 2017. Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process. International wound journal, 14(1), pp.89-96.
Farkhondeh, T., Folgado, S.L., Pourbagher-Shahri, A.M., Ashrafizadeh, M. and Samarghandian, S., 2020. The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway. Biomedicine & Pharmacotherapy, 127, p.110234.
Hecker, A., Schellnegger, M., Hofmann, E., Luze, H., Nischwitz, S. P., Kamolz, L. P., & Kotzbeck, P. (2022). The impact of resveratrol on skin wound healing, scarring, and aging. International Wound Journal, 19(1), 9-28.
Huang, X., Jin, L., & Zhu, Z. (2019). Resveratrol promotes diabetic wound healing via SIRT1-FOXO1-c-Myc signaling pathway-mediated angiogenesis. Frontiers in pharmacology, 10, 450457.
Jia, Y., Shao, J. H., Zhang, K. W., Zou, M. L., Teng, Y. Y., Tian, F., ... & Yuan, F. L. (2022). Emerging effects of resveratrol on wound healing: A Comprehensive Review. Molecules, 27(19), 6736.
Jia, Y., Shao, J.H., Zhang, K.W., Zou, M.L., Teng, Y.Y., Tian, F., Chen, M.N., Chen, W.W., Yuan, Z.D., Wu, J.J. and Yuan, F.L., 2022. Emerging effects of resveratrol on wound healing: A Comprehensive Review. Molecules, 27(19), p.6736.
Kaur, A., Tiwari, R., Tiwari, G., & Ramachandran, V. (2022). Resveratrol: A vital therapeutic agent with multiple health benefits. Drug Research, 72(01), 5-17.
Lee, I.T., Lin, H.C., Huang, T.H., Tseng, C.N., Cheng, H.T., Huang, W.C. and Cheng, C.Y., 2022. Anti-inflammatory effect of resveratrol derivatives via the downregulation of oxidative-stress-dependent and c-Src transactivation EGFR pathways on rat mesangial cells. Antioxidants, 11(5), p.835.
Luzardo-Álvarez, A., Lamela-Gómez, I., Otero-Espinar, F., & Blanco-Méndez, J. (2019). Development, characterization, and in vitro evaluation of resveratrol-loaded poly-(ε-caprolactone) microcapsules prepared by ultrasonic atomization for intra-articular administration. Pharmaceutics, 11(6), 249.
Parsamanesh, N., Asghari, A., Sardari, S., Tasbandi, A., Jamialahmadi, T., Xu, S., & Sahebkar, A. (2021). Resveratrol and endothelial function: A literature review. Pharmacological Research, 170, 105725.
Pignet, A. L., Schellnegger, M., Hecker, A., Kohlhauser, M., Kotzbeck, P., & Kamolz, L. P. (2021). Resveratrol-induced signal transduction in wound healing. International Journal of Molecular Sciences, 22(23), 12614.
Pinheiro, D.M.L., de Oliveira, A.H.S., Coutinho, L.G., Fontes, F.L., de Medeiros Oliveira, R.K., Oliveira, T.T., Faustino, A.L.F., da Silva, V.L., de Melo Campos, J.T.A., Lajus, T.B.P. and de Souza, S.J., 2019. Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation. Free Radical Biology and Medicine, 130, pp.8-22.
Poornima, B. and Korrapati, P.S. (2017) ‘Fabrication of chitosan-polycaprolactone composite nanofibrous scaffold for simultaneous delivery of ferulic acid and resveratrol’, Carbohydrate Polymers, 157, pp. 1741–1749. doi:10.1016/j.carbpol.2016.11.056.
Prabhakar, P. K., Singh, K., Kabra, D., & Gupta, J. (2020). Natural SIRT1 modifiers as promising therapeutic agents for improving diabetic wound healing. Phytomedicine, 76, 153252.
Rafe, T., Shawon, P.A., Salem, L., Chowdhury, N.I., Kabir, F., Bin Zahur, S.M., Akhter, R., Noor, H.B., Mohib, M.M. and Sagor, M.A., 2019. Preventive role of resveratrol against inflammatory cytokines and related diseases. Current pharmaceutical design, 25(12), pp.1345-1371..
Resnik, S.R., Egger, A., Abdo Abujamra, B. and Jozic, I., 2020. Clinical implications of cellular senescence on wound healing. Current Dermatology Reports, 9, pp.286-297.
Schilrreff, P., & Alexiev, U. (2022). Chronic inflammation in non-healing skin wounds and promising natural bioactive compounds treatment. International journal of molecular sciences, 23(9), 4928.
Shevelev, A.B., La Porta, N., Isakova, E.P., Martens, S., Biryukova, Y.K., Belous, A.S., Sivokhin, D.A., Trubnikova, E.V., Zylkova, M.V., Belyakova, A.V. and Smirnova, M.S., 2020. In vivo antimicrobial and wound-healing activity of resveratrol, dihydroquercetin, and dihydromyricetin against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. Pathogens, 9(4), p.296.
Stacchiotti, A., Favero, G., & Rezzani, R. (2018). Resveratrol and SIRT1 activators for the treatment of aging and age-related diseases. Resveratrol-Adding life to years, not adding years to life, 10.
Tao, K., Bai, X., Jia, W., Liu, Y., Zhu, X., Han, J., Dong, M., Li, J., Chen, D. and Hu, D., 2015. Effects of resveratrol on the treatment of inflammatory response induced by severe burn. Inflammation, 38, pp.1273-1280.
Vestergaard, M. and Ingmer, H., 2019. Antibacterial and antifungal properties of resveratrol. International Journal of Antimicrobial Agents, 53(6), pp.716-723.
Wen, S., Zhang, J., Yang, B., Elias, P.M. and Man, M.Q., 2020. Role of resveratrol in regulating cutaneous functions. Evidence-Based Complementary and Alternative Medicine, 2020.
Yang, G. et al. (2022) ‘A cellulose nanofibril-reinforced hydrogel with robust mechanical, self-healing, PH-responsive and antibacterial characteristics for wound dressing applications’, Journal of Nanobiotechnology, 20(1). doi:10.1186/s12951-022-01523-5.
Zhang, L. X., Li, C. X., Kakar, M. U., Khan, M. S., Wu, P. F., Amir, R. M., ... & Li, J. H. (2021). Resveratrol (RV): A pharmacological review and call for further research. Biomedicine & pharmacotherapy, 143, 112164.
Zhao, C.C., Zhu, L., Wu, Z., Yang, R., Xu, N. and Liang, L., 2020. Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation. Regenerative biomaterials, 7(1), pp.99-107.
Zhao, P., Sui, B.D., Liu, N., Lv, Y.J., Zheng, C.X., Lu, Y.B., Huang, W.T., Zhou, C.H., Chen, J., Pang, D.L. and Fei, D.D., 2017. Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application. Aging cell, 16(5), pp.1083-1093.
Zheng, Y. et al. (2020) ‘Injectable supramolecular gelatin hydrogel loading of resveratrol and histatin-1 for burn wound therapy’, Biomaterials Science, 8(17), pp. 4810–4820. doi:10.1039/d0bm00391c.
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