Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
Mohammed Abbas Al-Silaykhee1 , Saif Ddin Kadhoum Al-Zamili2 , Ahmed Ghdhban Al-Ziaydi1*
Australian Herbal Insight 7(1) 1-7 https://doi.org/10.25163/ahi.7110060
Submitted: 17 June 2024 Revised: 11 August 2024 Published: 12 August 2024
Abstract
Background: Nickel (II) phthalocyanine (Ni-Pc) is a prominent metallophthalocyanine compound known for its unique optical, electronic, and antioxidant properties. Its ability to form stable complexes with metal ions has made it a subject of interest in industrial and biomedical applications, including advanced material development and therapeutic interventions. Methods: Ni-Pc was synthesized using commercially obtained chemicals without additional purification. Its structural and physicochemical properties were analyzed through Fourier Transform Infrared (FTIR) spectroscopy, UV-Visible spectroscopy, and proton nuclear magnetic resonance (¹H NMR) spectroscopy. The antioxidant potential of Ni-Pc was evaluated via the DPPH radical scavenging assay, comparing its activity to ascorbic acid. Results: The synthesized Ni-Pc exhibited a melting point of 355°C with a yield of 75%. Elemental analysis confirmed its purity and composition (C: 66.17%, H: 19.88%, N: 20.01%). FTIR data revealed characteristic O–H, C=C, C=N, C–N, and Ni–N stretching vibrations, confirming its molecular structure. UV-Visible spectroscopy displayed prominent absorption bands, including a Q-band at ~670 nm, indicative of its intact aromatic macrocyclic system. ¹H NMR analysis confirmed the successful synthesis of Ni-Pc through characteristic aromatic CH group signals at 7.5–8.04 ppm. The DPPH assay demonstrated its antioxidant efficacy, with an 85% scavenging activity at 25 μg, comparable to ascorbic acid. Conclusion: Ni-Pc was successfully synthesized and characterized, exhibiting significant antioxidant potential alongside versatile structural properties. Its robust ability to coordinate with various metal ions underscores its importance in industrial applications, such as carbon nanotube development, and biomedical fields, including antitumor and antibacterial therapies. These findings highlight Ni-Pc’s potential as a multifunctional compound for advanced material science and therapeutic advancements.
Keywords: Nickel (II) phthalocyanine, antioxidant activity, DPPH assay, biomedical applications, FTIR spectroscopy
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