Homocysteine and Visfatin Upregulation for Type 2 Diabetes Etiology

Sabaa Ahmed ¹, Abdul-Rahim A. Ali ², Murooj G. Jameel ^2*, Mayada Talal Hamoo ²,  Mohammed fawzi majeed ², Dina Suhail M Saleh ², Sarah Hussain Khalaf ²

This study showed homocysteine and visfatin levels in diabetes offered insights into pathogenesis and potential therapeutic targets for managing complications.

Abstract

Background: Diabetes is a metabolic disorder characterized by insulin dysfunction. It has seen a surge in prevalence in recent years. Understanding the factors influencing diabetes pathogenesis is crucial for developing effective treatments. Recent studies have identified visfatin as a hormone with insulin-like properties, highlighting its potential role in diabetes. Methods: This study aimed to investigate the levels of homocysteine and its association with visfatin in diabetic patients compared to healthy individuals. Thirty patients with type 2 diabetes were enrolled, and their visfatin and homocysteine levels were measured. Results: Our findings revealed elevated levels of homocysteine and visfatin in diabetic patients compared to the control group. Statistical analysis demonstrated a significant difference between the two groups (P < 0.05). Furthermore, we observed a correlation between Apo.A1, Apo.B, and Apo.B / ApoA1 with visfatin and homocysteine levels, indicating a direct and significant relationship between visfatin levels and these apolipoproteins. Conclusion: The study underscores the importance of visfatin and homocysteine in diabetes pathophysiology. Elevated levels of these biomarkers in diabetic patients suggest their potential role as indicators or contributors to the disease. Further research into the mechanisms underlying their interaction may offer insights into novel therapeutic approaches for diabetes management.

Keywords: Diabetes mellitus, Homocysteine, Visfatin, Apolipoproteins, Case-control study

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