Two Forms of C-Reactive Protein and Their Implication for Atherogenesis: Focus on Monomeric Form

Anastasia V. Poznyak ^1*, Victoria A. Khotina ², Anton Y Postnov ², Vasily N. Sukhorukov ², Nikolay Sadykhov ², Alexander N. Orekhov ^2*

A review on inflammatory protein in atherosclerosis progression.

Abstract

In this review, we discuss the role of C-reactive protein (CRP), a biomarker of inflammation, in the development of atherosclerosis. CRP exists in two forms: the native pentameric form (nCRP) and the non-native form (mCRP), which is formed during inflammatory processes. The article explores the functions of both forms in atherosclerosis. nCRP binds to molecules with uncoated phosphocholine groups and activates the classical complement pathway. It can bind to enzymatically-modified LDL (E-LDL) and ox-LDL, affecting their pro-inflammatory properties and reducing LDL oxidation. nCRP also interacts with endothelial cells and reduces the absorption of acetylated LDL by these cells. In contrast, mCRP, formed in the presence of pathological conditions, exhibits distinct pro-inflammatory characteristics. While the role of nCRP in atherosclerosis remains unclear in animal models, mCRP has been associated with inflammation and is found in atherosclerotic lesions. The study suggests that nCRP may have atheroprotective effects, while mCRP may contribute to the progression of atherosclerosis. Further research is needed to fully understand the complex mechanisms of CRP in atherosclerosis.

Keywords:  Atherosclerosis; C-reactive protein; Inflammation; CRP; Cardiovascular disease

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