Environmental and physiological angiogenesis in causing CVD with oxidative pattern

Md. Fakruddin^1*, Md. Asaduzzaman Shishir², Kumkum Rahman Mouree², Shamsuddin Sultan Khan³

Oxidative stress plays critical role in angiogenesis and cardiovascular disease progression. Drugs targeting oxidative stress might provide a new treatment paradigm for related disorders.

Abstract

Oxidative stress is a mechanical pathway that regulates cellular function in different pathophysiology. Finding metabolic disease mechanisms with OS has a growing interest in pharmaceuticals. The therapeutic solution requires collaboration in different biopathway analyses using bioinformatics tools. However, OS has both environmental and physiological disturbances in treating cardiovascular diseases. Oxidative stress plays a vital role in cardiac remodeling and heart failure pathophysiology. OS induces insidious modification in the intracellular pathways, redox signaling, and causes cellular dysfunction and damage. The discovery of a wide variety of hypertrophy signaling kinases and transcription factors knowledge can provide gene/protein relations for new drug design and discovery. A good non-resistant anti-angiogenic medicine might better treat cardiac complications at any age. The alternative of VEGF or its combinatorial therapeutic approach might provide a better solution in the new treatment paradigm.

Keywords: Oxidative stress; ROS; Angiogenesis; Cardiovascular disease; Metabolic.

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