A Systematic Review on Temporal Lobe Epilepsy Patients with Corona Virus Infection

Pugazhandhi Bakthavatchalam¹, Fouad Saleih R.AL-Suede^2,3, Sudarshan S.^1*

Abstract

Objective: To systematically review the neurological symptoms and complications in temporal lobe epilepsy patients with Coronavirus infected patients. Methods: A systematic review of clinical studies on cases with neurological symptoms linked to COVID-19 and other coronaviruses was conducted. Following the PRISMA guidelines, a search for related scientific publications was performed in the following electronic databases: PubMed, Scopus, and Embase. The keywords used were “coronavirus" or "Sars-CoV-2" or "COVID-19" and "neurologic manifestations" or "neurological symptoms" or "meningitis" or "encephalitis" or "encephalopathy." Results: A total of 43 articles varying from case reports to case series, cohort studies, and systematic reviews were examined on SARS-CoV-2 and other human coronavirus infections with clinical symptoms in the central nervous system. Hyposmia, headaches, weakness, and altered awareness were among the most commonly reported symptoms. COVID-19 has been linked to encephalitis, demyelination, neuropathy, and stroke. Infection via the cribriform plate of the ethmoidal bone and olfactory bulb, as well as trans-synaptic transmission, are some of the proposed mechanisms. Invasion of the medullary cardiorespiratory center by SARS-CoV-2 may have a role in the refractory respiratory failure seen in corona virus-infected patients who are critically ill. Conclusion: Coronaviruses have a high potential to damage the central nervous system and can cause a variety of neurological symptoms, from moderate to severe. cephalalgy, lightheadedness, and altered level of consciousness were the most common neurological functional and structural signs discovered.

Keywords: COVID-19, SARS-CoV-2HCoVSARS, Middle East respiratory syndrome coronavirus (MERS-CoV),    Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Neurological manifestation, Encephalopathy

References

Atere, M., Singh, S., Arora, K., Khan, Z., Muzangwa, L., Bhavsar, U., & Nfonoyim, J. M. (2020). COVID-19: The Case of Three Patients with the Same Diagnosis but Different Clinical and Laboratory Features. Case Reports in Medicine, 2020.

Bell, M., Taub, D., & Perry, V. (1996). Overriding the brain's intrinsic resistance to leukocyte recruitment with intraparenchymal injections of recombinant chemokines. Neuroscience, 74(1), 283-292.

Bohmwald, K., Galvez, N., Ríos, M., & Kalergis, A. M. (2018). Neurologic alterations due to respiratory virus infections. Frontiers in cellular neuroscience, 12, 386.

Brownyn Lok a, Amin Malik Shah Abdul Majid a, b*, Aman Shah Abdul Majid c..(2019). Angiogenesis and its potential role in the growth and proliferation of pathogens. Journal of Angiotherapy 1(1).  https://doi.org/10.25163/angiotherapy.11000121421300417

De Stefano, P., Nencha, U., De Stefano, L., Mégevand, P., & Seeck, M. (2020). Focal EEG changes indicating critical illness associated cerebral microbleeds in a Covid-19 patient. Clinical Neurophysiology Practice.

Dixon, L., Varley, J., Gontsarova, A., Mallon, D., Tona, F., Muir, D., . . . Jones, B. (2020). COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia. Neurology-Neuroimmunology Neuroinflammation, 7(5).

Dorandeu, F., Barbier, L., Dhote, F., Testylier, G., & Carpentier, P. (2013). Ketamine combinations for the field treatment of soman-induced self-sustaining status epilepticus. Review of current data and perspectives. Chemico-biological interactions, 203(1), 154-159.

Elgamasy, S., Kamel, M. G., Ghozy, S., Khalil, A., Morra, M. E., & Islam, S. M. S. (2020). First Case of Focal Epilepsy Associated with SARS-Coronavirus-2. Journal of Medical Virology.

Farhadian, S., Glick, L. R., Vogels, C. B., Thomas, J., Chiarella, J., Casanovas-Massana, A., . . . Geng, B. (2020). Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.

Fasano, A., Cavallieri, F., Canali, E., & Valzania, F. (2020). First motor seizure as presenting symptom of SARS-CoV-2 infection. Neurological Sciences, 1.

Galanopoulou, A. S., Ferastraoaru, V., Correa, D. J., Cherian, K., Duberstein, S., Gursky, J., . . . Khodakivska, O. (2020). EEG findings in acutely ill patients investigated for SARS-CoV2/COVID-19: a small case series preliminary report. Epilepsia Open.

Garazzino, S., Montagnani, C., Donà, D., Meini, A., Felici, E., Vergine, G., . . . Marchisio, P. (2020). Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as of 10 April 2020. Eurosurveillance, 25(18), 2000600.

Hepburn, M., Mullaguri, N., George, P., Hantus, S., Punia, V., Bhimraj, A., & Newey, C. R. (2020). Acute symptomatic seizures in critically ill patients with COVID-19: is there an association? Neurocritical Care, 1-5.

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., . . . Gu, X. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497-506.

Lau, K.-K., Yu, W.-C., Chu, C.-M., Lau, S.-T., Sheng, B., & Yuen, K.-Y. (2004). Possible central nervous system infection by SARS coronavirus. Emerging infectious diseases, 10(2), 342.

Libbey, J. E., Kirkman, N. J., Smith, M. C., Tanaka, T., Wilcox, K. S., White, H. S., & Fujinami, R. S. (2008). Seizures following picornavirus infection. Epilepsia, 49(6), 1066-1074.

Lyons, S., O’Kelly, B., Woods, S., Rowan, C., Brady, D., Sheehan, G., & Smyth, S. (2020). Seizure with CSF lymphocytosis as a presenting feature of COVID-19 in an otherwise healthy young man. Seizure-European Journal of Epilepsy, 80, 113-114.

Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., . . . Wang, D. (2020). Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA neurology, 77(6), 683-690.

McDONOUGH JR, J. H., & SHIH, T.-M. (1997). Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neuroscience & Biobehavioral Reviews, 21(5), 559-579.

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & Group, P. (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS med, 6(7), e1000097.

Montalvan, V., Lee, J., Bueso, T., De Toledo, J., & Rivas, K. (2020). Neurological manifestations of COVID-19 and other coronavirus infections: a systematic review. Clin Neurol Neurosurg, 194, 105921.

Morassi, M., Bagatto, D., Cobelli, M., D’Agostini, S., Gigli, G. L., Bnà, C., & Vogrig, A. (2020). Stroke in patients with SARS-CoV-2 infection: case series. Journal of Neurology, 1.

Moriguchi, T., Harii, N., Goto, J., Harada, D., Sugawara, H., Takamino, J., . . . Myose, N. (2020). A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. International Journal of Infectious Diseases.

Organization, W. H. (2020). Novel Coronavirus (‎ 2019-nCoV)‎: situation report, 3.

Perlman, S. (2020). Another decade, another coronavirus. In: Mass Medical Soc.

Pinna, P., Grewal, P., Hall, J. P., Tavarez, T., Dafer, R. M., Garg, R., . . . Fegan, K. (2020). Neurological manifestations and COVID-19: Experiences from a tertiary care center at the Frontline. Journal of the Neurological Sciences, 116969.

Ramesh T V1, Gopi Ayyaswamy2, Zioni Sangeetha3, Vinod Kumar P*4 (2022). CNS Vasculitis in A Patient with Systemic Lupus Erythematosus: A Case Report. Journal of Angiotherapy 6(1)

               https://doi.org/10.25163/angiotherapy.6162186290707122

Saad, M., Omrani, A. S., Baig, K., Bahloul, A., Elzein, F., Matin, M. A., . . . Al Aidaroos, A. Y. (2014). Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia. International Journal of Infectious Diseases, 29, 301-306.

Sasi Kumar S1, Gopinath S2, Kalaichezhian M3 and Harish M4,..(2022). Surgical Management of Patients During Covid 19 Pandemic. Journal of Angiotherapy 6(1).

              https://doi.org/10.25163/angiotherapy.6122191290707122

Singhi, P. (2011). Infectious causes of seizures and epilepsy in the developing world. Developmental Medicine & Child Neurology, 53(7), 600-609.

Sohal, S., & Mossammat, M. (2020). COVID-19 Presenting with Seizures. IDCases, e00782.

Somani, S., Pati, S., Gaston, T., Chitlangia, A., & Agnihotri, S. (2020). De Novo Status Epilepticus in patients with COVID-19. Annals of Clinical and Translational Neurology.

Swanson II, P. A., & McGavern, D. B. (2015). Viral diseases of the central nervous system. Current opinion in virology, 11, 44-54.

Tohidpour, A., Morgun, A. V., Boitsova, E. B., Malinovskaya, N. A., Martynova, G. P., Khilazheva, E. D., . . . Salmina, A. B. (2017). Neuroinflammation and infection: molecular mechanisms associated with dysfunction of neurovascular unit. Frontiers in cellular and infection microbiology, 7, 276.

Tsai, L., Hsieh, S., & Chang, Y. (2005). Neurological manifestations in severe acute respiratory syndrome. Acta Neurologica Taiwanica, 14(3), 113.

Velavan, T. P., & Meyer, C. G. (2020). The COVID-19 epidemic. Tropical medicine & international health, 25(3), 278.

Verkhratsky, A., & Nedergaard, M. (2018). Physiology of astroglia. Physiological reviews, 98(1), 239-389.

Wang, C., Horby, P. W., Hayden, F. G., & Gao, G. F. (2020). A novel coronavirus outbreak of global health concern. The Lancet, 395(10223), 470-473.

Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., . . . Xiong, Y. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. Jama, 323(11), 1061-1069.

Yogarajan R1, Jayakumari S2, Sumathi K3 and Mohan Kumar P R*4…(2022). A Case of Uncontrolled Asthma. ournal of Angiotherapy 6(1). https://doi.org/10.25163/angiotherapy.61621762922220122

Zanin, L., Saraceno, G., Panciani, P. P., Renisi, G., Signorini, L., Migliorati, K., & Fontanella, M. M. (2020). SARS-CoV-2 can induce brain and spine demyelinating lesions. Acta Neurochirurgica, 1-4.