EMAN RESEARCH PUBLISHING | Journal | <p>Programmable DNA binding oligomers for control of transpcription in angiogenesis</p>
Angiogenesis biology and therapeutics
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Programmable DNA binding oligomers for control of transpcription in angiogenesis

Sarah Furkan

+ Author Affiliations

Journal of Angiotherapy 1(1) 033-035 https://doi.org/10.25163/angiotherapy.11000721108100517

Submitted: 11 September 2016  Revised: 16 February 2017  Published: 10 May 2017 

Small molecules that can be programmed to mimic transcription factors could be useful tools in biology and potentially in human medicine as they could bind a large repertoire of DNA sequences in the human genome.

Abstract


The drug discovery opportunities with chemistry, biology and human medicine are increasing by mapping and sequencing the genetic blueprint of humans, mice and other organisms. The realization of the function of 25,000 genes of humans and understanding the biological circles that control these genes will be a crucial starting point for new chemistry technologies. The cellular events that lead to cancer and diseases in human involve aberrant gene expression. Small molecules that can be programmed to mimic transcription factors could be useful tools in biology and potentially in human medicine as they could bind a large repertoire of DNA sequences in the human genome.

Keywords: Transcription, Oligomers, DNA, Chromatin, Drug Discovery, Angiogenesis

Committee on Publication Ethics

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