Integrative Biomedical Research
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Integrative Biomedical Research
Integrative Biomedical Research is an, international, peer-reviewed, Open Access journal that publishes research articles on all aspects of biomedical, medicine, public health,
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Integrative Biomedical Research
Volume 9 Number 1 2025
Table of Contents
Research Article
Natural Drug Development
Md. Shakil Ahmed1, Saima Jahan Oishe1, Farhana Rahman1, Rabeya Basri1, Mahbuba Haque1, Mirza Nipa Monalisa1, Nishat Rayhana1, Shamima Ahsan1, Shangita Dev1, Md. Atiqur Rahman1*
This study documents plant diversity, cultural significance, and regional ethnomedicinal similarities, promoting sustainable traditional knowledge preservation and pharmacological research.
Abstract | Full Text |PDF (850 KB) |Supplementary Material | Open Access Article
Bacteriophage Therapy for Staphylococcus aureus Induced Postoperative Acute Endophthalmitis In Vivo
Muhammad Indra Mahardika Iridika Humeri1, Ismi Zuhria2, Rozalina Loebis2*, Wimbo Sasono2, Lukisiari Agustini2, Diah Indriani4, Firman Setiawan5, Annise Proboningrat6, Djoko Legowo6
This study determined the bacteriophage therapy's potential in reducing inflammation and preserving retinal structure post-cataract surgery-induced endophthalmitis.
Abstract | Full Text |PDF (678 KB) | Open Access Article
Antifungal Efficacy of Garlic and Olive Oil Against Candida albicans and Penicillium palitans
Amani Alhejely 1*
The study demonstrates the potential of garlic and olive oil as natural antifungal agents in managing fungal infections.
Abstract | Full Text |PDF (169 KB) | Open Access Article
Antifungal Properties of Dracaena cinnabari Resin Extracts Against Candida albicans
Rola Ali-Saeed1*, Aied M. Alabsi2, Siti Sufiah Shaherah binti Zainudin1, Nur Nadhirah binti Harun1, Lee Min Quan1, Siddig Ibrahim abdelwahab3, Antony V Samrot 4, Vetriselvan Subramaniyan5, Ismail, Muhamad Fareez6
This study determined Dracaena cinnabari's resin as a promising natural antifungal agent against Candida albicans, particularly in oral candidiasis.
Abstract | Full Text |PDF (369 KB) | Open Access Article
Mohd Hasan Mujahid 1, Tarun Kumar Upadhyay 1*, Vijay Jagdish Upadhye 2*, Prasanna Sriram Mathad 3
This study determined the therapeutic potential of Aqueous Zingiber officinale rhizome extract (AZOME) in combating oxidative stress, microbial infections, diabetes, and glycation-related complications.
Abstract | Full Text |PDF (2 MB) |Supplementary Material | Open Access Article
Antibacterial Activity of Sidr (Ziziphus spina-christi) Plant Extracts against Urinary Pathogens
Amal Naif Alshammari 1*
Sidr plant extracts showed promising antibacterial activity against urinary pathogens as potential alternative of UTI treatments.
Abstract | Full Text |PDF (211 KB) | Open Access Article
Advancing Therapeutic Efficacy of Star Anise Oil with (Illicium verum) Nano-Emulsion Formulation
Sharad Visht 1, Sana Sirwan Salih 1, Belan Azad Ibrahim 1, Daniah Issa Ismael 1, Serwa Falah Abdalwaheed 1, Omji Porwal 1
Star anise oil-based nano-emulsions' extraction, purification, and formulation processes to improve therapeutic efficacy of drug substances
Abstract | Full Text |PDF (1 MB) | Open Access Article
Haryoto1*, Alysa Vivi Arnida1, Peni Indrayudha1, Cita Hanif Muflihah1, Khong Heng Yen2
Mareme and Sala leaves mix may be a strong blood sugar blocker, but it contains useful chemicals for potential medical research.
Abstract | Full Text |PDF (318 KB) | Open Access Article
Investigation Of Anti-Tumour Activity Of Orthosiphon Stamineus On Human Oral Squamous Cell Carcinoma
Shah kamal Bin Jamal Dina, Fouad Saleih Resq Al-Suedeb,c*,Farahnaz Aminid, Aman Shah Abdul Majide, JackTan Chun Keatd, Amin Malik Shah Abdul Majidf .
The potential of Nuvastatic in the treatment of oral squamous cell carcinoma.
Abstract | Full Text |PDF (602 KB) | Open Access Article
Prakash Dabadi1, Fouad Saleih Resq AL-Suede2,3*, Chandrashekhar VM4*, Mallappa Shalavadi 4 , Ashok Gnanasekaran5
Development of therapeutics for the treatment of hepatotoxicity and oxidative stress induced by ATDs
Abstract | Full Text |PDF (589 KB) | Open Access Article
Ashwaq Hamid Salem Yehyaa,*, Majed Ahmed Al-Mansoubb, Fouad Saleih Resq Al-Suedea, Siti Balkees Binti STN Hameed Sultana, Muhammad Asyraf Abduramana, Noor Amanina Azmic, Mufda jameel abedalhadi alrawashdehd, Seyedeh Fatemeh Jafarie, Amin Malik Shah Abdul Majida,f
Abstract | Full Text |PDF (1015 KB) | Open Access Article
Evaluation on Antibacterial Activity and Hepatoprotectivity of Rauwolfia serpentina
Gnanasekaran Ashok1,6*, Yukshna A/P Ramunaidu2, Fouad saleih R.AL-Suede3,4 Murugesan Karthikeyan1, Pugazhandhi Bakthavatchalam5, Sajeewa P. Rathnayake6
The results of this study provide scientific evaluation of antibacterial activity and hepatoprotective effect of Rauwolfia serpentina which will be useful to researchers investigating the compounds with this potential and encouraging the development of new findings in this field.
Abstract | Full Text |PDF (556 KB) | Open Access Article
Aishath Thahuseen Waheed1, Thurga Ayavoo2,3, Karthikeyan Murugesan2,3, Fouad Saleih R. AL-Suede4,5, Ashok Gnanasekaran2,3*
Development of anti-inflammatory herbal drug.
Abstract | Full Text |PDF (464 KB) | Open Access Article
Ben Enoluomen Ehigiator1, SamuelKelechi Mobisson2, Iheanyichukwu Wopara3*, Chinonye Cynthia Chibuife1, Uwaezuoke Chukwuekele Awarajih3, Harrison Ogheneochuko Eruotor3
Abstract | Full Text |PDF (521 KB) | Open Access Article
Fouad Saleih R. Al-Suede1*, Mohamed B. Khadeer Ahamed1, Aman S. Abdul Majid2 Sultan Ayesh Mohammed Saghir3, Chern E. Oon4, Amin Malik Shah Abdul Majid1,5*
C5OSEW5050ESA OS strongly curbs variety of angiogenesis modulators in vitro, ex vivo and in vivo.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Mansoureh Nazari Vishkaei a, Mohamed Khadeer Ahamed Basheer c, Amin Malik Shah Abdul Majid a,b
SLOS vesicles can be considered for effective dermal therapeutic agent for the treatment of skin cancer.
Abstract | Full Text |PDF (1 MB) | Open Access Article
Reviews
Natural Drug Development
Natural Polyphenol-Rich Inhibitors of Pancreatic Lipase for Obesity Management – A Systematic Review
Kamran Javed Naquvi 1*
This review discusses the plant-derived pancreatic lipase inhibitors as potential for natural, effective obesity management, reducing fat absorption and promoting metabolic health.
Abstract | Full Text |PDF (507 KB) | Open Access Article
Mechanisms and Future Perspectives of Curcumin in Diabetes Management
Kamran Javed Naquvi 1*
This review emphasizes curcumin's multifaceted roles in managing diabetes and its complications, highlighting the need for improved formulations to enhance efficacy.
Abstract | Full Text |PDF (570 KB) | Open Access Article
Rasmita Jena 1,2, Durga Madhab Kar 1*, Sovan Pattanaik 1, Bhisma Narayan Ratha 3
This review emphasizes the rich potential in traditional practices, offering valuable insights and solutions to current healing challenges.
Abstract | Full Text |PDF (934 KB) | Open Access Article
Moringa oleifera's Effect on Colorectal Cancer
Rolla Al-Shalabi 1,2, Nozlena abdul samad 1*, Lim Vuanghao 1, Ibrahim Al Deeb 2, Julia Joseph 1
The therapeutic benefit of Moringa plant in cancer treatment
Abstract | Full Text |PDF (2 MB) | Open Access Article
Efficacy of Herbal Medicine as Adjunctive Therapy for Skin Cancer
Norbayu Mansor1, Julia Joseph1, Rola Al Shalabi1, Nozlena Binti Abdul Samad*1
Phytochemicals can be used for skin cancer prevention and treatment.
Abstract | Full Text |PDF (373 KB) | Open Access Article
The peer-reviewed and edited version of record published online before inclusion in an issue
These articles have been peer reviewed and accepted for publication. They are still in production and have not been edited, so may differ from the final published form.
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Advanced Dissolution Testing for Novel Drug Formulations: Challenges, Emerging Methods, and Regulatory Perspectives
This study enhances drug release evaluation and improves therapeutic outcomes using advanced dissolution testing techniques.
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Analysis of Potential Biomarkers in Hypertension
Biomarker-driven hypertension diagnostics enhance early detection, predict complications, and support precision medicine strategies to reduce global cardiovascular disease burden.
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Predicting Habitat Suitability and Climate Change Impact on Medicinal plant Dalbergia latifolia and Dillenia pentagyna Using Ecological Niche Modelling
This study models current and future habitats, highlighting climate-driven distribution shifts and guiding conservation strategies for two economically valuable medicinal plants.
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A Comparative Analysis of Bioavailability and Stability of Anti-Diabetic Drugs in Conventional vs. Nanoparticle-Based Formulations – A Review
The study underscores nanoparticles' potential to improve stability, bioavailability, and therapeutic efficacy of anti-diabetic drugs versus conventional formulations.
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Effects of Physical Activity as A Treatment For Depression in the Elderly
Identifying effective physical activities for elderly depression supports holistic, low-cost, evidence-based interventions that enhance mental health and healthy aging.
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Strategic Impurity Control in Next-Generation Pharmaceuticals: Analytical Technologies, Toxicological Assessment, and Regulatory Integration
Effective impurity control safeguards patient safety while accelerating pharmaceutical innovation and regulatory approval.
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Collaborative Governance in Combating Illegal Cosmetics: A Study of Multi-Stakeholder Dynamics in South Sulawesi, Indonesia
This study evaluates collaborative governance in South Sulawesi to address illegal cosmetics, enhancing public health, regulatory compliance, and stakeholder coordination.
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High Viral Load is a Risk Factor for Hepatocellular Carcinoma: Clinical and Laboratory Insights from a Cross-Sectional Study
High viral load in HCC patients correlates with worsened liver function, systemic complications, and increased mortality, underscoring the need for early intervention.
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Cardiovascular Complications in Patients with Hepatocellular Carcinoma
The study seeks to develop an HCC risk profile framework for clinicians to identify patients who may be at risk.
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AI-driven Innovations in Cancer Research and Personalized Healthcare
This study demonstrated the potential of AI to revolutionize cancer care through improved diagnostics, personalized treatment, and ethical implementation.
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The Evolving Role of Hospital and Community Pharmacist in Post-COVID-19 Healthcare Delivery in Bangladesh: A Survey-Based Analysis
This study highlights post-pandemic roles of Bangladeshi pharmacists, emphasizing their evolving contributions to healthcare access, management, and therapeutic decision-making.
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Synthesis, Characterization, and Antioxidant Potential of Nickel (II) Phthalocyanine for Industrial and Biomedical Applications
This study determined Nickel (II) phthalocyanine's antioxidant efficacy, structural characterization, and versatile applications in industry and therapeutic advancements.
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An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease
AI improves diagnosis, treatment planning, and patient outcomes by enabling early, accurate Alzheimer's disease identification using sophisticated data analysis.
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Bacteriological Profile of Bacteremia and Antibiotic Resistance Patterns of the Isolated Pathogens
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Cardiometabolic Impact of Vitamin D Deficiency as a Determinant of Coronary Artery Disease: A Review
The results demonstrate a strong link between vitamin D deficiency and an increased risk of coronary heart disease in adults.
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Revolutionizing Healthcare: The Role of Artificial Intelligence in Drug Discovery and Delivery
This study shows how AI can change the way drugs are made and delivered, making healthcare faster, more personalized, and cheaper.
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Potential Therapeutic Targets Associated with the Autoimmune Response in Crohn's Disease
This review elucidates autoimmune mechanisms in Crohn’s disease, highlighting emerging molecular targets to advance precision immunotherapy and improve patient outcomes.
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Deep Mapping of Neuro-phenotypes Using AI-Enhanced MRI: A Contrast-Based Multiplanar Analysis
AI-driven contrast mapping enhances voxel-level T2-MRI brain analysis, revealing phenotypic variations crucial for early diagnosis and neurodevelopmental profiling
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TGF-β1 as a Molecular Target and Vitamin D Interaction in Diabetic Nephropathy: A Bio-clinical Correlation Study
Clarifies the potential role of vitamin D and kidney dysfunction in diabetic nephropathy through clinical and molecular analysis.
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Multichemical Endocrine Disruption of Thyroid and Sex Hormone Signaling Drives Early-Life Neurodevelopmental Impairments
This study highlights how prenatal endocrine disruptor exposure impairs neurodevelopment, emphasizing mixture effects, biological mechanisms, and urgent regulatory intervention needs.
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Integrating Molecular Modeling and Kinetic Insights to Decipher Structure–Activity Relationship Trends in Small-Molecule Inhibitors of α-Glycosidases
This study clarifies structural features driving potent α-glycosidase inhibition, enabling rational design of selective therapeutics through integrated computational–experimental mechanistic insights.