Severity and Prevalence in Non-Specific Interstitial Pneumonia and COVID-19 Associated Pneumonia
Shevchenko Olga Alexandrovna 1*, Shodikulova Gulandom Zikriyaevna 1, Ergashova Madina Mukhtorovna 1, Khazratkulov Javlonbek Jaloliddin ogli 1
Journal of Angiotherapy 8(7) 1-7 https://doi.org/10.25163/angiotherapy.879783
Submitted: 06 May 2024 Revised: 12 July 2024 Published: 16 July 2024
Abstract
Background: The non-specific clinical presentation and absence of definitive diagnostic markers further complicate the diagnosis of nterstitial lung diseases (ILD), particularly idiopathic interstitial pneumonia (IIP). This study aimed to investigate the clinical and epidemiological characteristics, along with imaging diagnostics, of patients with non-specific interstitial pneumonia (NsIP) in the Samarkand region from 2020 to 2023. Methods: A retrospective analysis of medical records was conducted for 262 patients diagnosed with ILD and hospitalized at the Samarkand State Medical Association (SamSMA). Using a multidisciplinary approach and adhering to the international classification of diseases (ICD-10) criteria, patients were categorized into two groups: those diagnosed with NsIP and a comparison group of patients with COVID-19-associated pneumonia (COVID-19 AP). The patients were further subdivided based on disease severity: moderate (IA) and severe (IB) for the NsIP group, and moderate (IIA) and severe (IIB) for the COVID-19 AP group. Results: The study found that 72.5% of ILD patients had NsIP, predominantly older males. Moderate disease severity was more common in NsIP patients, while severe cases were more prevalent in the COVID-19 AP group. The age groups 45-59 and 60-74 years represented 78% of the NsIP cases. Conclusion: The study found a higher prevalence of NsIP among men, with the majority of cases occurring in older age groups. Moderate disease severity was more common in NsIP patients, contrasting with COVID-19 AP patients, where severe cases were more prevalent.
Keywords: Non-Specific Interstitial Pneumonia, COVID-19 Associated Pneumonia, Interstitial Lung Disease, Epidemiology, Multidisciplinary Approach
References
Anaev, E. H. (2017). Modern ideas about idiopathic pulmonary fibrosis: Biomarkers are in focus. Pulmonology, 27(1), 56-64.
Avdeev, S. N. (2014). Idiopathic pulmonary fibrosis: A modern concept and approaches to diagnosis. Practical Pulmonology, 4, 16-23.
Avdeev, S. N., Chikina, S. Yu., Tyurin, I. E., Belevsky, A. S., Terpigorev, S. A., Ananyeva, L. P., Wiesel, A. A., Boldina, M. V., Demko, I. V., Leshchenko, I. V., Trofimenko, I. N., Kinyakin, M. F., Stepanyan, I. E., Zaitseva, A. S., & Petrov, D. V. (2021). Chronic fibrotic interstitial lung diseases with progressive fibrotic phenotype: Resolution of the Interdisciplinary Council of Experts. Pulmonology, 31(4), 505–510. https://doi.org/10.18093/0869-0189-2021-31-4-505-510
Bolotova, N. V., Cherednikova, K. A., Filina, N. Yu., Garifulina, L. M., & Logacheva, O. A. (2023). Modern view on the role of the intestinal microbiota in the development of metabolic disorders. Pediatriya - Zhurnal im G.N. Speranskogo, 102(4), 140–146.
Bolotova, N. V., Filina, N. Yu., Kurdiyan, M. S., Garifulina, L. M., & Meshcheryakova, I. Y. (2022). Using transcranial magnetic therapy in combination with electrostimulation for correcting neuroendocrine-immune disorders in obese boys. Russian Open Medical Journal, 11(1).
Boudlaie, H., Boghosian, A., Ahmad, I., Wekke, I. S., & Makhmudova, A. (2022). Investigating the mediating role of moral identity on the relationship between spiritual intelligence and Muslims’ self-esteem. HTS Teologiese Studies/Theological Studies, 78(4), 7570.
Calver, J. F., Fabbri, L., May, J., & Jenkins, R. G. (2023). COVID-19 in patients with chronic lung disease. Clinics in Chest Medicine, 44(2), 385-393. https://doi.org/10.1016/j.ccm.2022.11.013
Demura, S. A., Kogan, E. A., & Paukov, V. S. (2015). Pathological repair in the niche areas of the stem cells of the respiratory lung in idiopathic pulmonary fibrosis. Pulmonology, 25(3), 350-356.
Dvoretsky, L. I. (2009). The quality of life of an elderly patient. Consilium Medicum, 11, 98-102.
Dvoretsky, L. I. (2014). Interstitial lung diseases in the elderly. Pulmonology, 4, 91-99.
Ejam, S. S., Saleh, R. O., Catalan Opulencia, M. J., Karampoor, S., & Mirzaei, R. (2022). Pathogenic role of 25-hydroxycholesterol in cancer development and progression. Future Oncology, 18(39), 4415–4442.
Giryes, S., Bragazzi, N. L., Bridgewood, C., De Marco, G., & McGonagle, D. (2022). COVID-19 vasculitis and vasculopathy-distinct immunopathology emerging from the close juxtaposition of type II pneumocytes and pulmonary endothelial cells. Seminars in Immunopathology, 44(3), 375-390. https://doi.org/10.1007/s00281-022-00928-6
Makhmudova, A. (2020). Guarantee of legal basis of supporting human rights in new level of Uzbekistan’s development. International Journal of Advanced Science and Technology, 29(5), 1761–1770.
Makhmudova, A. (2020). Organizational and economic reasons preventing the development of ecological tourism in Uzbekistan. Journal of Advanced Research in Dynamical and Control Systems, 12(6), 1217–1220.
Makhmudova, A. N. (2020). Factors and means of the content of legal socialization of the individual in modern civil society. Journal of Advanced Research in Dynamical and Control Systems, 12(7 Special Issue), 2038–2046.
Ministry of Health of the Russian Federation. (2016). Idiopathic pulmonary fibrosis. Clinical Recommendations, 44C.
Mirekina, E. V., Yarmukhamedova, N. A., Galimzyanov, Kh. M., & Cherenova, L. P. (2020). Differential diagnostics of the Crimean hemorrhagic fever and measles at the modern stage. Infectious Diseases: News, Opinions, Training, 9(1), 103–108.
Mukhin, N. A. (Ed.). (2007). Interstitial lung diseases. Litterra.
Odilov, A., Volkov, A., Abdullaev, A., Gasanova, T., & Lipina, T. (2021). COVID-19: Multiorgan dissemination of SARS-CoV-2 is driven by pulmonary factors. Viruses, 14(1), 39. https://doi.org/10.3390/v14010039
Sebastiani, M., Faverio, P., Manfredi, A., Cassone, G., Vacchi, C., Stainer, A., Pozzi, M. R., Salvarani, C., Pesci, A., & Luppi, F. (2020). Interstitial pneumonia with autoimmune features: Why rheumatologist-pulmonologist collaboration is essential. Biomedicines, 9(1), 17. https://doi.org/10.3390/biomedicines9010017
Shodikulova, G. Z., & Babamuradova, Z. B. (2020). Assessment of extracellular matrix condition in persons with undifferentiated connective tissue dysplasia. International Journal of Pharmaceutical Research, 2850. https://doi.org/10.31838/ijpr/2020.SP1.265
Shodikulova, G. Z., & Babamuradova, Z. B. (2020). Occurrence of clinical options of undifferentiated connective tissue dysplasia in Uzbek population. International Journal of Psychosocial Rehabilitation, 24(2), 1347-1359.
Sommer, N., & Schmeck, B. (2022). Pulmonale manifestationen bei long-COVID [Pulmonary manifestations in long COVID]. Innere Medizin (Heidelberg), 63(8), 819-829. https://doi.org/10.1007/s00108-022-01371-3
Teoh, A. K. Y., & Corte, T. J. (2020). Nonspecific interstitial pneumonia. Seminars in Respiratory and Critical Care Medicine, 41(2), 184-201. https://doi.org/10.1055/s-0040-1708499
Tomassetti, S., Ryu, J. H., Piciucchi, S., Chilosi, M., & Poletti, V. (2016). Nonspecific interstitial pneumonia: What is the optimal approach to management? Seminars in Respiratory and Critical Care Medicine, 37(3), 378-394. https://doi.org/10.1055/s-0036-1583176
Vershinina, M. V. (2013). Idiopathic interstitial pneumonia. Attending Physician, 1, 3-9.
Xu, W., Xiao, Y., Liu, H., Qin, M., Zheng, W., & Shi, J. (2014). Nonspecific interstitial pneumonia: Clinical associations and outcomes. BMC Pulmonary Medicine, 14, 175. https://doi.org/10.1186/1471-2466-14-175
Zabozlaev, F. G., Kravchenko, E. V., Gallyamova, A. R., & Letunovsky, N. N. (2020). Pathological anatomy of the lungs in new coronavirus infection (COVID-19). Preliminary analysis of autopsy studies. Clinical Practice, 11(2). https://doi.org/10.17816/clinpract34849
View Dimensions
View Altmetric
Save
Citation
View
Share