Synthesis, Characterization, and Antimicrobial Activity of Spiro Heterocyclic Compounds from Statin
Zubaida Amir Al-Heety 1, Ali Kareem Al-Nasseri 2*
Journal of Angiotherapy 8(4) 1-8 https://doi.org/10.25163/angiotherapy.849525
Submitted: 01 March 2024 Revised: 02 April 2024 Published: 05 April 2024
Abstract
Background: Spiro compounds, particularly spiro heterocyclic compounds, are significant in various scientific domains due to their prevalence in natural products and their potential applications in medicines and functional materials. Heterocyclic compounds, including spiro compounds, constitute a diverse family of chemical substances with unique properties that make them relevant in biology, materials research, and medicinal chemistry. Computational chemistry techniques, particularly density functional theory (DFT), offer a means to explore the structural and electronic properties of these compounds, aiding in understanding their behavior and potential applications. Methods: In this study, a series of spiro heterocyclic compounds were synthesized from isatin and primary derivatives using various reagents. The compounds were characterized using various analytical techniques such as FT-IR, NMR spectroscopy, and mass spectrometry. Additionally, the electronic properties and geometric optimization of the synthesized compounds were investigated using computational methods based on DFT. Results: The synthesis of spiro heterocyclic compounds yielded moderate to good yields, which were confirmed by spectroscopic data. Biological evaluation of some synthesized compounds revealed antibacterial and antifungal activities against various strains of bacteria and fungi. Computational analysis provided insights into the geometric optimization and electronic properties of the compounds, shedding light on their stability and reactivity. Conclusion: The synthesis and characterization of spiro heterocyclic compounds, along with their biological evaluation and computational analysis, provide valuable information about their potential applications in various fields. The study demonstrates the versatility of spiro compounds and highlights their importance in medicinal chemistry and materials science. Further research on the synthesis and properties of spiro compounds could lead to the development of novel drugs and functional materials with enhanced efficacy and performance.
Keywords: Spiro compounds, Heterocyclic compounds, Synthesis, Density functional theory, Antibacterial, Antifungal.
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