Risk Factors for Mycobacterium Tuberculosis Infection Among HIV/AIDS Populations in China
Zhao Junpeng1,2,3, Richard Avoi1*, Azman Bin Atil Azmi1, Zheng Baiqin2, Wang Lei2, Qiang Rundong2, Cao Huihui2, Gao Weilin2, Zhang Xu2, Du Ruihuan2, Yao Yuhong4, Qi Wenjie4, Wang Lifang5
Journal of Angiotherapy 8(10) 1-7 https://doi.org/10.25163/angiotherapy.81010001
Submitted: 30 August 2024 Revised: 19 October 2024 Published: 21 October 2024
Abstract
Background: HIV/TB coinfection remains a significant concern, particularly in high-risk populations. In China, the HIV/AIDS population is at a heightened risk for TB, with those infected showing a 20-37 times higher likelihood of developing TB. This study aims to explore factors contributing to Mycobacterium tuberculosis (MTB) infection within the HIV/AIDS population in Hebei Province, China, a region with a notable TB burden despite its moderate HIV prevalence. Method: A retrospective cohort study was conducted using data from the Infectious Disease Monitoring System of the China Center for Disease Control and Prevention (IDMS CDC). Data were collected from HIV/AIDS patients in high-risk counties of Hebei Province, focusing on demographic, clinical, and transmission-related factors. A total of 608 HIV/AIDS patients were included, with 504 completing the cohort study. The analysis employed Cox proportional hazards regression to assess the relationship between transmission routes, CD4+ T lymphocyte counts, and MTB infection. Results: Among the 504 participants, 54 developed TB, with significant correlations found between transmission routes and initial CD4+ T lymphocyte counts. HIV patients with a same-sex transmission route were 4.77 times more likely to develop TB compared to those with blood-borne transmission. Furthermore, individuals with an initial CD4+ count of 0–350/μl had nearly three times the risk of TB infection compared to those with higher counts. These findings highlight the critical role of immune status and transmission routes in determining TB infection risk. Conclusion: This study underscores the importance of CD4+ T lymphocyte counts and transmission routes as key predictors of TB risk in HIV-positive individuals. Tailored interventions, including targeted TB screening for MSM populations and those with lower CD4+ counts, are crucial for improving TB prevention and control.
Keywords: HIV-TB coinfection, Hebei Province, CD4+ T lymphocytes, Transmission routes, Tuberculosis prevention.
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