Microbial Bioactives
Microbial Bioactives | Online ISSN 2209-2161
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Volume 9 Number 1 2026
REVIEWS (Open Access)
Blockchain-Based Traceability as a Foundational Enabler of Trust, Safety, and Sustainability in Modern Production Systems: A Systematic Review and Meta-Analytical Synthesis
Lahcen Hassani 1*, Marcello Iriti 2, Sara Vitalini 2, Chaima Alaoui Jamali 3, Ayoub Kasrati 4, Ahmed Nafis 5
Microbial Bioactives 9 (1) 1-8 https://doi.org/10.25163/microbbioacts.9110622
Submitted: 02 January 2026 Revised: 25 February 2026 Accepted: 05 March 2026 Published: 07 March 2026
Abstract
Modern production systems across agriculture, biomedicine, materials science, and engineering are increasingly challenged by fragmented supply chains, declining consumer trust, environmental pressures, and recurring safety failures. These challenges have intensified the demand for transparent, reliable, and sustainable frameworks capable of ensuring product integrity across complex value chains. Drawing on evidence synthesized from systematic reviews and meta-analytical studies, this work situates blockchain-based traceability (BBT) within a broader interdisciplinary landscape that includes food safety governance, natural bioactive compound research, sustainable material development, and bio-inspired design methodologies. In the agricultural sector, repeated food safety crises and the limitations of centralized traceability systems have exposed critical gaps in transparency, data integrity, and rapid response capability. Blockchain technology, characterized by decentralization, immutability, and shared consensus, has emerged as a promising infrastructure to address these deficiencies by enabling end-to-end, tamper-resistant traceability. Parallel challenges in pharmaceutical and nutraceutical research—particularly concerning the sourcing, reproducibility, and safety of natural compounds—further underscore the importance of verifiable data systems. Similarly, sustainability-driven industries such as smart textiles and advanced materials face growing scrutiny over unverifiable environmental claims and lifecycle impacts, reinforcing the need for trusted data governance. Bio-inspired design approaches complement these technological advances by offering systematic, data-driven methods for integrating performance, resilience, and environmental harmony. Collectively, the evidence highlights blockchain-based traceability not as an isolated technological intervention but as a foundational enabler of trust, accountability, and sustainability across diverse sectors. This synthesis provides a conceptual basis for evaluating BBT through systematic review and meta-analysis, supporting its role in future intelligent and sustainable production systems. Keywords: Blockchain-based traceability; food safety; supply chain transparency; sustainability; bioactive compounds; biomimetic design; systematic review; meta-analysis
References
Angelis, J., & Ribeiro da Silva, E. (2019). Blockchain adoption: A value driver perspective. Business Horizons, 62(3), 307–314. https://doi.org/10.1016/j.bushor.2018.12.001
Antonucci, F., Figorilli, S., Costa, C., Pallottino, F., Raso, L., & Menesatti, P. (2019). A review on blockchain applications in the agri-food sector. Journal of the Science of Food and Agriculture, 99(14), 6129–6138. https://doi.org/10.1002/jsfa.9912
Atanasov, A. G., Waltenberger, B., Pferschy-Wenzig, E.-M., Linder, T., Wawrosch, C., Uhrin, P., … Stuppner, H. (2015). Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnology Advances, 33(8), 1582–1614. https://doi.org/10.1016/j.biotechadv.2015.08.001
Aung, M. M., & Chang, Y. S. (2014). Traceability in a food supply chain: Safety and quality perspectives. Food Control, 39, 172–184. https://doi.org/10.1016/j.foodcont.2013.11.007
Azzi, R., Chamoun, R. K., & Sokhn, M. (2019). The power of a blockchain-based supply chain. Computers & Industrial Engineering, 135, 582–592. https://doi.org/10.1016/j.cie.2019.06.042
Babaei, A., Khedmati, M., Akbari Jokar, M. R., & Tirkolaee, E. B. (2023). Designing an integrated blockchain-enabled supply chain network under uncertainty. Scientific Reports, 13(1), 3928. https://doi.org/10.1038/s41598-023-30439-9
Babu, S., & Devarajan, H. (2023). Agro-food supply chain traceability using blockchain and IPFS. International Journal of Advanced Computer Science and Applications, 14, 0140142. https://doi.org/10.14569/IJACSA.2023.0140142
Bayramova, A., Edwards, D. J., & Roberts, C. (2021). The role of blockchain technology in augmenting supply chain resilience to cybercrime. Buildings, 11(7), 283. https://doi.org/10.3390/buildings11070283
Bosona, T., & Gebresenbet, G. (2013). Food traceability as an integral part of logistics management in food and agricultural supply chain. Food Control, 33(1), 32–48. https://doi.org/10.1016/j.foodcont.2013.02.004
Casino, F., Dasaklis, T. K., & Patsakis, C. (2019). A systematic literature review of blockchain-based applications: Current status, classification and open issues. Telematics and Informatics, 36, 55–81. https://doi.org/10.1016/j.tele.2018.11.006
Delmas, M. A., & Burbano, V. C. (2011). The drivers of greenwashing. California Management Review, 54(1), 64–87. https://doi.org/10.1525/cmr.2011.54.1.64
Deng, Y., Zhu, H., Xing, J., Gao, J., Duan, J., Liu, P., … Cai, X. (2025). The role of natural products in improving lipid metabolism disorder-induced mitochondrial dysfunction of diabetic kidney disease. Frontiers in Physiology, 16, 1624077. https://doi.org/10.3389/fphys.2025.1624077
Deshmukh, A., Patil, D., Tyagi, A. K., & Arumugam, S. (2022). Recent trends on blockchain for Internet of Things-based applications: Open issues and future trends. In Proceedings of the Fourteenth International Conference on Contemporary Computing (IC3-2022) (pp. 484–492). Association for Computing Machinery. https://doi.org/10.1145/3549206.3549289
Duan, J., Zhang, C., Gong, Y., Brown, S., & Li, Z. (2020). A content-analysis-based literature review on blockchain adoption within the food supply chain. International Journal of Environmental Research and Public Health, 17, 1784. https://doi.org/10.3390/ijerph17051784
Ekawati, R., Arkeman, Y., Suprihatin, S., & Sunarti, T. C. (2022). Implementation of Ethereum blockchain on transaction recording of white sugar supply chain data. Indonesian Journal of Electrical Engineering and Computer Science, 29(1), 396–403. https://doi.org/10.11591/ijeecs.v29.i1.pp396-403
Falcone, E. C., Steelman, Z. R., & Aloysius, J. A. (2021). Understanding managers' reactions to blockchain technologies in the supply chain: The reliable and unbiased software agent. Journal of Business Logistics, 42(1), 25–45. https://doi.org/10.1111/jbl.12263
Fan, Z.-P., Wu, X.-Y., & Cao, B.-B. (2022). Considering the traceability awareness of consumers: Should the supply chain adopt the blockchain technology? Annals of Operations Research, 309(2), 837–860. https://doi.org/10.1007/s10479-020-03729-y
Friedman, N., & Ormiston, J. (2022). Blockchain as a sustainability-oriented innovation? Opportunities for and resistance to blockchain technology as a driver of sustainability in global food supply chains. Technological Forecasting and Social Change, 175, 121403. https://doi.org/10.1016/j.techfore.2021.121403
Gupta, R., & Shankar, R. (2023). Managing food security using a blockchain-enabled traceability system. Benchmarking: An International Journal. Advance online publication. https://doi.org/10.1108/BIJ-01-2022-0029
Hariharan, R., Tyagi, A. K., & Soni, G. (2023). A survey on blockchain-Internet of Things-based solutions. In Privacy preservation and secured data storage in cloud computing. IGI Global. https://doi.org/10.4018/979-8-3693-0593-5.ch005
Iftekhar, A., Cui, X., Hassan, M., & Afzal, W. (2020). Application of blockchain and Internet of Things to ensure tamper-proof data availability for food safety. Journal of Food Quality, 2020, 5385207. https://doi.org/10.1155/2020/5385207
Jayaprakash, V., & Tyagi, A. K. (2022). Security optimization of resource-constrained Internet of Healthcare Things (IoHT) devices using asymmetric cryptography for blockchain network. In D. Giri, J. K. Mandal, K. Sakurai, & D. De (Eds.), Proceedings of the International Conference on Network Security and Blockchain Technology (ICNSBT 2021) (Lecture Notes in Networks and Systems, Vol. 481). Springer. https://doi.org/10.1007/978-981-19-3182-6_18
Kelepouris, T., Pramatari, K., & Doukidis, G. (2007). RFID-enabled traceability in the food supply chain. Industrial Management & Data Systems, 107(2), 183–200. https://doi.org/10.1108/02635570710723804
Kostakis, I., & Tsagarakis, K. P. (2022). The role of entrepreneurship, innovation and socioeconomic development on circularity rate: Empirical evidence from selected European countries. Journal of Cleaner Production, 348, 131267. https://doi.org/10.1016/j.jclepro.2022.131267
Kouhizadeh, M., Saberi, S., & Sarkis, J. (2021). Blockchain technology and the sustainable supply chain: Theoretically exploring adoption barriers. International Journal of Production Economics, 231, 107831. https://doi.org/10.1016/j.ijpe.2020.107831
Kumar, A., Liu, R., & Shan, Z. (2020). Is blockchain a silver bullet for supply chain management? Technical challenges and research opportunities. Decision Sciences, 51(1), 8–37. https://doi.org/10.1111/deci.12396
Leicht, K., Okpala, C. O. R., Nowicka, P., Pérez-Alvarez, J. A., & Korzeniowska, M. (2025). Antioxidant, polyphenol, physical, and sensory changes in myofibrillar protein gels supplemented with polyphenol-rich plant-based additives. Nutrients, 17(7), 1232. https://doi.org/10.3390/nu17071232
Lv, G., Xu, Z., & Zhang, Y. (2023). Blockchain-based traceability systems in agriculture: A systematic review. Agriculture, 13(9), 1757. https://doi.org/10.3390/agriculture13091757
Nair, M. M., & Tyagi, A. K. (2023). Blockchain technology for next-generation society: Current trends and future opportunities for the smart era. In Blockchain technology for secure social media computing. IET. https://doi.org/10.1049/PBSE019E_ch11
Niinimäki, K., Peters, G., Dahlbo, H., Perry, P., Rissanen, T., & Gwilt, A. (2020). The environmental price of fast fashion. Nature Reviews Earth & Environment, 1, 189–200. https://doi.org/10.1038/s43017-020-0039-9
Pandey, A. A., Fernandez, T. F., Bansal, R., & Tyagi, A. K. (2022). Maintaining scalability in blockchain. In A. Abraham, N. Gandhi, T. Hanne, T. P. Hong, T. N. Rios, & W. Ding (Eds.), Intelligent Systems Design and Applications (ISDA 2021) (Lecture Notes in Networks and Systems, Vol. 418). Springer. https://doi.org/10.1007/978-3-030-96308-8_4
Pournader, M., Shi, Y., Seuring, S., & Koh, S. L. (2020). Blockchain applications in supply chains, transport and logistics: A systematic review of the literature. International Journal of Production Research, 58(7), 2063–2081. https://doi.org/10.1080/00207543.2019.1650976
Saaty, T. L. (2008). Decision making with the analytic hierarchy process. International Journal of Services Sciences, 1(1), 83–98. https://doi.org/10.1504/IJSSCI.2008.017590
Saberi, S., Kouhizadeh, M., Sarkis, J., & Shen, L. (2019). Blockchain technology and its relationships to sustainable supply chain management. International Journal of Production Research, 57(7), 2117–2135. https://doi.org/10.1080/00207543.2018.1533261
Shin, K., Park, G., Choi, J. Y., & Choy, M. (2017). Factors affecting the survival of SMEs: A study of biotechnology firms in South Korea. Sustainability, 9(1), 108. https://doi.org/10.3390/su9010108
Tribis, Y., El Bouchti, A., & Bouayad, H. (2018). Supply chain management based on blockchain: A systematic mapping study. MATEC Web of Conferences, 200, 00020. https://doi.org/10.1051/matecconf/201820000020
Tyagi, A. K. (2023). Decentralized everything: Practical use of blockchain technology in future applications. In R. Pandey, S. Goundar, & S. Fatima (Eds.), Distributed computing to blockchain (pp. 19–38). Academic Press. https://doi.org/10.1016/B978-0-323-96146-2.00010-3
Vincent, J. F. V., Bogatyreva, O. A., Bogatyrev, N. R., Bowyer, A., & Pahl, A.-K. (2006). Biomimetics: Its practice and theory. Journal of the Royal Society Interface, 3(9), 471–482. https://doi.org/10.1098/rsif.2006.0127
Vyas, S., Shabaz, M., Pandit, P., Parvathy, L. R., & Ofori, I. (2022). Integration of artificial intelligence and blockchain technology in healthcare and agriculture. Journal of Food Quality, 2022, 4228448. https://doi.org/10.1155/2022/4228448
Wang, Y., Han, J. H., & Beynon-Davies, P. (2019). Understanding blockchain technology for future supply chains: A systematic literature review and research agenda. Supply Chain Management: An International Journal, 24(1), 62–84. https://doi.org/10.1108/SCM-03-2018-0148
Xue, X., Dou, J., & Shang, Y. (2021). Blockchain-driven supply chain decentralized operations: An information-sharing perspective. Business Process Management Journal, 27(1), 184–203. https://doi.org/10.1108/BPMJ-12-2019-0518
Yakubu, B. M., Latif, R., Yakubu, A., Khan, M. I., & Magashi, A. I. (2022). RiceChain: Secure and traceable rice supply chain framework using blockchain technology. PeerJ Computer Science, 8, e801. https://doi.org/10.7717/peerj-cs.801
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