Chlamydia trachomatis Infection: Clinical Burden, Diagnostic Approaches, and Evidence-Based Nursing Management

Nader Saad Awad Al-Mutairi; Faisal Zabin Hashar Alotaibi; Mohammad Naseer Ali Alqahtani; Muteb Abdullah Almutairi; 2; Faris Muqbil Alotaibi; 2; Hzam Alkorbi Zid Aldossri; 3; Abdullah Abdalalhelal; and Rakan Jadi Al-Harbi

doi:10.25163/angiotherapy.8810729

Integrative Biomedical Research

Integrative Biomedical Research (Journal of Angiotherapy) | Online ISSN 3068-6326

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Volume 8 Number 8 2024

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Chlamydia trachomatis Infection: Clinical Burden, Diagnostic Approaches, and Evidence-Based Nursing Management

Nader Saad Awad Al-Mutairi ¹, Faisal Zabin Hashar Alotaibi ¹, Mohammad Naseer Ali Alqahtani ¹, Muteb Abdullah Almutairi ^1,2, Faris Muqbil Alotaibi ^1,2, Hzam Alkorbi Zid Aldossri^2,3, Abdullah Abdalalhelal ³, and Rakan Jadi Al-Harbi ³

+ Author Affiliations

Journal of Angiotherapy 8 (8) 1-8 https://doi.org/10.25163/angiotherapy.8810729

Submitted: 27 May 2024 Revised: 26 July 2024 Published: 04 August 2024

Abstract

Chlamydia trachomatis infection remains one of the most frequently reported bacterial sexually transmitted infections worldwide and continues to pose a substantial burden on reproductive, sexual, and public health. Its clinical significance is complicated by the fact that many infections remain asymptomatic, allowing silent transmission and delayed diagnosis. If left untreated, Chlamydia may progress to serious complications, including pelvic inflammatory disease, infertility, ectopic pregnancy, epididymitis, conjunctivitis, and other systemic sequelae. In this context, early recognition, appropriate treatment, and nursing-led prevention strategies are particularly important. This updated narrative review synthesizes current evidence on the epidemiology, pathophysiology, clinical manifestations, risk factors, diagnostic evaluation, medical treatment, and nursing management of C. trachomatis infection. Particular emphasis was placed on multidisciplinary care, patient education, partner management, and health promotion strategies relevant to routine clinical and nursing practice. The review highlights that C. trachomatis infection frequently presents with absent or nonspecific symptoms despite its capacity to cause considerable reproductive and systemic morbidity. Nucleic acid amplification testing remains the diagnostic gold standard due to its high sensitivity and applicability across multiple specimen types. Recommended management includes timely antimicrobial therapy, screening of high-risk populations, partner notification, follow-up testing, and behavioral counseling. Nursing care plays a central role in improving treatment adherence, reducing stigma, supporting psychosocial well-being, and strengthening prevention efforts through education and coordinated care. Effective control of Chlamydia infection requires more than antibiotic treatment alone. It depends on timely diagnosis, patient-centered nursing interventions, partner management, and sustained public health strategies aimed at reducing reinfection, complications, and ongoing transmission.

Keywords: Chlamydia trachomatis, Sexually transmitted infection, Nucleic acid amplification test, Nursing management, Pelvic inflammatory disease

References

Banniettis, N., Wisecup, K., Boland, L., Watanabe, I., Hammerschlag, M. R., & Kohlhoff, S. (2021). Association of routine Chlamydia trachomatis screening during pregnancy and seroprevalence of chlamydial infection in children, 1991–2015. Journal of the Pediatric Infectious Diseases Society, 10(2), 172–174.

Crichton, J., Hickman, M., Campbell, R., Batista-Ferrer, H., & Macleod, J. (2015). Socioeconomic factors and other sources of variation in the prevalence of genital chlamydia infections: A systematic review and meta-analysis. BMC Public Health, 15, 729.

Currenti, S., O’Grady, T., Bomma, S., Gurram, N., Miranda, W., & Hart-Malloy, R. (2024). Epidemiology of Chlamydia trachomatis and repeat positivity following detection in New York State. Journal of Public Health Management and Practice, 30(5), E215–E223.

Detels, R., Green, A. M., Klausner, J. D., Katzenstein, D., Gaydos, C., Handsfield, H., Pequegnat, W., Mayer, K., Hartwell, T. D., & Quinn, T. C. (2011). The incidence and correlates of symptomatic and asymptomatic Chlamydia trachomatis and Neisseria gonorrhoeae infections in selected populations in five countries. Sexually Transmitted Diseases, 38(6), 503–509.

Ekabe, C. J., Kehbila, J., Njim, T., Kadia, B. M., Tendonge, C. N., & Monekosso, G. L. (2017). Chlamydia trachomatis-induced Fitz-Hugh-Curtis syndrome: A case report. BMC Research Notes, 10(1), 10.

Habtamu, E., Harding-Esch, E. M., Greenland, K., Wamyil-Mshelia, T., Talero, S. L., Mishra, S. K., Lietman, T. M., Solomon, A. W., & Burton, M. J. (2025). Trachoma. The Lancet, 405(10492), 1865–1878.

Hao, S., Tao, G., Pearson, W. S., Rochlin, I., Phillips, R. L., Rehkopf, D. H., & Kamdar, N. (2025). Treatment of chlamydia and gonorrhea in primary care and its patient-level variation: An American family cohort study. Annals of Family Medicine, 23(2), 136–144.

Hocking, J. S., Geisler, W. M., & Kong, F. Y. S. (2023). Update on the epidemiology, screening, and management of Chlamydia trachomatis infection. Infectious Disease Clinics of North America, 37(2), 267–288.

Kobayashi, S., & Kida, I. (2005). Reactive arthritis: Recent advances and clinical manifestations. Internal Medicine, 44(5), 408–412.

Mabey, D., & Peeling, R. W. (2002). Lymphogranuloma venereum. Sexually Transmitted Infections, 78(2), 90–92.

Mordhorst, C. H., & Dawson, C. (1971). Sequelae of neonatal inclusion conjunctivitis and associated disease in parents. American Journal of Ophthalmology, 71(4), 861–867.

Morré, S. A., Rozendaal, L., van Valkengoed, I. G., Boeke, A. J., van Voorst Vader, P. C., Schirm, J., de Blok, S., van den Hoek, J. A., van Doornum, G. J., Meijer, C. J., & van den Brule, A. J. (2000). Urogenital Chlamydia trachomatis serovars in men and women with a symptomatic or asymptomatic infection: An association with clinical manifestations? Journal of Clinical Microbiology, 38(6), 2292–2296.

Murray, S. M., & McKay, P. F. (2021). Chlamydia trachomatis: Cell biology, immunology and vaccination. Vaccine, 39(22), 2965–2975.

O’Connell, C. M., & Ferone, M. E. (2016). Chlamydia trachomatis genital infections. Microbial Cell, 3(9), 390–403.

Owusu-Edusei, K., Chesson, H. W., Gift, T. L., Tao, G., Mahajan, R., Ocfemia, M. C., & Kent, C. K. (2013). The estimated direct medical cost of selected sexually transmitted infections in the United States, 2008. Sexually Transmitted Diseases, 40(3), 197–201.

Pelvic inflammatory disease. (2012). American Family Physician, 85(8), 797–798.

Redgrove, K. A., & McLaughlin, E. A. (2014). The role of the immune response in Chlamydia trachomatis infection of the male genital tract: A double-edged sword. Frontiers in Immunology, 5, 534.

Schachter, J., Grossman, M., Sweet, R. L., Holt, J., Jordan, C., & Bishop, E. (1986). Prospective study of perinatal transmission of Chlamydia trachomatis. JAMA, 255(24), 3374–3377.

Taylor-Robinson, D. (1997). Evaluation and comparison of tests to diagnose Chlamydia trachomatis genital infections. Human Reproduction, 12(Suppl. 11), 113–120.

Tipple, M. A., Beem, M. O., & Saxon, E. M. (1979). Clinical characteristics of the afebrile pneumonia associated with Chlamydia trachomatis infection in infants less than 6 months of age. Pediatrics, 63(2), 192–197.

Torrone, E., Papp, J., Weinstock, H., & Centers for Disease Control and Prevention. (2014). Prevalence of Chlamydia trachomatis genital infection among persons aged 14–39 years—United States, 2007–2012. MMWR. Morbidity and Mortality Weekly Report, 63(38), 834–838.

Workowski, K. A., Bachmann, L. H., Chan, P. A., Johnston, C. M., Muzny, C. A., Park, I., Reno, H., Zenilman, J. M., & Bolan, G. A. (2021). Sexually transmitted infections treatment guidelines, 2021. MMWR Recommendations and Reports, 70(4), 1–187.

Zhao, P., Liang, P., Wang, J., Xu, W., Huang, S., & Wang, C. (2025). Chlamydia cases in women of reproductive age, 2006–2020: An analysis of surveillance data from Southern China. BMC Public Health, 25(1), 158.

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Chlamydia trachomatis Infection: Clinical Burden, Diagnostic Approaches, and Evidence-Based Nursing Management

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